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Developmental regulation of the monoclonally defined IIC3 antigen during primary and secondary trophoblast differentiation in vitro 单克隆IIC3抗原在体外初级和次级滋养细胞分化过程中的发育调控
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90086-3
Helen J. Hathaway , Bruce S. Babiarz
{"title":"Developmental regulation of the monoclonally defined IIC3 antigen during primary and secondary trophoblast differentiation in vitro","authors":"Helen J. Hathaway ,&nbsp;Bruce S. Babiarz","doi":"10.1016/0045-6039(88)90086-3","DOIUrl":"10.1016/0045-6039(88)90086-3","url":null,"abstract":"<div><p>The monoclonally defined IIC3 antigen has been found to be developmentally regulated during primary and secondary throphoblast differentiation in the mouse. Cell surface expression of the antigen was associated only with diploid and tetraploid trophoblast cell types. Endoreduplication to 8C DNA in differentiating trophoblast giant cells was associated with a loss of IIC3 cell surface expression and appearance of cytoplasmic expression. This developmental change was not temporally regulated, but dependent on the attachment and outgrowth of the trophoblast in vitro. The surface antigen was neither shed into the media nor masked by glycosylation, but was apparently internalized by the trophoblast giant cells.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 55-66"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90086-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14535177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Expression of gene coding for a melanosomal matrix protein transcriptionally regulated in the transdifferentiation of chick embryo pigmented epithelial cells 黑素体基质蛋白基因编码在鸡胚色素上皮细胞转分化中的转录调控表达
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90087-5
Makoto Mochii, Kiyokazu Agata, Hiroshi Kobayashi, Takamasa S. Yamamoto, Goro Eguchi
{"title":"Expression of gene coding for a melanosomal matrix protein transcriptionally regulated in the transdifferentiation of chick embryo pigmented epithelial cells","authors":"Makoto Mochii,&nbsp;Kiyokazu Agata,&nbsp;Hiroshi Kobayashi,&nbsp;Takamasa S. Yamamoto,&nbsp;Goro Eguchi","doi":"10.1016/0045-6039(88)90087-5","DOIUrl":"10.1016/0045-6039(88)90087-5","url":null,"abstract":"<div><p>Chicken 115-kDa melanosomal matrix protein (MMP115) was purified from cultured pigmented epithelia cells (PECs), and mouse antiserum was raised to isolate cDNA clones. λgt11 expression library made from poly(A) <sup>+</sup> RNA of the homogeneous population of PECs was screened with the antiserum. Nine positive clones were obtained from 5 × 10<sup>5</sup> independent phages, and inserts of them shared a common nucleotide sequence. The β-galactosidase fusion protein from the longest insert (MM-2, 1.0 kb long) was recognized by the anti-MMP115 antiserum in immunoblotting, and the antibody, which was affinity-selected by the fusion protein, specifically reacted with the 115-kDa protein in PEC extracts. The RNA blot analysis with the MM-2 insert as a probe revealed that a transcript of 2.6 kb was expressed by the PEC in a tissue-specific manner. mRNA expressions in the process of in vitro transdifferentiation from PECs to lens cells were analyzed using the MM-2 insert. The transcripts were detected in neither transdifferentiating, transdifferentiated lens cells nor bipotent dedifferentiated PECs, although the 2.6 kb transcript was vigorously synthesized by redifferentiating into PECs.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 67-74"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90087-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14535178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Factors related to the initiation of cell migration along the inner surface of the blastocoelic wall during amphibian gastrulation 两栖动物原肠形成过程中细胞沿胚腔壁内表面迁移的相关因素
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90083-8
Shinji Komazaki
