Alzheimer Disease & Associated Disorders最新文献_第8页

Gender, Pain, and Function Associated With Physical Activity After Hospitalization in Persons Living With Dementia. 痴呆症患者住院后与身体活动相关的性别、疼痛和功能。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-20 DOI: 10.1097/WAD.0000000000000583

Ashley Kuzmik, Marie Boltz, Barbara Resnick, Brittany F Drazich, James E Galvin

{"title":"Gender, Pain, and Function Associated With Physical Activity After Hospitalization in Persons Living With Dementia.","authors":"Ashley Kuzmik, Marie Boltz, Barbara Resnick, Brittany F Drazich, James E Galvin","doi":"10.1097/WAD.0000000000000583","DOIUrl":"10.1097/WAD.0000000000000583","url":null,"abstract":"Background: The purpose of this study was to identify factors that are associated with physical activity after hospitalization in persons living with dementia.Methods: Multiple linear regressions were conducted to test factors associated with objective activity levels (sedentary, low, moderate, and vigorous) among 244 patients living with dementia from a randomized controlled trial.Results: Within 48 hours of hospital discharge, time in sedentary behavior was associated with increased pain (β=0.164, P =0.015). Time in low activity was associated with less pain (β=-0.130, P =0.049) and higher physical function (β=0.300, P =<0.001). Time in moderate activity was associated with increased physical function (β=0.190, P =0.008) and male gender (β=0.155, P =0.016). No significant associations of potential factors were found with time in vigorous activity.Conclusions: Our findings suggest that managing or reducing pain, encouraging individual functional level, and gender could influence time spent in physical activity after acute hospitalization in persons living with dementia.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"357-362"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer Disease: A New Beginning in Therapeutics. 阿尔茨海默病:治疗学的新开端。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.1097/WAD.0000000000000592

Lawrence S Honig

引用次数: 0

A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers. 一项随机双盲研究评估健康志愿者每周一次的多奈哌齐透皮给药系统的皮肤刺激和致敏潜力。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-11 DOI: 10.1097/WAD.0000000000000578

Marwan N Sabbagh, Philip Mathew, Alan Blau

{"title":"A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers.","authors":"Marwan N Sabbagh, Philip Mathew, Alan Blau","doi":"10.1097/WAD.0000000000000578","DOIUrl":"10.1097/WAD.0000000000000578","url":null,"abstract":"Background: A once-weekly donepezil transdermal delivery system (TDS; Adlarity; Corium, LLC) is indicated for the treatment of mild, moderate, and severe dementia of the Alzheimer type. Methods: In this placebo-controlled, randomized, double-blind phase 1 trial, healthy volunteers aged 40 years or older were randomized to receive a placebo and donepezil TDS and were evaluated for the primary endpoints of skin irritation and sensitization potential. Skin irritation was scored. Results: Two hundred fifty-six participants were randomized and received ≥1 dose of any treatment. After the first weekly TDS application, no skin irritation or minimal irritation was evident between donepezil and placebo TDSs. At the third weekly TDS application, for donepezil TDS, the average of the mean combined skin irritation score was 0.55 of a possible maximum of 7, indicating none to minimal skin irritation, and for placebo, the score was 0.19, indicating no skin irritation. Of 198 participants, 4 (2.0%) were considered potentially sensitized to donepezil TDS, and 0 were potentially sensitized to placebo TDS. Conclusion: Once-weekly 5-mg/d donepezil TDS demonstrated minimal skin irritation under conditions of use of 3 consecutive weekly patch applications to the same skin site and minimal sensitization potential.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"290-295"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study. 高频rTMS可以改善中国轻度认知障碍患者的记忆受损:一项随机对照研究。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI: 10.1097/WAD.0000000000000577

