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GRAPPA 2020 Research Award Recipients. GRAPPA 2020 研究奖获得者。
Journal of biological standardization Pub Date : 2022-06-01 Epub Date: 2022-03-15 DOI: 10.3899/jrheum.211335
Rochelle L Castillo, Di Yan, Anneliese S Ashhurst, Ashley Elliott, Maria Maddalena Angioni, Jose U Scher, Shruti Naik, Andrea Neimann, Scott N Byrne, Richard J Payne, Oliver FitzGerald, Stephen R Pennington, Alberto Cauli, Vinod Chandran
{"title":"GRAPPA 2020 Research Award Recipients.","authors":"Rochelle L Castillo, Di Yan, Anneliese S Ashhurst, Ashley Elliott, Maria Maddalena Angioni, Jose U Scher, Shruti Naik, Andrea Neimann, Scott N Byrne, Richard J Payne, Oliver FitzGerald, Stephen R Pennington, Alberto Cauli, Vinod Chandran","doi":"10.3899/jrheum.211335","DOIUrl":"10.3899/jrheum.211335","url":null,"abstract":"<p><p>At the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting, a summary of the research conducted by the recipients of the 2020 GRAPPA Research Awards was presented by the awardees. The summary of the 4 presentations is provided here.</p>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"1 1","pages":"55-56"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75002179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study of diphtheria and tetanus anatoxins by electrofocusing on an agarose gel]. 用琼脂糖凝胶电聚焦法研究白喉和破伤风毒素。
Journal of biological standardization Pub Date : 1989-10-01
J Bourleaud
{"title":"[Study of diphtheria and tetanus anatoxins by electrofocusing on an agarose gel].","authors":"J Bourleaud","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 4","pages":"343-52"},"PeriodicalIF":0.0,"publicationDate":"1989-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13754728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitation of poliovirus antigens in inactivated viral vaccines by enzyme-linked immunosorbent assay using animal sera and monoclonal antibodies 用动物血清和单克隆抗体酶联免疫吸附法定量灭活病毒疫苗中的脊髓灰质炎病毒抗原
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90004-8
Carol Singer , Frederick Knauert , Grace Bushar , Michael Klutch , Ron Lundquist , Gerald V. Quinnan Jr.
{"title":"Quantitation of poliovirus antigens in inactivated viral vaccines by enzyme-linked immunosorbent assay using animal sera and monoclonal antibodies","authors":"Carol Singer ,&nbsp;Frederick Knauert ,&nbsp;Grace Bushar ,&nbsp;Michael Klutch ,&nbsp;Ron Lundquist ,&nbsp;Gerald V. Quinnan Jr.","doi":"10.1016/0092-1157(89)90004-8","DOIUrl":"10.1016/0092-1157(89)90004-8","url":null,"abstract":"<div><p>Recent advances in methods for the manufacture of inactivated poliovirus vaccines have resulted in increased vaccine immunogenicity. In conjunction with this capability it is important to have available highly sensitive and quantitative potency assays. The potential suitability of enzyme-linked immunoassay (ELISA) was evaluated using animal sera with neutralizing antibodies or neutralizing monoclonal antibodies for antigen detection in potency tests. The monoclonal antibodies developed, which bound D antigen but not C antigen, were neutralizing unless relatively weakly reactive. Those that bound C antigen only were non-neutralizing. Those that bound both C and D antigens were sometimes neutralizing. D-specific and D/C-specific neutralizing monoclonal antibodies against type-2 poliovirus protected mice on passive immunization against paralytic disease and death from the MEF strain virus. Potency measurements by ELISA using either D-specific neutralizing monoclonal antibodies or type-specific goat sera for antigen detection were sensitive and precise. Tests using C-specific monoclonal antibodies for antigen detection indicated that increased C antigen content may result in falsely elevated reactivities of animal sera with some vaccines. Monoclonal antibodies may be useful ELISA reagents for IPV potency testing.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 2","pages":"Pages 137-150"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90004-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13684989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Assay sensitivity and differentiation of monoclonal antibody specificity in ELISA with different coating buffers 不同包被缓冲液对ELISA单克隆抗体特异性的检测敏感性和分化
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90020-6
J.C. Craig , D. Parkinson , L. Goatley , N. Knowles
