喜树碱与石胆酸新型杂化化合物的合成及其抗肿瘤性能研究

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI:10.1007/s11172-025-4741-0

N. M. Chobanov, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov

{"title":"喜树碱与石胆酸新型杂化化合物的合成及其抗肿瘤性能研究","authors":"N. M. Chobanov, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov","doi":"10.1007/s11172-025-4741-0","DOIUrl":null,"url":null,"abstract":"<div><p>A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 8","pages":"2592 - 2597"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties\",\"authors\":\"N. M. Chobanov, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov\",\"doi\":\"10.1007/s11172-025-4741-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.</p></div>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":\"74 8\",\"pages\":\"2592 - 2597\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11172-025-4741-0\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-025-4741-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

首次合成了含有石胆酸和喜树碱片段的杂化化合物，喜树碱片段通过酸酐和琥珀酸片段的酯基相互连接。所得到的化合物被发现是一种有效的细胞凋亡诱导剂，能够引起细胞周期阻滞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties

A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.