Journal of biological standardization最新文献_第9页

A cell attachment assay for use in the standardization of serum products 用于血清产品标准化的细胞附着试验

Journal of biological standardization Pub Date : 1988-01-01 DOI: 10.1016/0092-1157(88)90002-9

Donald J. Giard

引用次数: 0

The use and standardization of combined vaccines. Report of the 19th Congress of IABS. International Association of Biological Standardization. 10-13 December, 1985, Amsterdam, The Netherlands. Summaries and recommendations. 联合疫苗的使用和标准化。IABS第十九次代表大会报告。国际生物标准化协会，1985年12月10-13日，荷兰阿姆斯特丹。总结和建议。

Journal of biological standardization Pub Date : 1987-07-01

引用次数: 0

Quantitative estimation of diphtheria and tetanus toxoids. 2. Single radial immuno-diffusion tests (Mancini) and rocket immuno-electrophoresis test in comparison with the flocculation test 白喉和破伤风类毒素的定量估计。2. 单径向免疫扩散试验(Mancini)和火箭免疫电泳试验与絮凝试验的比较

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/0092-1157(87)90019-9

Lene Ljungqvist , Jørn Lyng

{"title":"Quantitative estimation of diphtheria and tetanus toxoids. 2. Single radial immuno-diffusion tests (Mancini) and rocket immuno-electrophoresis test in comparison with the flocculation test","authors":"Lene Ljungqvist , Jørn Lyng","doi":"10.1016/0092-1157(87)90019-9","DOIUrl":"10.1016/0092-1157(87)90019-9","url":null,"abstract":"<div><p>The concentration in Lf units, of an unknown diphtheria or tetanus toxoid preparation is estimated in the flocculation test relative to reference preparations of tetanus and diphtheria antitoxins, respectively. By replacing the antitoxin reference preparations with toxoid reference preparations it should be possible to use immunological methods other than the flocculation test for the quantitative estimation of toxoids in Lf units.</p><p>A number of diphtheria and tetanus toxoids were tested by rocket immuno-electrophoresis and single radial immuno-diffusion (Mancini test). The concentrations of the unknown toxoids were expressed relative to a diphtheria toxoid calibrated in Lf units (DIFT) and a tetanus toxoid calibrated in Lf units (TEFT), respectively. These two toxoid preparations are regarded as candidates for establishment as international standard preparations. The results obtained in the two tests were compared with those obtained in the flocculation test. In most cases the differences between the results did not exceed 10%. It is concluded, therefore, that the rocket electrophoresis or the radial immuno-diffusion tests can be used as alternatives to the flocculation test.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"15 1","pages":"Pages 79-86"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(87)90019-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14235610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The effect of strain differences on the assay of rabies virus glycoprotein by single radial immunodiffusion 菌株差异对单径向免疫扩散法测定狂犬病毒糖蛋白的影响

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/0092-1157(87)90018-7

Morag Ferguson , Brenda Wachmann , Charles F. Needy , Edward A. Fitzgerald

引用次数: 10

A comparison of the indirect haemagglutination test with the toxin neutralization test for the estimation of diphtheria antitoxin in mouse sera 间接血凝试验与毒素中和试验测定小鼠血清白喉抗毒素的比较

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/S0092-1157(87)80004-5

S.C. Maheshwari , Suniti B. Sharma , Subhash Ahuja , S.N. Saxena

引用次数: 5

The effects of reductions in the numbers of animals used for the potency assay of the diphtheria and tetanus components of adsorbed vaccines by the methods of the european pharmacopoeia 用欧洲药典的方法测定吸附疫苗中白喉和破伤风成分的效力时，减少动物数量的影响

