American Journal of Reproductive Immunology最新文献

{"title":"Elevated Neutrophil, Lymphocyte, and Platelet Counts as Early Biomarkers of Preeclampsia Risk: A Retrospective Cohort Study","authors":"Ying-Ling Yao,&nbsp;Zhou Xu,&nbsp;Rui Xiao,&nbsp;Er-Han Li,&nbsp;Yong-Jia Zhang,&nbsp;Li-Yang Zhou,&nbsp;Zhao-Hui Zhong,&nbsp;Li-Juan Fu,&nbsp;Hong-Bo Qi,&nbsp;Xiao-Bin Wu,&nbsp;Yu-Bin Ding","doi":"10.1111/aji.70137","DOIUrl":"https://doi.org/10.1111/aji.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the association between peripheral immune markers during gestational weeks 11–28 and the risk of preeclampsia (PE), and to explore potential causal relationships using Mendelian randomization (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study involving 19, 028 singleton pregnancies between January 2020 and December 2023. Peripheral immune markers, including neutrophils, lymphocytes, monocytes, and platelets, and derived indices, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were analyzed in relation to PE incidence. Subgroup and interaction analyses were further stratified by maternal age, prepregnancy BMI, gestational age at blood test, and gestational diabetes mellitus (GDM). Causality was assessed using MR with the inverse-variance weighted multiplicative random effects (IVW MRE) method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Elevated neutrophil (RR per SD = 1.20; 95% CI: 1.09–1.33; <i>P</i> &lt; 0.001), lymphocyte (RR per SD = 1.16; 95% CI: 1.06–1.27; <i>P</i> = 0.002), and platelet (RR per SD = 1.19; 95% CI: 1.07–1.31; <i>P</i> = 0.001) counts were significantly associated with increased PE risk. Associations were stronger in women aged ≥35 years, with a significant interaction for platelet count (<i>P</i> = 0.004). MR analysis revealed no causal link between genetically predicted immune cell counts and PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher peripheral neutrophil, lymphocyte, and platelet levels are associated with increased PE risk, particularly among older pregnant women. While MR analysis did not support a causal effect, these immune markers may serve as accessible early indicators and offer insight into PE pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes Derived From Calycosin-Exposed Prostate Stromal Cells Inhibit Lipopolysaccharide-Induced Epithelial Cells Inflammatory Injury","authors":"Ming Li,&nbsp;Wenping Yao,&nbsp;Yingying Sun,&nbsp;Heng Wang","doi":"10.1111/aji.70113","DOIUrl":"https://doi.org/10.1111/aji.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic prostatitis (CP) is a common and serious disorder characterized by unknown pathogenic mechanisms and recurrent symptoms. Exosomes isolated from prostate stromal cells can also be used to treat chronic inflammation. This study aimed to elucidate the mechanism of action of Calycosin (CA) during CP therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>LPS volume of 10 µg/mL was applied for constructing the cell models of CP. RWPE-1 cells were co-cultivated with exosomes isolated from CA elicited-WPMY-1 cells (CA-WPMY-1-exo). Exosomes isolated from WPMY-1 cells were identified by TEM, NTA, and western blotting. MTT and flow cytometry analyses were performed to evaluate cell viability and apoptosis, respectively. The secretion of inflammatory cytokines was measured using ELISA. The expressions of cleaved-Caspase3, Caspase3, p-p65, and p65 were determined by western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LPS treatment decreased RWPE-1 cell viability and stimulated more apoptotic cells, which was partly abolished by CA treatment in a dose-dependent manner. Furthermore, CA alleviated the LPS-induced inflammatory response in a dose-dependent manner. NC-WPMY-1 and CA-WPMY-1 markedly enhanced RWPE-1 cell viability. We also found that both NC-WPMY-1-exo and CA-WPMY-1-exo reversed the effects of LPS on RWPE-1 cell viability, apoptosis, and inflammation. The effect of CA-WPMY-1-exo on RWPE-1 cells was more significant than that of NC-WPMY-1-exo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Exosomes derived from CA-exposed prostate stromal cells were identified as significant mediators of CP by inhibiting LPS-induced epithelial cells inflammatory injury.