American Journal of Reproductive Immunology最新文献

{"title":"Aging Is Associated With Decreased Lactobacillus and Increased Cervicovaginal Inflammation in Canadian Women","authors":"Ha T. Dang,&nbsp;Laura Noel-Romas,&nbsp;Samantha Knodel,&nbsp;Kenzie Birse,&nbsp;Alana Lamont,&nbsp;Kateryna Kratzer,&nbsp;Peter McQueen,&nbsp;Michelle Perner,&nbsp;Hossaena Ayele,&nbsp;Alicia R. Berard,&nbsp;John J. Schellenberg,&nbsp;Stuart McCorrister,&nbsp;Garrett Westmacott,&nbsp;Bonnie Sandberg,&nbsp;Adelicia Yu,&nbsp;Margaret Burnett,&nbsp;Vanessa Poliquin,&nbsp;Adam D. Burgener,&nbsp;Christina Farr Zuend","doi":"10.1111/aji.70058","DOIUrl":"https://doi.org/10.1111/aji.70058","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>Aging is characterized by a general dysregulation of systemic immune responses that increases susceptibility to infections and malignancies. Immune cells in the female genital tract (FGT) are regulated by sex hormones, but little is known about the impact of aging and menopause on immunology in the FGT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method of Study</h3>\u0000 \u0000 <p>This study conducted an age-focused sub-analysis of cervicovaginal samples collected from 47 women enrolled in the Vaginal Mucosal Systems study in Winnipeg, Canada. Paired cervicovaginal lavage and cervical cytobrush were collected and analyzed by Luminex cytokine array, mass spectrometry based metaproteomics, metabolomics, and high dimensional flow cytometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age of study participants was 38 (range 19–88), with 12 over the age of 50. Increasing age was significantly correlated with increased cervicovaginal inflammation, including inflammatory cytokine MIP-1β (<i>r</i> = 0.335, <i>p</i> = 0.023), and activated T cells (CD4+HLA-DR+ <i>r</i> = 0406, <i>p</i> = 0.009; CD8+HLA-DR+ <i>r</i> = 0.399, <i>p</i> = 0.010; CD8+CD38+HLA-DR+ <i>r</i> = 0.386, <i>p</i> = 0.013). Proteomic analysis of cervicovaginal mucus identified 925 human proteins, with 108 (11.7%) significantly correlated with age. Pathway analysis indicated biofunctions related to immune response, migration, and myeloid cell phagocytosis increased with age. Interestingly, neutrophil related pathways decreased with age, including G-CSF (<i>r</i> = −0.396, <i>p</i> = 0.006) and reactive oxygen species (<i>z</i>-score = −2.607, <i>p</i> = 2.31E-4). Vaginal <i>Lactobacillus crispatus</i>, a species associated with mucosal health, significantly decreased with age (<i>r</i> = −0.340, <i>p</i> = 0.022), with participants over the age of 50 more likely to have non-<i>Lactobacillus</i> dominant microbiomes compared to those under 40.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Together, our data suggests that there is an increase in cervicovaginal inflammation and a decrease in <i>L. crispatus</i> that occurs with aging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Treatment Strategies in Unexplained Recurrent Pregnancy Loss","authors":"Rui Cai,&nbsp;Qiaoran Yang,&nbsp;Yingjun Liao,&nbsp;Lang Qin,&nbsp;Jinbiao Han,&nbsp;Rui Gao","doi":"10.1111/aji.70060","DOIUrl":"https://doi.org/10.1111/aji.70060","url":null,"abstract":"<div>\u0000 \u0000 <p>Recurrent pregnancy loss (RPL) is characterized by the occurrence of two or more consecutive pregnancy losses. Approximately half of these cases lack a clear etiology and are termed unexplained recurrent pregnancy loss (URPL). Maternal–fetal immune dysfunction is thought to be involved in causing URPL. Increased human leukocyte antigen compatibility, susceptibility genes, lack of blocking antibodies, and dysfunction of immune cells can all disrupt the immune tolerance environment of the maternal–fetal interface. To correct the maternal–fetal immune imbalances, some immunotherapies were recently tried to be used for patients with URPL. This review summarizes the characteristics and mechanisms of the immune microenvironment at the maternal–fetal interface of URPL patients, and the present immunotherapies for URPL patients, to serve as a reference for future research.