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/S0092-1157(87)80008-2

C.F.M. Hendriken , J. W. v. d Gun , F.R. Marsman , J.G. Kreeftenberg

{"title":"The effects of reductions in the numbers of animals used for the potency assay of the diphtheria and tetanus components of adsorbed vaccines by the methods of the european pharmacopoeia","authors":"C.F.M. Hendriken , J. W. v. d Gun , F.R. Marsman , J.G. Kreeftenberg","doi":"10.1016/S0092-1157(87)80008-2","DOIUrl":"10.1016/S0092-1157(87)80008-2","url":null,"abstract":"<div><p>Forty eight assays of adsorbed diphtheria vaccine and seven assays of adsorbed tetanus vaccine using either a lethal challenge (38 assays) or a serum neutralization test (17 assays) were evaluated for the effects of reductions in the number of animais used at each dilution on the potency values and 95% confidence intervals. The results were assessed in the light of the requirements of the European Pharmacopoeia and the WHO.</p><p>In the majority of assays, 50% of the number of animals presently required would have sufficed for the determination of a potency within the limits of confidence stipulated by the European Pharmacopoeia and the WHO. Therefore it is concluded that a simplified assay with a reduced number of animals is suitable for the routine potency testing of the diphtheria and tetanus components of the combined vaccines and the monovalent that were examined. Flexibility in the national and international requirements in respect of the numbers of animals used at each dilution is suggested for the routine potency assay of the diphtheria and tetanus components of adsorbed vaccines.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"15 4","pages":"Pages 353-362"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0092-1157(87)80008-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14800227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The persistence of antibodies induced by meningococcal polysaccharides of groups A and C in human volunteers A组和C组脑膜炎球菌多糖诱导的抗体在人类志愿者体内的持久性

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/S0092-1157(87)80010-0

Sajida M. Al-Shamma , Maha R. Al-Sa'ad

引用次数: 4

Titrage biologique de l'hormone humaine de croissance 人类生长激素的生物测定

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/S0092-1157(87)80009-4

M. Parès , A. El Zaouk , J. Giroux

引用次数: 0

The effects of different inactivating agents on the potency, toxicity and stability of pertussis vaccine 不同灭活剂对百日咳疫苗效力、毒性及稳定性的影响

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/0092-1157(87)90020-5

R.K. Gupta , Suniti B. Sharma , Subhash Ahuja , S.N. Saxena

{"title":"The effects of different inactivating agents on the potency, toxicity and stability of pertussis vaccine","authors":"R.K. Gupta , Suniti B. Sharma , Subhash Ahuja , S.N. Saxena","doi":"10.1016/0092-1157(87)90020-5","DOIUrl":"10.1016/0092-1157(87)90020-5","url":null,"abstract":"<div><p>The effect of heat (56 °C for 10 min), formaldehyde (0·1% at 37 °C for 24h), glutaraldehyde (0·05% at room temperature for 10 min), thimerosal (0·02% at 37 °C for 24 h), acetone-I (three treatments at room temperature) and acetone-II (three treatments at room temperature and fourth treatment at 37 °C), when used as inactivating agents in the preparation of pertussis suspension, was studied with regard to potency, toxicity and stability. Five batches each of <em>Bordetella pertussis</em> strains 134 and 509 were used for the study. The thimerosal inactivated pertussis (TIP) preparation was 1·5−2 times more potent than the heat inactivated pertussis (HIP) preparation. The potency values of the formaldehyde inactivated pertussis (FIP) and glutaraldehyde inactivated pertussis (GIP) preparations were similar to those of the HIP preparation, while the potencies of the acetone-I treated pertussis (A(I)TP) and acetone-II treated pertussis (A(II)TP) preparations were about half those of the HIP preparation. The FIP preparation was the least toxic showing maximum weight gain in the mouse weight-gain test (MGWT), while the TIP preparation did not pass the MWGT. The weight gains shown the GIP, A(I)TP and A(II)TP preparations were greater than those shown by the HIP preparation. The potency of pertussis component in the adsorbed diphtheria-pertussis-tetanus (DPT) vaccine was stable at 4–8 °C and 25 °C for three months for all types of pertussis vaccine. There was about 54–65% loss in the potency of the samples after three months at 35 °C. The inactivating agents used in the manufacture of pertussis preparations had no effect on the stability of the vaccine.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"15 1","pages":"Pages 87-98"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(87)90020-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14235611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Glutaraldehyde inactivated pertussis vaccine: a less histamine sensitizing vaccine 戊二醛灭活百日咳疫苗:一种低组胺致敏疫苗

Journal of biological standardization Pub Date : 1987-01-01 DOI: 10.1016/0092-1157(87)90038-2

R.K. Gupta , Suniti B. Sharma , Subhash Ahuja , S.N. Saxena

引用次数: 14