Alzheimer Disease & Associated Disorders最新文献_第10页

Aspects of Rest-Activity Rhythms Associated With Behavioral and Psychological Symptoms in Moderate and Severe Dementia: Results of a Cross-sectional Analysis. 中度和重度痴呆患者与行为和心理症状相关的休息活动节律方面：横断面分析结果。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-13 DOI: 10.1097/WAD.0000000000000584

Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Takashi Nishikawa

{"title":"Aspects of Rest-Activity Rhythms Associated With Behavioral and Psychological Symptoms in Moderate and Severe Dementia: Results of a Cross-sectional Analysis.","authors":"Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Takashi Nishikawa","doi":"10.1097/WAD.0000000000000584","DOIUrl":"10.1097/WAD.0000000000000584","url":null,"abstract":"Objective: Disturbances in rest-activity rhythms (RAR) are commonly observed in patients with dementia; however, the influence thereof on behavioral and psychological symptoms of dementia (BPSD) remains unexplored. This study aimed to determine whether there is an association between RAR and BPSD among patients with moderate and severe dementia.Methods: RAR analyses of 64 participants were performed using actigraphy. BPSD was assessed using the Neuropsychiatric Inventory-Nursing Home (NPI-NH) scale, and other clinical variables were assessed by the Mini-Mental State Examination, Cognitive Test for Severe Dementia, and Hyogo Activities of Daily Living Scale. Correlations among RAR, sleep time, and BPSD were analyzed. A stepwise multiple linear regression analysis was conducted to examine the association of RAR and sleep time with BPSD. The demographic variables were also adjusted. Variables were compared between two groups with aberrant and nonaberrant activity peak timing.Results: Correlation analysis showed that longer maximum durations of activity and shorter daytime sleep were associated with higher NPI-NH scores. Stepwise multiple linear regression analysis showed that maximum activity duration predicted the NPI-NH score after adjustment for the demographic variables. There was no significant difference in any variables between the groups with aberrant and nonaberrant activity peak timing.Conclusion: RAR is associated with BPSD in moderate-to-severe dementia, which should be considered with regard to treatment.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"322-327"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease. 神经毒素暴露对神经变性和阿尔茨海默病血液生物标志物的影响。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.1097/WAD.0000000000000579

Carla R Schubert, Adam J Paulsen, A Alex Pinto, Richard J Chappell, Yanjun Chen, Luigi Ferrucci, Laura M Hancock, Karen J Cruickshanks, Natascha Merten

{"title":"Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease.","authors":"Carla R Schubert, Adam J Paulsen, A Alex Pinto, Richard J Chappell, Yanjun Chen, Luigi Ferrucci, Laura M Hancock, Karen J Cruickshanks, Natascha Merten","doi":"10.1097/WAD.0000000000000579","DOIUrl":"10.1097/WAD.0000000000000579","url":null,"abstract":"Aim: To determine whether exposure to neurotoxins in midlife is associated with changes in blood-based biomarkers of neurodegeneration and Alzheimer disease pathology.Methods: Blood cadmium, lead, neurofilament light (NfL) chain, total tau (TTau), and amyloid beta (Aβ) 40 and Aβ42 concentrations were measured in 1516 participants in the Beaver Dam Offspring Study. Linear mixed-effect models were used to determine associations between baseline cadmium and lead levels and baseline NfL, TTau, and Aβ42/Aβ40, and 10-year change in concentrations using repeated measures of these biomarkers as the outcome.Results: In women, higher cadmium and lead levels were associated with higher baseline TTau concentrations. A higher baseline cadmium level was associated with lower baseline Aβ42/Aβ40 in both men and women. In age-sex-adjusted models, a doubling in baseline cadmium level was associated with a 0.2% (95% CI: 0.0, 0.3) higher increase per year in NfL concentrations. In men, a doubling of baseline lead level was associated with a 0.9% (95% CI: 0.1, 1.7) higher increase per year in TTau concentration.Conclusions: Participants with relatively higher levels of cadmium and lead had blood biomarker concentrations consistent with more neuronal damage and Alzheimer disease pathology. Environmental exposure to neurotoxins may contribute to neurodegeneration.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"310-314"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function. 对早发和晚发痴呆症的疾病及其领域的认识：执行功能的作用。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-21 DOI: 10.1097/WAD.0000000000000561

Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Tatiana Belfort, Marcela Moreira Lima Nogueira, Felipe de Oliveira Silva, Marcia Cristina Nascimento Dourado

