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Reaction of 2,9-dichloro-1,10-phenanthroline with secondary amines as a convenient approach to a new class of promising ligands 2,9-二氯-1,10-菲罗啉与仲胺的反应是一类新的有前途的配体的便捷途径
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4722-3
V. M. Muzalevskiy, J. K. Isomiddinov, K. A. Lyssenko, V. G. Nenajdenko
{"title":"Reaction of 2,9-dichloro-1,10-phenanthroline with secondary amines as a convenient approach to a new class of promising ligands","authors":"V. M. Muzalevskiy,&nbsp;J. K. Isomiddinov,&nbsp;K. A. Lyssenko,&nbsp;V. G. Nenajdenko","doi":"10.1007/s11172-025-4722-3","DOIUrl":"10.1007/s11172-025-4722-3","url":null,"abstract":"<div><p>Nucleophilic substitution of the chlorine atoms in 2,9-dichloro-1,10-phenanthroline with secondary amines was studied. This reaction provides mono- and bis-substituted amines, including unsymmetrical compounds with two different moieties of secondary amines, in 97–99% yields. The product composition depends on the reaction temperature, solvent nature, and the amount of amine used. Symmetrical bisamine bearing the morpholine moieties was used as a starting material to synthesize complexes with AgNO<sub>3</sub> and HgCl<sub>2</sub>.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2403 - 2412"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic protonation states and vacancy migration modulate glutaminase C catalysis: essential role of Lys481 and Tyr466 动态质子化状态和空位迁移调节谷氨酰胺酶C催化：Lys481和Tyr466的重要作用
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4718-z
I. V. Polyakov, M. G. Khrenova
{"title":"Dynamic protonation states and vacancy migration modulate glutaminase C catalysis: essential role of Lys481 and Tyr466","authors":"I. V. Polyakov,&nbsp;M. G. Khrenova","doi":"10.1007/s11172-025-4718-z","DOIUrl":"10.1007/s11172-025-4718-z","url":null,"abstract":"<div><p>Computer modelling of the enzyme-substrate complex structure of the glutaminase C (GAC) filament was performed using molecular dynamics (MD) calculations with classical and combined (quantum mechanics/molecular mechanics, QM/MM) potentials. The modelling results demonstrate the necessity of a proton vacancy in the protein’s active site for the nucleophilic attack of the key residue Ser286 side chain on the substrate. The relative stability of various protonated states of amino acid residues in the active site of the protein-ligand complex was evaluated. It was revealed that the proton vacancy is most likely located on the amino group of the Lys481 side chain, but protons readily migrate between ionizable groups of the active site residues, facilitating the nucleophilic attack by enabling deprotonation of the serine residue side chain. The constructed models also explain the absence of catalytic activity in the GAC variant with the Tyr466Trp substitution, which is caused by Trp466 displacing the Lys481 side chain away from the active site.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2367 - 2376"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2392 - 2402"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminatory silylation of hydroxymethyl and hydroxyethyl groups in the product of the Grieco lactone conversion. Approaches to the total synthesis of (±)-methylenolactocin Grieco内酯转化产物中羟基甲基和羟基乙基的区别硅基化。（±）-甲基乳酸素的全合成方法
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4738-8
Z. R. Makaev, A. M. Gimazetdinov, R. A. Sadykov
