{"title":"孕激素占主导地位的绵羊子宫产生前列腺素","authors":"S.N. Alwachi , K.P. Bland, N.L. Poyser","doi":"10.1016/0161-4630(81)90118-X","DOIUrl":null,"url":null,"abstract":"<div><p>Daily treatment of sheep with progesterone resulted in the accumulation of sterile fluid in the uterus. The fluid contained high concentrations of prostaglandin (PG) F<sub>2α</sub> but low concentrations of PGE2 and 6-oxo-PGF<sub>1α</sub>. Uterine venous plasma also contained high concentrations of PGF2a and low concentrations of PGE2. PGF2a was the major PG synthesised by the sheep endometrium, but appreciable quantities of PGE2 and 6-oxo-PGF<sub>1α</sub> were also formed. The findings of this study suggest that biochemical mechanisms exist in the progesterone-dominated sheep uterus which specifically synthesise and secrete PGF2a.</p></div>","PeriodicalId":76381,"journal":{"name":"Prostaglandins and medicine","volume":"6 6","pages":"Pages 571-576"},"PeriodicalIF":0.0000,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-4630(81)90118-X","citationCount":"4","resultStr":"{\"title\":\"Prostaglandin production by the progesterone-dominated sheep uterus\",\"authors\":\"S.N. Alwachi , K.P. Bland, N.L. Poyser\",\"doi\":\"10.1016/0161-4630(81)90118-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Daily treatment of sheep with progesterone resulted in the accumulation of sterile fluid in the uterus. The fluid contained high concentrations of prostaglandin (PG) F<sub>2α</sub> but low concentrations of PGE2 and 6-oxo-PGF<sub>1α</sub>. Uterine venous plasma also contained high concentrations of PGF2a and low concentrations of PGE2. PGF2a was the major PG synthesised by the sheep endometrium, but appreciable quantities of PGE2 and 6-oxo-PGF<sub>1α</sub> were also formed. The findings of this study suggest that biochemical mechanisms exist in the progesterone-dominated sheep uterus which specifically synthesise and secrete PGF2a.</p></div>\",\"PeriodicalId\":76381,\"journal\":{\"name\":\"Prostaglandins and medicine\",\"volume\":\"6 6\",\"pages\":\"Pages 571-576\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-4630(81)90118-X\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/016146308190118X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/016146308190118X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prostaglandin production by the progesterone-dominated sheep uterus
Daily treatment of sheep with progesterone resulted in the accumulation of sterile fluid in the uterus. The fluid contained high concentrations of prostaglandin (PG) F2α but low concentrations of PGE2 and 6-oxo-PGF1α. Uterine venous plasma also contained high concentrations of PGF2a and low concentrations of PGE2. PGF2a was the major PG synthesised by the sheep endometrium, but appreciable quantities of PGE2 and 6-oxo-PGF1α were also formed. The findings of this study suggest that biochemical mechanisms exist in the progesterone-dominated sheep uterus which specifically synthesise and secrete PGF2a.
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