{"title":"Assay sensitivity and differentiation of monoclonal antibody specificity in ELISA with different coating buffers","authors":"J.C. Craig ,&nbsp;D. Parkinson ,&nbsp;L. Goatley ,&nbsp;N. Knowles","doi":"10.1016/0092-1157(89)90020-6","DOIUrl":"10.1016/0092-1157(89)90020-6","url":null,"abstract":"<div><p>Buffers of different pH and ionic strength were employed as coating buffers for antigen adsorption to microtitre plates. Their efficiency for coating plates with rinderpest virus (RPV) and foot-and-mouth disease virus (FMDV) antigens was studied by ELISA with polyclonal and monoclonal antibody preparations.</p><p>While the adsorption and detection of RPV antigen with polyclonal antiserum was highly dependent on the ionic strength and pH of coating buffer, adsorption of antigenically active FMDV antigen was relatively unaffected by the buffering conditions. Both antigens were adsorbed optimally in 0·01 <span>m</span> phosphate buffer, pH 8·0.</p><p>When monoclonal antibodies were used to detect antigen, there was a greater degree of dependence on the coating buffer than that found with polyclonal antisera. Moreover, when they were used to detect antigen adsorbed under several buffering conditions, monoclonal antibodies showed a variety of preferred buffers. The usefulness of this differential reactivity in distinguishing epitope specificity is demonstrated.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 3","pages":"Pages 281-289"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90020-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13695180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The pyrogenicity of pertussis vaccine in mice and the factors in the vaccine responsible for this effect 百日咳疫苗对小鼠的热原性及疫苗中导致这种效果的因素
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90027-9
S. Ishida , S. Iwasa , H. Fujiwara , M. Chazono , K. Akama
{"title":"The pyrogenicity of pertussis vaccine in mice and the factors in the vaccine responsible for this effect","authors":"S. Ishida ,&nbsp;S. Iwasa ,&nbsp;H. Fujiwara ,&nbsp;M. Chazono ,&nbsp;K. Akama","doi":"10.1016/0092-1157(89)90027-9","DOIUrl":"10.1016/0092-1157(89)90027-9","url":null,"abstract":"<div><p>The injection of whole cell pertussis vaccine into mice produced a biphasic fever reaction with two peaks appearing after about one and four hours, respectively. A method for the quantitative determination of each peak fever activity was developed and the factor responsible for each activity was investigated. The first and the second peak fever activities did not parallel each other in individual vaccines. The earlier fever activity appeared to correlate with endotoxin activity in individual vaccines while the later appeared to correlate with histamine-sensitizing factor (HSF) activity. The later peak fever activity was greatly reduced by heating the vaccine at 100 °C for 30 min while the first was little affected by such treatment. It was concluded that the fever activity of pertussis vaccine in mice may be ascribed to the combined actions of endotoxin and a heat-labile substance, possibly HSF.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 1","pages":"Pages 41-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90027-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13922509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Notes to applicants for marketing authorizations on the pre-clinical biological safety testing of medicinal products derived from biotechnology (and comparable products derived from chemical synthesis) 申请上市许可的生物技术衍生药品(以及化学合成衍生的类似产品)临床前生物安全性测试的申请人须知
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90012-7
Committee for Proprietary Medicinal Products: Ad Hoc Working Party on Biotechnology/Pharmacy and Working Party on Safety of Medicines
{"title":"Notes to applicants for marketing authorizations on the pre-clinical biological safety testing of medicinal products derived from biotechnology (and comparable products derived from chemical synthesis)","authors":"Committee for Proprietary Medicinal Products: Ad Hoc Working Party on Biotechnology/Pharmacy and Working Party on Safety of Medicines","doi":"10.1016/0092-1157(89)90012-7","DOIUrl":"10.1016/0092-1157(89)90012-7","url":null,"abstract":"","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 3","pages":"Pages 203-212"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90012-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13817585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibodies for therapy, prevention and in vivo diagnosis of human disease 用于治疗、预防和体内诊断人类疾病的单克隆抗体
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/S0092-1157(89)80010-1
Huib J.M. van de Donk (Meeting Secretary)
{"title":"Monoclonal antibodies for therapy, prevention and in vivo diagnosis of human disease","authors":"Huib J.M. van de Donk (Meeting Secretary)","doi":"10.1016/S0092-1157(89)80010-1","DOIUrl":"https://doi.org/10.1016/S0092-1157(89)80010-1","url":null,"abstract":"","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 4","pages":"Pages 381-384"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0092-1157(89)80010-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91760778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
