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Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism 低肾素血症性低醛固酮增多症肾血管活性系统的研究
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90116-6
J.A. Hahn, R.D. Zipser, A. Barg, R.A. Stone, P.K. Zia, W.A. Hsueh, R. Horton
{"title":"Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism","authors":"J.A. Hahn,&nbsp;R.D. Zipser,&nbsp;A. Barg,&nbsp;R.A. Stone,&nbsp;P.K. Zia,&nbsp;W.A. Hsueh,&nbsp;R. Horton","doi":"10.1016/0161-4630(81)90116-6","DOIUrl":"10.1016/0161-4630(81)90116-6","url":null,"abstract":"<div><p>Plasma renin activity, total renin, active renin, and aldosterone were measured as well as urinary prostaglandin E2 and kallikrein in a group of patients with hyperkalemia (6.1–7.7 mEq per liter) and hypo reninemic hypoaldosteronism. Plasma renin activity and aldosterone were low and the response was markedly blunted to upright posture, and furosemide. The rise in cortisol but not aldosterone was normal following ACTH stimulation. Active renin was depressed; however, total renin was normal. Urine PGE was variable including some low values, but the mean of the group was normal (p &gt;0.1). Urine kallikrein excretion was markedly diminished and undetectable in most cases. Fludrocortisone normalized potassium but minimally increased kallikrein in the patients. The possibility exists that kallikrein deficiency in these patients may underlie the inability to generate active renin.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 549-556"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90116-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17329515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of epinephrine on prostaglandin E2 and cyclic AMP levels in gingiva of patients with chronic periodontitis 肾上腺素对慢性牙周炎患者牙龈前列腺素E2和循环AMP水平的影响
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90121-X
Tawfik M.A. Elattar, HsienS. Lin, Daniel E. Tira
{"title":"Effect of epinephrine on prostaglandin E2 and cyclic AMP levels in gingiva of patients with chronic periodontitis","authors":"Tawfik M.A. Elattar,&nbsp;HsienS. Lin,&nbsp;Daniel E. Tira","doi":"10.1016/0161-4630(81)90121-X","DOIUrl":"10.1016/0161-4630(81)90121-X","url":null,"abstract":"<div><p>The levels of prostaglandin. E2 (PGE<sub>2</sub>) and cyclic AMP (cAMP) in human gingival samples were determined by means of radioimmunoassay after incubation with epinephrine (10-<sup>6</sup>M) at different time intervals. The levels of PGE<sub>2</sub> and cAMP reached a maximum in the control and hormone treated samples after 80 and 40 minutes, respectively. Epinephrine seemed to affect a lesser increase in PGE<sub>2</sub> and a greater increase in cAMP values in gingival tissues when compared with control samples. When the data were analysed, there was statistically significant differences found between the control and hormone treated samples regarding both PGE<sub>2</sub> and cAMP.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 601-612"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90121-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17329518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Prostaglandin production by the progesterone-dominated sheep uterus 孕激素占主导地位的绵羊子宫产生前列腺素
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90118-X
S.N. Alwachi , K.P. Bland, N.L. Poyser
{"title":"Prostaglandin production by the progesterone-dominated sheep uterus","authors":"S.N. Alwachi ,&nbsp;K.P. Bland,&nbsp;N.L. Poyser","doi":"10.1016/0161-4630(81)90118-X","DOIUrl":"10.1016/0161-4630(81)90118-X","url":null,"abstract":"<div><p>Daily treatment of sheep with progesterone resulted in the accumulation of sterile fluid in the uterus. The fluid contained high concentrations of prostaglandin (PG) F<sub>2α</sub> but low concentrations of PGE2 and 6-oxo-PGF<sub>1α</sub>. Uterine venous plasma also contained high concentrations of PGF2a and low concentrations of PGE2. PGF2a was the major PG synthesised by the sheep endometrium, but appreciable quantities of PGE2 and 6-oxo-PGF<sub>1α</sub> were also formed. The findings of this study suggest that biochemical mechanisms exist in the progesterone-dominated sheep uterus which specifically synthesise and secrete PGF2a.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 571-576"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90118-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17943397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Lack of effect of prostaglandins on rat heart myofibrillar ATPase activity 前列腺素对大鼠心肌纤维atp酶活性的影响