{"title":"Discriminatory silylation of hydroxymethyl and hydroxyethyl groups in the product of the Grieco lactone conversion. Approaches to the total synthesis of (±)-methylenolactocin","authors":"Z. R. Makaev,&nbsp;A. M. Gimazetdinov,&nbsp;R. A. Sadykov","doi":"10.1007/s11172-025-4738-8","DOIUrl":"10.1007/s11172-025-4738-8","url":null,"abstract":"<div><p>The racemic commercially available Grieco lactone was used as a starting material to synthesize new monocyclic precursors for the total synthesis of (±)-methylenolactocin. The key synthesis steps are the ozonolysis of the Grieco lactone derivative, preparation of regioisomeric silyl ethers, and Cu-catalyzed cross-coupling.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2572 - 2578"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IX International Conference Supramolecular Systems at the Interface 第九届界面超分子系统国际会议
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4742-z
{"title":"IX International Conference Supramolecular Systems at the Interface","authors":"","doi":"10.1007/s11172-025-4742-z","DOIUrl":"10.1007/s11172-025-4742-z","url":null,"abstract":"","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2598 - 2598"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chelate complexes of PdII, RhI, and PtII with P*,P-bidentate phosphine-bicyclophosphoramidite PdII， RhI和PtII与P*，P-双齿膦-双环磷酸酰胺的螯合配合物
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4739-7
I. V. Chuchelkin, A. I. Lukankov, V. K. Gavrilov, I. D. Firsin, E. S. Rud, D. A. Fedorov, A. N. Rodionov, K. N. Gavrilov
{"title":"Chelate complexes of PdII, RhI, and PtII with P*,P-bidentate phosphine-bicyclophosphoramidite","authors":"I. V. Chuchelkin,&nbsp;A. I. Lukankov,&nbsp;V. K. Gavrilov,&nbsp;I. D. Firsin,&nbsp;E. S. Rud,&nbsp;D. A. Fedorov,&nbsp;A. N. Rodionov,&nbsp;K. N. Gavrilov","doi":"10.1007/s11172-025-4739-7","DOIUrl":"10.1007/s11172-025-4739-7","url":null,"abstract":"<div><p>The synthesis of the <i>cis</i>-chelates [Pd(DPA<b>)L</b>]BF<sub>4</sub>, [Rh(COD)<b>L</b>]BF<sub>4</sub> (DPA is diphenylallyl, COD is 1,5-cyclooctadiene), and Pt<b>L</b>Cl<sub>2</sub> with a <i>P</i>*,<i>P</i>-ligand (<b>L</b>) containing the rigid <i>P</i>-chiral bicyclophosphoramidite and phosphine donor centers was reported. The composition and structures of the complexes were confirmed by NMR spectroscopy and elemental analysis. The cationic compounds [Rh(COD)<b>L</b>]BF<sub>4</sub> and [Pd(DPA)<b>L</b>]BF<sub>4</sub> were additionally characterized by high-resolution mass spectrometry. The use of [Rh(COD)<b>L</b>]BF<sub>4</sub> (1 mol.%) in the Rh-catalyzed asymmetric hydrogenation of dimethyl itaconate provided up to 98% <i>ee</i> with the complete conversion of the starting substrate.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2579 - 2584"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poly(vinyl alcohol) cryogels prepared in a frozen DMSO medium and filled with poly(3-hydroxybutyric acid)-based dispersed particles formed in situ by replacing the organic solvent for water 在冷冻的二甲基亚砜（DMSO）介质中制备的聚乙烯醇（乙烯醇）冷冻冰箱，并填充以聚（3-羟基丁酸）为基础的分散颗粒，通过代替水的有机溶剂在原位形成
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4732-1
D. A. Michurov, V. I. Lozinsky
{"title":"Poly(vinyl alcohol) cryogels prepared in a frozen DMSO medium and filled with poly(3-hydroxybutyric acid)-based dispersed particles formed in situ by replacing the organic solvent for water","authors":"D. A. Michurov,&nbsp;V. I. Lozinsky","doi":"10.1007/s11172-025-4732-1","DOIUrl":"10.1007/s11172-025-4732-1","url":null,"abstract":"<div><p>The cryogenic treatment of DMSO solutions of mixtures of poly(vinyl alcohol) (PVA) and poly-3-hydroxybutyric acid (PHB) yielded complex cryogels, the subsequent replacement of the organic medium for water in which led to the coagulation of PHB with the formation of dispersed polymeric particles entrapped as a filler in the matrix of the composite cryogel. The particles are capable of reversibly sorbing drug molecules, in particular, sodium salt of ibuprofen used as a model agent.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2510 - 2520"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties 喜树碱与石胆酸新型杂化化合物的合成及其抗肿瘤性能研究
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4741-0
