Alzheimer Disease & Associated Disorders最新文献_第2页

The Difference in Cognitive Profiles Between Patients With Alzheimer Dementia With and Without Psychosis: A Rapid Review. 有无精神病的阿尔茨海默氏症痴呆患者在认知方面的差异：快速回顾

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1097/WAD.0000000000000644

Jean-François Carmel, Doris Clerc, Vincent Couture, Isabelle Reid, Ali Filali, Juan Manuel Villalpando

{"title":"The Difference in Cognitive Profiles Between Patients With Alzheimer Dementia With and Without Psychosis: A Rapid Review.","authors":"Jean-François Carmel, Doris Clerc, Vincent Couture, Isabelle Reid, Ali Filali, Juan Manuel Villalpando","doi":"10.1097/WAD.0000000000000644","DOIUrl":"10.1097/WAD.0000000000000644","url":null,"abstract":"Background: Psychosis in Alzheimer disease (AD) is a major burden for patients and their family. Identifying the characteristics of delusions and hallucinations in the AD population is key to understanding the interconnection between the psychiatric and cognitive symptoms in neurocognitive disorders. The aim of this study is to compare the cognitive profiles of AD patients with and without psychosis.Methods: We conducted a rapid review to explore the relationship between psychotic symptoms and cognitive performances in patients with AD. We used MEDLINE, Embase, and PsychINFO literature databases between January 2015 and January 2023. This rapid review was guided by the Cochrane Rapid Reviews Methods Group.Results: We identified 2909 records from the initial searches. After reviewing the titles, abstracts, and full texts, we selected 8 cross-sectional and 5 cohort studies for the qualitative analysis. Among them, 6 studies were included in the final quantitative analysis. Most studies suggested a correlation between general cognitive decline and the risk of presenting psychotic symptoms. Three studies found an association between hallucinations and deficits in the visuocognitive domains (visuospatial, visuoperceptual, and visuoconstructive skills). Two studies found a relationship between psychotic symptoms and executive dysfunction. Two studies also found a correlation between psychotic symptoms and language. Our results are in line with previous data in the literature, especially regarding the outcome of psychosis on executive function and visuocognitive abilities.Conclusions: There appears to be an association between cognitive deficits and psychotic symptoms in AD, but the direction of causality is still unclear, and further studies using longitudinal designs would give more insight into the pathophysiological process of psychosis in AD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"369-376"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the Landscape of Those Left Behind When a Person With Dementia Dies: Roles of Race and Ethnicity. 绘制痴呆症患者去世后留守人员的分布图：种族和民族的作用。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI: 10.1097/WAD.0000000000000645

Zachary G Baker, SeungYong Han, Justine S Sefcik, Darina V Petrovsky, Kris Pui Kwan Ma, Matthew Lee Smith, Juanita-Dawne R Bacsu, Zahra Rahemi, Joseph Saenz

{"title":"Mapping the Landscape of Those Left Behind When a Person With Dementia Dies: Roles of Race and Ethnicity.","authors":"Zachary G Baker, SeungYong Han, Justine S Sefcik, Darina V Petrovsky, Kris Pui Kwan Ma, Matthew Lee Smith, Juanita-Dawne R Bacsu, Zahra Rahemi, Joseph Saenz","doi":"10.1097/WAD.0000000000000645","DOIUrl":"10.1097/WAD.0000000000000645","url":null,"abstract":"Introduction: People with dementia can have many family and friends who might be affected by their deaths. Pursuing the long-term aim of understanding how dementia deaths affect close family and friends, this project lays groundwork through estimates of who those close family and friends are, with special attention to race and ethnicity.Method: Regression models estimated associations between dementia, race/ethnicity, and close family and friend network size, controlling for age, sex, education, marital status, and household wealth for 1386 deceased people with dementia from the Health and Retirement Study (2004 to 2018).Results: Persons with dementia had an average of 9.4 close family and friends at death. But patterns of close family and friends were different among non-Latino Black (10.8), Latino (9.9), and non-Latino White (9.2) people with dementia at death. Notably, non-Latino White persons with dementia had the fewest close family (3.7), followed by non-Latino Black (5.1), and Latino (7.7) persons with dementia.Discussion: Knowing who might be affected by dementia deaths is the first step to explore how dementia-related deaths impact close family and friends. Future work can now sample bereaved family and friends of people with dementia to explore their experiences and develop culturally appropriate supports.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"332-337"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G2019S Mutation of Leucine-Rich Repeat Kinase 2 Is a Cause of Lewy Body Dementia in Patients With North African Ancestors. 富亮氨酸重复激酶 2 的 G2019S 突变是北非祖先路易体痴呆症的病因之一。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-08-07 DOI: 10.1097/WAD.0000000000000643

