Association of First-Trimester Combined Inflammatory Markers (NLR, SII, SIRI, and AISI) With Poor Obstetric Outcomes in Pregnancies With Ulcerative Colitis

IF 2.5 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-02-06 DOI:10.1111/aji.70055

Osman Onur Ozkavak, Atakan Tanacan, Hakki Serbetci, Esra Karatas, Murat Haksever, Ezgi Basaran, Melike Busra Atar, Dilek Sahin

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引用次数: 0

Abstract

Aim

To compare the first-trimester combined inflammatory markers between pregnant women diagnosed with ulcerative colitis (UC) and healthy pregnant women. Furthermore, to investigate the predictive value of these markers for adverse obstetric outcomes in pregnant women affected by UC.

Methods

In this retrospective study, data were collected from pregnant women with UC who gave birth at our hospital between January 2021 and May 2024 and from a control group of healthy pregnant women. A comparison was made between the two groups in terms of their demographic characteristics, neonatal outcomes, and the values of the first-trimester neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), and aggregated index of systemic inflammation (AISI). Furthermore, the relationship between these combined inflammatory markers and adverse obstetric outcomes in pregnant women with UC was investigated.

Results

No notable discrepancy was observed between the UC group and the control group with respect to SIRI and AISI. The first-trimester NLR and SII values were observed to be higher in the UC group in comparison to the control group. The data indicated that pregnant women with UC who experienced poor obstetric outcomes exhibited elevated levels of NLR, SII, SIRI, and AISI during the first trimester. In the ROC analysis, the predictive capacity of all four parameters for poor obstetric outcomes in UC patients was statistically significant.

Conclusion

There is an association between elevated combined inflammatory markers in the first trimester and poor obstetric outcomes in pregnant women with UC.

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妊娠早期联合炎症标志物（NLR， SII， SIRI和AISI）与溃疡性结肠炎妊娠不良产科结局的关系

目的：比较诊断为溃疡性结肠炎（UC）的孕妇与健康孕妇的妊娠早期联合炎症标志物。此外，研究这些标志物对UC孕妇不良产科结局的预测价值。方法：在这项回顾性研究中，收集了2021年1月至2024年5月期间在我院分娩的UC孕妇和对照组健康孕妇的数据。比较两组患者的人口统计学特征、新生儿结局、妊娠早期中性粒细胞与淋巴细胞比值（NLR）、全身炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症综合指数（AISI）。此外，研究了这些联合炎症标志物与UC孕妇不良产科结局之间的关系。结果：UC组与对照组在SIRI和AISI方面无显著差异。与对照组相比，UC组妊娠早期NLR和SII值更高。数据显示，产结局较差的UC孕妇在妊娠早期表现出NLR、SII、SIRI和AISI水平升高。在ROC分析中，所有四个参数对UC患者不良产科结局的预测能力具有统计学意义。结论：妊娠早期联合炎症标志物升高与UC孕妇的不良产科结局有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.