Russian Chemical Bulletin最新文献_第2页

Boronic acids: broad specificity of inhibition of penicillin-binding proteins and β-lactamases conferring bacterial antibiotic resistance 硼酸：广泛特异性抑制青霉素结合蛋白和β-内酰胺酶赋予细菌抗生素耐药性

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4716-1

A. M. Egorov, M. M. Ulyashova, M. G. Khrenova, D. D. Kholmanskikh, M. Yu. Rubtsova

{"title":"Boronic acids: broad specificity of inhibition of penicillin-binding proteins and β-lactamases conferring bacterial antibiotic resistance","authors":"A. M. Egorov, M. M. Ulyashova, M. G. Khrenova, D. D. Kholmanskikh, M. Yu. Rubtsova","doi":"10.1007/s11172-025-4716-1","DOIUrl":"10.1007/s11172-025-4716-1","url":null,"abstract":"<div><p>The wide spread of antibiotic-resistant bacterial pathogens has attracted great interest in the development of new drugs to suppress resistance emergence. They include inhibitors of β-lactamases (β-Ls), which confer bacterial resistance to β-lactam antibiotics. This class of antibiotics targets penicillin-binding proteins (PBPs), the inhibition of which leads to the disruption of the bacterial cell wall synthesis. β-Lactamases catalyze the hydrolysis of the amide bond of the β-lactam ring, causing inactivation of the antibiotic. Due to the structural diversity of β-Ls, it is relevant to search for their inhibitors characterized by broad specificity. Boronic acids are a promising class of compounds capable of inhibiting not only different molecular classes of β-Ls but also PBPs. The review considers the data on the mechanisms of interaction of β-lactams with PBPs and β-Ls, as well as on the effect of the structure of boronic acid derivatives on their inhibitory activity against various bacterial enzymes. Combinations of antibacterial drugs with β-L inhibitors that simultaneously inhibit PBPs are promising for overcoming antibiotic resistance of different pathogens.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2332 - 2359"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis of functionalized hydroxymethyl-substituted organophosphorus acids 功能化羟基甲基取代有机磷酸的合成

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4724-1

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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Chemical and microbiological degradation of polycaprolactone prepared under different synthesis conditions 不同合成条件下聚己内酯的化学及微生物降解研究

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4733-0

E. N. Efremenko, O. V. Maslova, M. U. Agaeva, O. V. Senko, N. A. Stepanov, A. G. Aslanli, S. S. Karlov

{"title":"Chemical and microbiological degradation of polycaprolactone prepared under different synthesis conditions","authors":"E. N. Efremenko, O. V. Maslova, M. U. Agaeva, O. V. Senko, N. A. Stepanov, A. G. Aslanli, S. S. Karlov","doi":"10.1007/s11172-025-4733-0","DOIUrl":"10.1007/s11172-025-4733-0","url":null,"abstract":"<div><p>Polycaprolactone (PCL) polymer samples with different molecular weights (30–33 000) were synthesized using gallium-containing catalysts for ring-opening polymerization of ε-caprolactone. The synthesized polymer samples were characterized by a set of physicochemical methods (GPC, IR spectroscopy, NMR). The processes of chemical degradation of the synthesized polymers were studied. The complete dissolution and degradation of polymer molecules, including to 6-hydroxycaproic acid, in an aqueous-ethanol solution (1: 1 <i>v/v</i>) of caustic soda (1 <i>M</i> NaOH) was shown to be achieved at 65 °C within 30 h with permanent stirring (300 rpm). The compositions of the prepared solutions were studied by IR spectroscopy and <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy. The solutions obtained after the destruction of various PCL were tested as components of culture media for growth of various microorganisms and biocatalytic transformation into diverse products: biogas, bacterial nanocellulose, biomass of oil-degrading bacterial cells, and microalgae. The two-stage process was proposed for PCL waste processing, which corresponds to requirements of the modern environmental standards from the viewpoint of safety and resource saving.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2521 - 2534"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis and study of binary and ternary selenium-containing nanodispersions based on amphiphilic molecular brushes and Photoditazine 基于两亲性分子刷和光二嗪的二元和三元含硒纳米分散体的合成与研究

