The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps

IF 2.5 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-02-07 DOI:10.1111/aji.70054

Da Zhang, Ying Chen, Liangyu Zhang, Yang Wang

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引用次数: 0

Abstract

Background

Postmenopausal women with endometrial polyps (EPs) often experience hormonal imbalances. Acupoint application, a traditional Chinese medicine (TCM) approach, shows the potential to influence hormonal levels. This study investigated the impact of acupoint application on hormone levels and receptors in postmenopausal women with EP, comparing its efficacy and safety to surgery.

Methods

We conducted a retrospective analysis of 170 postmenopausal patients with EP. Eighty-four patients received surgery alone, while 86 received surgery combined with acupoint application. Hormone levels, hormone receptor expression, TCM symptom scores, and adverse effects were compared between the two groups.

Results

The acupoint application group demonstrated a significantly higher total effective rate than the control group (p < 0.05). After treatment, the acupoint application group exhibited a significantly greater reduction in serum progesterone levels and vaginal pH compared to the control group (p < 0.05). Additionally, the acupoint application group showed a significant increase in endometrial estrogen receptor expression after treatment (p < 0.05). TCM symptom scores related to vaginal bleeding volume, duration, facial complexion, dry mouth, and thirst significantly improved in the acupoint application group post-treatment (p < 0.01). Furthermore, the acupoint application group demonstrated a notably lower incidence of adverse effects (including nausea, headache, breast tenderness, and dizziness) compared to the control group (p < 0.05).

Conclusion

Our study suggests acupoint application, alongside surgery, enhances clinical outcomes, hormonal balance, and symptom relief in postmenopausal women with EPs, compared to surgery alone. Its safety and sustained benefits support its use as a complementary treatment.

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背景患有子宫内膜息肉（EPs）的绝经后妇女通常会出现内分泌失调。穴位贴敷作为一种传统中医疗法，具有影响激素水平的潜力。本研究探讨了穴位贴敷对绝经后女性子宫内膜息肉患者激素水平和受体的影响，并将其疗效和安全性与手术进行了比较。方法我们对 170 名绝经后 EP 患者进行了回顾性分析。84名患者接受了单纯手术治疗，86名患者接受了手术联合穴位贴敷治疗。比较了两组患者的激素水平、激素受体表达、中医症状评分和不良反应。结果穴位贴敷组总有效率明显高于对照组（P < 0.05）。治疗后，与对照组相比，穴位贴敷组的血清孕酮水平和阴道 pH 值明显降低（p < 0.05）。此外，穴位贴敷组经治疗后子宫内膜雌激素受体表达明显增加（p < 0.05）。穴位贴敷组在治疗后与阴道出血量、持续时间、面色、口干和口渴相关的中医症状评分明显改善（p <0.01）。此外，与对照组相比，穴位贴敷组的不良反应（包括恶心、头痛、乳房胀痛和头晕）发生率明显较低（p < 0.05）。结论我们的研究表明，与单纯手术相比，穴位贴敷与手术并行可提高绝经后 EPs 妇女的临床疗效、激素平衡和症状缓解。穴位贴敷的安全性和持续疗效支持将其作为一种辅助治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.