In vitro induction of a diphtheria toxoid specific antibody response in human peripheral blood lymphocytes cultivated in the presence of diphtheria toxoid 在白喉类毒素存在下培养的人外周血淋巴细胞体外诱导白喉类毒素特异性抗体反应
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/S0092-1157(89)80002-2
H.G. Loggen , J.G. Kreeftenberg
{"title":"In vitro induction of a diphtheria toxoid specific antibody response in human peripheral blood lymphocytes cultivated in the presence of diphtheria toxoid","authors":"H.G. Loggen ,&nbsp;J.G. Kreeftenberg","doi":"10.1016/S0092-1157(89)80002-2","DOIUrl":"10.1016/S0092-1157(89)80002-2","url":null,"abstract":"<div><p>In comparison with the presently used potency test for diphtheria vaccine, <em>in vitro</em> examination of the immunogenicity of the vaccine would have great advantages. For this reason <em>in vitro</em> induction of diphtheria toxoid specific antibody synthesis in human peripheral blood lymphocytes cultivated in the presence of diphtheria toxoid was investigated. The results showed that a dose dependent synthesis of diphtheria antibody was induced by adsorbed diphtheria toxoid and combined vaccines containing the diphtheria toxoid component. Plain diphtheria toxoid appeared to be less immunogenic in comparison with adsorbed toxoid. There is some indication that the pertussis component had a stimulating effect on the diphtheria antibody synthesis. In conclusion, these results are promising for <em>in vitro</em> examination of the immunogenicity of diphtheria vaccines. The model will be validated for the routine control of diphtheria vaccine.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 4","pages":"Pages 311-319"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0092-1157(89)80002-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13755495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Notes to applicants for marketing authorizations on the production and quality control of monoclonal antibodies of murine origin intended for use in man 用于人的鼠源性单克隆抗体的生产和质量控制上市许可申请人须知
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90013-9
Committee for Proprietary Medicinal Products: Ad Hoc Working Party on Biotechnology/Pharmacy
{"title":"Notes to applicants for marketing authorizations on the production and quality control of monoclonal antibodies of murine origin intended for use in man","authors":"Committee for Proprietary Medicinal Products: Ad Hoc Working Party on Biotechnology/Pharmacy","doi":"10.1016/0092-1157(89)90013-9","DOIUrl":"10.1016/0092-1157(89)90013-9","url":null,"abstract":"","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 3","pages":"Pages 213-222"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90013-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13933356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The quantitative assay of the clustering activity of the lymphocytosis-promoting factor (pertussis toxin) of Bordetella pertussis on Chinese hamster ovary (CHO) cells 百日咳杆菌淋巴细胞促增殖因子(百日咳毒素)对中国仓鼠卵巢(CHO)细胞聚类活性的定量测定
Journal of biological standardization Pub Date : 1989-01-01 DOI: 10.1016/0092-1157(89)90028-0
H. Fujiwara , S. Iwasa
{"title":"The quantitative assay of the clustering activity of the lymphocytosis-promoting factor (pertussis toxin) of Bordetella pertussis on Chinese hamster ovary (CHO) cells","authors":"H. Fujiwara ,&nbsp;S. Iwasa","doi":"10.1016/0092-1157(89)90028-0","DOIUrl":"10.1016/0092-1157(89)90028-0","url":null,"abstract":"<div><p>An experimental design and a statistical method for the estimation of the clustering-response activity of lymphocytosis-promoting factor (LPF) in Chinese hamster ovary cells growing in wells on a microplate were investigated. The scoring method introduced by Ipsen<sup>1,2</sup> was adopted to express the grade of the clustering response rather than the end-point method generally used. The scoring method was validated by statistical analyses. The grade of response varied with the location of the wells on a microplate, and thus the expression of the clustering activity of a test sample in terms of the end-point may be inadequate in terms of accuracy and reproducibility. It was shown that the allocation of test samples to individual wells according to a Latin square design minimized the effect of the location of wells on the clustering response. Under such experimental conditions, a fairly precise and reproducible method for the quantification of the clustering activity was developed.</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 1","pages":"Pages 53-64"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90028-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14058066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
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