Faraday Discussions最新文献_第2页

Charge induced deformation of scanning electrolyte before contact 接触前扫描电解质的电荷诱导变形

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-20 DOI: 10.1039/d4fd00147h

Liang Liu

{"title":"Charge induced deformation of scanning electrolyte before contact","authors":"Liang Liu","doi":"10.1039/d4fd00147h","DOIUrl":"https://doi.org/10.1039/d4fd00147h","url":null,"abstract":"The recent developments of scanning electrochemical probe techniques focus on the strategy of scanning electrolyte. For example, scanning electrochemical cell microscopy (SECCM) is based on holding the electrolyte in a glass capillary, while scanning gel electrochemical microscopy (SGECM) immobilizes the gel electrolyte on micro-disk electrodes or etched metal wires. In both SECCM and SGECM, the first and essential step is to approach the electrolyte probe to be in contact with the sample, which is very often achieved by current feedback with a constant applied potential between the probe and the sample. This work attempts to theoretically analyse the deformation of electrolyte during this approaching process. For liquid electrolyte in SECCM, surface tension is considered to counterbalance the gravity and electrostatic force in 2D cylindrical coordinates with axial symmetry. The deformation at equilibrium is solved under certain conditions. For gel electrolyte, a viscoelastic gel is analysed with simplified 1D geometry. Both equilibrium and dynamic approaching are considered. The results suggest that for both liquid and gel electrolytes, critical conditions exist for breaking the equilibrium. When applied potential is higher or the distance is lower than the threshold, the force will not equilibrate and the electrolyte will deform until contact. The critical condition depends on the properties (surface tension for liquid, elastic and viscous modulus for gel) and geometry (radius of capillary for liquid, thickness for gel) of electrolyte. Prospects of further extending the work closer to real experimental scenarios, especially SGECM, are also discussed.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specialising and Analysing Instruction-Tuned and Byte-Level Language Models for Organic Reaction Prediction 针对有机反应预测的指令调整和字节级语言模型的专业化与分析

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-19 DOI: 10.1039/d4fd00104d

Jiayun Pang, Ivan Vulić

{"title":"Specialising and Analysing Instruction-Tuned and Byte-Level Language Models for Organic Reaction Prediction","authors":"Jiayun Pang, Ivan Vulić","doi":"10.1039/d4fd00104d","DOIUrl":"https://doi.org/10.1039/d4fd00104d","url":null,"abstract":"Transformer-based encoder-decoder models have demonstrated impressive results in chemical reaction prediction tasks. However, these models typically rely on pretraining using tens of millions of unlabelled molecules, which can be time-consuming and GPU-intensive. One of the central questions we aim to answer in this work is: Can FlanT5 and ByT5, the encode-decoder models pretrained solely on language data, be effectively specialised for organic reaction prediction through task-specific fine-tuning? We conduct a systematic empirical study on several key issues of the process, including tokenisation, the impact of (SMILES-oriented) pretraining, fine-tuning sample efficiency, and decoding algorithms at inference. Our key findings indicate that although being pretrained only on language tasks, FlanT5 and ByT5 provide a solid foundation to fine-tune for reaction prediction, and thus become 'chemistry domain compatible' in the process. This suggests that GPU-intensive and expensive pretraining on a large dataset of unlabelled molecules may be useful yet not essential to leverage the power of language models for chemistry. All our models achieve comparable Top-1 and Top-5 accuracy although some variation across different models does exist. Notably, tokenisation and vocabulary trimming slightly affect final performance but can speed up training and inference; The most efficient greedy decoding strategy is very competitive while only marginal gains can be achieved from more sophisticated decoding algorithms. In summary, we evaluate FlanT5 and ByT5 across several dimensions and benchmark their impact on organic reaction prediction, which may guide more effective use of these state-of-the-art language models for chemistry-related tasks in the future.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nafion Coated Nanopore Electrode for Improving Electrochemical Aptamer-Based Biosensing Nafion 涂层纳米孔电极用于改进基于电化学色聚体的生物传感

