Alzheimer Disease & Associated Disorders最新文献

Trends and Gaps in Public Perception of Genetic Testing for Dementia Risk: Unsupervised Deep Learning of Twitter Posts From 2010 to 2023. 公众对痴呆症风险基因检测认知的趋势和差距：2010年至2023年Twitter帖子的无监督深度学习。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-15 DOI: 10.1097/WAD.0000000000000667

Natalie Edna Pak, Li Chang Ang, Kaavya Narasimhalu, Tau Ming Liew

{"title":"Trends and Gaps in Public Perception of Genetic Testing for Dementia Risk: Unsupervised Deep Learning of Twitter Posts From 2010 to 2023.","authors":"Natalie Edna Pak, Li Chang Ang, Kaavya Narasimhalu, Tau Ming Liew","doi":"10.1097/WAD.0000000000000667","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000667","url":null,"abstract":"Background: Genetic testing for dementia has drawn public attention in recent years, albeit with concerns on its appropriate use. This study leveraged Twitter data to analyze public perceptions related to genetic testing for dementia.Methods: English tweets from January 1, 2010 to April 1, 2023, containing relevant terms, were extracted from Twitter API. A Bidirectional Encoder Representations from Transformers (BERT) model was used with Named Entity Recognition (NER) to identify individual and organizational users. BERT-based topic modeling was applied to identify the themes for relevant source tweets. Topic coherence was assessed through manual inspection, complemented by the Silhouette Coefficient. Manual thematic analysis, following Braun and Clarke's approach, refined the topics and themes.Results: The analysis of 3045 original/source tweets identified 9 topics (Silhouette Coefficient=0.19), categorized into 3 main themes: (1) opinions on the appropriateness of genetic testing in dementia diagnosis; (2) discussion on the psychosocial impact; (3) discussion on genetic testing's role in Alzheimer's disease treatment and prevention. Theme 1 comprised 90.6% of source tweets, demonstrating prevailing contentions. Tweets in theme 2 were increasingly contributed by organization users over time and included tweets containing misinformation about genetic testing in children. Tweets in theme 3 were increasingly contributed by individual users, possibly suggesting rising public interest in the treatment and prevention of dementia.Conclusion: The study highlighted limited public understanding of the nondeterministic nature of genetic testing for dementia, with concerns about unsupervised direct-to-consumer genetic test marketing, emphasizing the need to counter misinformation and raise public awareness.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Self-Administered Gerocognitive Examination (SAGE): Equivalence of Parallel Versions and Validity in Cognitively Unimpaired Controls and Patients With Mild Cognitive Impairment or Dementia in a Memory Clinic. 自我管理的老年认知检查（SAGE）：记忆诊所中认知功能未受损对照和轻度认知障碍或痴呆患者平行版本的等效性和有效性

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-15 DOI: 10.1097/WAD.0000000000000673

Roy P C Kessels, Floor S van Bergen, Iris J Harmsen, Daan K L Sleutjes, Paul L J Dautzenberg, Joukje M Oosterman

{"title":"The Self-Administered Gerocognitive Examination (SAGE): Equivalence of Parallel Versions and Validity in Cognitively Unimpaired Controls and Patients With Mild Cognitive Impairment or Dementia in a Memory Clinic.","authors":"Roy P C Kessels, Floor S van Bergen, Iris J Harmsen, Daan K L Sleutjes, Paul L J Dautzenberg, Joukje M Oosterman","doi":"10.1097/WAD.0000000000000673","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000673","url":null,"abstract":"Objective: Cognitive screens to diagnose mild cognitive impairment (MCI) or dementia require supervision and cannot be easily administered in primary care. Here, we validated the Self-Administered Gerontocognitive Examination (SAGE), investigating the alternate version equivalence, the convergent validity using neuropsychological tests, and its diagnostic accuracy.Patients: Thirty-two MCI patients and 34 with dementia were recruited from a memory clinic in the Netherlands, and 69 healthy controls over the age of 50.Methods: The 4 alternate versions of the SAGE were compared. Receiver operating characteristic (ROC) analyses were performed, comparing the controls to the MCI and dementia groups. Associations between SAGE scores and standard neuropsychological tests were examined.Results: No performance differences were found between the alternate versions. Performance differences were found on the SAGE between the 3 groups, with fair to good areas under the curve. A cutoff score of <18 had the best diagnostic accuracy for controls versus dementia, <20 for controls versus MCI and <19 for controls versus cognitively impaired. SAGE scores correlated with standard neuropsychological tests.Discussion: The SAGE is a valid tool for distinguishing cognitively unimpaired individuals from people with dementia or MCI.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum. 阿尔茨海默病谱系中基于表现的功能任务变异性的皮质厚度预测因子。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-13 DOI: 10.1097/WAD.0000000000000672