Tao Wang, Zhiwei Guo, Hongxia Wu, Yi Jiang, Qiwen Mu

{"title":"High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study.","authors":"Tao Wang, Zhiwei Guo, Hongxia Wu, Yi Jiang, Qiwen Mu","doi":"10.1097/WAD.0000000000000577","DOIUrl":"10.1097/WAD.0000000000000577","url":null,"abstract":"Objective: The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on improving memory deficits in mild cognitive impairment (MCI), as well as to provide visualized evidence for neuronal specificity by using resting-state functional magnetic resonance imaging.Materials and methods: Forty MCI patients were enrolled to receive 10-session and sham-controlled 10Hz-rTMS over the left dorsolateral prefrontal cortex. The resting-state functional magnetic resonance imaging combined with memory scales assessment were performed before and after the intervention. To elucidate the therapeutic mechanism of rTMS, amplitude of low-frequency fluctuations (ALFF) and functional connectivity were calculated. The Pearson correlation was used to measure the relationship between ALFF and memory performance.Results: Compared with the sham group, ALFF significantly increased in the right insula, right inferior frontal gyrus-opercular part, and decreased in the left middle occipital gyrus, left angular gyrus, and left lingual gyrus after rTMS. The change in Auditory Verbal Learning Test scores were negatively correlated with ALFF decreases in the left lingual gyrus. Functional connectivity significantly increased between the posterior cingulate cortex and right supramarginal gyrus, and decreased between the right frontoinsular cortex and right supramarginal gyrus after intervention.Conclusion: High-frequency rTMS over the left dorsolateral prefrontal cortex could facilitate improvement on impaired memory in patients with MCI via modulating the neuronal activity and brain network.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"296-302"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Longitudinal Evaluation of the Pattern of Social Cognition Impairment in Brazilians With Alzheimer's Disease. 巴西阿尔茨海默病患者社会认知障碍模式的纵向评估。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-02 DOI: 10.1097/WAD.0000000000000588

Tatiana Teresa Belfort Almeida Dos Santos, Marcela Moreira Lima Nogueira, Isabel Barbeito Lacerda, Michelle Brandt, Aline Tavares de Lucena, Rogeria Rangel, Julia Gaigher, Felipe Oliveira, Marcia Cristina Nascimento Dourado

{"title":"A Longitudinal Evaluation of the Pattern of Social Cognition Impairment in Brazilians With Alzheimer's Disease.","authors":"Tatiana Teresa Belfort Almeida Dos Santos, Marcela Moreira Lima Nogueira, Isabel Barbeito Lacerda, Michelle Brandt, Aline Tavares de Lucena, Rogeria Rangel, Julia Gaigher, Felipe Oliveira, Marcia Cristina Nascimento Dourado","doi":"10.1097/WAD.0000000000000588","DOIUrl":"10.1097/WAD.0000000000000588","url":null,"abstract":"Background: Social cognition (SC) impairments contribute to the dependence of people with Alzheimer disease (AD), influencing their functional disability and the burden on family members and caregivers. Our objective was to longitudinally investigate the relationship between SC and cognitive and clinical variables in persons with AD and their caregivers. We also evaluated the different SC predictors from 3 perspectives: people with AD, caregivers of people with AD, and discrepancy analysis.Methods: In all, 137 dyads (people with AD and their caregivers) underwent 2 assessments: at baseline (M1) and after 1 year (M2). During follow-up, 58 dyads were excluded, and the study was thus concluded with 79.Results: Longitudinal analysis of the people with AD showed that while some cognitive functions declined (which is consistent with disease progression), SC impairments showed a more stable pattern. Another interesting result was related to SC predictors. For people with AD, SC was associated with cognition at both time points. For caregivers, besides cognition, other predictors included reduced functional abilities and quality of life in people with AD. These results are consistent with the discrepancy predictors.Conclusion: The stable pattern in SC functioning over 12 months in AD suggests that this neurocognitive domain may be influenced more by emotional processing than by cognitive impairment. In addition, the SC predictors showed that the investigation of different points of view enables a more global understanding, contributing to better and more targeted treatment for the patient.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"363-369"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71419821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication. 摩洛哥阿尔茨海默病患者的新型APOE突变:一个病例研究和致病意义的探索。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.1097/WAD.0000000000000590

Youssef Razouqi, Ihssane El Bouchikhi, Hassan El-Abid, Soukayna Baammi, Ayoub Nedbour, Ahmed Omar Touhami Ahami, Achraf El Allali, Laila Bouguenouch