</p>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Associations of Urogenital Microbiomes With Fertility and In Vitro Fertilization","authors":"Alicia R. Berard,&nbsp;Douglas K. Brubaker,&nbsp;Dalí X. Nemecio,&nbsp;Christina Farr Zuend","doi":"10.1111/aji.70035","DOIUrl":"https://doi.org/10.1111/aji.70035","url":null,"abstract":"<p>Infertility, defined as the inability to establish a clinical pregnancy after a year of regular, unprotected sexual intercourse, impacts 8%–12% of couples worldwide. Many of these couples turn to in vitro fertilization (IVF) to build their families. The success rate of IVF procedures is variable, with estimates of up to 40% of embryo transfers being unsuccessful. Herein we review the existing literature on the role of the female and male urogenital microbiomes and genital inflammation on fertility and IVF outcomes. We discuss the microbiome across the female reproductive tract (FRT) and identify associations with female infertility, female genital tract inflammation, and success of IVF procedures. We also discuss the male urogenital microbiome and the associations between microbial taxa, genital inflammation, and male fertility parameters. Finally, we consider microbial transfer within couples and the impact this may have on fertility and the success of IVF procedures.</p>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Efficacy of Corticosteroids in Patients With Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis”","authors":"Nosaibah Razaqi,&nbsp;Rachana Mehta,&nbsp;Shubham Kumar,&nbsp;Ranjana Sah","doi":"10.1111/aji.70059","DOIUrl":"https://doi.org/10.1111/aji.70059","url":null,"abstract":"","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Potential Treatment Effect of Botulinum Toxin Type A in Ovarian Torsion: Findings From the Rat Model","authors":"Çağlayan Ateş,&nbsp;Berna Dilbaz,&nbsp;Seval Yılmaz Ergani,&nbsp;Pelin Seçken,&nbsp;Caner Köse","doi":"10.1111/aji.70057","DOIUrl":"https://doi.org/10.1111/aji.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to investigate the effects of botulinum toxin A on histological abnormalities, loss of ovarian reserve, and angiogenesis within the ovarian torsion–detorsion paradigm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 45 female Wistar albino rats were used for the study. The rats were randomly divided into five groups (<i>n</i> = 9 in each group): Control, Torsion, Torsion + Detorsion, Torsion + Detorsion + Botulinum toxin, and Botulinum toxin only. Follicular cell degeneration, vascular congestion, hemorrhage, inflammation, and vascular endothelial growth factor (VEGF) expression scores were compared histopathologically between the groups. Follicle numbers were compared. Anti-mullerian hormone levels were measured before and after torsion, detorsion, and treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Follicular cell degeneration, vascular congestion, hemorrhage, inflammation, and VEGF expression differed significantly between groups for each score (<i>p </i>&lt; 0.001). The VEGF expression score was found to increase more in the torsion + detorsion + botulinum toxin group than in the torsion + detorsion group (2.67 ± 0.71 and 2.22 ± 0.67, respectively). There was a significant difference between the groups in secondary follicle counts (<i>p</i> = 0.04). The groups showed statistically significant differences in their anti-mullerian hormone levels (<i>p </i>&lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This initial investigation of the effects of botulinum toxin on ovarian torsion (OT) has shown that botulinum toxin type A has the potential to be a useful adjunct treatment for fertility preservation. Our results proved the ovarian protective effect of botulinum toxin type A in rats with OT. Therefore, botulinum toxin type A may be a potential preventive agent against ovarian damage caused by torsion in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps","authors":"Da Zhang,&nbsp;Ying Chen,&nbsp;Liangyu Zhang,&nbsp;Yang Wang","doi":"10.1111/aji.70054","DOIUrl":"https://doi.org/10.1111/aji.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Postmenopausal women with endometrial polyps (EPs) often experience hormonal imbalances. Acupoint application, a traditional Chinese medicine (TCM) approach, shows the potential to influence hormonal levels. This study investigated the impact of acupoint application on hormone levels and receptors in postmenopausal women with EP, comparing its efficacy and safety to surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective analysis of 170 postmenopausal patients with EP. Eighty-four patients received surgery alone, while 86 received surgery combined with acupoint application. Hormone levels, hormone receptor expression, TCM symptom scores, and adverse effects were compared between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The acupoint application group demonstrated a significantly higher total effective rate than the control group (<i>p</i> &lt; 0.05). After treatment, the acupoint application group exhibited a significantly greater reduction in serum progesterone levels and vaginal pH compared to the control group (<i>p</i> &lt; 0.05). Additionally, the acupoint application group