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-14 DOI: 10.1039/d4fd00144c

Grayson Huldin, Junming Huang, Julius Reitemeier, Kaiyu Fu

{"title":"Nafion Coated Nanopore Electrode for Improving Electrochemical Aptamer-Based Biosensing","authors":"Grayson Huldin, Junming Huang, Julius Reitemeier, Kaiyu Fu","doi":"10.1039/d4fd00144c","DOIUrl":"https://doi.org/10.1039/d4fd00144c","url":null,"abstract":"The transition to a personalized point-of-care model in medicine will fundamentally change the way medicine is practiced, leading to better patient care. Electrochemical biosensors based on structure-switching aptamers can contribute to this medical revolution due to the feasibility and convenience of selecting aptamers for specific targets. Recent studies have reported that nanostructured electrodes can enhance the signals of aptamer-based biosensors. However, miniaturized systems and body fluid environments pose challenges such as signal-to-noise ratio reduction and biofouling. To address these issues, researchers have proposed various electrode coating materials, including zwitterionic materials, biocompatible polymers, and hybrid membranes. Nafion, a commonly used ion exchange membrane, is known for its excellent permselectivity and anti-biofouling properties, making it a suitable choice for biosensor systems. However, the performance and mechanism of Nafion-coated aptamer-based biosensor systems have not been thoroughly studied. In this work, we present a Nafion-coated gold nanoporous electrode, which excludes Nafion from the nanoporous structures and allows the aptamers immobilized inside the nanopores to freely detect chosen targets. The nanopore electrode is formed by a sputtering and dealloying process, resulting in a pore size in tens of nanometers. The biosensor is optimized by adjusting the electrochemical measurement parameters, aptamer density, Nafion thickness, and nanopore size. Furthermore, we propose an explanation for the unusual signaling behavior of the aptamers confined within the nanoporous structures. This work provides a generalizable platform to investigate membrane-coated aptamer-based biosensors.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical reflection on attempts to machine-learn materials synthesis insights from text-mined literature recipes 对从文本挖掘的文献配方中机器学习材料合成见解的尝试进行批判性反思

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-13 DOI: 10.1039/d4fd00112e

Wenhao Sun, Nicholas David

{"title":"A critical reflection on attempts to machine-learn materials synthesis insights from text-mined literature recipes","authors":"Wenhao Sun, Nicholas David","doi":"10.1039/d4fd00112e","DOIUrl":"https://doi.org/10.1039/d4fd00112e","url":null,"abstract":"Synthesis of predicted materials is the key and final step needed to realize a vision of computationally-accelerated materials discovery. Because so many materials have been previously synthesized, one would anticipate that text-mining synthesis recipes from the literature would yield a valuable dataset to train machine learning models that can predict synthesis recipes to new materials. Between 2016 and 2019, the corresponding author (Wenhao Sun) participated in efforts to text-mine 31,782 solid-state synthesis recipes and 35,675 solution-based synthesis recipes from the literature. Here, we characterize these datasets and show that they do not satisfy the “4 Vs” of data-science—that is: volume, veracity, variety, and velocity. For this reason, we believe that machine-learned regression or classification models built from these datasets will have limited utility in guiding the predictive synthesis of novel materials. On the other hand, these large datasets provided an opportunity to identify anomalous synthesis recipes—which in fact did inspire new hypotheses on how materials form, that we later validated by experiment. Our case study here urges a re-evaluation on how to extract the most value from large historical materials science datasets.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data-efficient fine-tuning of foundational models for first-principles quality sublimation enthalpies 对第一原理质量升华焓基础模型进行数据高效微调

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-09 DOI: 10.1039/d4fd00107a

Harveen Kaur, Flaviano Della Pia, Ilyes Batatia, Xavier R. Advincula, Benjamin X. Shi, Jinggang Lan, Gábor Csányi, Angelos Michaelides, Venkat Kapil