Michael Malek-Ahmadi, Kjera Schack, Kevin Duff, Vincent Koppelmans, Jace B King, Yi Su, Sydney Y Schaefer

{"title":"Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum.","authors":"Michael Malek-Ahmadi, Kjera Schack, Kevin Duff, Vincent Koppelmans, Jace B King, Yi Su, Sydney Y Schaefer","doi":"10.1097/WAD.0000000000000672","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000672","url":null,"abstract":"Purpose: Determine whether regional measures of cortical thickness are associated with functional task performance.Patients: One hundred six older adults who were classified as either cognitively unimpaired (CU), mild cognitive impairment (MCI), or Alzheimer disease (AD) completed a performance-based functional task.Methods: The SD of completion times of 6 consecutive trials within a session of the functional task was used as the primary measure for each participant, reflecting intraindividual variability. Regression tree analysis identified cortical gray matter thickness measures that best predicted intraindividual variability on the functional task.Results: Cortical thickness measures from temporal, parietal, frontal, and occipital regions best predicted intraindividual variability on the task, which are cortical regions associated with learning, executive function, and visuospatial function. Specifically, the fusiform gyrus was featured prominently in these and prior regression tree results, suggesting its possible involvement in this behavioral task.Conclusion: These analyses suggest a mechanistic focus of variability on this functional task, which could serve as an outcome in clinical trials.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers: A Systematic Review and Meta-Analysis. 患有阿尔茨海默病生物标志物的健康认知患者的视网膜和血管光学相干断层扫描结果：系统回顾和荟萃分析

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-13 DOI: 10.1097/WAD.0000000000000669

Carlos Leal-Bernal, Santiago Noriega-Ramírez, José V Álvarez-Martínez, Carlos Cifuentes-González, William Rojas-Carabali, Alejandro Manrique-Samer, Valeria Flórez-Esparza, Isabella Monsalve-García, Juan S Amézquita-Villanueva, Germán Mejía-Salgado, Mauricio O Nava-Mesa, Alejandra de-la-Torre

{"title":"Retinal and Vascular Findings in Optical Coherence Tomography in Healthy Cognitive Patients With Alzheimer Disease Biomarkers: A Systematic Review and Meta-Analysis.","authors":"Carlos Leal-Bernal, Santiago Noriega-Ramírez, José V Álvarez-Martínez, Carlos Cifuentes-González, William Rojas-Carabali, Alejandro Manrique-Samer, Valeria Flórez-Esparza, Isabella Monsalve-García, Juan S Amézquita-Villanueva, Germán Mejía-Salgado, Mauricio O Nava-Mesa, Alejandra de-la-Torre","doi":"10.1097/WAD.0000000000000669","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000669","url":null,"abstract":"Purpose: This systematic review and meta-analysis aimed to explore differences in optical coherence tomography (OCT) findings between cognitively healthy individuals with Alzheimer disease (AD) biomarkers and healthy controls.Methods: A thorough literature review was conducted on February 6, 2023, in PubMed, Embase, Cochrane Library, LILACS, and DANS EASY Archive. Studies that involved cognitively healthy individuals with AD biomarkers undergoing OCT or OCT angiography were included. The risk of bias was assessed using validated tools. A narrative synthesis and meta-analysis were performed with standardized mean differences and I2 heterogeneity assessments.Results: Seventeen studies comprising 601 participants with positive AD biomarkers and 881 controls were included. The reviewed studies varied in design, with notable findings indicating a reduction in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness, alongside an increase in inner plexiform layer (IPL) thickness. In addition, OCT angiography revealed reduced vascular density and an enlarged foveal avascular zone-however, variations and inconsistencies in results led to inconclusive outcomes for RNFL and GCL-IPL meta-analyses.Conclusion: In summary, cognitively healthy individuals with positive AD biomarkers demonstrated RNFL, GCL thinning, and IPL thickening trends. Future longitudinal studies using standardized methods are critical to validate these OCT changes as potential early indicators for AD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Manifestations of Sporadic Creutzfeldt-Jakob Disease in a Public Neurological Hospital in Thailand. 泰国一家公立神经医院散发性克雅氏病的临床表现

