Allergologia et immunopathologia最新文献

{"title":"Factors associated with the efficacy of omalizumab treatment in chronic spontaneous urticaria.","authors":"Fatma Arzu Akkuş, Fatih Çölkesen, Tuğba Önalan, Recep Evcen, Filiz Sadi Aykan, Mehmet Kılınç, Mehmet Emin Gerek, Şevket Arslan","doi":"10.15586/aei.v53i2.1207","DOIUrl":"10.15586/aei.v53i2.1207","url":null,"abstract":"<p><strong>Background: </strong>Omalizumab is a preferred treatment in antihistamine-refractory chronic spontaneous urticaria (CSU) patients. However, factors that may impact treatment response remain to be explored.</p><p><strong>Objective: </strong>This study aimed to examine the factors affecting treatment response in CSU patients receiving omalizumab.</p><p><strong>Methods: </strong>This was a retrospective study that included 123 patients who received omalizumab treatment for CSU between January 2015 and April 2024. After administering omalizumab, we evaluated therapeutic efficacy with the urticaria control test (UCT). According to UCT, patients were classified as complete responders, partial responders, and nonresponders.</p><p><strong>Results: </strong>The median age of the patients was 42 (31-50) years, and there were 77 (62.9%) female patients. Sixty-four (52%) patients exhibited complete response, and 43 (35%) patients exhibited partial response to omalizumab treatment, whereas 16 (13%) patients were nonresponders. Autoimmune disease (AID) was present in 31 (25.2%) patients. The most common AID was thyroid autoimmunity, seen in 24 (77.4%) patients. AID was significantly higher in omalizumab treatment nonresponders than in partial and complete responders. The presence of an autoimmune thyroid disease was an independent risk factor for failure to respond to omalizumab treatment. Baseline IgE levels were significantly higher in omalizumab treatment responders with a complete response compared to those with a partial response and nonresponders.</p><p><strong>Conclusion: </strong>Response to omalizumab treatment was influenced by the presence of an AID and baseline serum total IgE level. A concurrent autoimmune thyroid disease was found to be an independent risk factor affecting failed treatment response. Factors that can predict response to omalizumab treatment can help guide patients to more effective treatment.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Old Questions, new answers: real-world long-term efficiency of hymenoptera venom immunotherapy: prevalance of venom-induced anaphylaxis, risk factors, and field sting reactions.","authors":"Zeynep Yegin Katran, Ismet Bulut, Zeynep Ferhan Özşeker","doi":"10.15586/aei.v53i2.1237","DOIUrl":"10.15586/aei.v53i2.1237","url":null,"abstract":"<p><strong>Background: </strong>Hymenoptera venom allergy is a potentially life-threatening allergic reaction. Venom immunotherapy (VIT) is recommended to prevent severe allergic reactions. Field stings indicate the effectiveness of immunotherapy.</p><p><strong>Objective: </strong>The aim of this study was to investigate the prevalence of venom-induced anaphylaxis, risk factors, and field sting reactions during or after the completion of VIT.</p><p><strong>Methods: </strong>In this study, the records of patients who underwent VIT between 2015 and 2023 at one of the largest referral hospitals in Turkey were retrospectively analysed. The protocol followed during the initiation of immunotherapy, adverse reactions, clinical characteristics of the patients (including demographic characteristics, allergic diseases, laboratory findings), and field sting reactions during and after completion of immunotherapy were analysed.</p><p><strong>Results: </strong>A total of 194,526 unique patient files evaluated in the Allergy Outpatient Clinic between 2015 and 2023 were analysed. Of these, 384 patients were admitted with an allergic complaint following a bee sting. Among them, 113 patients (29.4%) were eligible for VIT. A total of 79 patients were included (F/M: 41/38). VIT was performed with honeybee venom in 39 patients, vespid venom in 36 patients, and both venoms in 4 patients. 62.0% (n=49) of the patients had been stung by a bee in the head and neck region. 