Aesthetic Surgery Journal最新文献

{"title":"A Controlled Phase 2b Trial to Assess the Efficacy and Safety of a Single Intervention of OnabotulinumtoxinA for Treating Masseter Muscle Prominence.","authors":"Steven Liew, Derek Jones, Steven Dayan, Sabrina Fabi, Alexander Rivkin, Brian Biesman, Tanya Brandstetter, Grace Pan, Julia K Garcia, Elisabeth Lee, Beta Bowen, Mitchell F Brin","doi":"10.1093/asj/sjaf042","DOIUrl":"10.1093/asj/sjaf042","url":null,"abstract":"<p><strong>Background: </strong>Masseter muscle prominence (MMP) is a benign condition characterized by a wide, square, or trapezoidal lower facial shape, which may be considered undesirable.</p><p><strong>Objectives: </strong>To evaluate onabotulinumtoxinA (onabotA) efficacy and safety for MMP treatment.</p><p><strong>Methods: </strong>In a Phase 2b study, adults with investigator- and participant-assessed bilateral Grade 4/5 MMP on the 5-grade MMP Scale (MMPS) and MMPS-Participant, respectively, were randomized 1:1:1 to receive a single intramuscular injection of onabotA 48 U, 72 U, or placebo in the masseter muscles. The primary endpoint was the proportion of patients achieving investigator-assessed MMPS Grade ≤3 at Day 90. Adverse events were monitored throughout.</p><p><strong>Results: </strong>Patients received onabotA 48 U (n = 53), 72 U (n = 46), or placebo (n = 46). Significantly greater proportions achieved MMPS Grade ≤3 with onabotA vs placebo (90.6%, 91.3%, and 21.7% for onabotA 48 U, 72 U, and placebo, respectively, at Day 90; P < .0001). Improvements in lower facial volume, width, and angle were significantly greater for onabotA vs placebo at all time points. At Day 90, the proportion of patients perceiving improvements was significantly greater with onabotA treatment vs placebo. Significantly more patients were \"satisfied/very satisfied\" with onabotA vs placebo through Day 180. Treatment was well tolerated; both onabotA groups had a similar incidence of treatment-emergent adverse events (TEAEs). Nasopharyngitis (onabotA, 3.9% vs placebo, 0%) and upper respiratory infection (2.9% vs 0%, respectively) were the most common TEAEs.</p><p><strong>Conclusions: </strong>One injection of onabotA 48 or 72 U was well tolerated and effective in reducing MMP severity as assessed by investigators and patients.</p><p><strong>Level of evidence: 1 (therapeutic): </strong></p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":"1043-1050"},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diced Cartilage Grafts Semi-wrapped in Rectus Abdominis Fascia for Nasal Dorsum Augmentation.","authors":"Kehui Niu, Hongbo Xie, Siying He, Zhe Wei, Qianying Liu, Ziyuan Ye, Hui Zhu, Damao Dai","doi":"10.1093/asj/sjaf183","DOIUrl":"https://doi.org/10.1093/asj/sjaf183","url":null,"abstract":"<p><strong>Background: </strong>Diced costal cartilage wrapped in autogenous fascia are favored by rhinoplasty surgeons because of their high stability and low resorption rate. However, the volume of fascial bags is difficult to adjust, and diced costal cartilage is prone to undernourished.</p><p><strong>Objectives: </strong>To investigate the clinical effect, long-term absorption rate and patient satisfaction of filling nasal dorsum with autogenous diced costal cartilage semi-wrapped in autogenous rectus abdominis fascia.</p><p><strong>Methods: </strong>From May 2020 to December 2022, a total of 95 patients with costal cartilage nasal repair were enrolled in this study. After constructing a nasal tip scaffold with costal cartilage, the autologous rectus abdominal fascia was introduced into the stripped dorsal nasal space and fixed at the golden point of the nasal root. The prepared autologous diced costal cartilage were injected into the dorsal nasal space, and shaped according to the height and curvature of the preoperative design.</p><p><strong>Results: </strong>During the follow-up of 18 to 24 months, the morphology was satisfactory, the bilateral transition was natural and smooth, and there was no graininess at the back of the nose. Four cases had slight depression in the nasal tip turning area more than half a year after operation. The absorption rate of the graft was about 10%.</p><p><strong>Conclusions: </strong>Autogenous diced costal cartilage semi-wrapped in autogenous rectus abdominis fascia have low absorption, relatively natural postoperative effect and high patient satisfaction as nasal dorsum filler. They may be particularly suitable for those who repair nose after infection, take nasal dorsal bone powder, and have thinning, redness and light transmission after thread carving.