Alzheimer Disease & Associated Disorders最新文献_第9页

Mild Cognitive Impairment Subtype Performance in Comparison to Healthy Older Controls on the NIH Toolbox and Cogstate. NIH Toolbox和Cogstate上与健康老年对照组相比的轻度认知障碍亚型表现。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-20 DOI: 10.1097/WAD.0000000000000587

Sarah Garcia, Robert L Askew, Voyko Kavcic, Sarah Shair, Arijit K Bhaumik, Edna Rose, Stephen Campbell, Nicolas May, Benjamin M Hampstead, Hiroko H Dodge, Judith L Heidebrink, Henry L Paulson, Bruno Giordani

{"title":"Mild Cognitive Impairment Subtype Performance in Comparison to Healthy Older Controls on the NIH Toolbox and Cogstate.","authors":"Sarah Garcia, Robert L Askew, Voyko Kavcic, Sarah Shair, Arijit K Bhaumik, Edna Rose, Stephen Campbell, Nicolas May, Benjamin M Hampstead, Hiroko H Dodge, Judith L Heidebrink, Henry L Paulson, Bruno Giordani","doi":"10.1097/WAD.0000000000000587","DOIUrl":"10.1097/WAD.0000000000000587","url":null,"abstract":"Background: Early detection is necessary for the treatment of dementia. Computerized testing has become more widely used in clinical trials; however, it is unclear how sensitive these measures are to early signs of neurodegeneration. We investigated the use of the NIH Toolbox-Cognition (NIHTB-CB) and Cogstate-Brief computerized neuropsychological batteries in the identification of mild cognitive impairment (MCI) versus healthy older adults [healthy control (HC)] and amnestic (aMCI) versus nonamnestic MCI (naMCI). Exploratory analyses include investigating potential racial differences.Methods: Two hundred six older adults were diagnosed as aMCI (n = 58), naMCI (n = 15), or cognitively healthy (HC; n = 133).Results: The NIH Toolbox-CB subtests of Flanker, Picture Sequence Memory, and Picture Vocabulary significantly differentiated MCI from HC. Further, subtests from both computerized batteries differentiated patients with aMCI from those with naMCI. Although the main effect of race differences was noted on tests and in diagnostic groups was significant, there were no significant race-by-test interactions.Conclusions: Computer-based subtests vary in their ability to help distinguish MCI subtypes, though these tests provide less expensive and easier-to-administer clinical screeners to help identify patients early who may qualify for more comprehensive evaluations. Further work is needed, however, to refine computerized tests to achieve better precision in distinguishing impairment subtypes.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"328-334"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome. 平衡和步态：唐氏综合症患者认知障碍和痴呆的关系。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-02 DOI: 10.1097/WAD.0000000000000580

Aline S G G Conceição, Lívea F G Sant Ana, Guilherme P Mattar, Maria de Fátima R Silva, Andressa R Ramos, Alexandra M Oliveira, Claudia L Carvalho, Octavio R Gonçalves, Bruna L R Varotto, Luana D Martinez, Vinícius Leduc, Luciana M Fonseca, Orestes V Forlenza

{"title":"Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome.","authors":"Aline S G G Conceição, Lívea F G Sant Ana, Guilherme P Mattar, Maria de Fátima R Silva, Andressa R Ramos, Alexandra M Oliveira, Claudia L Carvalho, Octavio R Gonçalves, Bruna L R Varotto, Luana D Martinez, Vinícius Leduc, Luciana M Fonseca, Orestes V Forlenza","doi":"10.1097/WAD.0000000000000580","DOIUrl":"10.1097/WAD.0000000000000580","url":null,"abstract":"Background: Atypical aging in Down syndrome (DS) is associated with neuropathological characteristics consistent with Alzheimer disease. Gait abnormalities have been shown to be associated with an increased risk of dementia for the general population. The aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with DS.Methods: We evaluated 66 individuals with DS (≥20 y of age), divided into 3 groups: stable cognition, prodromal dementia, and dementia (presumed Alzheimer disease). Each individual was evaluated with the Performance-Oriented Mobility Assessment (POMA), Timed Up and Go test, and Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS), in addition to a comprehensive clinical protocol to ascertain the occurrence of medical or psychiatric comorbidities.Results: The score on the POMA-Gait subscale score and body mass index were found to be independent predictors of prodromal dementia and dementia ( P <0.001 for both). With the exception of perception, all cognitive domains correlated with the POMA-Total score ( P <0.05).Conclusion: A lower POMA-Gait score increases the chance of prodromal dementia and dementia in adults with DS. Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia. In those individuals, applying the POMA could facilitate the early diagnosis of dementia, help identify fall risks, and promote the adoption of geriatric interventions focused on improving functional mobility.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"349-356"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of amyloid PET Imaging in a Memory Clinic. 淀粉样蛋白PET成像在记忆诊所中的应用。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-08-11 DOI: 10.1097/WAD.0000000000000575