{"title":"Factors related to the initiation of cell migration along the inner surface of the blastocoelic wall during amphibian gastrulation","authors":"Shinji Komazaki","doi":"10.1016/0045-6039(88)90083-8","DOIUrl":"10.1016/0045-6039(88)90083-8","url":null,"abstract":"<div><p>Changes in the quantity of extracellular matrix on the inner surface of the blastocoelic wall (BW) and the adhesiveness of cells to fibronectin were examined in relation to the timing of initiation of cell migration along the BW during gastrulation of the newt, <em>Cynops pyrrhogaster</em>. Extracellular matrix fibrils were already abundantly present all over the inner surface of the BW prior to the beginning of cell migration. On the other hand, the adhesiveness of cells to fibronectin rapidly increased in the cells of the dorsal region at the same time as the cell migration initiated along the BW.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 25-32"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90083-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14535174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Cyclic changes in the differentiation of lymphoid cells in reptiles 爬行动物淋巴样细胞分化的循环变化
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90081-4
R. El Ridi, S. Zada, A. Afifi, S. El Deeb, S. El Rouby, M. Farag, A.-H. Saad
{"title":"Cyclic changes in the differentiation of lymphoid cells in reptiles","authors":"R. El Ridi,&nbsp;S. Zada,&nbsp;A. Afifi,&nbsp;S. El Deeb,&nbsp;S. El Rouby,&nbsp;M. Farag,&nbsp;A.-H. Saad","doi":"10.1016/0045-6039(88)90081-4","DOIUrl":"10.1016/0045-6039(88)90081-4","url":null,"abstract":"","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90081-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14176972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Close juxtaposition between inducing chordamesoderm and reacting neuroectoderm is a prerequisite for neural induction in Xenopus laevis 诱导脊索内胚层与反应神经外胚层的紧密并列是非洲爪神经诱导的先决条件
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90084-X
Lothar Tacke, Horst Grunz
{"title":"Close juxtaposition between inducing chordamesoderm and reacting neuroectoderm is a prerequisite for neural induction in Xenopus laevis","authors":"Lothar Tacke,&nbsp;Horst Grunz","doi":"10.1016/0045-6039(88)90084-X","DOIUrl":"10.1016/0045-6039(88)90084-X","url":null,"abstract":"<div><p>The results of this study indicate that the induction of the central nervous system in <em>Xenopus laevis</em> depends on the close juxtaposition of inducing chordamesoderm and reacting ectoderm, which is necessary for the short distance migration of neural inducing factors. The examination of the neuroectoderm-chordamesoderm interface at intervals of 1 h up to 5 h showed that the onset of neural induction is correlated to the degree of contact formation between ectodermal and mesodermal cells. In the ectoderm cells the number of coated pits, a feature of receptor-mediated endocytosis, is increased. Furthermore there exist telophase bridges between some ectoderm cells, which are possibly correlated to secondary cell interactions.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 33-43"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90084-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14535175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Development of the fetal rat liver: ultrastructural and stereological study of hepatocytes 胎鼠肝脏发育:肝细胞超微结构和体视学研究
Cell differentiation Pub Date : 1988-06-01 DOI: 10.1016/0045-6039(88)90082-6
J. Vassy, M. Kraemer, M.T. Chalumeau, J. Foucrier