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and Behçet Syndrome: A Large Retrospective Italian Study","authors":"Pietro Leccese,&nbsp;Nancy Lascaro,&nbsp;Assunta Iuliano,&nbsp;Michele Gilio,&nbsp;Salvatore D'Angelo,&nbsp;Sergio C. A. Schettini,&nbsp;Angela Anna Padula,&nbsp;Maria Carmela Padula","doi":"10.1111/aji.70133","DOIUrl":"https://doi.org/10.1111/aji.70133","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Behçet syndrome (BS) is a multifactorial disorder with several clinical manifestations that occurs during the childbearing age. The relationship between pregnancy and BS has been previously analysed as the pregnancy immunometabolic reprogramming in case of autoinflammatory and/or autoimmune diseases can influence both the course of the disease and the pregnancy outcomes. We aim to analyse the relationship between BS and pregnancy, investigating: (1) the prevalence and clinical characteristics of disease flares during pregnancy and (2) the pregnancy outcomes in a large cohort of Italian patients with BS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study was conducted recruiting a cohort of BS patients according to the criteria of the International Study Group for Behçet (ISG), following at the Rheumatology Department of Lucania (San Carlo Hospital, Potenza) from January 2000 to December 2021. We reviewed medical records and collected demographic and clinical data besides pregnancy-related data, in particular: maternal age, disease flares during and after pregnancy, post-partum maternal and neonatal complications (up to 6 months after pregnancy).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We studied 153 pregnancies in 96/117 subjects (21/117 patients did not get pregnant). Three patients showed active disease (oral ulcers) at the time of conception. Disease flares were observed during gestation for 25/153 (16.3%) pregnancies, mainly mucocutaneous (oral and genital ulcers, erythema nodosum) and joint (arthralgia and arthritis) manifestations. A total of 27/153 (17.6%) cases of disease flares were observed after pregnancy, with mucocutaneous (oral and genital ulcers, erythema nodosum) and joint (arthralgia and arthritis) involvement, as well as anterior uveitis. Miscarriages, preterm delivery, pre-eclampsia and eclampsia were observed in 27/153 (17.6%), 19/153 (12.4%), 6/153 (3.9%) and 2/153 (1.3%) pregnancies, respectively. No cases of neonatal complications or death were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of the present study underlined that: (a) BS disease clinical symptoms do not appear to worsen during pregnancy and (b) the pregnancy does not appear to be associated with increased gestational complications and adverse maternal-fetal outcomes in case of BS. However, due to the potential adverse events, especially of the vascular involvement, a strong multidisciplinary pregnancy follow-up is recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Immune Cell Populations From Two Sampling Techniques of Human Term Decidua Utilizing High-Parameter Full-Spectrum Flow Cytometry","authors":"Abigail L. P. Spray,&nbsp;Shahrokh Paktinat,&nbsp;Cara Tobey,&nbsp;Maryam Kalatehjari,&nbsp;Nolawit M. Mulugeta,&nbsp;Michelle Asencio,&nbsp;Sam Rosen,&nbsp;Michael G. Gravett,&nbsp;Lucia Vojtech,&nbsp;Stephen A. McCartney","doi":"10.1111/aji.70130","DOIUrl":"https://doi.org/10.1111/aji.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>The decidua is the interface between the uterus and the fetus. Studying decidual cells can reveal how healthy pregnancies are supported and mechanisms of pregnancy complications. There are two methods of obtaining decidual tissue following delivery. The placental bed can be suctioned following C-section deliveries, or a thin layer of decidual tissue can be dissected from the placenta. This study aimed to compare immune cell populations obtained using the two methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method of Study</h3>\u0000 \u0000 <p>From individuals with scheduled C-sections, we collected peripheral blood, decidua via vacuum suction of the placental bed, and decidua via dissection of the uterine-facing side of the placenta. Samples were analyzed using a 22-color full-spectrum flow cytometry panel to identify immune cell subsets and functional markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cellular composition of both decidual tissue collection methods were more similar to each other than to peripheral blood. Decidua collected via vacuum suction (Suc. decidua) had more live CD45+ cells. Decidua collected via dissection of the uterine-facing side of the placenta (Plac. decidua) had significantly higher expression of Helios in CD4+ cells, suggesting more fetal T cells. Both types of decidual samples contained similar levels of Tr1-like regulatory T lymphocytes expressing LAG3 and CD49b, whereas peripheral blood did not have this cell type.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Collecting decidual tissue using either method resulted in largely similar immune cell populations, suggesting studies are largely comparable regardless of whether samples were collected via suction or placental dissection. This will allow for greater flexibility in sample collection methods.