Alzheimer Disease & Associated Disorders最新文献_第8页

Rescreening on RBANS Delayed Memory Index? Forget About It! 重新评估 RBANS 延迟记忆指数？算了吧

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.1097/WAD.0000000000000606

Marwan N Sabbagh, Wojciech Michalak, Charlotte Thim Hansen, Christian Ahmad Wichmann, Alice Clark

{"title":"Rescreening on RBANS Delayed Memory Index? Forget About It!","authors":"Marwan N Sabbagh, Wojciech Michalak, Charlotte Thim Hansen, Christian Ahmad Wichmann, Alice Clark","doi":"10.1097/WAD.0000000000000606","DOIUrl":"10.1097/WAD.0000000000000606","url":null,"abstract":"Objective: To assess the value of rescreening patients with Alzheimer's disease who do not meet the inclusion criteria for the Repeatable Battery for the Assessment of Neuropsychological Status Delayed Memory Index (RBANS DMI) at the initial assessment.Patients and methods: Participants (aged 50-85 years, without dementia, Mini-Mental State Examination score ≥22, valid Clinical Dementia Rating [CDR] global score, and amyloid status at baseline) were identified in the European Prevention of Alzheimer's Dementia database. Changes from baseline in RBANS DMI were estimated using a mixed model for repeated measurements. Logistic regressions were used to estimate the probability of participants with baseline RBANS DMI 86-95 having RBANS DMI ≤85, CDR global score ≥0.5, and amyloid positivity at 6 and 12 months.Results: There was significant variability in the change in RBANS DMI scores over time (median change at 6 months: 2.0). An estimated 15% of participants with RBANS DMI 86-95 at baseline progressed to ≤85 at 6 months; 8% also achieved CDR global score ≥0.5 and 5% were also amyloid positive.Conclusions: The results from our analysis indicate that there is limited value in rescreening patients based on their initial RBANS DMI score.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"8-13"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compassion Versus Accuracy: Lenient Scoring of the Spatial Orientation Items on the Mini-mental State Exam Lowers Sensitivity. 同情心与准确性：小型精神状态测验空间定向项目的宽松评分降低了灵敏度。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI: 10.1097/WAD.0000000000000609

Katrina Kent, Nesrine Adly Ibrahim, Kristoffer Romero, Shannon Baker, Matthew Greenacre, Chantal M Boucher, Robert M Roth, Laszlo A Erdodi

{"title":"Compassion Versus Accuracy: Lenient Scoring of the Spatial Orientation Items on the Mini-mental State Exam Lowers Sensitivity.","authors":"Katrina Kent, Nesrine Adly Ibrahim, Kristoffer Romero, Shannon Baker, Matthew Greenacre, Chantal M Boucher, Robert M Roth, Laszlo A Erdodi","doi":"10.1097/WAD.0000000000000609","DOIUrl":"10.1097/WAD.0000000000000609","url":null,"abstract":"The Mini-mental State Examination (MMSE) is a commonly used screening tool for cognitive impairment. Lenient scoring of spatial orientation errors (SOEs) on the MMSE is common and negatively affects its diagnostic utility. We examined the effect of lenient SOE scoring on MMSE classification accuracy in a consecutive case series of 103 older adults (age 60 or above) clinically referred for neuropsychological evaluation. Lenient scoring of SOEs on the MMSE occurred in 53 (51.4%) patients and lowered the sensitivity by 7% to 18%, with variable gains in specificity (0% to 11%) to psychometrically operationalized cognitive impairment. Results are consistent with previous reports that lenient scoring is widespread and attenuates the sensitivity of the MMSE. Given the higher clinical priority of correctly detecting early cognitive decline over specificity, a warning against lenient scoring of SOEs (on the MMSE and other screening tools) during medical education and in clinical practice is warranted.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"98-100"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons From the Coronavirus Disease Experience: Research Participant and Staff Satisfaction With Remote Cognitive Evaluations. 冠状病毒疾病的经验教训：研究参与者和工作人员对远程认知评估的满意度。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1097/WAD.0000000000000605

Margaret Sewell, Judith Neugroschl, Carolyn W Zhu, Maria Loizos, Xiaoyi Zeng, Kelly Pun, Jonathan Greenberg, Nelly Velasco, Faye Sheppard, Carly Tocco, Kirsten Evans, Allison Ardolino, Caroline Meuser, Clara Li, Jonah Melnick, Hillel Grossman, Mary Sano