Alexandra Pletnikova, Hamid R Okhravi, Nimra Jamil, Mackenzie Kirby, Constantine G Lyketsos, Esther S Oh

引用次数: 0

Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease. 神经毒素暴露对神经变性和阿尔茨海默病血液生物标志物的影响。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.1097/WAD.0000000000000579

Carla R Schubert, Adam J Paulsen, A Alex Pinto, Richard J Chappell, Yanjun Chen, Luigi Ferrucci, Laura M Hancock, Karen J Cruickshanks, Natascha Merten

{"title":"Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease.","authors":"Carla R Schubert, Adam J Paulsen, A Alex Pinto, Richard J Chappell, Yanjun Chen, Luigi Ferrucci, Laura M Hancock, Karen J Cruickshanks, Natascha Merten","doi":"10.1097/WAD.0000000000000579","DOIUrl":"10.1097/WAD.0000000000000579","url":null,"abstract":"Aim: To determine whether exposure to neurotoxins in midlife is associated with changes in blood-based biomarkers of neurodegeneration and Alzheimer disease pathology.Methods: Blood cadmium, lead, neurofilament light (NfL) chain, total tau (TTau), and amyloid beta (Aβ) 40 and Aβ42 concentrations were measured in 1516 participants in the Beaver Dam Offspring Study. Linear mixed-effect models were used to determine associations between baseline cadmium and lead levels and baseline NfL, TTau, and Aβ42/Aβ40, and 10-year change in concentrations using repeated measures of these biomarkers as the outcome.Results: In women, higher cadmium and lead levels were associated with higher baseline TTau concentrations. A higher baseline cadmium level was associated with lower baseline Aβ42/Aβ40 in both men and women. In age-sex-adjusted models, a doubling in baseline cadmium level was associated with a 0.2% (95% CI: 0.0, 0.3) higher increase per year in NfL concentrations. In men, a doubling of baseline lead level was associated with a 0.9% (95% CI: 0.1, 1.7) higher increase per year in TTau concentration.Conclusions: Participants with relatively higher levels of cadmium and lead had blood biomarker concentrations consistent with more neuronal damage and Alzheimer disease pathology. Environmental exposure to neurotoxins may contribute to neurodegeneration.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"310-314"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspects of Rest-Activity Rhythms Associated With Behavioral and Psychological Symptoms in Moderate and Severe Dementia: Results of a Cross-sectional Analysis. 中度和重度痴呆患者与行为和心理症状相关的休息活动节律方面：横断面分析结果。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-13 DOI: 10.1097/WAD.0000000000000584

Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Takashi Nishikawa

{"title":"Aspects of Rest-Activity Rhythms Associated With Behavioral and Psychological Symptoms in Moderate and Severe Dementia: Results of a Cross-sectional Analysis.","authors":"Daiki Ishimaru, Hiroyuki Tanaka, Yuma Nagata, Yasuhiro Ogawa, Keita Fukuhara, Takashi Nishikawa","doi":"10.1097/WAD.0000000000000584","DOIUrl":"10.1097/WAD.0000000000000584","url":null,"abstract":"Objective: Disturbances in rest-activity rhythms (RAR) are commonly observed in patients with dementia; however, the influence thereof on behavioral and psychological symptoms of dementia (BPSD) remains unexplored. This study aimed to determine whether there is an association between RAR and BPSD among patients with moderate and severe dementia.Methods: RAR analyses of 64 participants were performed using actigraphy. BPSD was assessed using the Neuropsychiatric Inventory-Nursing Home (NPI-NH) scale, and other clinical variables were assessed by the Mini-Mental State Examination, Cognitive Test for Severe Dementia, and Hyogo Activities of Daily Living Scale. Correlations among RAR, sleep time, and BPSD were analyzed. A stepwise multiple linear regression analysis was conducted to examine the association of RAR and sleep time with BPSD. The demographic variables were also adjusted. Variables were compared between two groups with aberrant and nonaberrant activity peak timing.Results: Correlation analysis showed that longer maximum durations of activity and shorter daytime sleep were associated with higher NPI-NH scores. Stepwise multiple linear regression analysis showed that maximum activity duration predicted the NPI-NH score after adjustment for the demographic variables. There was no significant difference in any variables between the groups with aberrant and nonaberrant activity peak timing.Conclusion: RAR is associated with BPSD in moderate-to-severe dementia, which should be considered with regard to treatment.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"322-327"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function. 对早发和晚发痴呆症的疾病及其领域的认识：执行功能的作用。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-21 DOI: 10.1097/WAD.0000000000000561

Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Tatiana Belfort, Marcela Moreira Lima Nogueira, Felipe de Oliveira Silva, Marcia Cristina Nascimento Dourado

