Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-21 DOI:10.1097/WAD.0000000000000561

Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Tatiana Belfort, Marcela Moreira Lima Nogueira, Felipe de Oliveira Silva, Marcia Cristina Nascimento Dourado

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引用次数: 0

Abstract

Introduction: Executive function (EF) involves a general cognitive process linked to strategic organization and control of complex goal-oriented tasks. In young-onset dementia (YOD), especially Alzheimer's disease, the symptoms that stand out in the initial stage are deficits in attention, visual-spatial function, praxis, and language. The present study aims to investigate what components of EF differ in young and late-onset dementia (LOD) and its impact on awareness and its domains.

Methods: Using a cross-sectional design, we included 44 people with YOD and 70 with LOD. We assessed awareness and its domains, cognition, dementia severity, EF, functionality, and neuropsychiatric symptoms.

Results: The YOD group was more impaired in general cognition ( P =0.017) and had a worse performance in Wechsler Digit Span Backward (DSB) ( P =0.007) and Phonemic fluency task (FAS) ( P =0.046) tests. In the LOD group, deficits in EF had a greater impact on awareness and on most domains (awareness total score, cognitive functioning and health condition, functional activity impairments and social function).

Conclusions: Our study findings support the heterogeneity of awareness, not only with regard to the difference between the domains and the measures of EF, but also to the groups studied.

查看原文本刊更多论文

对早发和晚发痴呆症的疾病及其领域的认识：执行功能的作用。

引言：执行功能（EF）涉及一个与战略组织和控制复杂目标导向任务相关的一般认知过程。在年轻痴呆症（YOD），尤其是阿尔茨海默病中，初期最突出的症状是注意力、视觉空间功能、实践和语言方面的缺陷。本研究旨在调查EF在年轻和晚发性痴呆（LOD）中的哪些成分不同，以及它对意识及其领域的影响。方法：采用横断面设计，我们包括44名YOD患者和70名LOD患者。我们评估了意识及其领域、认知、痴呆严重程度、EF、功能和神经精神症状。结果：YOD组的一般认知能力受损程度较高（P=0.017），韦氏数字后跨测验（DSB）和语音流利性任务测验（FAS）较差（P=0.046）。在LOD组中，EF缺陷对意识和大多数领域（意识总分、认知功能和健康状况、功能活动障碍和社会功能）的影响更大。结论：我们的研究结果支持意识的异质性，不仅在EF的领域和测量之间的差异方面，而且在所研究的群体方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.