{"title":"Development of the fetal rat liver: ultrastructural and stereological study of hepatocytes","authors":"J. Vassy,&nbsp;M. Kraemer,&nbsp;M.T. Chalumeau,&nbsp;J. Foucrier","doi":"10.1016/0045-6039(88)90082-6","DOIUrl":"10.1016/0045-6039(88)90082-6","url":null,"abstract":"<div><p>Qualitative and quantitative changes in the liver tissue composition have been studied during prenatal development of the Wistar rat by electron microscopy and stereologic methods. The absolute volume of the fetal liver is multiplied by 84 between days 13 and 20 of gestation. In the meantime, the average hepatocyte volume is multiplied by 1.5 between days 12 and 20. The volumetric fraction of hepatocytes increases from 35% of the volumetric fraction of the liver on day 12 to 66% on day 20 of gestation. The non-hepatocyte cells decrease from 49% on day 12 to 25% on day 20. By days 12 and 13, the rough endoplasmic reticulum and the Golgi apparatus are well differentiated, indicating that young fetal hepatocytes are able to synthesize and export plasma proteins. The volumetric fraction of free ribosomes decreases from 38% of the hepatocytic cytoplasm on days 12 and 13 to 6% on day 20. The mitochondrial compartment occupies about 10% of the hepatocyte cytoplasm. The mitochondria, small and round on days 12, 13 and 14, become oblong from day 18 of gestation. The shape of hepatocytes changes during the prenatal development, from potato-like on days 12, 13, 14 to cubic on day 20, with an intermediate, more spheric, stage on day 18.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"24 1","pages":"Pages 9-24"},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90082-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14535179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Cell to cell adhesion systems in Xenopus laevis, the South African clawed toad II: Monoclonal antibody against a novel Ca2+-dependent cell—cell adhesion glycoprotein on amphibian cells 非洲爪蟾(Xenopus laevis, the South African claw toad)的细胞间粘附系统II:单克隆抗体对抗两栖动物细胞上一种新的Ca2+依赖性细胞-细胞粘附糖蛋白
Cell differentiation Pub Date : 1988-04-01 DOI: 10.1016/0045-6039(88)90073-5
K. Nomura, T. Tajima, H. Nomura, H. Shiraishi, M. Uchida, K. Yamana
{"title":"Cell to cell adhesion systems in Xenopus laevis, the South African clawed toad II: Monoclonal antibody against a novel Ca2+-dependent cell—cell adhesion glycoprotein on amphibian cells","authors":"K. Nomura,&nbsp;T. Tajima,&nbsp;H. Nomura,&nbsp;H. Shiraishi,&nbsp;M. Uchida,&nbsp;K. Yamana","doi":"10.1016/0045-6039(88)90073-5","DOIUrl":"10.1016/0045-6039(88)90073-5","url":null,"abstract":"<div><p>We isolated a mouse monoclonal antibody that disrupts Ca<sup>2+</sup>-dependent cell—cell adhesion of amphibian (<em>Xenopus laevis</em>) cells. When added to culture medium, the monoclonal antibody completely disrupted cell—cell adhesion of amphibian cells in monolayer culture and specifically inhibited Ca<sup>2+</sup>-dependent cell—cell adhesion of dissociated cells in reaggregation experiments. The monoclonal antibody recognized a 140 kDa cell surface glycoprotein antigenically different from the previously reported Ca<sup>2+</sup>-dependent cell—cell adhesion molecules (cadherins).</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"23 3","pages":"Pages 207-212"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90073-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14503963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Responses in Xenopus to the thymus independent antigen polyvinylpyrrolidone (PVP) and its haptenated derivative, trinitrophenylated PVP (TNP-PVP) 非洲爪蟾对胸腺非依赖性抗原聚乙烯吡咯烷酮(PVP)及其半化衍生物三硝基苯化PVP (TNP-PVP)的反应
Cell differentiation Pub Date : 1988-04-01 DOI: 10.1016/0045-6039(88)90074-7
Richard H. Clothier , Linda Kandola , Meena Mirchandani , Andrew Ellis , Paul Wood , Zoe Last , Michael Balls , Laurens N. Ruben
{"title":"Responses in Xenopus to the thymus independent antigen polyvinylpyrrolidone (PVP) and its haptenated derivative, trinitrophenylated PVP (TNP-PVP)","authors":"Richard H. Clothier ,&nbsp;Linda Kandola ,&nbsp;Meena Mirchandani ,&nbsp;Andrew Ellis ,&nbsp;Paul Wood ,&nbsp;Zoe Last ,&nbsp;Michael Balls ,&nbsp;Laurens N. Ruben","doi":"10.1016/0045-6039(88)90074-7","DOIUrl":"10.1016/0045-6039(88)90074-7","url":null,"abstract":"<div><p><em>Xenopus laevis</em> (the South African clawed toad) can respond to thymus dependent (TD) and thymus independent (TI) antigens. However, the response to trinitrophenylated Ficoll (TNP-Ficoll), a TI-2 antigen