showed a significant increase in endometrial estrogen receptor expression after treatment (<i>p</i> &lt; 0.05). TCM symptom scores related to vaginal bleeding volume, duration, facial complexion, dry mouth, and thirst significantly improved in the acupoint application group post-treatment (<i>p</i> &lt; 0.01). Furthermore, the acupoint application group demonstrated a notably lower incidence of adverse effects (including nausea, headache, breast tenderness, and dizziness) compared to the control group (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study suggests acupoint application, alongside surgery, enhances clinical outcomes, hormonal balance, and symptom relief in postmenopausal women with EPs, compared to surgery alone. Its safety and sustained benefits support its use as a complementary treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decrease of Antibodies Against SARS-CoV-2 Antigens Does Not Reflect a Decrease of Neutralization Rate: A Prospective Study to Evaluate Kinetic and Dynamic Humoral Immune Response After Vaccination During Pregnancy","authors":"Gabriela Mattoso Coelho,&nbsp;Hellen Geremias dos Santos,&nbsp;Allan Henrique Depieri Cataneo,&nbsp;Yara Zancanaro,&nbsp;Gabriela Lunardelli,&nbsp;Taciane Elisabete Cesca,&nbsp;Jaqueline Makiyama,&nbsp;Jean Alexandre Furtado Correa Francisco,&nbsp;Thelma Skare,&nbsp;Felipe Francisco Tuon,&nbsp;Camila Zanluca,&nbsp;João Paulo Telles,&nbsp;Claudia Nunes Duarte dos Santos","doi":"10.1111/aji.70053","DOIUrl":"10.1111/aji.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>Despite being at increased risk for severe COVID-19, pregnant women were initially excluded from vaccine clinical trials, which limited data regarding vaccine effectiveness and protection in this group. Aiming to better understand the immune response to vaccination during pregnancy, we compared the kinetics and titers of neutralizing and IgG antibodies generated against SARS-CoV-2 during vaccination with BNT162b2 (Pfizer-BioNTech) or CoronaVac (Sinovac Biotech) in a cohort of pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods of Study</h3>\u0000 \u0000 <p>We evaluated participants before vaccination and 30 days after each vaccine dose, using a multiplex bead assay to measure IgG antibodies against SARS-CoV-2 antigens (total spike, spike-1, spike-2, receptor binding domain, and nucleocapsid) and a live virus fluorescence reduction neutralization assay (FRNA) to quantify neutralizing antibodies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our data showed that vaccination resulted in a robust humoral response, with a considerable increase in the levels of IgG and neutralizing antibodies after the first vaccine dose and a sustained neutralizing response after the vaccine boost. In addition, antispike IgG assays presented a slight decrease after the second dose, while the neutralization rate remained stable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Immune response to the SARS-CoV-2 vaccine in pregnant women demonstrated an important increase in neutralizing antibodies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of First-Trimester Combined Inflammatory Markers (NLR, SII, SIRI, and AISI) With Poor Obstetric Outcomes in Pregnancies With Ulcerative Colitis","authors":"Osman Onur Ozkavak,&nbsp;Atakan Tanacan,&nbsp;Hakki Serbetci,&nbsp;Esra Karatas,&nbsp;Murat Haksever,&nbsp;Ezgi Basaran,&nbsp;Melike Busra Atar,&nbsp;Dilek Sahin","doi":"10.1111/aji.70055","DOIUrl":"10.1111/aji.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the first-trimester combined inflammatory markers between pregnant women diagnosed with ulcerative colitis (UC) and healthy pregnant women. Furthermore, to investigate the predictive value of these markers for adverse obstetric outcomes in pregnant women affected by UC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective study, data were collected from pregnant women with UC who gave birth at our hospital between January 2021 and May 2024 and from a control group of healthy pregnant women. A comparison was made between the two groups in terms of their demographic characteristics, neonatal outcomes, and the values of the first-trimester neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), and aggregated index of systemic inflammation (AISI). Furthermore, the relationship between these combined inflammatory markers and adverse obstetric outcomes in pregnant women with UC was investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No notable discrepancy was observed between the UC group and the control group with respect to SIRI and AISI. The first-trimester NLR and SII values were observed