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90125-7
G.N. Pierce, M. Karmazyn, M.J. Daly, N.S. Dhalla
{"title":"Lack of effect of prostaglandins on rat heart myofibrillar ATPase activity","authors":"G.N. Pierce,&nbsp;M. Karmazyn,&nbsp;M.J. Daly,&nbsp;N.S. Dhalla","doi":"10.1016/0161-4630(81)90125-7","DOIUrl":"10.1016/0161-4630(81)90125-7","url":null,"abstract":"<div><p>Although various prostaglandins have been shown to elicit an isotropic response in the rat heart, the subcellular basis responsible for this effect is unknown. The purpose of this study was to examine the influence of three prostaglandins with varying inotropic potencies on myofibrillar ATPase activity in the rat heart. PGF2α, PGI2 and PGE2 were found to have no influence on basal or Ca-stimulated myofibrillar ATPase activity. In addition, no influence <sup>2+</sup> s observed on the sensitivity of myofibrillar ATPase activity to Ca . Alternative mechanisms to explain the isotropic effect are discussed.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 633-639"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90125-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17515615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forearm ischaemia as a test of prostacyclin production: Studies in normal subjects and in patients with diabetes mellitus 前臂缺血作为前列环素产生的测试:在正常受试者和糖尿病患者中的研究
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90129-4
J. Webster, P.J. Lewis, J. MacDermot, C.N. Hensby, E.M. Kohner, M. Porta
{"title":"Forearm ischaemia as a test of prostacyclin production: Studies in normal subjects and in patients with diabetes mellitus","authors":"J. Webster,&nbsp;P.J. Lewis,&nbsp;J. MacDermot,&nbsp;C.N. Hensby,&nbsp;E.M. Kohner,&nbsp;M. Porta","doi":"10.1016/0161-4630(81)90129-4","DOIUrl":"10.1016/0161-4630(81)90129-4","url":null,"abstract":"<div><p>Plasma levels of 6-oxo-PGF<sub>1α</sub>, the hydrolysis product of prostacyclin, were significantly reduced in men with proliferative diabetic retinopathy, compared with normal controls. Male diabetics with back ground or no retinopathy formed an intermediate group with plasma levels of 6-oxo-PGF lower than controls and higher than patients with proliferative retinopathy. Forearm ischaemia increased plasma levels of 6-oxo-PGF by 30% in normal subjects.The increase occurred during arterial occlusion and was diminished by pretreatment with aspirin. The increase after ischaemia may reflect increased prosta cyclin production. In diabetic patients forearm ischaemia produced an increase in plasma 6-oxo-PGF la similar to that seen in control subjects.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 661-667"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90129-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17943398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Transformation of arachidonic acid in leukocytes. isolation and structural analysis of a novel dihydroxy derivative 花生四烯酸在白细胞中的转化。一种新型二羟基衍生物的分离与结构分析
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90117-8
Pierre Borgeat , Serge Picard, Pierre Vallerand, Pierre Sirois
{"title":"Transformation of arachidonic acid in leukocytes. isolation and structural analysis of a novel dihydroxy derivative","authors":"Pierre Borgeat ,&nbsp;Serge Picard,&nbsp;Pierre Vallerand,&nbsp;Pierre Sirois","doi":"10.1016/0161-4630(81)90117-8","DOIUrl":"10.1016/0161-4630(81)90117-8","url":null,"abstract":"<div><p>A suspension of mixed peripheral blood leukocytes was incubated with arachidonic acid. After ether extraction and silicic acid fractionation of the products, the fraction containing the mono- and dihydroxy derivatives of arachidonic acid was further analyzed by high pressure liquid chromatography on silica gel and octadecyl silica (reversed-phase) columns. A previously undescribed metabolite was detected and isolated in pure form. The compound co-chromatographed with leukotriene B<sub>4</sub> on octadecyl silica but was eluted earlier than leukotriene B<sub>4</sub> from silica gel columns. Ultraviolet spectrophotometry, gas chromatography-mass spectrometry, ozonolysis and steric analysis indicated that the new metabolite was the 5S,12S-dihydroxy-6,8,10,14-icosatetraenoic acid. The yield of the novel dihydroxy acid was 1 to 4% of the added substrate. The new metabolite showed less than 1% of the myotropic activity of leukotriene B4 on the guinea pig lung parenchymal strip.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 557-570"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90117-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17329516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 118
