Alzheimer Disease & Associated Disorders最新文献_第10页

Can Depressive Symptomatology at Diagnosis Predict Cognitive and Functional Decline Over 1 Year in Rural Canadian Patients With Dementia? 诊断时的抑郁症状能预测加拿大农村痴呆患者1年内的认知和功能下降吗？

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-31 DOI: 10.1097/WAD.0000000000000574

Shuang Cai, Andrew Kirk, Chandima Karunanayake, Megan E O'Connell, Debra Morgan

{"title":"Can Depressive Symptomatology at Diagnosis Predict Cognitive and Functional Decline Over 1 Year in Rural Canadian Patients With Dementia?","authors":"Shuang Cai, Andrew Kirk, Chandima Karunanayake, Megan E O'Connell, Debra Morgan","doi":"10.1097/WAD.0000000000000574","DOIUrl":"10.1097/WAD.0000000000000574","url":null,"abstract":"Introduction: Depressive symptomatology is often associated with the onset of dementia, although the exact form and directionality of this association is still unclear. The aim of this study is to investigate whether depressive symptomatology at the time of dementia diagnosis was predictive of cognitive, functional, and behavioral decline over 1 year.Methods: In a Rural and Remote Memory Clinic, 375 patients consecutively diagnosed with mild cognitive impairment, Alzheimer disease, or non-Alzheimer disease dementia completed the Center for Epidemiological Studies Depression Scale at first visit and 1-year follow-up to assess depressive symptomatology. The same cohort was evaluated for cognitive, functional, and behavioral decline through the completion of 5 clinical tests performed at the first visit and at 1-year follow-up.Results: Depressive symptomatology at time of dementia diagnosis did not predict cognitive or functional decline over 1 year, although increases in depressive symptomatology over 1 year significantly correlated with higher caregiver ratings of neuropsychiatric symptom severity and related distress over that time.Conclusion: Increasingly severe depressive symptomatology over 1 year correlated with greater caregiver distress. This study points the way for future studies delineating the relationship between depression, dementia progression, and caregiver distress.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"179-183"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dementia Prevalence and Risk Factors: Data From Rural Tanzania. 痴呆症患病率和危险因素：坦桑尼亚农村的数据。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-10 DOI: 10.1097/WAD.0000000000000564

Caitlin Roe, Ssenku Safic, Lwitiko Mwaipopo, Catherine L Dotchin, Joanna Klaptocz, William Gray, Marcyella Joseph, Aimee Spector, Sarah Urasa, Richard W Walker

{"title":"Dementia Prevalence and Risk Factors: Data From Rural Tanzania.","authors":"Caitlin Roe, Ssenku Safic, Lwitiko Mwaipopo, Catherine L Dotchin, Joanna Klaptocz, William Gray, Marcyella Joseph, Aimee Spector, Sarah Urasa, Richard W Walker","doi":"10.1097/WAD.0000000000000564","DOIUrl":"10.1097/WAD.0000000000000564","url":null,"abstract":"Objectives: The burden of dementia is increasing in sub-Saharan Africa (SSA), but there are limited epidemiological data on dementia in SSA. This study investigated the prevalence and associations of dementia in older adults (less than 60 y) attending the outpatient department of Mount Meru Hospital in Tanzania.Methods: This one-phase cross-sectional study screened a sample using the Identification of Dementia in Elderly Africans (IDEA) cognitive screening tool. Those that screened as having possible and probable dementia were further assessed, and diagnosis of dementia was made according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Demographic and risk factor data were collected.Results: Within those screened, 57/1141 (5.0%) (95% CI: 3.7-6.3) had dementia. Female sex [odds ratio (OR)=2.778, 95% CI: 1.074-7.189], having never attended school (OR=6.088, 95% CI: 1.360-27.256), alcohol (U/wk) (OR=1.080, 95% CI: 1.016-1.149), uncorrected visual impairment (OR=4.260, 95% CI: 1.623-11.180), body mass index <18.5 kg/m 2 (OR=6.588, 95% CI: 2.089-20.775), and stroke (OR=15.790, 95% CI: 3.48-74.475) were found to be significantly, independently associated with dementia.Conclusions: The prevalence of dementia in this population is similar to a recent community-based rate in Tanzania and lower than a hospital-based rate in Senegal. This is the first time the association between visual impairment and dementia has been reported in SSA. Other associations are in keeping with previous literature.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"229-236"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To the Editor and Readership of Alzheimer Disease and Associated Disorders. 致阿尔茨海默病和相关疾病的编辑和读者。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-05 DOI: 10.1097/WAD.0000000000000566