{"title":"Data-efficient fine-tuning of foundational models for first-principles quality sublimation enthalpies","authors":"Harveen Kaur, Flaviano Della Pia, Ilyes Batatia, Xavier R. Advincula, Benjamin X. Shi, Jinggang Lan, Gábor Csányi, Angelos Michaelides, Venkat Kapil","doi":"10.1039/d4fd00107a","DOIUrl":"https://doi.org/10.1039/d4fd00107a","url":null,"abstract":"Calculating sublimation enthalpies of molecular crystal polymorphs is relevant to a wide range of technological applications. However, predicting these quantities at first-principles accuracy – even with the aid of machine learning potentials – is a challenge that requires sub-kJ/mol accuracy in the potential energy surface and finite-temperature sampling. We present an accurate and data- efficient protocol for training machine learning interatomic potentials by fine-tuning the foundational MACE-MP-0 model and showcase its capabilities on sublimation enthalpies and physical properties of ice polymorphs. Our approach requires only a few tens of training structures to achieve sub-kJ/mol accuracy in the sublimation enthalpies and sub-1 % error in densities at finite temperature and pressure. Exploiting this data efficiency, we perform preliminary N P T simulations of hexagonal ice at the random phase approximation level and demonstrate a good agreement with experiments. Our results shows promise for finite-temperature modelling of molecular crystals with the accuracy of correlated electronic structure theory methods.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion Concentration Polarization Causes a Nearly Pore-Length-Independent Conductance of Nanopores 离子浓度极化导致纳米孔隙的电导率几乎与孔隙长度无关

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-08 DOI: 10.1039/d4fd00148f

DaVante Cain, Ethan Cao, Ivan Vlassiouk, Tilman E Schäffer, Zuzanna Siwy

{"title":"Ion Concentration Polarization Causes a Nearly Pore-Length-Independent Conductance of Nanopores","authors":"DaVante Cain, Ethan Cao, Ivan Vlassiouk, Tilman E Schäffer, Zuzanna Siwy","doi":"10.1039/d4fd00148f","DOIUrl":"https://doi.org/10.1039/d4fd00148f","url":null,"abstract":"There has been a great amount of interest in nanopores as the basis for sensors and templates for preparation of biomimetic channels as well as model systems to understand transport properties at the nanoscale. The presence of surface charges on the pore walls has been shown to induce ion selectivity as well as enhance ionic conductance compared to uncharged pores. Here, using three-dimensional continuum modeling, we examine the role of length of charged nanopores as well as applied voltage for controlling ion selectivity and ionic conductance of single nanopores and small nanopore arrays. First, we present conditions where the ion current and ion selectivity of nanopores with homogeneous surface charges remain unchanged even if the pore length decreases by a factor of 6. This length-independent conductance is explained through the effect of ion concentration polarization (ICP) that modifies local ionic concentrations not only at the pore entrances but also in the pore in a voltage-dependent manner. We describe how voltage controls ion selectivity of nanopores with different lengths and present conditions when charged nanopores conduct less current than uncharged pores of the same geometrical characteristics. The manuscript provides different measures of the extent of the depletion zone induced by ICP in single pores and nanopore arrays including systems with ionic diodes. The modeling shown here will help design selective nanopores for a variety of applications where single nanopores and nanopore arrays are used.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond theory driven discovery: introducing hot random search and datum derived structures 超越理论驱动的发现：引入热随机搜索和基准衍生结构

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-06 DOI: 10.1039/d4fd00134f

Chris J. Pickard

{"title":"Beyond theory driven discovery: introducing hot random search and datum derived structures","authors":"Chris J. Pickard","doi":"10.1039/d4fd00134f","DOIUrl":"https://doi.org/10.1039/d4fd00134f","url":null,"abstract":"Data driven methods have transformed the prospects of the computational chemical sciences, with machine learned interatomic potentials (MLIPs) speeding up calculations by several orders of magnitude. I reflect on theory driven, as opposed to data driven, discovery based on ab initio random structure searching (AIRSS), and then introduce two new methods which exploit machine learning acceleration. I show how long high throughput anneals, between direct structural relaxation, enabled by ephemeral data derived potentials (EDDPs), can be incorporated into AIRSS to bias the sampling of challenging systems towards low energy configurations. Hot AIRSS (hot-AIRSS) preserves the parallel advantage of random search, while allowing much more complex systems to be tackled. This is demonstrated through searches for complex boron structures in large unit cells. I then show how low energy carbon structures can be directly generated from a single, experimentally determined, diamond structure. An extension to the generation of random sensible structures, candidates are stochastically generated and then optimised to minimise the difference between the EDDP environment vector and that of the reference diamond structure. The distance-based cost function is captured in an actively learned EDDP. Graphite, small nanotubes and caged, fullerene- like, structures emerge from searches using this potential, along with a rich variety of tetrahedral framework structures. Using the same approach, the pyrope, Mg3Al2(SiO4)3, garnet structure is recovered from a low energy AIRSS structure generated in a smaller unit cell with a different chemical composition. The relationship of this approach to modern diffusion model based generative methods is discussed.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-evaluating Retrosynthesis Algorithms with Syntheseus 用 Syntheseus 重新评估逆合成算法

