Prostaglandins and medicine最新文献_第9页

Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity 从女性和男性分离的脂蛋白对PGI2合成酶活性的差异影响

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90110-5

J. Beitz, W. Förster

引用次数: 20

Vascular 6-keto-prostaglandin F1α production in term vaginal versus cesarean section deliveries 阴道和剖宫产足月分娩时血管6-酮-前列腺素F1α的产生

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90111-7

Shirazali G. Sunderji , Marie J. Stuart

引用次数: 2

Low dose aspirin, platelet function and prostaglandin synthesis: Influence of epinephrine and alpha adrenergic blockade 低剂量阿司匹林、血小板功能和前列腺素合成:肾上腺素和α -肾上腺素能阻断的影响

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90107-5

Gundu H.R. Rao , Ratnammal K. Reddy , James G. White

引用次数: 24

Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man 静脉和口服卡前列环素对血小板聚集的抑制作用

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90112-9

S.M.M. Karim, P.G. Adaikan, L.C. Lau, M.Y. Tai

引用次数: 12

The effect of cigarette smoke on the metabolism of arachidonic acid to myotropic compounds in rat and hamster isolated lungs 香烟烟雾对大鼠和仓鼠离体肺花生四烯酸代谢成促肌化合物的影响

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90114-2

Pekka Uotila, Jussi Männistö

{"title":"The effect of cigarette smoke on the metabolism of arachidonic acid to myotropic compounds in rat and hamster isolated lungs","authors":"Pekka Uotila, Jussi Männistö","doi":"10.1016/0161-4630(81)90114-2","DOIUrl":"10.1016/0161-4630(81)90114-2","url":null,"abstract":"<div>Perfusion effluent from isolated rat and hamster lungs caused a relaxation of superfused strip of bovine coronary artery (BCA). This relaxation was abolished by pulmonary infusion of indomethacin. Pre-exposure of rats and hamsters to cigarette smoke during half an hour before the lung perfusion did not change the degree of this initial relaxation of BCA. Injection of 10 μg of sodium arachidonate (AA) into the pulmonary circulation of isolated hamster lungs caused a contraction of BCA, which was not changed by cigarette smoke pre-exposure. When AA (10 μg) was injected into the pulmonary circulation of isolated hamster lungs during cigarette smoke ventilation the contractions of superfused BCA and rat stomach strip (RSS) were not significantly different from those during the preceding and following air ventilation. In experiments with isolated rat lungs the initial relaxation of superfused BCA was accompanied by a contraction of superfused RSS. AA injection (10 μg) into rat lungs caused a further relaxation of BCA and contraction of RSS, which were abolished by pulmonary infusion of indomethacin. Cigarette smoke ventilation of isolated rat lungs caused a relaxation of superfused BCA, which was not abolished by indomethacin. During cigarette smoke ventilation injection of AA (10 μg) into the pulmonary circulation of rat lungs caused a relaxation of BCA and a contraction of RSS.The present study indicates that neither cigarette smoke ventilation nor pre-exposure to cigarette smoke has a drastic effect on the metabolism of arachidonic acid to myotropic compounds in isolated hamster and rat lungs.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 5","pages":"Pages 537-547"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90114-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Indomethacin inhibition of intralipid-induced lung dysfunction 吲哚美辛对脂内性肺功能障碍的抑制作用

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90109-9

Richard J. Inwood , Paul Gora, Carl E. Hunt

{"title":"Indomethacin inhibition of intralipid-induced lung dysfunction","authors":"Richard J. Inwood , Paul Gora, Carl E. Hunt","doi":"10.1016/0161-4630(81)90109-9","DOIUrl":"10.1016/0161-4630(81)90109-9","url":null,"abstract":"<div>Intralipid-related pulmonary alterations have been attributed to hyperlipemia. To better quantitate and explain these alterations, Intralipid (0.4 gm/kg over one hour) was infused into three groups of rabbits and saline into a fourth group. Group I had normal lung function; Groups II-IV were pretreated with oleic acid and Group III also received indomethacin. Serum triglyceride (TG) levels, arterial (a) and end-tidal (A) PC02 and P02 were measured at baseline and then hourly for six hours. There was no ventilatory deterioration in Group I despite a peak TG level of 638 mg/dl. In Group II there was an Intralipid-related Pa02 decrease of 11–13 mmHg(p < .01)and aΔ AaP02 increase of 16 mm Hg (p < .O1); both returned to baseline without significant TG normalization. Since indomethacin prevented these Pa02 and Δ AaP02 changes despite a significant TG increase, the effects of Intralipid appear not to be TG-related but rather to be related to PG-mediated alterations in pulmonary vasomotor tone. Our results are most consistent with a net increase in vasodilating prostaglandins and resultant hypoxemia secondary to unblocking of baseline hypoxic vasoconstriction.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 5","pages":"Pages 503-514"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90109-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17844623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Effects of indomethacin treatment on human peripheral blood monocytes 吲哚美辛对人外周血单核细胞的影响

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90113-0

E. Razin , B. Klein , A. Globerson

引用次数: 4

Monthly bibliography on prostaglandins prepared by the University of Sheffield biomedical information service 谢菲尔德大学生物医学信息服务处编写的前列腺素月度参考书目

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90115-4

引用次数: 0

Comparisons between the abilities of various human and ovine plasmas to inhibit prostaglandin synthesis 不同人、羊血浆抑制前列腺素合成能力的比较

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90108-7

M.D. Mitchell , S.P. Brennecke , P.A. Denning-Kendall , W.J. McDonald Gibson , S.A. Saeed , H.O.J. Collier

引用次数: 7

Inhibition of platelet aggregation by 6-keto-PGE1; lack of an effect on cyclic GMP levels 6-酮- pge1对血小板聚集的抑制作用对环GMP水平没有影响

Prostaglandins and medicine Pub Date : 1981-05-01 DOI: 10.1016/0161-4630(81)90106-3

Eugene G. Pontecorvo, Carl B. Myers, Howard L. Lippton , Philip J. Kadowitz

{"title":"Inhibition of platelet aggregation by 6-keto-PGE1; lack of an effect on cyclic GMP levels","authors":"Eugene G. Pontecorvo, Carl B. Myers, Howard L. Lippton , Philip J. Kadowitz","doi":"10.1016/0161-4630(81)90106-3","DOIUrl":"10.1016/0161-4630(81)90106-3","url":null,"abstract":"<div>The effects of 6-keto-PGE1 on aggregatory responses to arachidonic acid (AA), adenosine diphosphate (ADP) and collagen were studied in human platelet-rich plasma (PRP). In addition, experiments were carried out to determine if these effects correlate with changes in platelet cyclic AMP and cyclic GMP levels. 6-Keto-PGE1 incubated in PRP produced dose-related increases in platelet cyclic AMP levels whereas platelet cyclic GMP levels were unchanged. Control aggregations induced by AA and ADP did not alter cyclic AMP and cyclic GMP levels whereas control aggregations induced by collagen elevated cyclic GMP levels while cyclic AMP levels were unchanged. 6-Keto-PGE1 produced a dose-dependent inhibition of platelet aggregation induced by AA, ADP and collagen and this inhibition correlated with a dose-related increase in cyclic AMP levels. Since 6-keto-PGE1 does not consistently alter cyclic GMP levels in human PRP, the present data support previous studies suggesting that 6-keto-PGE1 produces inhibition of platelet aggregation through the stimulation of cyclic AMP accumulation.</div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 5","pages":"Pages 473-483"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90106-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17329514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2