Laura M Tidmore, Grant H Skrepnek

引用次数: 0

Meta-Analysis of Animal Fluency Performance in Amnestic Mild Cognitive Impairment and Cognitively Unimpaired Older Adults. 失智性轻度认知障碍和认知无障碍老年人动物流利性表现的Meta分析。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-24 DOI: 10.1097/WAD.0000000000000568

Vivek Sharma, Michael Malek-Ahmadi

{"title":"Meta-Analysis of Animal Fluency Performance in Amnestic Mild Cognitive Impairment and Cognitively Unimpaired Older Adults.","authors":"Vivek Sharma, Michael Malek-Ahmadi","doi":"10.1097/WAD.0000000000000568","DOIUrl":"10.1097/WAD.0000000000000568","url":null,"abstract":"Animal fluency is a commonly used neuropsychological measure that is used in the diagnosis of amnestic mild cognitive impairment (aMCI) and Alzheimer disease. Although most individuals with aMCI have clinically normal scores on this test, several studies have shown that aMCI individuals' performance is significantly lower than that of cognitively unimpaired (CU) individuals. The aim of this meta-analysis was to characterize the effect size of animal fluency performance differences between aMCI and CU individuals. Literature search with search terms used were: \"animal fluency and mild cognitive impairment,\" \"semantic fluency and mild cognitive impairment,\" \"category fluency and mild cognitive impairment.\" Both the standardized mean difference and the raw mean difference were derived from random effects analyses. Demographically adjusted z-scores for animal fluency performance for the aMCI groups were obtained to determine normative performance. Nineteen studies were included in the analysis. The standardized mean difference for animal fluency performance between CU and aMCI was 0.89 (95% confidence interval: [0.73; 1.04], P <0.001), I2 =70.3% [52.7%; 81.4%], which reflects a large effect size with moderate heterogeneity. The raw mean difference was -4.08 [-4.75; -3.38], P <0.001. The mean animal fluency z-score for aMCI groups was in the Low Average range (z=-0.77). This study found a substantial difference in animal fluency performance between aMCI and CU individuals. The aMCI groups' normative performance did not fall into the impaired range, indicating that there are important subclinical differences in animal fluency performance that may inform the design of cognitive end points for Alzheimer's disease prevention trials.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"259-264"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Education as a Moderator of Help Seeking Behavior in Subjective Cognitive Decline. 教育是主观认知衰退中求助行为的调节因子。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-31 DOI: 10.1097/WAD.0000000000000571

Martina Azar, Silvia Chapman, Jillian Joyce, Maria Schultheis, Zoe Zhang, Leah Waltrip, Shaina Shagalow, Peter Zeiger, Preeti Sunderaraman, Stephanie Cosentino

{"title":"Education as a Moderator of Help Seeking Behavior in Subjective Cognitive Decline.","authors":"Martina Azar, Silvia Chapman, Jillian Joyce, Maria Schultheis, Zoe Zhang, Leah Waltrip, Shaina Shagalow, Peter Zeiger, Preeti Sunderaraman, Stephanie Cosentino","doi":"10.1097/WAD.0000000000000571","DOIUrl":"10.1097/WAD.0000000000000571","url":null,"abstract":"Objective: Disparities in Alzheimer disease (AD) and differences in help seeking (HS) across sociodemographic groups warrant public health concern. Research addressing such disparities must shift toward the earliest clinical manifestations of AD to optimize diagnosis, intervention and care planning. Subjective cognitive decline (SCD), a risk state for AD, provides an important context in which to examine sociodemographic-related disparities in HS.Participants and methods: One hundred sixty-seven cognitively healthy older adults (M age =73, M education =16) (26.4% Black, Asian, or \"Other\") completed SCD questionnaire, HS questions, and mood measures (depression and anxiety). Binary logistic adjusted regressions examined: (a) the association between SCD and HS; and (b) the extent to which education moderated the relationship between SCD and HS. SCD [b = 0.06, SE=0.13, P <0.001, odds ratio=1.06, 95% CI (1.03, 1.08)] and education [b=0.32, SE=0.09, P <0.001, odds ratio=1.37, 95% CI (1.15, 1.64)] were independently associated with HS, with significant interaction between education and SCD on HS [b=0.2, SE=0.01, P =0.01, odds ratio=1.02, 95% CI (1.00, 1.03)].Conclusions: Findings elucidate the importance of tailoring SCD-related psychoeducational resources depending on educational background as a preliminary stepping-stone in encouraging HS among older adults who may be at particular risk for developing dementia.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"184-188"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired Emotion Recognition: A Potential Marker for Social Behavioral Problems in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease? 情绪识别受损：老年性轻度认知障碍和早期阿尔茨海默病患者社会行为问题的潜在标志物？