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4725-0

S. V. Valueva, L. N. Borovikova, A. Ya. Volkov, E. L. Krasnopeeva, I. V. Ivanov, A. V. Yakimansky

{"title":"Synthesis and study of binary and ternary selenium-containing nanodispersions based on amphiphilic molecular brushes and Photoditazine","authors":"S. V. Valueva, L. N. Borovikova, A. Ya. Volkov, E. L. Krasnopeeva, I. V. Ivanov, A. V. Yakimansky","doi":"10.1007/s11172-025-4725-0","DOIUrl":"10.1007/s11172-025-4725-0","url":null,"abstract":"<div><p>Amphiphilic molecular brushes with a polyimide or cellulose main chain and polymethacrylic acid (PMAA) side chains, as well as binary and ternary selenium-containing nanodispersions based on these brushes and the photosensitizer Photoditazine (PD) were synthesized. A comparative study of graft copolymers (graft-CPs) with a polyimide or cellulose main chain (with a variable degree of polymerization of the PMAA side chains) and graft-CPs loaded with selenium nanoparticles (NPs) and PD was carried out using UV-Vis and luminescence spectroscopy and X-ray diffraction analysis (XRD). The influence of the structure and topology of the graft-CPs on the structural and spectral characteristics of both free amphiphilic molecular brushes and brushes loaded with selenium NPs and PD was determined. It is suggested that the formation of selenium-containing compositions is carried out mainly <i>via</i> the steric stabilization of selenium NPs with brush macromolecules and the incorporation of selenium NPs similar to the case of metal-porphyrin complexes. Based on the results of spectroscopy in the UV-Vis region, the band gap energies and the diameters of the selenium NPs were calculated for binary and ternary systems. Luminescence quantum yields were determined for ternary systems.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2449 - 2458"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical properties of ommochromes as natural antioxidants 同色色素作为天然抗氧化剂的理化性质

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4731-2

A. E. Dontsov, M. A. Yakovleva, M. A. Ostrovsky

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Analysis of molecular dynamics and structure of adsorption layers on silica gel in various solvents by the spin probe technique 用自旋探针技术分析不同溶剂下硅胶吸附层的分子动力学和结构

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4717-0

M. V. Motyakin, V. V. Kasparov, A. I. Sergeev, I. S. Ionova, I. I. Barashkova

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Carbocyanines with metal chelating groups as promising tools for diagnostics and therapy 具有金属螯合基团的碳菁作为诊断和治疗的有前途的工具

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4711-6

I. A. Doroshenko, N. V. Shmychkov, A. O. Govtvan, A. V. Shik, M. K. Beklemishev, T. A. Podrugina

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Nanoparticle conjugation with polymer ligands: influence of surface modification on protein corona formation 纳米粒子与聚合物配体的偶联：表面修饰对蛋白质电晕形成的影响

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4726-z

M. A. Klimenko, M. B. Sokol, I. A. Gulyaev, O. E. Kamaeva, N. G. Yabbarov, M. R. Mollaeva, M. V. Chirkina, M. S. Rumyantsev, A. A. Maltsev, E. D. Nikolskaya

{"title":"Nanoparticle conjugation with polymer ligands: influence of surface modification on protein corona formation","authors":"M. A. Klimenko, M. B. Sokol, I. A. Gulyaev, O. E. Kamaeva, N. G. Yabbarov, M. R. Mollaeva, M. V. Chirkina, M. S. Rumyantsev, A. A. Maltsev, E. D. Nikolskaya","doi":"10.1007/s11172-025-4726-z","DOIUrl":"10.1007/s11172-025-4726-z","url":null,"abstract":"<div><p>The protein corona (an adsorbed protein layer on the surface of nanoparticles) unpredictably alters the pharmacokinetics and biodistribution of nanosomal forms in the body. In this study, the nanoparticle surface was modified with polymer ligands to investigate their influence on the protein corona formation of nanoparticles. Nanoparticles based on a copolymer of lactic and glycolic acids were synthesized using the single emulsion method. A technique for nanoparticle conjugation with poly-<i>N</i>-isopropylacrylamide (PNIPAM) and chitosan (Ch) was developed. The nanoparticle—ligand conjugates (ConjNP) were synthesized by the carbodiimide method; the target product was purified using gel exclusion chromatography. The resulting particles were characterized by Fourier transform IR spectroscopy and dynamic light scattering. It was found that the total protein concentration increased in the order of ConjNP—PNIPAM—NP—ConjNP—Ch. Thus, PNIPAM modification reduces the concentration of the protein layer on nanoparticles in comparison with unmodified ones. The revealed correlation is aimed at optimizing the design of nanosystems and improving their pharmacokinetic profiles.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2459 - 2465"},"PeriodicalIF":1.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Role of singlet and triplet states in thermal cis—trans isomerization of azo dyes with dihydroquinoline and tetrazole moieties 单线态和三重态在含二氢喹啉和四氮唑偶氮染料热顺反异构化中的作用

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4730-3

V. V. Kuzmin, G. V. Golovina, A. E. Egorov, E. N. Timokhina, T. Yu. Astakhova, T. D. Nekipelova

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Synthesis of possible metabolites of 16α, 17α-cyclohexaprogesterone and evaluation of their antiproliferative activity in hormone-dependent breast cancer cell lines 16α， 17α-环己孕酮可能代谢物的合成及其在激素依赖性乳腺癌细胞系中的抗增殖活性评价

IF 1.7 4区化学

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI: 10.1007/s11172-025-4737-9

M. O. Tserfas, F. B. Bogdanov, A. L. Mikhaylova, Yu. V. Kuznetsov, I. V. Zavarzin, A. M. Scherbakov, I. S. Levina

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