Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-09-12 DOI:10.1007/s11172-025-4741-0

N. M. Chobanov, L. U. Dzhemileva, U. M. Dzhemilev, V. A. D’yakonov

引用次数: 0

Abstract

A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.

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喜树碱与石胆酸新型杂化化合物的合成及其抗肿瘤性能研究

首次合成了含有石胆酸和喜树碱片段的杂化化合物，喜树碱片段通过酸酐和琥珀酸片段的酯基相互连接。所得到的化合物被发现是一种有效的细胞凋亡诱导剂，能够引起细胞周期阻滞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.