Prediction of Delivery Timing in Preterm Premature Rupture of Membranes: The Role of Inflammation-Related Indices

Objective

The aim of this study was to evaluate the predictivevalue of inflammatory parameters platelet-albumin ratio (PAR), systemic immune-inflammation index (SII), and multi-inflammatory indices (MII) in forecasting the timing of delivery in pregnancies diagnosed with preterm premature rupture of membranes (PPROM).

Materials and Methods

A retrospective analysis was conducted on 292 pregnant women diagnosed with PPROM between 24 and 34 gestational weeks at Etlik City Hospital from January 2023 to December 2024. The patients were grouped according to their time of delivery: those delivering within 48, 72, and 96 h. Inflammatory indices, including PAR, SII, MII-1, and MII-2 were calculated using complete blood count and biochemical parameters obtained at admission, and their predictive performance for delivery timing was assessed using receiver operating characteristic (ROC) analysis.

Results

For predicting delivery within 48 h, the AUC (areas under the curve) values were 0.566 for PAR (p = 0.050), 0.575 for SII (p = 0.027), and 0.567 for MII-1 (p = 0.046). For predicting delivery within 72 h, the AUC values were 0.603 for SII (p = 0.003), 0.591 for MII-1 (p = 0.008), and 0.584 for MII-2 (p = 0.015), indicating a moderate level of predictive value. For predicting delivery within 96 h, SII (AUC = 0.627, p < 0.001) and MII-1 (AUC = 0.617, p = 0.001) demonstrated the highest predictive power.

Conclusion

PAR, SII, and MII-1/2 may assist in predicting the timing of delivery in PPROM cases. However, prospective multicenter studies with larger patient cohorts are needed before these parameters can be routinely implemented in clinical practice.