Kurt Segers, Florence Benoit, Sophie Levy, Valérie Martinet, Joachim G Schulz, Frédéric Bertrand, Gabrielle De Bourgoing, Chiara Tatillo, Jean-Philippe Praet, Isabelle Vandernoot, Laurence Desmyter, Xavier Peyrassol, Pashalina Kehagias, Guillaume Smits, Baptiste Dumoulin, Tatiana Besse-Hammer, Bernard Dachy, Murielle Surquin

{"title":"G2019S Mutation of Leucine-Rich Repeat Kinase 2 Is a Cause of Lewy Body Dementia in Patients With North African Ancestors.","authors":"Kurt Segers, Florence Benoit, Sophie Levy, Valérie Martinet, Joachim G Schulz, Frédéric Bertrand, Gabrielle De Bourgoing, Chiara Tatillo, Jean-Philippe Praet, Isabelle Vandernoot, Laurence Desmyter, Xavier Peyrassol, Pashalina Kehagias, Guillaume Smits, Baptiste Dumoulin, Tatiana Besse-Hammer, Bernard Dachy, Murielle Surquin","doi":"10.1097/WAD.0000000000000643","DOIUrl":"10.1097/WAD.0000000000000643","url":null,"abstract":"Background: Mutations in the LRRK2 gene are the most common genetic cause of Parkinson disease but are believed to play no significant role in Lewy body disease (LBD).Objectives: As the frequency of G2019S LRRK2 mutation is extremely high in North African patients with Parkinson disease, we postulate that the high prevalence of LBD in North Africa might be due to the same mutation because LBD and Parkinson disease share many clinical, pathological, and genetic features.Methods: We screened patients with LBD or prodromal LBD for the G2019S mutation of LRRK2.Results: A total of 162 patients were tested for the mutation, which was present in 5 of the 47 patients with North African ancestors. This is a much higher prevalence (10.6%) than in healthy North African subjects (1.45%) but lower than in North African patients with Parkinson disease (36% to 39%). Carriers tended to develop more often orthostatic hypotension and swallowing problems.Conclusions: Where previous studies in European and North American patients found no link between LRRK2 mutations and LBD, we found an LRRK2 mutation associated with Lewy body disease, namely the G2019S mutation that might be restricted to patients with North African ancestors. Our study illustrates the need to introduce ethnic diversity as stratifying factor in the analysis of genetic causes of neurodegenerative disorders. The current development of disease-modifying drugs modulating LRRK2 kinase activity could justify to screen North African patients with LBD for the G2019S LRRK2 mutation.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 4","pages":"328-331"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Measurement Equivalence of Alzheimer Disease Research Centers' Neuropsychological Test Battery (Version 3) Between Singapore and US Samples. 研究阿尔茨海默病研究中心神经心理测试库（第 3 版）在新加坡和美国样本之间的测量等效性。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-10-28 DOI: 10.1097/WAD.0000000000000649