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage Switching in Pregnancy: Regulatory Mechanisms Governing Term Labour and Preterm Birth","authors":"G. Ravi Prakash,&nbsp;Ayushi Vaidhya,&nbsp;V. Deepthi,&nbsp;Laxmi Singh Rathore,&nbsp;Manjit Panigrahi,&nbsp;C. L. Madhu,&nbsp;T. U. Singh,&nbsp;Subhashree Parida","doi":"10.1111/aji.70123","DOIUrl":"https://doi.org/10.1111/aji.70123","url":null,"abstract":"<div>\u0000 \u0000 <p>Macrophages play a pivotal role in the immune adaptations required for pregnancy, influencing both term and preterm labour (PTL) through their activation and polarisation. These immune cells originate from the yolk sac, foetal liver, and bone marrow, differentiating into diverse subtypes, including pro-inflammatory (M1) and anti-inflammatory (M2) macrophages. The dynamic transition between these states, termed macrophage switching, is crucial for maintaining pregnancy and orchestrating labour. This switch is tightly regulated by hormones, cytokines and immune signals, ensuring a controlled inflammatory response at term whilst preventing pathological inflammation leading to preterm birth. During term labour, macrophages accumulate in the cervix, decidua and myometrium, responding to signals from placental aging, foetal lung maturation and endocrine changes. They secrete pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), matrix metalloproteinases (MMPs) and prostaglandins, promoting uterine contractions and cervical remodelling. The sources of these macrophages include maternal monocytes recruited from circulation and resident decidual macrophages (DMs). In contrast, PTL often arises from dysregulated macrophage activation due to infection, sterile inflammation, or stress signals, triggering an early pro-inflammatory shift. Premature M1 dominance leads to excessive inflammation, extracellular matrix degradation and foetal membrane rupture. Understanding the mechanisms regulating macrophage switching in PTL, including TLR signalling and hormonal modulation, may uncover therapeutic targets and suitable interventions. This review explores the origins, activation, and functional switching of macrophages in term and preterm labor, emphasising their regulatory mechanisms and potential interventions to prevent preterm birth.</p>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Th1-Th2 Balance in Patients With Unexplained Recurrent Spontaneous Abortion: A Systematic Review and Meta-Analysis","authors":"Reza Kargar,&nbsp;Zahra Yahoo,&nbsp;Hosein Rafiemanesh,&nbsp;Saeed Aslani,&nbsp;Atefeh Shamosi,&nbsp;Hamed Mohammadi","doi":"10.1111/aji.70125","DOIUrl":"https://doi.org/10.1111/aji.70125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Unexplained recurrent spontaneous abortion (URSA) poses a major challenge in reproductive medicine, with increasing evidence of maternal immune dysregulation. This systematic review and meta-analysis assessed differences in T helper (Th) 1 and Th2 cell frequencies and their ratio between women with URSA and healthy fertile controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search of PubMed, Scopus, and Web of Science (WoS), up to October 2024, included studies evaluating peripheral blood Th subsets by flow cytometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Meta-analyses were performed for Th1(IFN-γ), Th1(TNF-α), Th2(IL-4), Th2(IL-10), and Th1/Th2 ratios. Th1(IFN-γ) frequencies were significantly higher in URSA (mean difference [MD] = 2.31, 95% CI = 0.30–4.33, <i>p</i> = 0.02), while Th2(IL-4) levels were lower (MD = −0.51, 95% CI = −0.91 to −0.11, <i>p</i> = 0.01). No significant differences were observed for Th1(TNF-α) (SMD = 0.25, 95% CI = −0.06 to 0.55, <i>p</i> = 0.11) and Th2(IL-10) (SMD = −0.28, 95% CI = −0.62 to 0.05, <i>p</i> = 0.10). The Th1(IFN-γ)/Th2(IL-4) ratio was significantly elevated (MD = 5.37, 95% CI = 1.47–9.27, <i>p</i> = 0.007), reflecting a shift toward a Th1-dominant immune profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings support the role of Th1/Th2 imbalance in URSA and suggest its potential value as a diagnostic or prognostic marker.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvianolic Acid B Promotes Placental and Decidual Angiogenesis by Restoring the Normal Expression of Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor in Mice With Recurrent Pregnancy Loss","authors":"Fangfang Hu,&nbsp;Chao Yang,&nbsp;Lujun Dai,&nbsp;Dan Gao,&nbsp;Heng Luo,&nbsp;Xingming Zhong,&nbsp;Panpan Chen,&nbsp;Leilei Zhu,&nbsp;Ziwen Xiao,&nbsp;Shuyun Zhao,&nbsp;Guanyou Huang","doi":"10.1111/aji.70105","DOIUrl":"https://doi.org/10.1111/aji.70105","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Accumulating evidence suggests the association between abnormal angiogenesis at the maternal–fetal interface and recurrent pregnancy loss (RPL); nonetheless, the mechanism remains largely unknown. Previous studies have reported the clinical effect of the traditional Chinese medicine Danshen in the treatment of RPL. This study aimed to investigate whether salvianolic acid B (SalB), the primary water-soluble component of Danshen, could reduce the embryonic absorption rate (EAR) by increasing placental and decidual angiogenesis in RPL mice and to explore the possible mechanism.