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of ICAP Flaps in the Transition From Cosmetic to Effective Modern Breast Surgery.","authors":"Donato Casella, Stefano Bacchini, Silvia Sordi, Nicola Rocco, Giuseppe Catanuto, Pietro Maria Ferrando, Alessandro Neri, Donato Abbaticchio, Alessia Pagnotta, Juste Kaciulyte","doi":"10.1093/asj/sjaf176","DOIUrl":"https://doi.org/10.1093/asj/sjaf176","url":null,"abstract":"<p><strong>Background: </strong>Breast conservation surgery (BCS) evolved with oncoplastic techniques to improve aesthetic outcomes while maintaining oncological safety. However, a lack of objective criteria for selecting appropriate reconstruction techniques remains.</p><p><strong>Objectives: </strong>This study presents a novel patient-centred decisional algorithm for oncoplastic breast surgery using intercostal artery perforator (ICAP) flaps, aiming to standardize techniques based on patient expectations and objective symmetry evaluation.</p><p><strong>Methods: </strong>A retrospective observational study was conducted including patients who underwent BCS between January 2020 and December 2023. The decisional algorithm guided surgical planning, considering patient preferences, pre-existing breast symmetry/asymmetry, and tumor location. Patient satisfaction was evaluated using BREAST-Q questionnaire, while symmetry outcomes were assessed by external surgeons using a visual analog scale (VAS).</p><p><strong>Results: </strong>Of 900 patients who underwent BCS, 256 (28.44%) required volume replacement with ICAP flaps. Contralateral symmetrization was performed in 86 patients (9.55%) and bilateral mastopexy or breast reduction in 180 cases (20%). During an average follow-up of 22 months, the rate of early minor complications was 10.2%. Major complications requiring reoperation occurred in 7.7% of cases. Post-operative BREAST-Q results showed significant improvement in satisfaction (p<0.05), while the mean aesthetic outcome score at 6 months was 4.1.</p><p><strong>Conclusions: </strong>The proposed patient-centred decisional algorithm incorporates both objective preoperative assessment and patient preferences, promoting a tailored approach that enhances functional and aesthetic outcomes while maintaining oncological safety. ICAP flaps represent valuable and less invasive tools for volume replacement, contributing to satisfactory symmetry outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Guidance for Botulinum Toxin Injection of Muscles Innervated by the Facial Nerve: A Systematic Review of Anatomical Precision, Safety, and Outcomes.","authors":"Raisa Chowdhury, Benjamin Schiff, Yan H Lee, Suresh Mohan","doi":"10.1093/asj/sjaf175","DOIUrl":"https://doi.org/10.1093/asj/sjaf175","url":null,"abstract":"<p><p>Botulinum toxin type A (BoNT-A) chemodenervation is commonly used for facial synkinesis and aesthetic indications, but landmark-based techniques are limited by anatomical variability and risk of off-target delivery. High-resolution ultrasound can be used to enhance precision and safety. This systematic review explores the role of ultrasound-guided BoNT-A facial chemodenervation in evaluating anatomical accuracy, clinical efficacy, complications, and patient satisfaction. A comprehensive search of six databases through April 2025 identified studies assessing ultrasound-guided BoNT-A chemodenervation for facial indications. Sixteen studies were included, comprising randomized controlled trials, prospective cohorts, cadaveric trials, and anatomical mapping investigations. Data on injection accuracy, clinical outcomes, adverse events, and patient-reported measures were extracted. Risk of bias was assessed using validated tools. Ultrasound guidance improved injection accuracy, with cadaveric trials demonstrating up to 88% accuracy, while landmark-based techniques reported 50%. Clinical studies reported improvements in rhytid reduction, oral commissure elevation, neck relaxation, and facial symmetry. Adverse events were infrequent and mild. Patient satisfaction was consistently higher with ultrasound guidance. Anatomical studies identified muscle depth variation and vascular risk zones, supporting real-time sonographic targeting. As a result, we found that ultrasound-guided BoNT-A chemodenervtion improves the safety, precision, and outcomes and should be considered in both therapeutic and aesthetic applications.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Inferior Epigastric Perforator In-Basket? Evaluation of Patient Electronic Communication Following Autologous Breast Reconstruction.","authors":"Skyler K Palmer, Ananya Shah, Zain Aryanpour, David Le, Julian Winocour, Christodoulos Kaoutzanis, David W Mathes, Katie G Egan","doi":"10.1093/asj/sjaf177","DOIUrl":"https://doi.org/10.1093/asj/sjaf177","url":null,"abstract":"<p><strong>Background: </strong>Patient electronic communication (PEC) via secure messaging is important for patient engagement. While PEC has been studied in primary care, data on surgical specialties, particularly plastic surgery, remain limited.