{"title":"Lessons From the Coronavirus Disease Experience: Research Participant and Staff Satisfaction With Remote Cognitive Evaluations.","authors":"Margaret Sewell, Judith Neugroschl, Carolyn W Zhu, Maria Loizos, Xiaoyi Zeng, Kelly Pun, Jonathan Greenberg, Nelly Velasco, Faye Sheppard, Carly Tocco, Kirsten Evans, Allison Ardolino, Caroline Meuser, Clara Li, Jonah Melnick, Hillel Grossman, Mary Sano","doi":"10.1097/WAD.0000000000000605","DOIUrl":"10.1097/WAD.0000000000000605","url":null,"abstract":"Objective: In New York City in 2020 the pandemic shut down in-person research. Icahn School of Medicine's Alzheimer's Disease Research Center transitioned longitudinal evaluations from in-person to telephone to enhance equity of access. We assessed diverse research participants' and clinical research coordinators' (CRC) satisfaction with remote evaluation and examined sociodemographic, cognitive, and behavioral factors that might impact satisfaction.Methods: Data collected: 241 participants with Clinical Dementia Rating (CDR) = 0/0.5 (3/2020 to 6/2021). A Telehealth Satisfaction Questionnaire for CRCs and participants was administered at the end of remote evaluations. We compared Telehealth Satisfaction Questionnaire items by CDR and Geriatric Depression Scale.Results: Participants' mean age was 78.4, 61.4% were females, 16.2% were Hispanic, 17.1% Asian, 15.8% were non-Hispanic black, and 72.6% CDR = 0. Participant satisfaction was high [14.1 ± 1.4 (out of 15)] but was lower among those with depression. CRC satisfaction was high [16.9 ± 1.8 (out of 18)] but was lower concerning the ability to explain the test battery and interact with participants with CDR = 0.5.Conclusion: Telephone research assessments provide flexibility in a hybrid model. They offer equitable access to research participation for those who do not use computer technology and may promote the retention of diverse elderly research participants.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"65-69"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caregivers of People With Mild Cognitive Impairment and Dementia: Characterizing Social and Psychological Outcomes. 轻度认知障碍和痴呆症患者的照顾者：社会和心理结果的特征。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.1097/WAD.0000000000000603

Oanh L Meyer, Shichen Zheng, Raquel Alto, Duyen Tran, San Luu, Uyen Vu, Ladson Hinton, Danielle Harvey

{"title":"Caregivers of People With Mild Cognitive Impairment and Dementia: Characterizing Social and Psychological Outcomes.","authors":"Oanh L Meyer, Shichen Zheng, Raquel Alto, Duyen Tran, San Luu, Uyen Vu, Ladson Hinton, Danielle Harvey","doi":"10.1097/WAD.0000000000000603","DOIUrl":"10.1097/WAD.0000000000000603","url":null,"abstract":"Objective: Little is known about caregiving across the spectrum of cognitive impairment [mild cognitive impairment (MCI) to dementia] and how early life and sociocultural factors affect caregiver health. In this study, we characterized differences between caregivers of those with MCI versus those with dementia.Methods: A total of 158 caregivers were enrolled in this cross-sectional study, most of whom were dementia caregivers (65%). Caregivers completed questionnaires on depressive symptoms, self-rated health (SRH), perceived burden and stress, as well as psychosocial and demographic measures.Results: Caregivers of those with MCI reported fewer depressive symptoms and lower stress and burden compared with dementia caregivers. In adjusted analyses caregivers with greater stress reported more depressive symptoms. For SRH, at lower stress levels, having a sibling die before age 18 (ie, early life adversity) was associated with poorer SRH; at higher stress levels, having early life adversity was associated with better SRH. At lower burden levels, more live births were associated with worse SRH; at higher burden levels, more live births were associated with better SRH.Conclusions: Early life factors are relevant for caregivers of those with cognitive impairment and targeted prevention and early intervention may be helpful in alleviating caregiver burden and stress.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"51-58"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives From Black and White Participants and Care Partners on Return of Amyloid and Tau PET Imaging and Other Research Results. 黑人和白人参与者以及护理伙伴对淀粉样蛋白和Tau PET成像和其他研究结果的回报的看法。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-30 DOI: 10.1097/WAD.0000000000000591

Annalise Rahman-Filipiak, Mary Lesniak, Shima Sadaghiyani, Scott Roberts, Peter Lichtenberg, Benjamin M Hampstead