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The decidual and chorionic tissues were collected from normal pregnancies and unknown recurrent pregnancy loss (URPL) patients. Western blotting was used to determine the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in the tissues. Different doses of SalB and/or the VEGF inhibitor PTC299 were intragastrically administered to normal and RPL pregnant mice daily at 0.5 day of pregnancy for 10 days. The EAR, mean placental weight (MPW), and micro vessel density (MVD) were determined in placental and decidual tissues, and the number of live pups per litter was counted. The expression of VEGF and HIF-1α in the tissues was evaluated using western blotting and immunohistochemistry.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The VEGF protein levels in decidual and chorionic tissues were significantly lower, and HIF-1α levels were significantly higher than that of normal pregnancies. The EAR was significantly higher, MVD, MPW, and protein levels of VEGF in the placental and decidual tissues of RPL mice were significantly lower than those in normal mice. In contrast, the protein levels of HIF-1α were significantly higher in RPL mice than in normal mice. SalB restored the morphological changes in the uterus of RPL mice, as well as the number of blood vessels in the placenta and decidua, and ameliorated adverse embryonic development in mice (such as neural tube defects and reduced crown-rump length), thereby increasing the pups per. Additionally, SalB increased the VEGF/VEGFR2/p-VEGFR2 levels, placental and decidual MVD, and MPW and decreased the HIF-1α levels and EAR in a dose-dependent manner. A positive association of daily SalB dose (0–100 mg/kg) with the VEGF levels, placental and decidual MVD and MPW, and a negative association of daily SalB dose with the HIF-1α levels and EAR were observed.PTC299 reversed the aforementioned increases and decreases in the daily SalB intake of RPL mice. Among these, the daily dose of 100 mg/kg of SalB was deemed optimal, and a daily dose of SalB exceeding 100 mg/kg did not ","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Delivery Timing in Preterm Premature Rupture of Membranes: The Role of Inflammation-Related Indices","authors":"Merve Ayas Ozkan,&nbsp;Zeynep Seyhanlı,&nbsp;Seval Yılmaz Ergani,&nbsp;Kadriye Yakut Yücel","doi":"10.1111/aji.70124","DOIUrl":"https://doi.org/10.1111/aji.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the predictivevalue of inflammatory parameters platelet-albumin ratio (PAR), systemic immune-inflammation index (SII), and multi-inflammatory indices (MII) in forecasting the timing of delivery in pregnancies diagnosed with preterm premature rupture of membranes (PPROM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on 292 pregnant women diagnosed with PPROM between 24 and 34 gestational weeks at Etlik City Hospital from January 2023 to December 2024. The patients were grouped according to their time of delivery: those delivering within 48, 72, and 96 h. Inflammatory indices, including PAR, SII, MII-1, and MII-2 were calculated using complete blood count and biochemical parameters obtained at admission, and their predictive performance for delivery timing was assessed using receiver operating characteristic (ROC) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For predicting delivery within 48 h, the AUC (areas under the curve) values were 0.566 for PAR (<i>p</i> = 0.050), 0.575 for SII (<i>p</i> = 0.027), and 0.567 for MII-1 (<i>p</i> = 0.046). For predicting delivery within 72 h, the AUC values were 0.603 for SII (<i>p</i> = 0.003), 0.591 for MII-1 (<i>p</i> = 0.008), and 0.584 for MII-2 (<i>p</i> = 0.015), indicating a moderate level of predictive value. For predicting delivery within 96 h, SII (AUC = 0.627, <i>p</i> &lt; 0.001) and MII-1 (AUC = 0.617, <i>p</i> = 0.001) demonstrated the highest predictive power.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PAR, SII, and MII-1/2 may assist in predicting the timing of delivery in PPROM cases. However, prospective multicenter studies with larger patient cohorts are needed before these parameters can be routinely implemented in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Periconceptional Dietary Inflammatory Index and Hypertensive Disorders of Pregnancy and Its Subtype","authors":"McKenzie K. Jancsura,&nbsp;Nathan P. Helsabeck,&nbsp;Michael D. Wirth,&nbsp;Hanna Griffis,&nbsp;Tamera Hatfield,&nbsp;Elizabeth A. Ferries-Rowe,&nbsp;Uma M. Reedy,&nbsp;Hyagriv Simhan,&nbsp;Lynn Yee,&nbsp;Robert M. Silver,&nbsp;Kartik K. Venkatesh,&nbsp;William A. Grobman","doi":"10.1111/aji.70122","DOIUrl":"https://doi.org/10.1111/aji.