{"title":"Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication.","authors":"Youssef Razouqi, Ihssane El Bouchikhi, Hassan El-Abid, Soukayna Baammi, Ayoub Nedbour, Ahmed Omar Touhami Ahami, Achraf El Allali, Laila Bouguenouch","doi":"10.1097/WAD.0000000000000590","DOIUrl":"10.1097/WAD.0000000000000590","url":null,"abstract":"Alzheimer disease (AD) is a major public health concern worldwide. It is a severe neurodegenerative disease that primarily affects the elderly and causes significant brain cell death. According to the most complete scientific research, the APOE gene, which encodes the APOE protein, maybe the key to identifying the likely cause of delayed AD. The development of plaques and tangles, as well as increased amyloid (amyloid-β) levels and deposition, have been linked to APOE4. Pathogenic mutations in this gene can impact how beta-amyloid deposits and how they are cleared from the body. In this study, we report a novel pathogenic mutation, Arg160Leu, in APOE that was identified in a Moroccan patient. The magnetic resonance imaging of this 67-year-old woman revealed hippocampal shrinkage, and the results of her cognition testing revealed that she is suffering from severe AD. The current study may increase awareness of the genetic risk factors for AD caused by APOE4 mutations.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 4","pages":"370-372"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic Analysis Reveals Potential Exosomal Biomarkers in Patients With Sporadic Alzheimer Disease. 蛋白质组学分析揭示散发性阿尔茨海默病患者潜在的外泌体生物标志物

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.1097/WAD.0000000000000589

Konstanze Plaschke, Jürgen Kopitz, Johannes Gebert, Nadine D Wolf, Robert Christian Wolf

{"title":"Proteomic Analysis Reveals Potential Exosomal Biomarkers in Patients With Sporadic Alzheimer Disease.","authors":"Konstanze Plaschke, Jürgen Kopitz, Johannes Gebert, Nadine D Wolf, Robert Christian Wolf","doi":"10.1097/WAD.0000000000000589","DOIUrl":"10.1097/WAD.0000000000000589","url":null,"abstract":"Background: Despite substantial progress made in the past decades, the pathogenesis of sporadic Alzheimer disease (sAD) and related biological markers of the disease are still controversially discussed. Cerebrospinal fluid and functional brain imaging markers have been established to support the clinical diagnosis of sAD. Yet, due to the invasiveness of such diagnostics, less burdensome markers have been increasingly investigated in the past years. Among such markers, extracellular vesicles may yield promise in (early) diagnostics and treatment monitoring in sAD.Materials and methods: In this pilot study, we collected the blood plasma of 18 patients with sAD and compared the proteome of extracted extracellular vesicles with the proteome of 11 age-matched healthy controls. The resulting proteomes were characterized by Gene Ontology terms and between-group statistics.Results: Ten distinct proteins were found to significantly differ between sAD patients and controls (P<0.05, False Discovery Rate, corrected). These proteins included distinct immunoglobulins, fibronectin, and apolipoproteins.Conclusions: These findings lend further support for exosomal changes in neurodegenerative disorders, and particularly in sAD. Further proteomic research could decisively advance our knowledge of sAD pathophysiology as much as it could foster the development of clinically meaningful biomarkers.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 4","pages":"315-321"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia. 区域白质高强度与无痴呆老年人的特定认知能力有关。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.1097/WAD.0000000000000585

Rachel Membreno, Kelsey R Thomas, Amanda T Calcetas, Lauren Edwards, Maria Bordyug, Maya Showell, Morgan Stanfill, Einat K Brenner, Kayla S Walker, Lindsay J Rotblatt, Adam M Brickman, Emily C Edmonds, Katherine J Bangen

{"title":"Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia.","authors":"Rachel Membreno, Kelsey R Thomas, Amanda T Calcetas, Lauren Edwards, Maria Bordyug, Maya Showell, Morgan Stanfill, Einat K Brenner, Kayla S Walker, Lindsay J Rotblatt, Adam M Brickman, Emily C Edmonds, Katherine J Bangen","doi":"10.1097/WAD.0000000000000585","DOIUrl":"10.1097/WAD.0000000000000585","url":null,"abstract":"Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or total WMH; less is known about associations of regional WMHs and cognitive abilities among older adults without dementia.Methods: A total of 610 older adults with normal cognition (n=302) or mild cognitive impairment (n=308) from the Alzheimer's Disease Neuroimaging Initiative underwent neuropsychological testing and magnetic resonance imaging. Linear regression models examined associations between regional WMH volumes and cognition, adjusting for age, sex, education, apolipoprotein E ε4 allele frequency, and pulse pressure.Results: Among all participants, greater regional WMH volume in all lobes was associated with poorer performance on memory and speed/executive functioning. Among participants with normal cognition, greater temporal and occipital WMH volumes were associated with poorer memory, whereas no regional WMH volumes were associated with speed/executive function.Discussion: Results show that greater regional WMH volume relates to poorer cognitive functioning-even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 4","pages":"303-309"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Visual Analog Scale for Self-Reported Quality of Life: A Comparison of VAS and QoL-AD in Older Adults. 自我报告生活质量的视觉模拟量表：老年人VAS和QoL AD的比较。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-22 DOI: 10.1097/WAD.0000000000000581