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-12 DOI: 10.1097/WAD.0000000000000671

Jedsada Khieukhajee, Arada Rojana-Udomsart

{"title":"Clinical Manifestations of Sporadic Creutzfeldt-Jakob Disease in a Public Neurological Hospital in Thailand.","authors":"Jedsada Khieukhajee, Arada Rojana-Udomsart","doi":"10.1097/WAD.0000000000000671","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000671","url":null,"abstract":"Introduction: Sporadic Creutzfeldt-Jakob disease (sCJD) is one of the common causes of rapidly progressive dementia. However, because of the variety of its clinical presentations, a definite diagnosis in public hospitals is not always possible. Therefore, this study will provide more information about the clinical data of probable sCJD cases in Thailand.Methods: This case series of probable sCJD patients who visited the Neurological Institute of Thailand during 2018 to 2023 was conducted. Demographic data, clinical presentations, brain MRI, EEG, CSF analyses, and clinical course were reviewed.Results: A total of 17 probable sCJD cases were studied. Eleven patients were female (64.71%) with a median age of 62 (IQR: 14.5) years. The median onset of symptoms was 2 months (IQR: 2) before hospital visit, in which cognitive impairment was the most common first presentation (29.41%) followed by ataxia (23.53%), and visual disturbances (17.65%). Most patients had typical high signal intensities at both caudate/putamen and cortical regions (76.47%). Generalized periodic discharges with triphasic morphology were found in 11/14 patients with EEG results (78.57%).Conclusion: sCJD has a diverse clinical presentation that resembles other cognitive disorders. Detailed assessment of signs and symptoms, together with proper investigations, could help to differentiate this condition in a resource-limited setting.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language Dominance and Education Considerations in the Neuropsychological Assessment of Southwestern American Indians Using the National Alzheimer Coordinating Center's Uniform Data Set Version 3. 使用国家阿尔茨海默病协调中心统一数据集版本3的美国西南部印第安人神经心理学评估中的语言优势和教育考虑。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-09 DOI: 10.1097/WAD.0000000000000668

Sephira G Ryman, Steven P Verney, Michelle Quam, Donica Ghahate, Jillian Prestopnik, Erika Partridge, John Adair, Lynette Abrams-Silva, Janice Knoefel, Vernon S Pankratz, Erik Erhardt, Mark Unruh, Gary Rosenberg, Vallabh Shah

{"title":"Language Dominance and Education Considerations in the Neuropsychological Assessment of Southwestern American Indians Using the National Alzheimer Coordinating Center's Uniform Data Set Version 3.","authors":"Sephira G Ryman, Steven P Verney, Michelle Quam, Donica Ghahate, Jillian Prestopnik, Erika Partridge, John Adair, Lynette Abrams-Silva, Janice Knoefel, Vernon S Pankratz, Erik Erhardt, Mark Unruh, Gary Rosenberg, Vallabh Shah","doi":"10.1097/WAD.0000000000000668","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000668","url":null,"abstract":"To address disparities in dementia diagnosis and care in American Indian and Alaska Native communities, it is crucial to understand how sociocultural factors, such as language dominance and education, impact performances on standardized neuropsychological assessments. We discuss sociocultural considerations that are important to consider when evaluating cognition in American Indians. We conducted t tests/Kruskal-Wallis tests and correlation analyses to evaluate the impact of language and education factors on performances on the National Alzheimer Coordinating Center's Uniform Data Set Version 3 Neuropsychological assessments in a community of Southwestern American Indians. There were no significant differences in cognitive performances between the Zuni (Shiwi)-dominant and English-dominant individuals. Number of years of education had a greater effect on cognitive performances relative to language dominance, particularly for the common cognitive screening measure, the Montreal Cognitive Assessment. Our results highlight that education factors have a greater effect on cognitive performances relative to language dominance in this unique cohort. The associations with the Montreal Cognitive Assessment raise concerns for the use of this tool in this population, highlighting a need to develop culturally appropriate cognitive testing tools as well as ensuring comprehensive, culturally competent neuropsychological assessments are accessible.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Safety Net Enclosures as an Additional Treatment of Neuropsychiatric Symptoms in Dementia: A Prospective Cohort Study. 使用安全网围栏作为痴呆患者神经精神症状的额外治疗：一项前瞻性队列研究