to be higher in the UC group in comparison to the control group. The data indicated that pregnant women with UC who experienced poor obstetric outcomes exhibited elevated levels of NLR, SII, SIRI, and AISI during the first trimester. In the ROC analysis, the predictive capacity of all four parameters for poor obstetric outcomes in UC patients was statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is an association between elevated combined inflammatory markers in the first trimester and poor obstetric outcomes in pregnant women with UC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Complete Blood Parameters and Inflammation Markers in Spontaneous Preterm Labor","authors":"Betül Tokgöz Çakır,&nbsp;Gizem Aktemur,&nbsp;Gülşan Karabay,&nbsp;Zeynep Şeyhanlı,&nbsp;Sadun Sucu,&nbsp;Mevlüt Bucak,&nbsp;Ahmet Arif Filiz,&nbsp;Nazan Vanlı Tonyalı,&nbsp;Seda Aydoğan,&nbsp;İzzet Özgürlük,&nbsp;Şevki Çelen","doi":"10.1111/aji.70051","DOIUrl":"10.1111/aji.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to evaluate the relationship between systemic inflammatory markers, derived from complete blood count (CBC) parameters, and spontaneous preterm labor. By comparing these markers between preterm and term pregnancies, the study seeks to determine their potential predictive value for adverse neonatal outcomes, including birth weight, APGAR (appearance, pulse, grimace, activity, and respiration) scores, and neonatal intensive care unit (NICU) admission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study evaluated inflammatory markers in 478 women with spontaneous preterm labor and a gestational age-matched control group. Blood samples were collected prior to the onset of labor to assess CBC parameters (white blood cells [WBC], red blood cells [RBC], neutrophils, lymphocytes, and platelet counts), as well as various inflammatory ratios, such as the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Neonatal outcomes, such as birth weight, APGAR scores, and NICU admission, were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The preterm group showed significantly higher WBC, RBC, neutrophil, lymphocyte, and platelet counts compared to the control group. MLR, MPR, and MPVLR were notably lower in the preterm group. However, these hematological parameters and inflammatory markers demonstrated limited predictive value for adverse neonatal outcomes, with area under the curve (AUC) values hovering around 0.5.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>WBC, RBC, neutrophils, lymphocytes, and platelet counts, along with inflammatory markers such as MLR, MPR, and MPVLR differ between preterm and term groups and can be derived from a simple CBC test. However, their predictive value for adverse neonatal outcomes remains limited.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Mediators of Celiac Disease and Premature Ovarian Failure: Hypothyroidism and Systemic Lupus Erythematosus","authors":"Yuxi Hou,&nbsp;Weihong Song,&nbsp;Guoguo Wei,&nbsp;Yuanhang Mo,&nbsp;Manna Zhang,&nbsp;Xiaohu Chen,&nbsp;Chunge Cao,&nbsp;Chaoyan Yue,&nbsp;Xiaowen Shao","doi":"10.1111/aji.70038","DOIUrl":"10.1111/aji.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Observational studies suggested celiac disease (CD) possibly be a risk factor for premature ovarian failure (POF). However, causality remains unclear. And hypothyroidism and systemic lupus erythematosus may be the mediating factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed 2-sample Mendelian randomization (2SMR) to infer a causal relationship between CD and POF using genome-wide association study summary data obtained from IEU OpenGWAS database and FinnGen R12 database. Inverse-variance weighted method was used as the main analysis of MR. Heterogeneity was measured based on Cochran's <i>Q</i> value. We used the Two-Step MR to analyze whether hypothyroidism and SLE are mediators of the causal relationship between CD and POF. Summary level data of the hypothyroidism and SLE were obtained from IEU OpenGWAS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Genetically predicted CD may increase the risk of POF by 16% (odds ratio [OR]: 1.16, 95% CI: 1.06–1.26, <i>p</i> = 0.001). Hypothyroidism and SLE could mediate 13.46% and 26.36% of the association between CD and POF, respectively (<i>p</i> = 0.038, <i>p</i> = 0.025).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study revealed that CD has a positive contribution effect on POF. CD can elevate the risk of POF by 16%. Besides, hypothyroidism and SLE played a partial mediating role in the causal relationship between the two.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}