{"title":"Awareness of Disease and Its Domains in Young-onset and Late-onset Dementia: The Role of Executive Function.","authors":"Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Tatiana Belfort, Marcela Moreira Lima Nogueira, Felipe de Oliveira Silva, Marcia Cristina Nascimento Dourado","doi":"10.1097/WAD.0000000000000561","DOIUrl":"10.1097/WAD.0000000000000561","url":null,"abstract":"Introduction: Executive function (EF) involves a general cognitive process linked to strategic organization and control of complex goal-oriented tasks. In young-onset dementia (YOD), especially Alzheimer's disease, the symptoms that stand out in the initial stage are deficits in attention, visual-spatial function, praxis, and language. The present study aims to investigate what components of EF differ in young and late-onset dementia (LOD) and its impact on awareness and its domains.Methods: Using a cross-sectional design, we included 44 people with YOD and 70 with LOD. We assessed awareness and its domains, cognition, dementia severity, EF, functionality, and neuropsychiatric symptoms.Results: The YOD group was more impaired in general cognition ( P =0.017) and had a worse performance in Wechsler Digit Span Backward (DSB) ( P =0.007) and Phonemic fluency task (FAS) ( P =0.046) tests. In the LOD group, deficits in EF had a greater impact on awareness and on most domains (awareness total score, cognitive functioning and health condition, functional activity impairments and social function).Conclusions: Our study findings support the heterogeneity of awareness, not only with regard to the difference between the domains and the measures of EF, but also to the groups studied.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"200-206"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review. 淀粉样蛋白-βPET扫描披露后认知障碍患者和护理人员的心理社会和行为结果：系统综述。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-07-24 DOI: 10.1097/WAD.0000000000000569

Elyse Couch, Miriam T Ashford, Wenhan Zhang, Matthew Prina

{"title":"Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review.","authors":"Elyse Couch, Miriam T Ashford, Wenhan Zhang, Matthew Prina","doi":"10.1097/WAD.0000000000000569","DOIUrl":"10.1097/WAD.0000000000000569","url":null,"abstract":"Background: Positron emission tomography (PET) scans for amyloid-β can aid in the early and accurate detection of Alzheimer disease. The results of amyloid PET scans could help people with cognitive impairment and caregivers better understand their diagnosis; however, there are concerns that they could also cause psychological harm.Methods: A systematic review of psychosocial and behavioral quantitative outcomes following the disclosure of an amyloid PET scan for persons living with cognitive impairment (subjective cognitive decline, mild cognitive impairment, Alzheimer's Disease, and other dementias) and caregivers.Findings: Ten papers were identified from 7 studies. There was little evidence of an association between disclosure and depression. However, persons with mild cognitive impairment and their caregivers with elevated levels of amyloid had an increased risk of distress or anxiety compared with those without elevated amyloid. Participants correctly recalled the scan results; however, it is unclear whether this led to an increased understanding of their diagnosis. We did not identify any studies measuring behavioral outcomes.Conclusions: We found mixed evidence on the relationship between amyloid scans and psychosocial and behavioral outcomes in people with cognitive impairment and caregivers. These findings highlight the need for more methodologically rigorous research on this topic.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"246-258"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory. 沙特阿拉伯阿尔茨海默氏症的行为和精神负担：沙特版神经精神量表的验证。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-26 DOI: 10.1097/WAD.0000000000000563

Haythum O Tayeb, Nadeem S Butt, Roaa Khallaf, Bassam Yaghmoor, Mohammed A Basheikh, Sultan H Alamri, Abrar O Baduwailan, Faten Alzaben, Haifa K Abdulghaffar, Harold G Koenig