{"title":"Perspectives From Black and White Participants and Care Partners on Return of Amyloid and Tau PET Imaging and Other Research Results.","authors":"Annalise Rahman-Filipiak, Mary Lesniak, Shima Sadaghiyani, Scott Roberts, Peter Lichtenberg, Benjamin M Hampstead","doi":"10.1097/WAD.0000000000000591","DOIUrl":"10.1097/WAD.0000000000000591","url":null,"abstract":"Purpose: Alzheimer disease (AD) biomarker testing is now common in research and approaching clinical translation. Disclosure protocols must be informed by diverse participants' perspectives on if/how the information would be useful.Methods: This study utilized semistructured interviews assessing interest in receiving positron emission tomography (PET) amyloid and tau results, as well as perceived risks and benefits of hypothetical PET disclosure as a function of race and participant diagnosis.Participants: Participants [39% Black; 61% White; Mage =74.28 (5.98)] included 57 adults diagnosed as either cognitively healthy (58%) or with mild cognitive impairment (42%) and their respective care partners [33% Black; 67% White; Mage =66.93 (10.92)].Results: Most dyads endorsed strong interest in PET results (82.5% of both participants and partners) regardless of race or diagnosis. Black care partners were less interested in receiving the participant's results than White care partners ( χ2(4) =8.31, P =0.047). Reasons for disclosure were diverse and highly personalized, including access to treatments or clinical trials (23.2% participants; 29.8% partners), advance planning (14.3% participants; 17.5% partners), and improved health knowledge (12.5% participants; 15.8% partners). In contrast, over 80% of respondents denied any risks of disclosure.Discussion: Results suggest that predisclosure education, decisional capacity assessment, and a flexible disclosure approach are needed.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"274-281"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61559834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Assessment as a Way to Reduce Help-seeking Barriers in Older Adults With Subjective Cognitive Decline. 虚拟评估是减少老年人主观认知能力下降求助障碍的一种方法。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-19 DOI: 10.1097/WAD.0000000000000582

Michael R Kann, Peter J Zeiger, Sandra J Rizer, Stephanie Cosentino, Martina Azar

{"title":"Virtual Assessment as a Way to Reduce Help-seeking Barriers in Older Adults With Subjective Cognitive Decline.","authors":"Michael R Kann, Peter J Zeiger, Sandra J Rizer, Stephanie Cosentino, Martina Azar","doi":"10.1097/WAD.0000000000000582","DOIUrl":"10.1097/WAD.0000000000000582","url":null,"abstract":"Subjective cognitive decline (SCD), a potential early marker for neurodegenerative disease such as Alzheimer's disease, is common among older adults. Although it is often regarded as a personal health concern, most individuals with SCD do not seek help from a health care professional. Help-seeking (HS) is a complex, individualized process with significant life-course implications, and older adults often face several barriers to HS across personal, socioeconomic, and cultural domains. The pandemic exacerbated these barriers by imposing additional limitations on in-person care. In response, virtual assessment became a popular method to conduct remote care. We provide a narrative review of the challenges and triumphs that came with the transition from in-person, pen-paper cognitive assessments to virtual cognitive assessments. In addition, we address the impact virtual assessment had in tackling barriers that previously limited individuals with SCD from formal HS. We argue that virtual cognitive assessment helps alleviate health access barriers to HS (e.g., cost, transportation, and physician availability) and allows individuals with different coping styles to undergo assessment within more convenient environments. We hope the findings presented in this review inform health care practice, public education, and future research targeted towards the use of virtual assessment to facilitate HS in older adults with SCD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"373-378"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41092322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender, Pain, and Function Associated With Physical Activity After Hospitalization in Persons Living With Dementia. 痴呆症患者住院后与身体活动相关的性别、疼痛和功能。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-20 DOI: 10.1097/WAD.0000000000000583