Elizabeth Redford, Sabine Heuer

{"title":"A Visual Analog Scale for Self-Reported Quality of Life: A Comparison of VAS and QoL-AD in Older Adults.","authors":"Elizabeth Redford, Sabine Heuer","doi":"10.1097/WAD.0000000000000581","DOIUrl":"10.1097/WAD.0000000000000581","url":null,"abstract":"Purpose: People with dementia (PWD) are one of the fastest-growing clinical populations for speech-language pathologists. Self-reported quality of life (QoL) assessments are critical patient-reported outcome measures that align with person-centered care principles. However, proxy-reporting is most often used due to assumptions that PWD cannot provide reliable self-report. Visual analog scales (VASs) have been successfully used with people with expressive and cognitive deficits to measure subjective constructs such as QoL, mood, and pain. The purpose of this project is to evaluate the feasibility and reliability of a VAS QoL assessment tool.Methods: Twenty older adults free of cognitive impairment were assessed using the quality of life in Alzheimer's disease (QoL-AD) and the QoL-AD in combination with a VAS (VAS QoL-AD). The construct validity, internal consistency, and test-retest reliability of the VAS QoL-AD were assessed by performing both assessments twice, 4 weeks apart.Results: Significant correlations between the overall VAS QoL-AD and the QoL-AD scale ratings, between most of the QoL-AD and VAS QoL-AD subtests, and between the first and second assessment scores were observed.Conclusions: Results indicated strong construct validity, internal consistency, and test-retest reliability of the VAS QoL-AD in people without dementia. These results warrant further research into the development of a dementia-specific, self-reported VAS QoL scale for PWD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"343-348"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41119190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticipated Psychological or Behavioral Reactions to Learning Alzheimer Biomarker Results: Associations With Contextual Factors. 学习阿尔茨海默氏症生物标志物结果的预期心理或行为反应：与情境因素的关联。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-12 DOI: 10.1097/WAD.0000000000000586

Lindsay R Clark, Claire M Erickson, Nathaniel A Chin, Kristin E Basche, Erin M Jonaitis, Fred B Ketchum, Carey E Gleason

{"title":"Anticipated Psychological or Behavioral Reactions to Learning Alzheimer Biomarker Results: Associations With Contextual Factors.","authors":"Lindsay R Clark, Claire M Erickson, Nathaniel A Chin, Kristin E Basche, Erin M Jonaitis, Fred B Ketchum, Carey E Gleason","doi":"10.1097/WAD.0000000000000586","DOIUrl":"10.1097/WAD.0000000000000586","url":null,"abstract":"Background: As Alzheimer disease (AD) biomarker testing becomes more widely available, adults may opt to learn results. Considering potential reactions to learning biomarker results can guide prebiomarker and postbiomarker testing education and counseling programs.Methods: Cognitively healthy adults enrolled in observational Alzheimer research responded to a telephone survey about learning AD risk information (n=334; 44% Black or African American; mean age=64.9±7.0). Multiple linear regression models tested if contextual factors predicted anticipated psychological impact (distress, stigma, and cognitive symptoms) or behavior change (planning and risk-reduction). Secondary analyses tested for differences in relationships by racial identity.Results: Internal health locus of control, concern about AD, self-identified sex, education, family dementia history, and belief in AD modifiability predicted anticipated psychological impact. Concern about AD, age, racial identity, belief in AD modifiability, research attitudes, and exposure to brain health-related social norms predicted anticipated behavior change. For Black respondents, there were no sex differences in anticipated distress, whereas there were stronger relationships between health locus of control, brain health social norms, and education on outcomes compared with White respondents.Conclusions: Results may inform personalized and culturally tailored biomarker testing education and counseling to minimize psychological impacts and increase behavior change related to learning AD risk information.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"282-289"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0