Aesthetic Surgery Journal最新文献

{"title":"Multiplex CD30/Carbonic Anhydrase IX Lateral Flow Assay for Rapid Triage of Suspected BIA-ALCL in Peri-implant Seroma Fluid.","authors":"Peng Xu, Katerina Kourentzi, Richard Willson, Honghua Hu, Anand Deva, William P Adams, Caroline Glicksman, Patricia McGuire, Christopher Campbell, Marshall Kadin","doi":"10.1093/asj/sjag066","DOIUrl":"10.1093/asj/sjag066","url":null,"abstract":"<p><strong>Background: </strong>Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare lymphoma associated with textured implants. Earlier detection and timely implant removal/capsulectomy reduce morbidity and improve outcomes. CD30 is a sensitive biomarker for BIA-ALCL; carbonic anhydrase IX (CA9) has been identified as a complementary marker in effusion samples.</p><p><strong>Objectives: </strong>The aim was to develop and evaluate a multiplex lateral flow assay (LFA) for CD30 and CA9 in peri-implant seroma fluid/effusions to support rapid clinical triage of suspected BIA-ALCL.</p><p><strong>Methods: </strong>Recombinant CD30 and CA9 were spiked into benign seroma matrix to establish assay detection range under defined conditions. A retrospective cohort of 50 seroma samples (25 pathologically confirmed BIA-ALCL; 25 benign seromas) was tested. Performance was assessed by (1) visual interpretation; (2) image-based quantification (test line/control line ratio, TL/CL); and (3) combined interpretation approach. Sensitivity, specificity, predictive values (study-conditional), and receiver operating characteristic/area under the curve (ROC/AUC) were calculated.</p><p><strong>Results: </strong>In matrix spike-in experiments, CD30 was detectable down to 500 pg/mL; CA9 was detectable down to 1000 pg/mL. In clinical samples, both CD30 and CA9 TL/CL were significantly higher in BIA-ALCL than benign seromas. Visual interpretation yielded 76% sensitivity and 88% specificity. Image-based interpretation increased sensitivity to 96% but reduced specificity to 80%. A prespecified combined interpretation approach maintained 96% sensitivity and 88% specificity (positive predictive value [PPV] 89%, negative predictive value [NPV] 96% within this case-control cohort). ROC analysis demonstrated AUC of 0.96 for CD30 and 0.85 for CA9.</p><p><strong>Conclusions: </strong>In this retrospective cohort, a multiplex CD30/CA9 LFA distinguished BIA-ALCL from benign peri-implant seromas with high sensitivity and favorable study-conditional NPV, supporting feasibility as a rapid triage adjunct to prioritize confirmatory pathology. Prospective studies with standardized preanalytics, blinded interpretation, and prevalence-representative cohorts are required to establish real-world predictive values and clinical utility.</p><p><strong>Level of evidence: 3 (therapeutic): </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1205-1211"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review on Mechanically Micronized Adipose-Derived Products: Technological Innovations and Regenerative Potential.","authors":"Xuan Ma, Zhijin Li, Yuqiao Zhang, Miao Dong, Facheng Li, Xiaojun Wang","doi":"10.1093/asj/sjag025","DOIUrl":"10.1093/asj/sjag025","url":null,"abstract":"<p><p>Adipose-derived stromal vascular fraction (SVF) is a cornerstone of regenerative medicine, yet traditional enzymatic digestion faces significant regulatory and technical hurdles. This scoping review systematically categorizes mechanical micronization and purification techniques as viable alternatives, following PRISMA-ScR guidelines across PubMed (National Institutes of Health, Bethesda, MD), MEDLINE (National Institutes of Health), and Embase (Elsevier, Amsterdam, the Netherlands). A total of 89 studies were analyzed, identifying 3 primary micronization techniques: shuffling-based emulsification, rotating blade systems, and filtration bag systems. Furthermore, we summarize 4 major postprocessing purification methods, including filtration, centrifugation, combined filtration centrifugation, and fluid washing. Based on these techniques, final adipose-derived products are categorized into 2 distinct types: mechanically processed SVF (mSVF) combined with adipocytes and mSVF concentrates, each offering unique structural and functional properties. Our findings highlight that mechanical processing provides a promising, regulatory-friendly approach that prioritizes the preservation of the adipose niche. This review offers plastic surgeons a comprehensive guide to selecting optimal mechanical processing parameters to enhance clinical outcomes in fat grafting and regenerative procedures. Future advancements should focus on further optimizing these parameters to develop next-generation regenerative products tailored to specific therapeutic applications. Level of Evidence: 3 (Therapeutic)  For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1263-1271"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: Multiplex CD30/Carbonic Anhydrase IX Lateral Flow Assay for Rapid Triage of Suspected BIA-ALCL in Peri-implant Seroma Fluid.","authors":"Mark W Clemens, Geoffrey C Gurtner","doi":"10.1093/asj/sjag111","DOIUrl":"10.1093/asj/sjag111","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1212-1213"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: Research Requirements for Residency Applicants Need to Be Reconsidered.","authors":"Andrew Y Zhang","doi":"10.1093/asj/sjag004","DOIUrl":"10.1093/asj/sjag004","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"NP145-NP147"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intramuscular Human Fat Grafting on Muscle Structure and Function Using Nude Mice.","authors":"Carolyn Kim, Bhavana Thota, Ariane Lazzarini, Jennifer Barillas, Tre Welch, Daniel Del Vecchio, Jeffrey M Kenkel, Yucel Akgul","doi":"10.1093/asj/sjag149","DOIUrl":"10.1093/asj/sjag149","url":null,"abstract":"<p><strong>Background: </strong>Intramuscular fat grafting is used for soft tissue augmentation, yet its effects on muscle structure and function remain unclear.