Sze Yan Tay, Way Inn Koay, Simon Kang Seng Ting, Tau Ming Liew

{"title":"Examining the Measurement Equivalence of Alzheimer Disease Research Centers' Neuropsychological Test Battery (Version 3) Between Singapore and US Samples.","authors":"Sze Yan Tay, Way Inn Koay, Simon Kang Seng Ting, Tau Ming Liew","doi":"10.1097/WAD.0000000000000649","DOIUrl":"10.1097/WAD.0000000000000649","url":null,"abstract":"Purpose: Standardization of neuropsychological tests is crucial for consistency in cognitive assessment, as well as for validity and comparability of results across different populations. We examined the applicability and measurement equivalence of the Alzheimer Disease Research Centers' Neuropsychological Test Battery (version 3) (ADRC-NTB3) in Singapore.Methods: The ADRC-NTB3 was administered to 978 older persons with normal cognition in Singapore. To provide comparison between Singapore and US samples, a US sample with similar profile was retrieved from the National Alzheimer Coordinating Center (NACC) database.Patients: Scores were compared with 1853 participants with similar profile from the United States. Score-difference between the populations was computed using multiple linear regression (adjusted for covariates), with equivalent score considered present when 90% CI of the score-difference fell within the predefined margin of equivalence.Results: Tasks assessing for memory, processing speed, and executive functioning showed equivalence in scores between US and Singapore samples (adjusted-score difference=-0.94 to 0.09). Singapore sample performed marginally better on the visuospatial task (adjusted-score difference=0.50), but poorer on the language task (adjusted-score difference=-3.22).Discussion: Nonequivalence of visuospatial and language tasks, which may increase potential misinterpretation of cognitive profiles and misdiagnosis, are related to educational and cultural differences. This highlights the need for different normative data for more accurate diagnostic accuracy as well as research priorities.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"319-327"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discontinuation of Alzheimer Disease Medications in Patients Receiving Home Care Medicine. 接受家庭护理药物治疗的阿尔茨海默病患者停药问题。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-10-28 DOI: 10.1097/WAD.0000000000000650

Kiwami Kidana, Ryonosuke Yamaga, Hiroko Fujii, Masahiro Akishita, Takashi Yamanaka

引用次数: 0

DXA-Measured Abdominal Adipose Depots and Structural Brain Integrity in Postmenopausal Women. 通过 DXA 测量的绝经后妇女腹部脂肪沉积和大脑结构完整性。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1097/WAD.0000000000000642

Zeinah Al-Darsani, Hailey R Banack, Mallory N Ziegler, Stephen R Rapp, Maria M Corrada, Andrew O Odegaard

{"title":"DXA-Measured Abdominal Adipose Depots and Structural Brain Integrity in Postmenopausal Women.","authors":"Zeinah Al-Darsani, Hailey R Banack, Mallory N Ziegler, Stephen R Rapp, Maria M Corrada, Andrew O Odegaard","doi":"10.1097/WAD.0000000000000642","DOIUrl":"10.1097/WAD.0000000000000642","url":null,"abstract":"Background: This study extends prior research from the MRI substudy of the Women's Health Initiative Memory Study (WHIMS-MRI) linking BMI to reduced brain atrophy and ischemic lesion load by examining DXA-based measurements of total body fat, total abdominal adipose tissue (TAT), abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue, gynoid fat, and overall leg fat.Methods: The analytic sample consisted of 61 postmenopausal women (baseline mean age 69.5 [3.6]) enrolled in WHIMS-MRI who had undergone DXA scans. DXA scans were completed at years 0, 3, and 6, and MRI scans were conducted ~8 years after baseline. Adjusted linear regression models were used to analyze the association between adiposity averaged across the 3-time points and volumes of brain regions previously linked to dementia.Results: Higher levels of total body fat, TAT, VAT, SAT, gynoid, and overall leg fat were associated with larger hippocampal volume (β 0.02 [95% CI, 0.004-0.04]; 0.11 [0.02-0.21]; 0.26 [0.04-0.47]; 0.18 [0.03-0.33]; 0.18 [0.05-0.30]; 0.07 [0.009-0.12], respectively). No other significant associations were observed.Conclusion: Higher levels of adiposity were positively associated with hippocampal volume. Additional research with larger sample sizes is needed to ascertain the significance of this association.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"305-310"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social and Emotional Self-perception in People With Mild to Moderate Alzheimer Disease Compared to Caregiver's Perspective in Brazil. 巴西轻度至中度阿尔茨海默病患者的社交和情感自我认知与照顾者的观点对比。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-11-08 DOI: 10.1097/WAD.0000000000000651

