Poly(vinyl alcohol) cryogels prepared in a frozen DMSO medium and filled with poly(3-hydroxybutyric acid)-based dispersed particles formed in situ by replacing the organic solvent for water

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI:10.1007/s11172-025-4732-1

D. A. Michurov, V. I. Lozinsky

引用次数: 0

Abstract

The cryogenic treatment of DMSO solutions of mixtures of poly(vinyl alcohol) (PVA) and poly-3-hydroxybutyric acid (PHB) yielded complex cryogels, the subsequent replacement of the organic medium for water in which led to the coagulation of PHB with the formation of dispersed polymeric particles entrapped as a filler in the matrix of the composite cryogel. The particles are capable of reversibly sorbing drug molecules, in particular, sodium salt of ibuprofen used as a model agent.

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在冷冻的二甲基亚砜（DMSO）介质中制备的聚乙烯醇（乙烯醇）冷冻冰箱，并填充以聚（3-羟基丁酸）为基础的分散颗粒，通过代替水的有机溶剂在原位形成

对聚乙烯醇（PVA）和聚3-羟基丁酸（PHB）混合物的DMSO溶液进行低温处理，得到复合低温凝胶，随后用有机介质代替水，导致PHB凝固，形成分散的聚合物颗粒，作为填料被包裹在复合低温凝胶的基质中。这种颗粒能够可逆地吸收药物分子，特别是作为模型剂的布洛芬钠盐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.