{"title":"Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function.","authors":"Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Tatiana Belfort, Marcela Moreira Lima Nogueira, Felipe de Oliveira Silva, Marcia Cristina Nascimento Dourado","doi":"10.1097/WAD.0000000000000561","DOIUrl":"10.1097/WAD.0000000000000561","url":null,"abstract":"Introduction: Executive function (EF) involves a general cognitive process linked to strategic organization and control of complex goal-oriented tasks. In young-onset dementia (YOD), especially Alzheimer's disease, the symptoms that stand out in the initial stage are deficits in attention, visual-spatial function, praxis, and language. The present study aims to investigate what components of EF differ in young and late-onset dementia (LOD) and its impact on awareness and its domains.Methods: Using a cross-sectional design, we included 44 people with YOD and 70 with LOD. We assessed awareness and its domains, cognition, dementia severity, EF, functionality, and neuropsychiatric symptoms.Results: The YOD group was more impaired in general cognition ( P =0.017) and had a worse performance in Wechsler Digit Span Backward (DSB) ( P =0.007) and Phonemic fluency task (FAS) ( P =0.046) tests. In the LOD group, deficits in EF had a greater impact on awareness and on most domains (awareness total score, cognitive functioning and health condition, functional activity impairments and social function).Conclusions: Our study findings support the heterogeneity of awareness, not only with regard to the difference between the domains and the measures of EF, but also to the groups studied.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"200-206"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review. 淀粉样蛋白-βPET扫描披露后认知障碍患者和护理人员的心理社会和行为结果：系统综述。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-24 DOI: 10.1097/WAD.0000000000000569

Elyse Couch, Miriam T Ashford, Wenhan Zhang, Matthew Prina

{"title":"Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review.","authors":"Elyse Couch, Miriam T Ashford, Wenhan Zhang, Matthew Prina","doi":"10.1097/WAD.0000000000000569","DOIUrl":"10.1097/WAD.0000000000000569","url":null,"abstract":"Background: Positron emission tomography (PET) scans for amyloid-β can aid in the early and accurate detection of Alzheimer disease. The results of amyloid PET scans could help people with cognitive impairment and caregivers better understand their diagnosis; however, there are concerns that they could also cause psychological harm.Methods: A systematic review of psychosocial and behavioral quantitative outcomes following the disclosure of an amyloid PET scan for persons living with cognitive impairment (subjective cognitive decline, mild cognitive impairment, Alzheimer's Disease, and other dementias) and caregivers.Findings: Ten papers were identified from 7 studies. There was little evidence of an association between disclosure and depression. However, persons with mild cognitive impairment and their caregivers with elevated levels of amyloid had an increased risk of distress or anxiety compared with those without elevated amyloid. Participants correctly recalled the scan results; however, it is unclear whether this led to an increased understanding of their diagnosis. We did not identify any studies measuring behavioral outcomes.Conclusions: We found mixed evidence on the relationship between amyloid scans and psychosocial and behavioral outcomes in people with cognitive impairment and caregivers. These findings highlight the need for more methodologically rigorous research on this topic.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"246-258"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory. 沙特阿拉伯阿尔茨海默氏症的行为和精神负担：沙特版神经精神量表的验证。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-26 DOI: 10.1097/WAD.0000000000000563

Haythum O Tayeb, Nadeem S Butt, Roaa Khallaf, Bassam Yaghmoor, Mohammed A Basheikh, Sultan H Alamri, Abrar O Baduwailan, Faten Alzaben, Haifa K Abdulghaffar, Harold G Koenig

{"title":"Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory.","authors":"Haythum O Tayeb, Nadeem S Butt, Roaa Khallaf, Bassam Yaghmoor, Mohammed A Basheikh, Sultan H Alamri, Abrar O Baduwailan, Faten Alzaben, Haifa K Abdulghaffar, Harold G Koenig","doi":"10.1097/WAD.0000000000000563","DOIUrl":"10.1097/WAD.0000000000000563","url":null,"abstract":"Background: The burden of behavioral and psychiatric symptoms in dementia (BPSD) has not been characterized in Saudi patients with Alzheimer disease (AD). Moreover, the Saudi version of the Neuropsychiatric Inventory (SNPI) has not been validated.Objectives: The purpose of this study was to validate the SNPI and describe frequency and determinants of BPSD in Saudi AD patients.Methods: The SNPI and BEHAVE-AD instruments were administered to community-dwelling Saudi AD patients and their caregivers.Results: The sample size was 192. The first 59 constituted the validation cohort. Cronbach alpha of the SNPI and BEHAVE-AD were 0.91 and 0.79, respectively. There were significant correlations between: (1) the total SNPI and BEHAVE-AD scores ( r =0.84, P <0.001); (2) analogous SNPI and BEHAVE-AD symptom subscores ( P <0.05); (3) SNPI and BEHAVE-AD caregiver distress ( F =22.6, P <0.001). Inter-rater reliability of the SNPI was excellent (kappa=0.74). Ninety percent of patients experienced 4 SNPI symptoms or more. Patients with stroke and prior psychiatric history were most likely to experience BPSDs. The most common symptom was apathy (82%). Caregiver distress was determined by the total NPI score and impulsiveness subscale score.Conclusions: The SNPI is valid and reliable for assessing BPSD in Saudi AD patients. Longitudinal studies of BPSDs in Saudi specialized dementia clinics are needed.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"222-228"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International Variations in Dementia and Alzheimer Disease Diagnosis and Certification Habits and Their Associations With Dementia and Alzheimer Disease Mortality: A Cross-Sectional Study of 38 Countries. 痴呆症和阿尔茨海默病诊断和认证习惯的国际差异及其与痴呆症和帕金森病死亡率的关系：对38个国家的横断面研究。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-08-24 DOI: 10.1097/WAD.0000000000000573

