Can Sleep Predict Conversion to Mild Cognitive Impairment and Dementia? Results From the Hellenic Longitudinal Investigation of Aging and Diet Study.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2025-01-20 DOI:10.1097/WAD.0000000000000661

Styliani Bairami, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Paraskevi Sakka, Georgios Hadjigeorgiou, Angeliki Tsapanou, Mary H Kosmidis

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引用次数: 0

Abstract

Objective: Sleep disturbance is considered a risk factor for cognitive decline in elderly individuals. Our aim in the current study was to investigate whether baseline sleep parameters can predict the conversion from normal cognition to mild cognitive impairment or dementia at follow-up. The Hellenic Longitudinal Investigation of Aging and Diet is a longitudinal population-based study designed to estimate the prevalence and incidence of cognitive decline and dementia in the older Greek population.

Methods: A total of 955 cognitively normal older adults (aged ≥65 y) were drawn from the Hellenic Longitudinal Investigation of Aging and Diet study. A comprehensive neurological and neuropsychological assessment was conducted at baseline and a mean of 3.1 (SD = 0.85) years later, resulting in 160 individuals diagnosed with mild cognitive impairment and 34 with dementia at follow-up, whereas 761 remained cognitively normal.

Results: Using Cox regression analyses, no sleep parameters increased the risk of conversion status adjusting for demographics and clinical factors. Napping, however, decreased this risk by 19.3% (P < 0.001).

Conclusions: As several previous studies have proposed, napping constitutes a protective factor against cognitive decline. Thus, clinicians should encourage their elderly patients to adopt this healthy habit.

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睡眠能预测轻度认知障碍和痴呆的转变吗？希腊老龄化纵向调查与饮食研究的结果。

目的：睡眠障碍被认为是老年人认知能力下降的危险因素。我们本研究的目的是研究基线睡眠参数是否可以预测随访中从正常认知到轻度认知障碍或痴呆的转变。希腊老龄化与饮食纵向调查是一项以人口为基础的纵向研究，旨在估计希腊老年人口中认知能力下降和痴呆的患病率和发病率。方法：从希腊老龄化与饮食纵向调查研究中抽取955名认知正常的老年人（年龄≥65岁）。在基线和平均3.1年后（SD = 0.85）进行了全面的神经学和神经心理学评估，结果在随访时，160人被诊断为轻度认知障碍，34人被诊断为痴呆，而761人认知正常。结果：采用Cox回归分析，经人口统计学和临床因素调整后，无睡眠参数会增加转换状态的风险。然而，午睡使这种风险降低了19.3% （P < 0.001）。结论：正如之前的几项研究所提出的，午睡是防止认知能力下降的保护因素。因此，临床医生应鼓励老年患者养成这种健康的习惯。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.