{"title":"Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory.","authors":"Haythum O Tayeb, Nadeem S Butt, Roaa Khallaf, Bassam Yaghmoor, Mohammed A Basheikh, Sultan H Alamri, Abrar O Baduwailan, Faten Alzaben, Haifa K Abdulghaffar, Harold G Koenig","doi":"10.1097/WAD.0000000000000563","DOIUrl":"10.1097/WAD.0000000000000563","url":null,"abstract":"Background: The burden of behavioral and psychiatric symptoms in dementia (BPSD) has not been characterized in Saudi patients with Alzheimer disease (AD). Moreover, the Saudi version of the Neuropsychiatric Inventory (SNPI) has not been validated.Objectives: The purpose of this study was to validate the SNPI and describe frequency and determinants of BPSD in Saudi AD patients.Methods: The SNPI and BEHAVE-AD instruments were administered to community-dwelling Saudi AD patients and their caregivers.Results: The sample size was 192. The first 59 constituted the validation cohort. Cronbach alpha of the SNPI and BEHAVE-AD were 0.91 and 0.79, respectively. There were significant correlations between: (1) the total SNPI and BEHAVE-AD scores ( r =0.84, P <0.001); (2) analogous SNPI and BEHAVE-AD symptom subscores ( P <0.05); (3) SNPI and BEHAVE-AD caregiver distress ( F =22.6, P <0.001). Inter-rater reliability of the SNPI was excellent (kappa=0.74). Ninety percent of patients experienced 4 SNPI symptoms or more. Patients with stroke and prior psychiatric history were most likely to experience BPSDs. The most common symptom was apathy (82%). Caregiver distress was determined by the total NPI score and impulsiveness subscale score.Conclusions: The SNPI is valid and reliable for assessing BPSD in Saudi AD patients. Longitudinal studies of BPSDs in Saudi specialized dementia clinics are needed.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"222-228"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International Variations in Dementia and Alzheimer Disease Diagnosis and Certification Habits and Their Associations With Dementia and Alzheimer Disease Mortality: A Cross-Sectional Study of 38 Countries. 痴呆症和阿尔茨海默病诊断和认证习惯的国际差异及其与痴呆症和帕金森病死亡率的关系：对38个国家的横断面研究。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-08-24 DOI: 10.1097/WAD.0000000000000573

Ying-Chen Chi, Wei-Min Chu, Hsin-Yun Chang, Tsung-Hsueh Lu

{"title":"International Variations in Dementia and Alzheimer Disease Diagnosis and Certification Habits and Their Associations With Dementia and Alzheimer Disease Mortality: A Cross-Sectional Study of 38 Countries.","authors":"Ying-Chen Chi, Wei-Min Chu, Hsin-Yun Chang, Tsung-Hsueh Lu","doi":"10.1097/WAD.0000000000000573","DOIUrl":"10.1097/WAD.0000000000000573","url":null,"abstract":"Objective: To examine international variations in national diagnosis and certification habits prefer recording dementia (D) versus Alzhiemer disease (AD) as the underlying cause of death (UCOD) and their associations with mortality rates of dementia and AD.Methods: We calculated proportions of D/D+AD and AD/D+AD deaths as proxies of national diagnosis and certification habits. Pearson correlation coefficients (r) were estimated to assess the associations of proportions with the mortality rates of dementia or AD among adults aged 75 to 84 years across 38 countries.Results: The countries with a high preference for recording dementia as the UCOD were Taiwan and Latvia with proportion of D/D+AD deaths of 92% and 88%, respectively, and those with a high preference for recording AD as the UCOD were Slovenia, Turkey, and Poland with proportion of AD/D+AD deaths of 100%, 99%, and 89%, respectively. The r values for the proportions and mortality rate for dementia and AD were 0.67 (95% CI: 0.44-0.81) and 0.46 (95% CI: 0.16-0.68), respectively.Conclusion: We identified a small number of countries with obvious natonal diagnosis and certification habits preferring dementia or AD and had moderate effects on international variations in the mortality rates of dementia and AD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"215-221"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Discrepancies in Dementia Mortality Reported in Vital Statistics: The Need for Improved Data to Inform Policy. 生命统计中痴呆症死亡率的巨大差异：需要改进数据来告知政策。

IF 2.1 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-08 DOI: 10.1097/WAD.0000000000000562

Tim Adair, Hang Li, Jeromey Temple, Kaarin J Anstey

{"title":"Large Discrepancies in Dementia Mortality Reported in Vital Statistics: The Need for Improved Data to Inform Policy.","authors":"Tim Adair, Hang Li, Jeromey Temple, Kaarin J Anstey","doi":"10.1097/WAD.0000000000000562","DOIUrl":"10.1097/WAD.0000000000000562","url":null,"abstract":"Purpose: There is limited understanding of the intercountry comparability of dementia mortality data. This study compares reported dementia mortality in national vital statistics between countries and over time. In countries with low dementia reporting, this study identifies other causes to which dementia may be misclassified.Methods: Using the World Health Organization (WHO) Mortality Database, we calculated the ratio of reported to expected (Global Burden of Disease estimated) age-standardized dementia death rates in 90 countries from 2000 to 2019. Other causes to which dementia may be misclassified were identified as having relatively high cause fractions compared with other countries.Patients: No patients were involved.Results: There is a large intercountry variation in reported dementia mortality rates. The ratio of reported to expected dementia mortality exceeded 100% in high-income countries but was below 50% in other super regions. In countries with low reported dementia mortality, cardiovascular diseases, ill-defined causes, and pneumonia have relatively high cause fractions and may be misclassified from dementia.Discussion: Large discrepancies in dementia mortality reporting between countries, including often implausibly low reported mortality, makes comparison extremely difficult. Improved guidance for and training of certifiers and the use of multiple cause-of-death data can help strengthen the policy utility of dementia mortality data.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"37 3","pages":"207-214"},"PeriodicalIF":2.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10111792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0