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-03-14 DOI: 10.1097/WAD.0000000000000666

Katinka Hummelen, Charlotte Schrama, Rob Kok

{"title":"Use of Safety Net Enclosures as an Additional Treatment of Neuropsychiatric Symptoms in Dementia: A Prospective Cohort Study.","authors":"Katinka Hummelen, Charlotte Schrama, Rob Kok","doi":"10.1097/WAD.0000000000000666","DOIUrl":"10.1097/WAD.0000000000000666","url":null,"abstract":"Objective: Safety net enclosures are used in addition to (non-) pharmacological interventions in patients suffering from neuropsychiatric symptoms in dementia. However, no data on effectiveness are available.Methods: In a prospective observational cohort study of 81 patients diagnosed with dementia, and admitted to a geriatric ward of a psychiatric hospital, available behavioral assessment scores were used to compare 45 patients who used safety net enclosures with 36 patients who never used safety net enclosures. Behavior was evaluated weekly using the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory Questionnaire (NPI-Q) at admission, start of the enclosure, and before discharge.Results: At baseline, the intervention group had a significantly higher CMAI and NPI-Q-score. At follow-up, the intervention group showed a greater improvement in CMAI [median -13.0 (interquartile range: -27.3 to 0.05) vs 0.0 (interquartile range: -6.0 to 2.5); Mann-Whitney U = 338.5 ( P = 0.005)] compared with the comparison group. Only some NPI-Q subscales showed significantly greater improvement during the intervention than in the comparison group.Conclusions: Our observational study is the first to present effectiveness data on Neuropsychiatric symptoms in persons suffering from dementia and suggests significantly greater improvement in CMAI scores when using safety net enclosures. However, almost no significant differences were found in other outcomes.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental Education, Midlife Hypertension, and Disparities in Late-Life Cognitive Test Scores: Application of an Equity-Focused Causal Decomposition Approach. 父母教育、中年高血压和晚年认知测试成绩的差异：以公平为中心的因果分解方法的应用。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-02-10 DOI: 10.1097/WAD.0000000000000662

Tamare V Adrien, Andrew K Hirst, Indira C Turney, Rachel L Peterson, Laura B Zahodne, Ruijia Chen, Paul K Crane, Shellie-Anne Levy, Ryan M Andrews, Elizabeth R Mayeda, Rachel A Whitmer, Paola Gilsanz, John W Jackson, Eleanor Hayes-Larson

{"title":"Parental Education, Midlife Hypertension, and Disparities in Late-Life Cognitive Test Scores: Application of an Equity-Focused Causal Decomposition Approach.","authors":"Tamare V Adrien, Andrew K Hirst, Indira C Turney, Rachel L Peterson, Laura B Zahodne, Ruijia Chen, Paul K Crane, Shellie-Anne Levy, Ryan M Andrews, Elizabeth R Mayeda, Rachel A Whitmer, Paola Gilsanz, John W Jackson, Eleanor Hayes-Larson","doi":"10.1097/WAD.0000000000000662","DOIUrl":"10.1097/WAD.0000000000000662","url":null,"abstract":"Background: Parental education is an important determinant of late-life cognition, but the extent to which intervening on midlife risk factors, such as hypertension, mitigates the impact of early-life factors is unclear. Novel methodological approaches, such as causal decomposition, facilitate the assessment of contributors to health inequities through hypothetical interventions on mediating risk factors.Methods: Using harmonized cohorts (Kaiser Healthy Aging and Diverse Life Experiences Study; Study of Healthy Aging in African Americans) and a ratio of mediator probability weights decomposition approach, we quantified disparities in late-life cognitive test scores (semantic memory, executive function, and verbal memory z-scores) across high versus low parental education, and evaluated whether socioeconomic disparities in late-life cognitive test scores would change if the corresponding disparity in midlife hypertension were eliminated.Results: We observed substantial disparities across levels of parental education in late-life cognitive test scores (eg, =-0.72 95% CI: -0.84 to -0.60 for semantic memory). Hypothetical intervention on midlife hypertension did not substantially reduce disparities in any cognitive domain. Patterns were similar when stratified by race.Conclusions: Future work should evaluate other points of intervention across the lifecourse (eg, participant education) to reduce late-life cognitive disparities across levels of parental education.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Social Restriction Due to the COVID-19 Pandemic on Activity of Daily Living and Disease Severity of Patients With Alzheimer Disease: Sub-analysis of a Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets. COVID-19大流行导致的社会限制对阿尔茨海默病患者日常生活活动和疾病严重程度的影响：多奈哌齐贴片和多奈哌齐片双盲非劣效性研究的亚分析

