{"title":"静脉和口服卡前列环素对血小板聚集的抑制作用","authors":"S.M.M. Karim, P.G. Adaikan, L.C. Lau, M.Y. Tai","doi":"10.1016/0161-4630(81)90112-9","DOIUrl":null,"url":null,"abstract":"<div><p>Intravenous infusion of carboprostacyclin, a chemically stable analogue of prostacyclin (PGI<sub>2</sub>) resulted in ex-vivo inhibition of ADP-induced platelet aggregation at doses that did not produce significant changes in blood pressure or heart rate. Oral administration of relatively large doses of this compound also inhibited ex-vivo ADP-induced platelet aggregation but this was accompanied by headache, facial flush, tachycardia and changes in blood pressure.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 5","pages":"Pages 521-527"},"PeriodicalIF":0.0000,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90112-9","citationCount":"12","resultStr":"{\"title\":\"Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man\",\"authors\":\"S.M.M. Karim, P.G. Adaikan, L.C. Lau, M.Y. Tai\",\"doi\":\"10.1016/0161-4630(81)90112-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Intravenous infusion of carboprostacyclin, a chemically stable analogue of prostacyclin (PGI<sub>2</sub>) resulted in ex-vivo inhibition of ADP-induced platelet aggregation at doses that did not produce significant changes in blood pressure or heart rate. Oral administration of relatively large doses of this compound also inhibited ex-vivo ADP-induced platelet aggregation but this was accompanied by headache, facial flush, tachycardia and changes in blood pressure.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"6 5\",\"pages\":\"Pages 521-527\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90112-9\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161463081901129\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161463081901129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man
Intravenous infusion of carboprostacyclin, a chemically stable analogue of prostacyclin (PGI2) resulted in ex-vivo inhibition of ADP-induced platelet aggregation at doses that did not produce significant changes in blood pressure or heart rate. Oral administration of relatively large doses of this compound also inhibited ex-vivo ADP-induced platelet aggregation but this was accompanied by headache, facial flush, tachycardia and changes in blood pressure.
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