Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-10-02 DOI:10.1097/WAD.0000000000000580

Aline S G G Conceição, Lívea F G Sant Ana, Guilherme P Mattar, Maria de Fátima R Silva, Andressa R Ramos, Alexandra M Oliveira, Claudia L Carvalho, Octavio R Gonçalves, Bruna L R Varotto, Luana D Martinez, Vinícius Leduc, Luciana M Fonseca, Orestes V Forlenza

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引用次数: 0

Abstract

Background: Atypical aging in Down syndrome (DS) is associated with neuropathological characteristics consistent with Alzheimer disease. Gait abnormalities have been shown to be associated with an increased risk of dementia for the general population. The aim of this study was to determine whether gait disorders are associated with worse cognitive performance and dementia in adults with DS.

Methods: We evaluated 66 individuals with DS (≥20 y of age), divided into 3 groups: stable cognition, prodromal dementia, and dementia (presumed Alzheimer disease). Each individual was evaluated with the Performance-Oriented Mobility Assessment (POMA), Timed Up and Go test, and Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS), in addition to a comprehensive clinical protocol to ascertain the occurrence of medical or psychiatric comorbidities.

Results: The score on the POMA-Gait subscale score and body mass index were found to be independent predictors of prodromal dementia and dementia ( P <0.001 for both). With the exception of perception, all cognitive domains correlated with the POMA-Total score ( P <0.05).

Conclusion: A lower POMA-Gait score increases the chance of prodromal dementia and dementia in adults with DS. Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia. In those individuals, applying the POMA could facilitate the early diagnosis of dementia, help identify fall risks, and promote the adoption of geriatric interventions focused on improving functional mobility.

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平衡和步态：唐氏综合症患者认知障碍和痴呆的关系。

背景：唐氏综合征（DS）的非典型衰老与阿尔茨海默病的神经病理学特征一致。步态异常已被证明与普通人群患痴呆症的风险增加有关。本研究的目的是确定步态障碍是否与DS患者认知能力较差和痴呆有关。方法：我们评估了66名DS患者（年龄≥20岁），分为3组：稳定认知、前驱痴呆和痴呆（假定为阿尔茨海默病）。每个人都接受了以表现为导向的行动能力评估（POMA）、定时上下测试和剑桥唐氏综合征和其他智力残疾老年人精神障碍检查（CAMDEX-DS），以及全面的临床方案，以确定医疗或精神共病的发生。结果：POMA-Gait分量表评分和体重指数被发现是前驱期痴呆和痴呆的独立预测因素（P结论：较低的POMA-Geit评分会增加DS患者患前驱期痴呆的几率。与其他研究不同，在这项研究中，较高的体重指数也被发现会增加前驱痴呆和痴呆的几率。在这些人中，应用POMA可以促进痴呆症的早期诊断，有助于识别跌倒风险，并促进采用以改善功能移动性为重点的老年干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.