Rogéria Cristina Rangel da Silva, José Pedro Simões Neto, Tatiana Belfort, Marcia Cristina Nascimento Dourado

{"title":"Social and Emotional Self-perception in People With Mild to Moderate Alzheimer Disease Compared to Caregiver's Perspective in Brazil.","authors":"Rogéria Cristina Rangel da Silva, José Pedro Simões Neto, Tatiana Belfort, Marcia Cristina Nascimento Dourado","doi":"10.1097/WAD.0000000000000651","DOIUrl":"10.1097/WAD.0000000000000651","url":null,"abstract":"Introduction: There was limited evidence on the ability of people with Alzheimer disease (AD) to perceive their own emotions. We aimed to compare socioemotional self-perception in persons with mild and moderate AD to their caregivers' perspective.Method: Cross-sectional assessment of people with mild (n=102) and moderate (n=59) AD and caregivers. Each participant and their caregivers completed the socioemotional questionnaire (SEQ); a 30-item rating scale assessing five dimensions of socioemotional cognition (empathy, emotion recognition, social conformity, antisocial behavior, sociability). We evaluated global cognition, awareness of disease, dementia severity, functionality, neuropsychiatric symptoms, and caregiver burden.Results: Participants in the mild and moderate groups showed a similar pattern of socioemotional self-perception. They differed in the anger domain of the emotion recognition subscale, in the antisocial behavior dimension, and in the sociability subscale. In contrast, the caregivers' perspective of people with mild and moderate AD showed a significant difference in the emotion recognition domain for fear, disgust, and sadness. There were also significant differences in the empathy subscale for disgust and in the sociability subscale. Cognition was correlated with self-reported reduced perception in social conformity, antisocial behavior, and sociability. Awareness was correlated with emotion recognition, antisocial behavior, and sociability. Neuropsychiatric symptoms were correlated with empathy, emotion recognition, and social conformity.Conclusions: Significant differences were found between caregivers' perspectives of socioemotional functioning in people with mild and moderate AD. Meanwhile, there were minimal differences in self-perception between the mild and moderate groups.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"358-366"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease: Subanalysis of Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets. COVID-19大流行导致的社会隔离对阿尔茨海默病患者认知功能障碍的影响：多奈哌齐贴剂和多奈哌齐片剂双盲非劣效性研究子分析》。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-11-13 DOI: 10.1097/WAD.0000000000000648

Yu Nakamura, Takumi Omori, Kenichi Nishiyama, Ichiro Ishikawa, Hiroshi Aoki, Naoki Nagakura

{"title":"Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease: Subanalysis of Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets.","authors":"Yu Nakamura, Takumi Omori, Kenichi Nishiyama, Ichiro Ishikawa, Hiroshi Aoki, Naoki Nagakura","doi":"10.1097/WAD.0000000000000648","DOIUrl":"10.1097/WAD.0000000000000648","url":null,"abstract":"Background: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group.Methods: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After demonstrating the noninferiority of both treatments, we used combined data for this analysis.Results: The analyzed subpopulation of the per-protocol set groups was balanced (n=126 and 135, respectively). Patient demographics were similar between subgroups. The difference of ADAS-JCOG scores [least-squares mean (95%CI)] between the groups was 0.388 (-0.377 to 1.152, not statistically significant).Conclusion: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 4","pages":"351-357"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics. 中晚年西班牙裔阿尔茨海默病成像生物标志物与 NIH 工具箱认知能力测试成绩之间的关系

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-11-26 DOI: 10.1097/WAD.0000000000000641

