Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2025-05-13 DOI:10.1097/WAD.0000000000000672

Michael Malek-Ahmadi, Kjera Schack, Kevin Duff, Vincent Koppelmans, Jace B King, Yi Su, Sydney Y Schaefer

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Abstract

Purpose: Determine whether regional measures of cortical thickness are associated with functional task performance.

Patients: One hundred six older adults who were classified as either cognitively unimpaired (CU), mild cognitive impairment (MCI), or Alzheimer disease (AD) completed a performance-based functional task.

Methods: The SD of completion times of 6 consecutive trials within a session of the functional task was used as the primary measure for each participant, reflecting intraindividual variability. Regression tree analysis identified cortical gray matter thickness measures that best predicted intraindividual variability on the functional task.

Results: Cortical thickness measures from temporal, parietal, frontal, and occipital regions best predicted intraindividual variability on the task, which are cortical regions associated with learning, executive function, and visuospatial function. Specifically, the fusiform gyrus was featured prominently in these and prior regression tree results, suggesting its possible involvement in this behavioral task.

Conclusion: These analyses suggest a mechanistic focus of variability on this functional task, which could serve as an outcome in clinical trials.

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阿尔茨海默病谱系中基于表现的功能任务变异性的皮质厚度预测因子。

目的：确定皮质厚度的区域测量是否与功能性任务表现有关。患者：106名被分类为认知未受损（CU）、轻度认知障碍（MCI）或阿尔茨海默病（AD）的老年人完成了一项基于表现的功能任务。方法：在一组功能任务中连续6次试验的完成时间标准差作为每个参与者的主要测量指标，反映了个体的可变性。回归树分析发现，皮质灰质厚度测量最能预测功能性任务的个体差异性。结果：颞、顶叶、额叶和枕叶区域的皮质厚度测量最能预测任务中的个体变异，这些皮质区域与学习、执行功能和视觉空间功能相关。具体来说，梭状回在这些和先前的回归树结果中表现突出，表明它可能参与了这一行为任务。结论：这些分析表明，这种功能任务的变异性的机制焦点，可以作为临床试验的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.