</p><p><strong>Objectives: </strong>The aim of this study was to evaluate structural and functional outcomes of intramuscular fat grafting using human lipoaspirate in a nude mouse model and assess its regenerative potential.</p><p><strong>Methods: </strong>Fifty-nine female athymic mice received 100 µL injections of low-density fat (n = 20), high-density fat (n = 20), or saline (n = 19) into hind limb muscles. In vivo grip strength was measured weekly for 6 months. Ex vivo mechanical testing was performed at the study endpoint. Histology (hematoxylin and eosin, Masson's trichrome) assessed muscle architecture and fibrosis, whereas immunofluorescence with human-specific markers evaluated graft persistence and cellular contribution.</p><p><strong>Results: </strong>No statistically significant differences in muscle strength were observed between groups. Peak in vivo hind limb grip strength ranged from 82 to 96 grams-force (gf), with saline-treated limbs generally demonstrating higher final values (78 gf) than high-density (61 gf) and low-density fat groups (50 gf). Ex vivo peak force measured 9.0 ± 1.8 N (saline), 8.0 ± 0.4 N (high-density), and 7.8 ± 0.5 N (low-density). At 6 months, most adipocytes were resorbed and replaced by collagen-rich extracellular matrix. Fibrosis was greater in high-density fat grafts (25.49 ± 3.28%) than saline (19.42 ± 4.05%) or low-density fat (19.61 ± 3.53%). Limited new muscle formation was observed, predominantly of mouse origin.</p><p><strong>Conclusions: </strong>Intramuscular fat grafting resulted in transient graft survival followed by fibrosis and structural remodeling without functional improvement at 6 months, suggesting a primarily structural rather than regenerative role.</p><p><strong>Level of evidence: 4 (therapeutic): </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1193-1204"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Peptide Plastic Surgeon: A Review of Evidence on Regenerative Peptide Supplementation and Potential in Aesthetic Plastic Surgery.","authors":"Aaron L Wiegmann, Matthew J Trovato, Pedro González, Tara M Chadab, Rod J Rohrich","doi":"10.1093/asj/sjag020","DOIUrl":"10.1093/asj/sjag020","url":null,"abstract":"<p><p>Regenerative peptides are gaining attention in regenerative medicine and plastic surgery for their potential to enhance surgical recovery and tissue regeneration. This review synthesizes evidence on 4 key peptides-focusing on their potential applications in wound healing, scar optimization, and aesthetic plastic surgery. Preclinical studies show promise, safety profiles appear favorable, but rigorous clinical trials are lacking. The paucity of human studies highlights an urgent need for high-quality research. Plastic surgeons are well-positioned to lead investigations, integrating regenerative peptides into perioperative care and evaluating their ability to optimize outcomes in aesthetic procedures.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1253-1262"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Journey in Time: Aesthetic Surgery Research Evolution and Aesthetic Surgery Journal.","authors":"Ivona Percec, Yucel Akgul, Sebastian Cotofana, Anand Deva, Afshin Mosahebi","doi":"10.1093/asj/sjag045","DOIUrl":"10.1093/asj/sjag045","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":"46 11","pages":"1164-1167"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subdomal Graft Control of Nasal Tip Aesthetics: A Long-term Digital Photographic Evaluation.","authors":"Ramon Tarragona, Stefano Rubolino, Carlo Mirra, Osama Khouj, Paolo Persichetti","doi":"10.1093/asj/sjag143","DOIUrl":"10.1093/asj/sjag143","url":null,"abstract":"<p><strong>Background: </strong>Achieving long-term stability and symmetry of the nasal tip remains a challenge for rhinoplasty. Despite meticulous suturing techniques, postoperative deformities such as asymmetry or pinched tip can occur. The subdomal graft has been proposed to reinforce tip support, but its long-term efficacy compared with standard suturing remains unclear.</p><p><strong>Objectives: </strong>The aim of this study was to evaluate whether subdomal grafting improves long-term control of the interdomal angle and domal symmetry compared with standard tip suturing.</p><p><strong>Methods: </strong>A retrospective comparative study included 379 female patients undergoing primary closed preservation rhinoplasty between January 2022 and December 2023. Group 1 (n = 223) underwent standard tip suturing, whereas Group 2 (n = 156) received subdomal grafting. Standardized photographs were obtained intraoperatively and at 12 months postoperatively. Interdomal angle variation was measured by digital analysis (ImageJ/Fiji), and domal symmetry was independently assessed by 3 blinded plastic surgeons using a 3-point Likert scale.