Ying-Chen Chi, Wei-Min Chu, Hsin-Yun Chang, Tsung-Hsueh Lu

{"title":"International Variations in Dementia and Alzheimer Disease Diagnosis and Certification Habits and Their Associations With Dementia and Alzheimer Disease Mortality: A Cross-Sectional Study of 38 Countries.","authors":"Ying-Chen Chi, Wei-Min Chu, Hsin-Yun Chang, Tsung-Hsueh Lu","doi":"10.1097/WAD.0000000000000573","DOIUrl":"10.1097/WAD.0000000000000573","url":null,"abstract":"Objective: To examine international variations in national diagnosis and certification habits prefer recording dementia (D) versus Alzhiemer disease (AD) as the underlying cause of death (UCOD) and their associations with mortality rates of dementia and AD.Methods: We calculated proportions of D/D+AD and AD/D+AD deaths as proxies of national diagnosis and certification habits. Pearson correlation coefficients (r) were estimated to assess the associations of proportions with the mortality rates of dementia or AD among adults aged 75 to 84 years across 38 countries.Results: The countries with a high preference for recording dementia as the UCOD were Taiwan and Latvia with proportion of D/D+AD deaths of 92% and 88%, respectively, and those with a high preference for recording AD as the UCOD were Slovenia, Turkey, and Poland with proportion of AD/D+AD deaths of 100%, 99%, and 89%, respectively. The r values for the proportions and mortality rate for dementia and AD were 0.67 (95% CI: 0.44-0.81) and 0.46 (95% CI: 0.16-0.68), respectively.Conclusion: We identified a small number of countries with obvious natonal diagnosis and certification habits preferring dementia or AD and had moderate effects on international variations in the mortality rates of dementia and AD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"215-221"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Discrepancies in Dementia Mortality Reported in Vital Statistics: The Need for Improved Data to Inform Policy. 生命统计中痴呆症死亡率的巨大差异：需要改进数据来告知政策。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-08 DOI: 10.1097/WAD.0000000000000562

Tim Adair, Hang Li, Jeromey Temple, Kaarin J Anstey

{"title":"Large Discrepancies in Dementia Mortality Reported in Vital Statistics: The Need for Improved Data to Inform Policy.","authors":"Tim Adair, Hang Li, Jeromey Temple, Kaarin J Anstey","doi":"10.1097/WAD.0000000000000562","DOIUrl":"10.1097/WAD.0000000000000562","url":null,"abstract":"Purpose: There is limited understanding of the intercountry comparability of dementia mortality data. This study compares reported dementia mortality in national vital statistics between countries and over time. In countries with low dementia reporting, this study identifies other causes to which dementia may be misclassified.Methods: Using the World Health Organization (WHO) Mortality Database, we calculated the ratio of reported to expected (Global Burden of Disease estimated) age-standardized dementia death rates in 90 countries from 2000 to 2019. Other causes to which dementia may be misclassified were identified as having relatively high cause fractions compared with other countries.Patients: No patients were involved.Results: There is a large intercountry variation in reported dementia mortality rates. The ratio of reported to expected dementia mortality exceeded 100% in high-income countries but was below 50% in other super regions. In countries with low reported dementia mortality, cardiovascular diseases, ill-defined causes, and pneumonia have relatively high cause fractions and may be misclassified from dementia.Discussion: Large discrepancies in dementia mortality reporting between countries, including often implausibly low reported mortality, makes comparison extremely difficult. Improved guidance for and training of certifiers and the use of multiple cause-of-death data can help strengthen the policy utility of dementia mortality data.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"207-214"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10111792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Depressive Symptomatology at Diagnosis Predict Cognitive and Functional Decline Over 1 Year in Rural Canadian Patients With Dementia? 诊断时的抑郁症状能预测加拿大农村痴呆患者1年内的认知和功能下降吗？