</p><p><strong>Objectives: </strong>This study assessed the volume and content of post-discharge PECs among patients undergoing post-mastectomy autologous breast reconstruction.</p><p><strong>Methods: </strong>We conducted a retrospective mixed-methods study of PECs from patients undergoing autologous breast reconstruction at a large academic institution from January 2021 to December 2023. Primary outcomes included the quantity and thematic content of PECs sent within 30 days post-discharge. Covariates of interest included patient demographics, comorbidities, and operative details. Quantitative analysis included descriptive statistics and multivariable regression to identify predictors of PEC frequency. Qualitative content analysis was used to identify thematic categories of PECs.</p><p><strong>Results: </strong>A total of 297 patients underwent autologous breast reconstruction from January 2021 to December 2023. Of these, 230 patients (77.44%) sent 806 PECs within 30 days post-discharge. The most frequent message topics related to drains, wounds, pain, and activity restrictions. Younger age was a significant negative predictor of total PEC volume (p < .001) and wound-related (p=0.021) or pain-related (p<0.001) PECs, while immediate reconstruction was associated with more wound-related messages (p=0.011). Depression was a positive predictor of pain-related PECs (p=0.029).</p><p><strong>Conclusions: </strong>This is the first comprehensive study evaluating the quantity and content of post-discharge PECs in a large cohort of patients undergoing autologous breast reconstruction. Understanding volume and content of PEC following autologous breast reconstruction may inform strategies for improving perioperative patient education.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Breast Reconstruction Strategies Using Exclusive Lipofilling or Prosthesis After Total Mastectomy for Breast Cancer: Satisfaction and Morbidity After More Than 2 Years.","authors":"Matthieu Beque, Gabrielle Aubry, Jean-Christophe Bichet, Catherine Uzan, Geoffroy Canlorbe","doi":"10.1093/asj/sjaf174","DOIUrl":"https://doi.org/10.1093/asj/sjaf174","url":null,"abstract":"<p><strong>Background: </strong>Total mastectomy for breast cancer is an impactful procedure, and breast reconstruction plays a crucial role for women diagnosed with the disease.</p><p><strong>Objectives: </strong>The objective of our study is to compare satisfaction, morbidity, and timelines of two breast reconstruction techniques after breast cancer: breast prosthesis and exclusive lipofilling.</p><p><strong>Methods: </strong>This is a comparative, retrospective, unicentric study on patients who underwent total mastectomy between May 2014 and May 2020. Satisfaction is assessed using the BREAST-Q questionnaire at least 2 years after the start of the reconstruction (4.8 (± 0.16) years in the implant group and 5.4 (± 0.12) years the lipofilling group, p value = 0.044). Morbidity is evaluated using the Clavien-Dindo classification.</p><p><strong>Results: </strong>One hundred and one patients were included in the study (60 in the prosthesis group and 41 in the lipofilling group). The response rate to the questionnaire was 63.3% (38 patients) in the prosthesis group and 70.7% (29 patients) in the lipofilling group. The lipofilling technique appears to provide better satisfaction for the \"sexual well-being\" item of the BREAST-Q in multivariate analysis (65.75 +/-1.92 versus 54.87 +/-1.46, multivariate p-value = 0.03). Major complication (grade III, IV or V) rate was 20% in the prosthesis reconstruction group compared to 0% in the lipofilling group (multivariate p-value = 0.05). Lipofilling often requires longer reconstruction times, but reoperations are more frequent in prosthesis reconstruction, extending the reconstruction periods.</p><p><strong>Conclusions: </strong>Our data should be confirmed by other studies to better guide the choice of reconstruction type.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Considerations on Polyurethane-coated Implants in Breast Reconstruction.","authors":"Manuel Cabrera Charleston, Daniela Guadalupe Oscura Paredes","doi":"10.1093/asj/sjaf171","DOIUrl":"https://doi.org/10.1093/asj/sjaf171","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Montelukast vs Tranilast Administration in the Prevention of Capsular Contracture in Alloplastic Breast Surgeries: An Experimental Mice Model.","authors":"Yidan Xu, Shujie Xu, Han Yang, Yuchen Zhang, Cheng Zhou, Feng Lu, Jianhua Gao, Yao Yao","doi":"10.1093/asj/sjaf143","DOIUrl":"https://doi.org/10.1093/asj/sjaf143","url":null,"abstract":"<p><strong>Background: </strong>Capsular contracture remains a prevalent complication following breast implant augmentation. Despite growing interest in pharmacological prevention, optimal drug selection and administration timing remain unclear.