Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-06-26 DOI:10.1097/WAD.0000000000000563

Haythum O Tayeb, Nadeem S Butt, Roaa Khallaf, Bassam Yaghmoor, Mohammed A Basheikh, Sultan H Alamri, Abrar O Baduwailan, Faten Alzaben, Haifa K Abdulghaffar, Harold G Koenig

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引用次数: 0

Abstract

Background: The burden of behavioral and psychiatric symptoms in dementia (BPSD) has not been characterized in Saudi patients with Alzheimer disease (AD). Moreover, the Saudi version of the Neuropsychiatric Inventory (SNPI) has not been validated.

Objectives: The purpose of this study was to validate the SNPI and describe frequency and determinants of BPSD in Saudi AD patients.

Methods: The SNPI and BEHAVE-AD instruments were administered to community-dwelling Saudi AD patients and their caregivers.

Results: The sample size was 192. The first 59 constituted the validation cohort. Cronbach alpha of the SNPI and BEHAVE-AD were 0.91 and 0.79, respectively. There were significant correlations between: (1) the total SNPI and BEHAVE-AD scores ( r =0.84, P <0.001); (2) analogous SNPI and BEHAVE-AD symptom subscores ( P <0.05); (3) SNPI and BEHAVE-AD caregiver distress ( F =22.6, P <0.001). Inter-rater reliability of the SNPI was excellent (kappa=0.74). Ninety percent of patients experienced 4 SNPI symptoms or more. Patients with stroke and prior psychiatric history were most likely to experience BPSDs. The most common symptom was apathy (82%). Caregiver distress was determined by the total NPI score and impulsiveness subscale score.

Conclusions: The SNPI is valid and reliable for assessing BPSD in Saudi AD patients. Longitudinal studies of BPSDs in Saudi specialized dementia clinics are needed.

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沙特阿拉伯阿尔茨海默氏症的行为和精神负担：沙特版神经精神量表的验证。

背景：在沙特阿尔茨海默病（AD）患者中，痴呆症（BPSD）的行为和精神症状负担尚未得到表征。此外，沙特版本的神经精神问卷（SNPI）尚未得到验证。目的：本研究的目的是验证SNPI，并描述沙特AD患者BPSD的频率和决定因素。方法：对居住在社区的沙特AD患者及其护理人员使用SNPI和BEHAVE-AD仪器。结果：样本量为192。前59人构成了验证队列。SNPI和BEHAVE-AD的Cronbachα分别为0.91和0.79。（1）总SNPI和BEHAVE-AD评分之间存在显著相关性（r=0.84，P）。结论：SNPI用于评估沙特AD患者的BPSD是有效和可靠的。需要在沙特痴呆专科诊所对BPSD进行纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.