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-24 DOI: 10.1097/WAD.0000000000000567

Fijanne Strijkert, Rients B Huitema, Barbara C van Munster, Jacoba M Spikman

{"title":"Impaired Emotion Recognition: A Potential Marker for Social Behavioral Problems in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease?","authors":"Fijanne Strijkert, Rients B Huitema, Barbara C van Munster, Jacoba M Spikman","doi":"10.1097/WAD.0000000000000567","DOIUrl":"10.1097/WAD.0000000000000567","url":null,"abstract":"Objective: Emotion recognition, an important aspect of social cognition, can be impaired already in early Alzheimer disease dementia and amnestic mild cognitive impairment (aMCI) and may underly social behavioral changes, which can increase caregiver burden. However, social behavior is difficult to assess in outpatient settings. We evaluated whether impaired emotion recognition is related to proxy-rated social behavioral problems and thus can serve as a marker of these changes.Patients and method: Emotion recognition was assessed with Ekman 60 Faces Test (EFT-total, 6 separate emotions) in patients (n = 31 AD; n = 37 aMCI) and healthy controls (n = 60 HCs). Social behavioral problems were rated by proxies with the neuropsychiatric inventory (agitation, apathy, irritability, disinhibition, and a sum score). It tested whether EFT scores differed between patients with and without behavioral problems.Results: AD had worse EFT-total ( P <0.001), disgust ( P = 0.02), and fear ( P = 0.001) than HC, but not than aMCI, who did not differ from HC. AD displayed more disinhibition ( P < 0.05). EFT and neuropsychiatric inventory sum scores were not significantly correlated. Patients with apathy had lower EFT-total ( P = 0.02).Conclusions: Measuring emotion recognition adds value: it is impaired in early neurodegeneration and associated with apathy but not necessarily related to overall changes in social behavior in this population.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"189-194"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/d1/wad-37-189.PMC10443627.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias. 阿米什人阿尔茨海默病及相关痴呆症的视觉空间和言语记忆差异。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-08-02 DOI: 10.1097/WAD.0000000000000570

Michael B Prough, Andrew Zaman, Laura J Caywood, Jason E Clouse, Sharlene D Herington, Susan H Slifer, Daniel A Dorfsman, Larry A Adams, Reneé A Laux, Yeunjoo E Song, Audrey Lynn, Denise Fuzzell, Sarada L Fuzzell, Sherri D Miller, Kristy Miskimen, Leighanne R Main, Michael D Osterman, Paula Ogrocki, Alan J Lerner, Jeffery M Vance, Jonathan L Haines, William K Scott, Margaret Pericak-Vance, Michael L Cuccaro

