High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI:10.1097/WAD.0000000000000577

Tao Wang, Zhiwei Guo, Hongxia Wu, Yi Jiang, Qiwen Mu

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引用次数: 0

Abstract

Objective: The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on improving memory deficits in mild cognitive impairment (MCI), as well as to provide visualized evidence for neuronal specificity by using resting-state functional magnetic resonance imaging.

Materials and methods: Forty MCI patients were enrolled to receive 10-session and sham-controlled 10Hz-rTMS over the left dorsolateral prefrontal cortex. The resting-state functional magnetic resonance imaging combined with memory scales assessment were performed before and after the intervention. To elucidate the therapeutic mechanism of rTMS, amplitude of low-frequency fluctuations (ALFF) and functional connectivity were calculated. The Pearson correlation was used to measure the relationship between ALFF and memory performance.

Results: Compared with the sham group, ALFF significantly increased in the right insula, right inferior frontal gyrus-opercular part, and decreased in the left middle occipital gyrus, left angular gyrus, and left lingual gyrus after rTMS. The change in Auditory Verbal Learning Test scores were negatively correlated with ALFF decreases in the left lingual gyrus. Functional connectivity significantly increased between the posterior cingulate cortex and right supramarginal gyrus, and decreased between the right frontoinsular cortex and right supramarginal gyrus after intervention.

Conclusion: High-frequency rTMS over the left dorsolateral prefrontal cortex could facilitate improvement on impaired memory in patients with MCI via modulating the neuronal activity and brain network.

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高频rTMS可以改善中国轻度认知障碍患者的记忆受损:一项随机对照研究。

目的:探讨重复经颅磁刺激(rTMS)对轻度认知障碍(MCI)患者记忆缺陷的改善作用，并利用静息状态功能磁共振成像技术为神经元特异性提供可视化证据。材料与方法:选取40例轻度认知障碍患者，在左前额叶背外侧皮质区接受10期假对照10Hz-rTMS。干预前后分别进行静息状态功能磁共振成像及记忆量表评估。为了阐明rTMS的治疗机制，我们计算了低频波动幅度(ALFF)和功能连通性。使用Pearson相关来衡量ALFF与记忆性能之间的关系。结果:与假手术组比较，rTMS后右侧脑岛、右侧额下回-眼部ALFF明显升高，左侧枕中回、左侧角回、左侧舌回ALFF明显降低。听觉语言学习测试成绩的变化与左舌回ALFF的减少呈负相关。干预后，后扣带皮层与右侧边缘上回之间的功能连通性显著增加，右侧额岛皮层与右侧边缘上回之间的功能连通性显著降低。结论:左背外侧前额叶皮层高频rTMS可通过调节神经元活动和脑网络促进MCI患者记忆受损的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.