in mammals, is thymus dependent in <em>Xenopus</em>. Polyvinylpyrrolidone (PVP), classed as a TI antigen in mammals, is also a TI antigen in <em>Xenopus</em>, but responses to PVP and TNP-PVP are thymus regulated. As with TNP-Ficoll, capacity to respond to TNP-PVP diminishes during metamorphosis, and tolerance can be induced via the stimulation of TD suppression with trinitrobenzene sulphonic acid. Animals treated with <em>N</em>-methyl-<em>N</em>-nitrosourea and adult-thymectomised <em>Xenopus</em>, which lack certain TD responses, can nevertheless respond to TNP-PVP. Based on this and other information, it is concluded that TNP-PVP should be classed as a TI-2 antigen in <em>Xenopus</em>.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"23 3","pages":"Pages 213-220"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90074-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14503964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Analysis of proteins in the peripheral and central regions of amphibian oocytes and eggs 两栖动物卵母细胞和卵的外周和中心区域的蛋白质分析
Cell differentiation Pub Date : 1988-04-01 DOI: 10.1016/0045-6039(88)90068-1
David G. Capco, Michael D. Mecca
{"title":"Analysis of proteins in the peripheral and central regions of amphibian oocytes and eggs","authors":"David G. Capco,&nbsp;Michael D. Mecca","doi":"10.1016/0045-6039(88)90068-1","DOIUrl":"10.1016/0045-6039(88)90068-1","url":null,"abstract":"<div><p>Proteins in oocytes, meiotically mature eggs and zygotes of <em>Xenopus laevis</em> were examined to determine whether proteins in the peripheral region differ from those in the central region of these cells. We show that different regions contain different amounts of newly synthesized proteins and that during meiotic maturation and fertilization the periphery of the animal hemisphere becomes the site where most newly synthesized proteins are found. Examination of two-dimensional gels indicates that most of these proteins are found in all parts of the egg, but certain proteins demonstrate patterns of distribution which are indicative of (1) polarity, (2) developmental stage, and (3) the position within the hemisphere (central or peripheral). These results suggest that the periphery of oocytes, eggs, and zygotes is a site of greater metabolic activity compared with the central region.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"23 3","pages":"Pages 155-164"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90068-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14503959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Alveolar type II-like cell colonies: effect of alveolar macrophages and macrophage-conditioned media 肺泡ii型样细胞集落:肺泡巨噬细胞和巨噬细胞条件培养基的作用
Cell differentiation Pub Date : 1988-04-01 DOI: 10.1016/0045-6039(88)90076-0
Moshe Kalina, Shoshana Riklis
{"title":"Alveolar type II-like cell colonies: effect of alveolar macrophages and macrophage-conditioned media","authors":"Moshe Kalina,&nbsp;Shoshana Riklis","doi":"10.1016/0045-6039(88)90076-0","DOIUrl":"10.1016/0045-6039(88)90076-0","url":null,"abstract":"<div><p>Alveolar type II-like colonies were obtained after a low density plating (5 × 10<sup>3</sup>/60 mm tissue culture dish) of primary type II cells. These colonies were formed only when type II cells were either cocultured with alveolar macrophages or with conditioned media generated by alveolar macrophages. Cells in the colonies appeared homogeneous and kept their lamellar bodies over a period of 8 weeks and more, as observed by electron microscopy. These cells reacted immunocytochemically with antibodies directed against the 32–38 kDa protein fractions of rat surfactant.</p></div>","PeriodicalId":75684,"journal":{"name":"Cell differentiation","volume":"23 3","pages":"Pages 231-236"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0045-6039(88)90076-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14503965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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