{"title":"Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias.","authors":"Michael B Prough, Andrew Zaman, Laura J Caywood, Jason E Clouse, Sharlene D Herington, Susan H Slifer, Daniel A Dorfsman, Larry A Adams, Reneé A Laux, Yeunjoo E Song, Audrey Lynn, Denise Fuzzell, Sarada L Fuzzell, Sherri D Miller, Kristy Miskimen, Leighanne R Main, Michael D Osterman, Paula Ogrocki, Alan J Lerner, Jeffery M Vance, Jonathan L Haines, William K Scott, Margaret Pericak-Vance, Michael L Cuccaro","doi":"10.1097/WAD.0000000000000570","DOIUrl":"10.1097/WAD.0000000000000570","url":null,"abstract":"Background: Verbal and visuospatial memory impairments are common to Alzheimer disease and Related Dementias (ADRD), but the patterns of decline in these domains may reflect genetic and lifestyle influences. The latter may be pertinent to populations such as the Amish who have unique lifestyle experiences.Methods: Our data set included 420 Amish and 401 CERAD individuals. Sex-adjusted, age-adjusted, and education-adjusted Z-scores were calculated for the recall portions of the Constructional Praxis Delay (CPD) and Word List Delay (WLD). ANOVAs were then used to examine the main and interaction effects of cohort (Amish, CERAD), cognitive status (case, control), and sex on CPD and WLD Z-scores.Results: The Amish performed better on the CPD than the CERAD cohort. In addition, the difference between cases and controls on the CPD and WLD were smaller in the Amish and Amish female cases performed better on the WLD than the CERAD female cases.Discussion: The Amish performed better on the CPD task, and ADRD-related declines in CPD and WLD were less severe in the Amish. In addition, Amish females with ADRD may have preferential preservation of WLD. This study provides evidence that the Amish exhibit distinct patterns of verbal and visuospatial memory loss associated with aging and ADRD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"195-199"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Randomized Trial of a Purposeful and Stimulating Volunteer Opportunity: Program Satisfaction and Potential Impacts on Perceived Cognitive Change in a Neurologically Mixed Sample of Older Adults. 一项有目的、有刺激的志愿者机会的试点随机试验：在一个神经系统混合的老年人样本中，项目满意度和对感知认知变化的潜在影响。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-08-24 DOI: 10.1097/WAD.0000000000000572

John D Piette, Benjamin M Hampstead, Nicolle Marinec, Jenny Chen, J Scott Roberts

{"title":"A Pilot Randomized Trial of a Purposeful and Stimulating Volunteer Opportunity: Program Satisfaction and Potential Impacts on Perceived Cognitive Change in a Neurologically Mixed Sample of Older Adults.","authors":"John D Piette, Benjamin M Hampstead, Nicolle Marinec, Jenny Chen, J Scott Roberts","doi":"10.1097/WAD.0000000000000572","DOIUrl":"10.1097/WAD.0000000000000572","url":null,"abstract":"Background: Purposeful social interactions are important for healthy aging. We conducted a pilot trial of SPEAK! (Seniors Promoting English Acquisition and Knowledge), an intervention providing older volunteers with a safe, accessible opportunity to converse via webcam with English-language learners.Methods: A neurologically mixed sample of older adults was randomized to 8 weekly, webcam conversations with English-language learners or a waitlist control. Outcomes included the Cognitive Change Index (CCI) and surveys of program satisfaction. Here, we report on session completion, intervention satisfaction, and follow-up CCI scores. Exploratory analyses of CCI intervention effects controlled for baseline CCI scores and the interaction between group and baseline CCI.Results: Participants (N=38) were on average 70.8 years of age, 28/38 were White, and 16/38 demonstrated possible cognitive impairment on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Pairs completed 115/136 sessions (85%) and all volunteers said they would recommend the program. Controlling for the interaction between baseline CCI and randomization group, SPEAK! volunteers had better follow-up CCI scores than controls (P=0.018). Improvements in CCI were greater among participants with fewer baseline memory problems.Conclusions: SPEAK! was feasible and appreciated by older adults with and without cognitive impairment. Larger studies should confirm benefits for memory and other determinants of quality of life.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"237-242"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease. 一例伴有阿尔茨海默病生物标志物的皮质鼻综合征和后皮质萎缩。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-22 DOI: 10.1097/WAD.0000000000000560

Yoko Sugimura, Toru Baba, Michinori Ezura, Akio Kikuchi, Takafumi Hasegawa, Isao Nagano, Kyoko Suzuki, Atsushi Takeda

引用次数: 0

A National Assessment of Alzheimer Disease and Antipsychotic Medication Prescribing Among Older Adults in Ambulatory Care Settings. 在门诊护理环境中老年人阿尔茨海默病和抗精神病药物处方的国家评估。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-05 DOI: 10.1097/WAD.0000000000000565

Tomoyuki Kawada

引用次数: 0