Ashley Kuzmik, Marie Boltz, Barbara Resnick, Brittany F Drazich, James E Galvin

{"title":"Gender, Pain, and Function Associated With Physical Activity After Hospitalization in Persons Living With Dementia.","authors":"Ashley Kuzmik, Marie Boltz, Barbara Resnick, Brittany F Drazich, James E Galvin","doi":"10.1097/WAD.0000000000000583","DOIUrl":"10.1097/WAD.0000000000000583","url":null,"abstract":"Background: The purpose of this study was to identify factors that are associated with physical activity after hospitalization in persons living with dementia.Methods: Multiple linear regressions were conducted to test factors associated with objective activity levels (sedentary, low, moderate, and vigorous) among 244 patients living with dementia from a randomized controlled trial.Results: Within 48 hours of hospital discharge, time in sedentary behavior was associated with increased pain (β=0.164, P =0.015). Time in low activity was associated with less pain (β=-0.130, P =0.049) and higher physical function (β=0.300, P =<0.001). Time in moderate activity was associated with increased physical function (β=0.190, P =0.008) and male gender (β=0.155, P =0.016). No significant associations of potential factors were found with time in vigorous activity.Conclusions: Our findings suggest that managing or reducing pain, encouraging individual functional level, and gender could influence time spent in physical activity after acute hospitalization in persons living with dementia.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"357-362"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer Disease: A New Beginning in Therapeutics. 阿尔茨海默病:治疗学的新开端。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.1097/WAD.0000000000000592

Lawrence S Honig

引用次数: 0

A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers. 一项随机双盲研究评估健康志愿者每周一次的多奈哌齐透皮给药系统的皮肤刺激和致敏潜力。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-11 DOI: 10.1097/WAD.0000000000000578

Marwan N Sabbagh, Philip Mathew, Alan Blau

{"title":"A Randomized Double-blind Study to Assess the Skin Irritation and Sensitization Potential of a Once-weekly Donepezil Transdermal Delivery System in Healthy Volunteers.","authors":"Marwan N Sabbagh, Philip Mathew, Alan Blau","doi":"10.1097/WAD.0000000000000578","DOIUrl":"10.1097/WAD.0000000000000578","url":null,"abstract":"Background: A once-weekly donepezil transdermal delivery system (TDS; Adlarity; Corium, LLC) is indicated for the treatment of mild, moderate, and severe dementia of the Alzheimer type. Methods: In this placebo-controlled, randomized, double-blind phase 1 trial, healthy volunteers aged 40 years or older were randomized to receive a placebo and donepezil TDS and were evaluated for the primary endpoints of skin irritation and sensitization potential. Skin irritation was scored. Results: Two hundred fifty-six participants were randomized and received ≥1 dose of any treatment. After the first weekly TDS application, no skin irritation or minimal irritation was evident between donepezil and placebo TDSs. At the third weekly TDS application, for donepezil TDS, the average of the mean combined skin irritation score was 0.55 of a possible maximum of 7, indicating none to minimal skin irritation, and for placebo, the score was 0.19, indicating no skin irritation. Of 198 participants, 4 (2.0%) were considered potentially sensitized to donepezil TDS, and 0 were potentially sensitized to placebo TDS. Conclusion: Once-weekly 5-mg/d donepezil TDS demonstrated minimal skin irritation under conditions of use of 3 consecutive weekly patch applications to the same skin site and minimal sensitization potential.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"290-295"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study. 高频rTMS可以改善中国轻度认知障碍患者的记忆受损:一项随机对照研究。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI: 10.1097/WAD.0000000000000577

Tao Wang, Zhiwei Guo, Hongxia Wu, Yi Jiang, Qiwen Mu

{"title":"High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study.","authors":"Tao Wang, Zhiwei Guo, Hongxia Wu, Yi Jiang, Qiwen Mu","doi":"10.1097/WAD.0000000000000577","DOIUrl":"10.1097/WAD.0000000000000577","url":null,"abstract":"Objective: The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on improving memory deficits in mild cognitive impairment (MCI), as well as to provide visualized evidence for neuronal specificity by using resting-state functional magnetic resonance imaging.Materials and methods: Forty MCI patients were enrolled to receive 10-session and sham-controlled 10Hz-rTMS over the left dorsolateral prefrontal cortex. The resting-state functional magnetic resonance imaging combined with memory scales assessment were performed before and after the intervention. To elucidate the therapeutic mechanism of rTMS, amplitude of low-frequency fluctuations (ALFF) and functional connectivity were calculated. The Pearson correlation was used to measure the relationship between ALFF and memory performance.Results: Compared with the sham group, ALFF significantly increased in the right insula, right inferior frontal gyrus-opercular part, and decreased in the left middle occipital gyrus, left angular gyrus, and left lingual gyrus after rTMS. The change in Auditory Verbal Learning Test scores were negatively correlated with ALFF decreases in the left lingual gyrus. Functional connectivity significantly increased between the posterior cingulate cortex and right supramarginal gyrus, and decreased between the right frontoinsular cortex and right supramarginal gyrus after intervention.Conclusion: High-frequency rTMS over the left dorsolateral prefrontal cortex could facilitate improvement on impaired memory in patients with MCI via modulating the neuronal activity and brain network.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"296-302"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0