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The association between diet and hypertensive disorders of pregnancy (HDP) is inconclusive due incomplete assessment of dietary measures and HDP subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We determined the association between the energy-adjusted Dietary Inflammatory Index (E-DII) and the risk of HDP subtypes in a large, diverse cohort of pregnant individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We completed a secondary analysis of data from the nuMoM2b study. Participants (<i>n</i> = 7309) were recruited from eight sites across the United States in the first trimester and followed through delivery. Participants completed the Block Food Frequency Questionnaire during the first trimester, which assessed the periconceptional period. Calculated macro and micronutrients from the questionnaire were used to calculate E-DII scores. HDP subtypes included gestational hypertension, preeclampsia without severe features, and preeclampsia with severe features. Multivariable ordinal logistic regression models were used to assess the association between E-DII and HDP subtypes, adjusting for baseline age, body mass index, education, race, and ethnicity as a social construct, and insurance status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 7309 assessed individuals, the mean E-DII score was −0.61, and the frequency of gestational hypertension was 15.5%, preeclampsia without severe features was 4.3%, and preeclampsia with severe features was 4.1%. A higher E-DII score was associated with greater odds of developing an HDP, with worsening E-DII scores associated with greater odds of experiencing a more severe HDP subtype (adjusted OR = 1.15, 95% CI: 1.08, 1.22).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In a multisite prospective US cohort of nulliparous individuals, higher periconceptional E-DII scores indicative of a pro-inflammatory diet was associated with a slightly increased risk of HDP. And the severity of HDP progressively increased with worsening dietary inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Blood Count-Derived Inflammatory Indices in the Short-Term Prediction of Delivery in Women With Threatened Preterm Labor","authors":"Murat Levent Dereli,&nbsp;Sadun Sucu,&nbsp;Ahmet Kurt,&nbsp;Enes Kumcu,&nbsp;Emre Mat,&nbsp;Ali Turhan Çağlar","doi":"10.1111/aji.70126","DOIUrl":"https://doi.org/10.1111/aji.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the association between inflammatory indices derived from complete blood count (CBC) and delivery within 1 week for threatened preterm labor (tPTL) in order to contribute to the management algorithm for women with tPTL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study of women with a singleton pregnancy and tPTL admitted to a large tertiary referral hospital between October 1, 2022, and May 31, 2023. After exclusion, the study groups were formed with 42 women who gave birth within 1 week of admission (group 1) and 84 women who gave birth later than 1 week after admission (group 2). The comparison focused mainly on whether there was a difference between the two groups in the systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune inflammation value (PIV), as well as other inflammatory indices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Monocyte count, monocyte-to-lymphocyte ratio (MLR), SIRI, and PIV were significantly higher in group 1 (<i>p</i> = 0.038, 0.019, 0.029, and 0.037, respectively) and receiver operating characteristics curve analysis for discriminatory power to predict PTB within 1 week revealed area under the curve values of 0.613, 0.628, 0.620, and 0.614, respectively. The overall predictive power showed no significant superiority between the individual parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our preliminary results showed an association between increased inflammatory indices and an increased risk of delivery within 1 week in women with tPTL. In particular, SIRI and PIV with cut-off values of &gt;4.3 × 10³/µL and &gt;677 × 10⁶/µL² respectively may facilitate decision-making in the management algorithm for women with tPTL. Further randomized controlled trials with a larger cohort are needed to better define efficacy and limitations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"94 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}