</p><p><strong>Results: </strong>The mean interdomal angle change from intraoperative to 12 months postoperative was 12.5° ± 7.5° in Group 1 and 6.3° ± 4.8° in Group 2 (P < .05). Mean domal symmetry scores were higher in the graft group (2.7 ± 0.35 vs 2.3 ± 0.41; P < .05). Revision surgery was required in 2 patients in Group 1 (0.9%) and 1 patient in Group 2 (0.6%).</p><p><strong>Conclusions: </strong>Subdomal grafting improves long-term control of the interdomal angle and enhances nasal tip symmetry compared with suturing alone, supporting more predictable and stable aesthetic outcomes in primary closed preservation rhinoplasty.</p><p><strong>Level of evidence: 3 (therapeutic): </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"NP133-NP141"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porous Architecture and Pressure-Induced Latent Injury: New Insights Into Large-Volume Fat Grafting.","authors":"Yuchen Zhang, Bin Li, Jiancong Liang, Yucheng Luo, Yinuo Chen, Yujin Lai, Ye Li, Feng Lu, Ziqing Dong","doi":"10.1093/asj/sjag133","DOIUrl":"10.1093/asj/sjag133","url":null,"abstract":"<p><strong>Background: </strong>Large-volume autologous fat grafting for aesthetic augmentation is often complicated by cysts and fibrosis, suggesting that its survival mechanisms differ from those of small-volume grafts.</p><p><strong>Objectives: </strong>This study aims to investigate the survival biology of large-volume fat grafts and evaluate the effects of mechanical pressure on tissue structure, viability, and long-term graft outcome.</p><p><strong>Methods: </strong>A 3-dimensional in vitro model using human adipose tissue in a scaffold was established. Constructs were cultured under 0, 6, or 12 mmHg of pressure to assess structural integrity, solute permeability, cell viability, and molecular changes. The viable outer layer was then transplanted into nude mice to evaluate volume retention, necrosis, and fibrosis.</p><p><strong>Results: </strong>In vitro, a porous interstitial network supported tissue survival to a depth of approximately 8 mm. Pressure dose-dependently disrupted this network, reducing solute permeability from 76.4% to 21.3% and impairing viability. Pressure also induced a form of \"latent injury,\" consistent with Yes-associated protein-related mechanotransductive signaling, lineage-related molecular changes and metabolic stress. In vivo, although gross volume retention was similar among groups, pressure-conditioned grafts developed marked necrosis, with fibrosis increasing from 22.1% in controls to 53.3% in the 12 mmHg group at 8 weeks.</p><p><strong>Conclusions: </strong>Large-volume fat graft survival depends in part on the integrity of a pressure-sensitive porous network. Mechanical pressure may induce a clinically relevant \"latent injury,\" consistent with molecular changes observed in vitro, which may contribute to later fibrosis. Minimizing mechanical stress during harvest, processing, handling, and implantation may help preserve graft integrity and improve long-term outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1184-1192"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Stromal Vascular Fraction for Scar Prevention: A Multicenter, Double-Blinded, Randomized Controlled Trial.","authors":"Jung Min Oh, Hyung Min Hahn, Young Chul Suh, Ki Yong Hong, Byung Jun Kim, Ung Sik Jin, Dong Won Lee","doi":"10.1093/asj/sjag018","DOIUrl":"10.1093/asj/sjag018","url":null,"abstract":"<p><strong>Background: </strong>Addressing postoperative scarring remains a significant challenge across all surgical procedures, often leading to long-term aesthetic deficits. Traditional methods for scar management have shown limited efficacy, prompting exploration into innovative approaches such as the application of stromal vascular fraction (SVF).</p><p><strong>Objectives: </strong>The efficacy of intraoperative SVF injection in modulating scar formation was assessed by evaluating postoperative scar quality in patients undergoing free tissue transfer.</p><p><strong>Methods: </strong>This multicenter, double-blinded, placebo-controlled, randomized study assessed the efficacy of intraoperative SVF injections in mitigating scar formation in patients undergoing free tissue transfer. A total of 45 patients were enrolled from 3 institutions, undergoing either breast reconstruction with abdominal flaps or soft tissue reconstruction with anterolateral thigh flaps. The donor site incision was split in half, with one side receiving SVF injections and the other saline injections, assigned randomly. Scar quality was evaluated using the Vancouver Scar Scale (VSS) and Patient Scar Assessment Questionnaire (PSAQ), along with objective measures of pigmentation using an analyzing device.</p><p><strong>Results: </strong>The primary analysis endpoint at 6 months after surgery showed a statistically significant improvement in VSS scores in the SVF group compared to the saline group. However, these differences were not maintained at the 9-month follow-up. PSAQ results indicated improved satisfaction with scar appearance at 6 and 9 months in the SVF group, despite no significant changes in erythema and melanin levels.</p><p><strong>Conclusions: </strong>Intraoperative SVF infection can improve postoperative scar appearance in patients undergoing free tissue transfer. This study supports further exploration of SVF as a potential tool for enhancing aesthetic outcomes in scar management.</p><p><strong>Level of evidence: 2 (therapeutic): </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1272-1280"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}