</p><p><strong>Objectives: </strong>The authors of this study aim to compare the efficacy of tranilast vs montelukast and evaluate prophylactic vs postoperative administration in preventing capsular contracture.</p><p><strong>Methods: </strong>Eighty male C57BL/6J mice were randomized into 5 groups: control, post-montelukast, pre-montelukast, post-tranilast, and pre-tranilast. For 1 preoperative month, the control group received daily saline (1 mL) through gavage, whereas drug-treated groups received montelukast (10 mg/kg/day) or tranilast (50 mg/kg/day). Prophylactic groups initiated drug administration preoperatively. Miniature implants were bilaterally placed dorsally, followed by 3 months of postoperative drug continuation. Histopathological evaluation assessed capsule thickness, macrophage infiltration, collagen density, and inflammatory response.</p><p><strong>Results: </strong>At 90 days post surgery, all drug interventions significantly reduced capsular thickness compared with the control group (control: 232.4 ± 43 μm; post-montelukast: 137.5 ± 24 μm; pre-montelukast: 107.7 ± 20 μm; post-tranilast: 93.3 ± 22 μm; pre-tranilast: 70.2 ± 11 μm; P < .0001). The pre-tranilast group demonstrated the lowest collagen deposition at 90 days (16.0 ± 5% vs control: 76.6 ± 13%; P < .001). Pre-tranilast exhibited superior macrophage inhibitory effects compared with post-tranilast administration. Furthermore, tranilast outperformed montelukast in efficacy regardless of administration timing.</p><p><strong>Conclusions: </strong>Prophylactic tranilast administration significantly attenuates capsular contracture by reducing inflammation, macrophage infiltration, and collagen deposition, surpassing both postoperative tranilast and montelukast. These findings support prioritizing preoperative tranilast in clinical trials to improve breast implant outcomes.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Computed Tomography Indicates No Negative Impact of OnabotulinumtoxinA on Mandibular Bone Density in a 12-Month, Double-Blind, Randomized, Repeat Treatment, Placebo-Controlled Study in Healthy Adults With Masseter Muscle Prominence.","authors":"Paul Kostenuik, Sanjay M Mallya, René Hopfinger, Tara Aghaloo, Shawneen Gonzalez, James Mah, Mansur Ahmad, Grace Pan, Donna L Faletto, Elisabeth Lee, Beta Bowen, Mitchell F Brin","doi":"10.1093/asj/sjaf167","DOIUrl":"https://doi.org/10.1093/asj/sjaf167","url":null,"abstract":"<p><strong>Background: </strong>Botulinum neurotoxins are used to treat masseter muscle prominence (MMP), benign bilateral masseter muscle enlargement which can be aesthetically undesirable. Limited data report botulinum neurotoxin injections in the muscles of mastication, with subsequent reduction in biomechanical loading, may impact mandibular bone density.</p><p><strong>Objectives: </strong>This study evaluates whether changes in mandibular bone density occur after bilateral masseter treatment with a botulinum neurotoxin, onabotulinumtoxinA, in individuals with MMP.</p><p><strong>Methods: </strong>Analyses were performed on a prespecified subpopulation (n=123) from a 12-month, double-blind, placebo-controlled, dose-escalation, Phase 2 study (N=187). Participants received 1 or 2 bilateral masseter treatments of onabotulinumtoxinA (48, 72, or 96 U) or placebo and had multi-detector computed tomography (MDCT) scans at baseline and Days 90 and 360 post-treatment. Cortical and trabecular bone densities, estimated in Hounsfield units, were calculated for the bilateral condyle, premolar dentoalveolus, and ramus.</p><p><strong>Results: </strong>No clinically significant changes in mandibular bone density were observed in condyle, premolar area, or ramus of onabotulinumtoxinA-treated participants, as compared to placebo or baseline, after 1 or 2 treatments.</p><p><strong>Conclusions: </strong>In healthy adults with MMP, 1 or 2 bilateral masseter treatments with onabotulinumtoxinA at doses of 48, 72, or 96 U over 1 year did not negatively impact mandibular bone density.</p>","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Aesthetic Surgery Consultation: A Professional Act That Should Be Valued-At Every Stage of a Surgeon's Career.","authors":"Paolo Montemurro","doi":"10.1093/asj/sjaf170","DOIUrl":"https://doi.org/10.1093/asj/sjaf170","url":null,"abstract":"","PeriodicalId":7728,"journal":{"name":"Aesthetic Surgery Journal","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}