The Role of Blood Count-Derived Inflammatory Indices in the Short-Term Prediction of Delivery in Women With Threatened Preterm Labor

IF 2.4 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-07-07 DOI:10.1111/aji.70126

Murat Levent Dereli, Sadun Sucu, Ahmet Kurt, Enes Kumcu, Emre Mat, Ali Turhan Çağlar

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引用次数: 0

Abstract

Objectives

To investigate the association between inflammatory indices derived from complete blood count (CBC) and delivery within 1 week for threatened preterm labor (tPTL) in order to contribute to the management algorithm for women with tPTL.

Materials and Methods

We conducted a retrospective cohort study of women with a singleton pregnancy and tPTL admitted to a large tertiary referral hospital between October 1, 2022, and May 31, 2023. After exclusion, the study groups were formed with 42 women who gave birth within 1 week of admission (group 1) and 84 women who gave birth later than 1 week after admission (group 2). The comparison focused mainly on whether there was a difference between the two groups in the systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune inflammation value (PIV), as well as other inflammatory indices.

Results

Monocyte count, monocyte-to-lymphocyte ratio (MLR), SIRI, and PIV were significantly higher in group 1 (p = 0.038, 0.019, 0.029, and 0.037, respectively) and receiver operating characteristics curve analysis for discriminatory power to predict PTB within 1 week revealed area under the curve values of 0.613, 0.628, 0.620, and 0.614, respectively. The overall predictive power showed no significant superiority between the individual parameters.

Conclusions

Our preliminary results showed an association between increased inflammatory indices and an increased risk of delivery within 1 week in women with tPTL. In particular, SIRI and PIV with cut-off values of >4.3 × 10³/µL and >677 × 10⁶/µL² respectively may facilitate decision-making in the management algorithm for women with tPTL. Further randomized controlled trials with a larger cohort are needed to better define efficacy and limitations.

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血球计数衍生炎症指标在短期预测先兆早产妇女分娩中的作用

目的探讨全血细胞计数（CBC）炎症指标与先兆早产（tPTL） 1周内分娩的关系，为tPTL妇女的管理算法提供依据。材料和方法我们对2022年10月1日至2023年5月31日在一家大型三级转诊医院就诊的单胎妊娠和tPTL妇女进行了回顾性队列研究。排除后，将入院1周内分娩的42名妇女（第一组）和入院后1周后分娩的84名妇女（第二组）组成研究组。比较主要关注两组患者在全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）、泛免疫炎症值（PIV）等炎症指标上是否存在差异。结果1组患者单核细胞计数、单核淋巴细胞比（MLR）、SIRI、PIV均显著升高（p值分别为0.038、0.019、0.029、0.037），1周内预测PTB的受试者工作特征曲线判别能力分析显示曲线下面积分别为0.613、0.628、0.620、0.614。整体预测能力在各个参数之间没有显着的优势。我们的初步结果显示，tPTL患者炎症指数升高与1周内分娩风险增加之间存在关联。其中，截断值为>；4.3 × 103/µL的SIRI和截断值为>；677 × 106/µL2的PIV可能有助于tPTL女性管理算法的决策。需要更多的随机对照试验来更好地定义疗效和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.