Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man

Abstract

Intravenous infusion of carboprostacyclin, a chemically stable analogue of prostacyclin (PGI₂) resulted in ex-vivo inhibition of ADP-induced platelet aggregation at doses that did not produce significant changes in blood pressure or heart rate. Oral administration of relatively large doses of this compound also inhibited ex-vivo ADP-induced platelet aggregation but this was accompanied by headache, facial flush, tachycardia and changes in blood pressure.