Monthly bibliography on prostaglandins prepared by the University of Sheffield Biomedical Information Service Sheffield S10 2TN, England May 1981 英国谢菲尔德大学生物医学信息服务中心编制的前列腺素月度参考书目，1981年5月，谢菲尔德S10 2TN
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90130-0
{"title":"Monthly bibliography on prostaglandins prepared by the University of Sheffield Biomedical Information Service Sheffield S10 2TN, England May 1981","authors":"","doi":"10.1016/0161-4630(81)90130-0","DOIUrl":"https://doi.org/10.1016/0161-4630(81)90130-0","url":null,"abstract":"","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages i-x"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90130-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72292150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of indomethacin on hematopoiesis in mice 吲哚美辛对小鼠造血功能的影响
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90122-1
E. Razin , Y. Hayari, A. Globerson
{"title":"Effects of indomethacin on hematopoiesis in mice","authors":"E. Razin ,&nbsp;Y. Hayari,&nbsp;A. Globerson","doi":"10.1016/0161-4630(81)90122-1","DOIUrl":"10.1016/0161-4630(81)90122-1","url":null,"abstract":"<div><p>The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 613-620"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90122-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18023141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Biosynthesis of prostaglandins from arachidonic acid by the rat ovary 花生四烯酸在大鼠卵巢生物合成前列腺素的研究
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90120-8
Kazuo Satoh, Naoki Mitsuhashi, Katsuyuki Kinoshita, Yasuo Kawai, Ryoko Maeda, Shoichi Sakamoto
{"title":"Biosynthesis of prostaglandins from arachidonic acid by the rat ovary","authors":"Kazuo Satoh,&nbsp;Naoki Mitsuhashi,&nbsp;Katsuyuki Kinoshita,&nbsp;Yasuo Kawai,&nbsp;Ryoko Maeda,&nbsp;Shoichi Sakamoto","doi":"10.1016/0161-4630(81)90120-8","DOIUrl":"10.1016/0161-4630(81)90120-8","url":null,"abstract":"<div><p>Biosynthesis of prostaglandins (PGs) from <sup>14</sup>C-arachidonic acid was studied using homogenates of the ovaries from immature rats. In ascending order of metabolizing potency were, the ovaries from untreated rats, from rats treated with pregnant mare's serum gonadotropin (PMS), and from PMS-human chorionic gonadotropin (hCG) treated rats. Among the radioactive metabolites extracted, PGE<sub>2</sub> and 6-keto PGF<sub>1∝</sub> were purified and identified by silicic acid column-, thin layer-, reversed phase partition chromatographies, and radiogaschromatography. Production of PGE<sub>2</sub> and 6-keto PGF<sub>1∝</sub> was observed in homogenates of the ovaries of intact and PMS-hCG treated rats at conversion rates of 0.72; 0.43% and 7.62; 2.31%, but not by FMS treated rat ovaries. Treatment with PMS-hCG activated metabolism of arachidonic acid into radioactive metabolites including PGE2 and 6-keto PGF<sub>1α</sub> to a large extent. Accordingly, it is concluded that luteinizing hormone and hCG play a significant role in the biosynthesis of PGs by the rat ovarian follicle.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 589-600"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90120-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17844625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Development of the chick embryo following PGE1 treatment PGE1对鸡胚发育的影响
Prostaglandins and medicine Pub Date : 1981-06-01 DOI: 10.1016/0161-4630(81)90123-3
S.H. Gilani , T.V.N. Persaud
{"title":"Development of the chick embryo following PGE1 treatment","authors":"S.H. Gilani ,&nbsp;T.V.N. Persaud","doi":"10.1016/0161-4630(81)90123-3","DOIUrl":"10.1016/0161-4630(81)90123-3","url":null,"abstract":"<div><p>Chick embryos were treated with prostaglandin El (10, 20, 30, and 50 μg) at 48 and 72 hours incubation. Live embryos were recovered on day 9, staged, and examined for external malformations after weighing. There was no significant increase in embryonic mortality and malformation rates compared to the controls. Embryonic growth was also not affected.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 621-626"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90123-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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