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-31 DOI: 10.1097/WAD.0000000000000574

Shuang Cai, Andrew Kirk, Chandima Karunanayake, Megan E O'Connell, Debra Morgan

{"title":"Can Depressive Symptomatology at Diagnosis Predict Cognitive and Functional Decline Over 1 Year in Rural Canadian Patients With Dementia?","authors":"Shuang Cai, Andrew Kirk, Chandima Karunanayake, Megan E O'Connell, Debra Morgan","doi":"10.1097/WAD.0000000000000574","DOIUrl":"10.1097/WAD.0000000000000574","url":null,"abstract":"Introduction: Depressive symptomatology is often associated with the onset of dementia, although the exact form and directionality of this association is still unclear. The aim of this study is to investigate whether depressive symptomatology at the time of dementia diagnosis was predictive of cognitive, functional, and behavioral decline over 1 year.Methods: In a Rural and Remote Memory Clinic, 375 patients consecutively diagnosed with mild cognitive impairment, Alzheimer disease, or non-Alzheimer disease dementia completed the Center for Epidemiological Studies Depression Scale at first visit and 1-year follow-up to assess depressive symptomatology. The same cohort was evaluated for cognitive, functional, and behavioral decline through the completion of 5 clinical tests performed at the first visit and at 1-year follow-up.Results: Depressive symptomatology at time of dementia diagnosis did not predict cognitive or functional decline over 1 year, although increases in depressive symptomatology over 1 year significantly correlated with higher caregiver ratings of neuropsychiatric symptom severity and related distress over that time.Conclusion: Increasingly severe depressive symptomatology over 1 year correlated with greater caregiver distress. This study points the way for future studies delineating the relationship between depression, dementia progression, and caregiver distress.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"179-183"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dementia Prevalence and Risk Factors: Data From Rural Tanzania. 痴呆症患病率和危险因素：坦桑尼亚农村的数据。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-10 DOI: 10.1097/WAD.0000000000000564

Caitlin Roe, Ssenku Safic, Lwitiko Mwaipopo, Catherine L Dotchin, Joanna Klaptocz, William Gray, Marcyella Joseph, Aimee Spector, Sarah Urasa, Richard W Walker

{"title":"Dementia Prevalence and Risk Factors: Data From Rural Tanzania.","authors":"Caitlin Roe, Ssenku Safic, Lwitiko Mwaipopo, Catherine L Dotchin, Joanna Klaptocz, William Gray, Marcyella Joseph, Aimee Spector, Sarah Urasa, Richard W Walker","doi":"10.1097/WAD.0000000000000564","DOIUrl":"10.1097/WAD.0000000000000564","url":null,"abstract":"Objectives: The burden of dementia is increasing in sub-Saharan Africa (SSA), but there are limited epidemiological data on dementia in SSA. This study investigated the prevalence and associations of dementia in older adults (less than 60 y) attending the outpatient department of Mount Meru Hospital in Tanzania.Methods: This one-phase cross-sectional study screened a sample using the Identification of Dementia in Elderly Africans (IDEA) cognitive screening tool. Those that screened as having possible and probable dementia were further assessed, and diagnosis of dementia was made according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Demographic and risk factor data were collected.Results: Within those screened, 57/1141 (5.0%) (95% CI: 3.7-6.3) had dementia. Female sex [odds ratio (OR)=2.778, 95% CI: 1.074-7.189], having never attended school (OR=6.088, 95% CI: 1.360-27.256), alcohol (U/wk) (OR=1.080, 95% CI: 1.016-1.149), uncorrected visual impairment (OR=4.260, 95% CI: 1.623-11.180), body mass index <18.5 kg/m 2 (OR=6.588, 95% CI: 2.089-20.775), and stroke (OR=15.790, 95% CI: 3.48-74.475) were found to be significantly, independently associated with dementia.Conclusions: The prevalence of dementia in this population is similar to a recent community-based rate in Tanzania and lower than a hospital-based rate in Senegal. This is the first time the association between visual impairment and dementia has been reported in SSA. Other associations are in keeping with previous literature.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"229-236"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To the Editor and Readership of Alzheimer Disease and Associated Disorders. 致阿尔茨海默病和相关疾病的编辑和读者。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-05 DOI: 10.1097/WAD.0000000000000566

Laura M Tidmore, Grant H Skrepnek

引用次数: 0