Mouna Tahmi, Brady Rippon, Priya Palta, Greysi Sherwood, Gabriela Hernandez, Luisa Soto, Sandino Cespedes, Michelle Pardo, Krystal Laing, Kay Igwe, Aubrey Johnson, Zeljko Tomljanovic, Hengda He, José Gutierrez, Jeanne A Teresi, Herman Moreno, William Kreisl, Qolamreza Razlighi, Adam M Brickman, José A Luchsinger

{"title":"Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics.","authors":"Mouna Tahmi, Brady Rippon, Priya Palta, Greysi Sherwood, Gabriela Hernandez, Luisa Soto, Sandino Cespedes, Michelle Pardo, Krystal Laing, Kay Igwe, Aubrey Johnson, Zeljko Tomljanovic, Hengda He, José Gutierrez, Jeanne A Teresi, Herman Moreno, William Kreisl, Qolamreza Razlighi, Adam M Brickman, José A Luchsinger","doi":"10.1097/WAD.0000000000000641","DOIUrl":"10.1097/WAD.0000000000000641","url":null,"abstract":"Purpose: The National Institute of Health Toolbox Cognition Battery (NIHTB-CB) is increasingly used in Alzheimer disease (AD) research. We examined the relation of AD biomarkers with performance in the NIHTB-CB in late middle age.Methods: This is a cross-sectional analysis of 334 Hispanic participants aged 64.22±3.35 years from a study of AD biomarkers. White matter hyperintensities (WMH), infarcts, and cortical thickness in AD regions (CT) were assessed with 3T magnetic resonance imaging. Amyloid and tau were assessed with 18F-Florbetaben and 18F-MK6240 positron emission tomography, respectively.Results: Lower CT and infarcts were associated with worse Oral Reading Recognition and Cognition Crystallized Composite scores. Lower CT and higher WMH were associated with worse Pattern Comparison Processing Speed. Amyloid and tau were not associated with any test.Discussion: Amyloid and tau, the culprits of AD, are not related to the NIHTB-CB in late middle age. Continued follow-up will reveal if AD impacts performance on the NIHTB-CB.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 4","pages":"311-318"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of Using a Novel, Multimodal Motor Function Assessment Platform With Machine Learning to Identify Individuals With Mild Cognitive Impairment. 利用新型多模态运动功能评估平台和机器学习识别轻度认知障碍患者的可行性。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-10-01 Epub Date: 2024-10-17 DOI: 10.1097/WAD.0000000000000646

Jamie B Hall, Sonia Akter, Praveen Rao, Andrew Kiselica, Rylea Ranum, Jacob M Thomas, Trent M Guess

{"title":"Feasibility of Using a Novel, Multimodal Motor Function Assessment Platform With Machine Learning to Identify Individuals With Mild Cognitive Impairment.","authors":"Jamie B Hall, Sonia Akter, Praveen Rao, Andrew Kiselica, Rylea Ranum, Jacob M Thomas, Trent M Guess","doi":"10.1097/WAD.0000000000000646","DOIUrl":"10.1097/WAD.0000000000000646","url":null,"abstract":"Introduction: Early identification of clinical conditions associated with Alzheimer disease and related dementias (ADRD) is vital for intervention. One promising early detection method is the use of instrumented assessment to identify subtle motor declines associated with ADRD. This pilot study sought to establish the feasibility of building a machine learning model to identify individuals with mild cognitive impairment (MCI) using motor function data obtained from an inexpensive, portable device.Methods: Our novel, multimodal motor function assessment platform integrates a depth camera, forceplate, and interface board. Healthy older adults (n=28) and older adults with MCI (n=19) were assessed during static balance, gait, and sit-to-stand activities in both single- and dual-task conditions. Three machine learning models (ie, support vector machine, decision trees, and logistic regression) were trained and tested with the goal of classification of MCI.Results: Our best model was decision trees, which demonstrated an accuracy of 83%, a sensitivity of 0.83, a specificity of 1.00, and an F1 score of 0.83. The top features were extracted and ranked on importance.Discussion: This study demonstrates the feasibility of building a machine learning model capable of identifying individuals with mild cognitive impairment using motor function data obtained with a portable, inexpensive, multimodal device.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"344-350"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0