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-01-31 DOI: 10.1097/WAD.0000000000000657

Yu Nakamura, Takumi Omori, Kenichi Nishiyama, Ichiro Ishikawa, Hiroshi Aoki, Naoki Nagakura

{"title":"Effect of Social Restriction Due to the COVID-19 Pandemic on Activity of Daily Living and Disease Severity of Patients With Alzheimer Disease: Sub-analysis of a Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets.","authors":"Yu Nakamura, Takumi Omori, Kenichi Nishiyama, Ichiro Ishikawa, Hiroshi Aoki, Naoki Nagakura","doi":"10.1097/WAD.0000000000000657","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000657","url":null,"abstract":"Background: We previously reported that social restrictions due to the COVID-19 pandemic led to a decline in cognitive function in patients with Alzheimer disease (AD). Here, we assessed the effects of COVID-19 restrictions on the activities of daily living (ADL) and disease severity in patients by comparing them to a control group.Methods: We examined the impact on ADL, evaluated using disability assessment for dementia (DAD), and disease severity, evaluated using the ABC dementia scale, in patients with mild-to-moderate AD. We conducted a post hoc subgroup analysis of a double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After showing the noninferiority of both treatments, we combined the data from both groups for analysis.Results: The subpopulation of the per-protocol set grouped by completing the double-blinded evaluation before and on/after the mild lockdown was balanced (n=136 and n=120). Patient demographics were similar between the subgroups. The decline in the DAD and ABC dementia scale scores [least-squares mean (SE)] was ameliorated by social restriction [-3.810 (0.743) and -1.871 (0.697) and -1.147 (0.285) and -0.419 (0.267), respectively (not significant)].Conclusion: Normalcy and expectation biases can affect the evaluation of ADL and disease severity by caregivers under high stress and deterioration of mental conditions.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival of Patients at a Neurology Clinic: No Improvement Over 12 Years. 神经内科门诊患者的生存率：12年无改善。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2025-01-30 DOI: 10.1097/WAD.0000000000000658

Kyle Steenland, Youran Tan, Shirley M Mullins, Taylor E Kidd, Qiyun Gong, James J Lah

{"title":"Survival of Patients at a Neurology Clinic: No Improvement Over 12 Years.","authors":"Kyle Steenland, Youran Tan, Shirley M Mullins, Taylor E Kidd, Qiyun Gong, James J Lah","doi":"10.1097/WAD.0000000000000658","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000658","url":null,"abstract":"Introduction: We previously followed Emory patients with neurodegenerative disease from 1993 to 2006. Here, we follow survivor and new patients for 2007 to 2018.Methods: We studied mortality from 10 different diagnostic groups among 4322 research volunteers, and compared mortality rates to controls with normal cognition, using Cox regression. We assessed mortality through the National Death Index, controlling for sex, education, race, comorbidities, and age. Supplemental analyses considered APOE and cognitive test scores.Results: Fifty-nine percent of patients died during follow-up. Mortality rate ratios, compared with controls (n=641) in descending order were 12.54, 6.61, 4.77, 4.92, 3.36, 2.25, 2.21 1.71, 1.39, and 1.17 for diagnostic groups ALS, (n=571), FTD (n=197), LBD (n=134), PD (n=584), AD (n=1118), MCI/dementia (n=82), dementia not specified (n=165), PD symptoms (n=256), vascular dementia (n=234), and MCI (n=340), respectively. Women, non-whites, those with higher education, with no comorbidities, and lower ages had lower mortality rates for most diagnostic groups. Mortality rates were higher in the presence of APOE4 variants for several diagnostic groups. Lower MMSEs predicted worse survival for most diseases. Overall, 41% of patients survived during 12 years of follow-up, compared with an expected 75% in the US population.Conclusion: Survival times for different diagnostic groups have changed little over several decades.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0