N. M. Chobanov, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov
{"title":"Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties","authors":"N. M. Chobanov,&nbsp;L. U. Dzhemileva,&nbsp;U. M. Dzhemilev,&nbsp;V. A. D’yakonov","doi":"10.1007/s11172-025-4741-0","DOIUrl":"10.1007/s11172-025-4741-0","url":null,"abstract":"<div><p>A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2592 - 2597"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physicochemical analysis for the structure-forming role of plant antioxidants in the formation of biopolymer-liposomal complexes 植物抗氧化剂在生物聚合物-脂质体复合物形成中的结构形成作用的理化分析
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4736-x
M. G. Semenova, A. S. Antipova, E. I. Martirosova, D. V. Zelikina, M. S. Anokhina, N. P. Palmina, N. G. Bogdanova, V. V. Kasparov
{"title":"Physicochemical analysis for the structure-forming role of plant antioxidants in the formation of biopolymer-liposomal complexes","authors":"M. G. Semenova,&nbsp;A. S. Antipova,&nbsp;E. I. Martirosova,&nbsp;D. V. Zelikina,&nbsp;M. S. Anokhina,&nbsp;N. P. Palmina,&nbsp;N. G. Bogdanova,&nbsp;V. V. Kasparov","doi":"10.1007/s11172-025-4736-x","DOIUrl":"10.1007/s11172-025-4736-x","url":null,"abstract":"<div><p>Physicochemical analysis performed using the data acquired by DSC, EPR, as well as static, dynamic, and electrophoretic laser light scattering allowed us for the first time to reveal the fact that plant antioxidants possess a significant structure-forming potential in addition to their antioxidant activity. They are actively participating in the formation of both local and overall structure of biopolymer-liposomal complexes, which is accompanied by a significant increase in the protective capability of such delivery systems against autoxidation of omega-3 and omega-6 PUFAs encapsulated in them.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2555 - 2564"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaffold models based on terpolymers of collagen—chitosan—(meth)acrylic monomer synthesized in the presence of an amine complex of triethylborane 在三乙基硼烷胺配合物存在下合成的基于胶原-壳聚糖-（甲基）丙烯酸单体三元聚合物的支架模型
IF 1.7 4区 化学
Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4735-y
Yu. L. Kuznetsova, K. S. Gushchina, A. S. Vavilova, K. S. Lobanova, K. S. Gubareva, V. O. Rumyantseva, M. N. Egorikhina, I. N. Charykova, D. G. Fukina, L. L. Semenycheva
{"title":"Scaffold models based on terpolymers of collagen—chitosan—(meth)acrylic monomer synthesized in the presence of an amine complex of triethylborane","authors":"Yu. L. Kuznetsova,&nbsp;K. S. Gushchina,&nbsp;A. S. Vavilova,&nbsp;K. S. Lobanova,&nbsp;K. S. Gubareva,&nbsp;V. O. Rumyantseva,&nbsp;M. N. Egorikhina,&nbsp;I. N. Charykova,&nbsp;D. G. Fukina,&nbsp;L. L. Semenycheva","doi":"10.1007/s11172-025-4735-y","DOIUrl":"10.1007/s11172-025-4735-y","url":null,"abstract":"<div><p>The graft polymerization of acrylamide and methyl methacrylate onto a mixture of collagen and chitosan in an acetic acid dispersion in the presence of the complex of triethylborane with hexamethylenediamine has been studied. It was found that monomer conversion depends on the molecular weight of chitosan and the nature of the monomer, while the resulting terpolymers have a cross-linked structure. The models of hydrogel scaffolds based on terpolymers of collagen—chitosan—(meth)acrylic monomer were developed and water absorption and stability in buffer solutions were determined for these materials. The cytotoxicity of the obtained scaffold models was assessed using the MTT assay on human dermal fibroblast cultures. The results suggest that some samples are promising materials for regenerative medicine.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2545 - 2554"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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