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-05 DOI: 10.1039/d4fd00093e

Krzysztof Maziarz, Austin Tripp, Guoqing Liu, Megan Stanley, Shufang Xie, Piotr Gainski, Philipp Seidl, Marwin Segler

引用次数: 0

Modelling ligand exchange in metal complexes with machine learning potentials 用机器学习势能模拟金属复合物中的配体交换

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-03 DOI: 10.1039/d4fd00140k

Veronika Jurásková, Gers Tusha, Hanwen Zhang, Lars V Schäfer, Fernanda Duarte

{"title":"Modelling ligand exchange in metal complexes with machine learning potentials","authors":"Veronika Jurásková, Gers Tusha, Hanwen Zhang, Lars V Schäfer, Fernanda Duarte","doi":"10.1039/d4fd00140k","DOIUrl":"https://doi.org/10.1039/d4fd00140k","url":null,"abstract":"Metal ions are irreplaceable in many areas of chemistry, including (bio)catalysis, self-assembly and charge transfer processes. Yet, modelling their structural and dynamic properties in diverse chemical environments remains challenging for both force fields and ab initio methods. Here, we introduce a strategy to train machine learning potentials (MLPs) using MACE, an equivariant message-passing neural network, for metal-ligand complexes in explicit solvents. We explore the structure and ligand exchange dynamics of Mg2+ in water and Pd2+ in acetonitrile as two illustrative model systems. The trained potentials accurately reproduce equilibrium structures of the complexes in solution, including different coordination numbers and geometries. Furthermore, the MLPs can model structural changes between metal ions and ligands in the first coordination shell, and reproduce the free energy barriers for the corresponding ligand exchange. The strategy presented here provides a computationally efficient approach to model metal ions in solution, paving the way for modelling larger and more diverse metal complexes relevant to biomolecules and supramolecular assemblies.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141887128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning 通过分子动力学和主动学习研究蛋白质相分离和蛋白质相分离凝聚物识别的序列决定因素

IF 3.4 3区化学

Faraday Discussions Pub Date : 2024-08-03 DOI: 10.1039/d4fd00099d

Arya Changiarath Sivadasan, Aayush Arya, Vasileios A. Xenidis, Jan Padeken, Lukas S. Stelzl

{"title":"Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning","authors":"Arya Changiarath Sivadasan, Aayush Arya, Vasileios A. Xenidis, Jan Padeken, Lukas S. Stelzl","doi":"10.1039/d4fd00099d","DOIUrl":"https://doi.org/10.1039/d4fd00099d","url":null,"abstract":"Elucidating how protein sequence determines the properties of disordered proteins and their phase-separated condensates is a great challenge in computational chemistry, biology, and biophysics. Quantitative molecular dynamics simulations and derived free energy values can in principle capture how a sequence encodes the chemical and biological properties of a protein. These calculations are, however, computationally demanding, even after reducing the representation by coarse-graining; exploring the large spaces of potentially relevant sequences remains a formidable task. We employ an \"active learning\" scheme introduced by Yang et al.(bioRxiv 2022.08.05.502972) to reduce the number of labelled examples needed from simulations, where a neural network-based model suggests the most useful examples for the next training cycle. Applying this Bayesian Optimisation framework, we determine properties of protein sequences with coarse-grained molecular dynamics, which enables the network to establish sequence-property relationships for disordered proteins and their self-interactions and their interactions in phase-separated condensates. We show how iterative training with second virial coefficients derived from the simulations of disordered protein sequences leads to a rapid improvement in predicting peptide self-interactions. We employ this Bayesian approach to efficiently search for new sequences that bind to condensates of disordered C-terminal domain (CTD) of RNA Polymerase II, by simulating molecular recognition of peptides to phase-separated condensates in coarse-grained molecular dynamics. By searching for protein sequences which prefer to self-interact rather than interact with another protein sequence we are able to shape the morphology of protein condensates and design multiphasic protein condensates.","PeriodicalId":76,"journal":{"name":"Faraday Discussions","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141884834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0