69.6% (n=55) of the patients had a stage 3 reaction before VIT. The cluster scheme was applied to 54.4% (n=43) of all patients. There was no statistically significant difference in the number of field stings or the use of adrenaline autoinjectors between the VIT groups (p>0.05). Stage 3-4 reactions developed in 87.8% of patients stung in the head and neck region, compared to 53.3% of patients stung in other regions. During and after VIT, field stings were reviewed both from patient files and by follow-up inquiries during control visits. During VIT, field stings were observed in 19 patients. Systemic allergic reactions developed in 5 patients, and local allergic reactions developed in 6 patients; no allergic complaints were observed in 8 patients. After VIT was discontinued, 56 field sting reactions developed in 25 patients. Local allergic reactions developed in 9 patients, but no systemic allergic reactions were observed. Mastocytosis was diagnosed in a patient whose tryptase level was 42.4 and whose c-kit mutation was positive following haematological evaluation.</p><p><strong>Conclusions: </strong>This study confirms that the prevalence of venom-induced anaphylaxis was calculated to be 0.058%. Being stung in the head and neck region was identified as a risk factor for the development of stage 3-4 (severe allergic reactions).</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"82-88"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerance to cooked egg in infants with risk factors for egg allergy after early introduction of baked egg.","authors":"Claudia Rosillo Gil, Davinia Vázquez, Adrianna Machinena-Spera, Mª Del Mar Folqué Jiménez, Jaime Lozano-Blasco, Rosa Jiménez Feijoo, Olga Domínguez Sánchez, Monica Piquer Gibert, Marcia Dias Costa, Montserrat Alvaro-Lozano","doi":"10.15586/aei.v53i2.1257","DOIUrl":"10.15586/aei.v53i2.1257","url":null,"abstract":"<p><p>Egg allergy (EA),along with cow's milk allergy (CMA) and atopic dermatitis (AD is one of the most frequent allergies in children. Tolerance to food allergens seems to be related to the early and regular intake and the cooking method. The objective of this study is to prove that the introduction of baked eggs at 4-6 months of age and its daily maintenance for 6 months prevents EA. Controlled randomized clinical trial from February 2019 to November 2023 was done for all patients under 6 months of age, including those with CMA and/or AD without previous egg consumption. Skin prick test (SPT), specific immunoglobulin E (sIgE), basophil activation test (BAT), and oral food challenge (OFC) on baked eggs were performed at the beginning of the study (T0). Patients were classified into group A (nontolerant to baked egg) following an egg-free diet and group B (tolerant to baked egg). These were randomized into B1 who ate baked egg daily and B2 who avoided egg. Six months later, at time 1 (T1), an OFC to hard-boiled egg was performed. There were 27 patients in all. Those who ate baked egg daily for 6 months tolerated boiled eggs and only 47.4% of patients who followed an egg-free diet tolerated boiled eggs (<i>P</i>-value 0.012). All three tests-sIgE, SPT, and BAT-are considered good techniques to discriminate between tolerant versus not tolerant patients toward eggs.Patients under 6 months of age with CMA and/or AD who ate baked eggs daily for 6 months tolerated cooked eggs more frequently than patients who avoided eggs. Early introduction of baked eggs could prevent EA.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"59-66"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization profile of Thai children with fish allergy.","authors":"Supaluk Tangvalelerd, Surapon Piboonpocanun, Unchalee Raungsirarak, Manaporn Sirichuwong, Pakit Vichyanond, Punchama Pacharn","doi":"10.15586/aei.v53i2.1209","DOIUrl":"10.15586/aei.v53i2.1209","url":null,"abstract":"<p><strong>Introduction: </strong>Fish allergies are common food allergies, and in Thailand, the prevalence of fish allergies in children ranges from 0.29% to 1.1%. Common fish allergens include parvalbumin, enolase, and aldolase.</p><p><strong>Method: </strong>This cross-sectional study included children with immunoglobulin E (IgE)-mediated fish allergies. The diagnosis was based on clinical history with a positive skin prick test (SPT) and/or specific IgE (sIgE). Serum IgE binding profiles to allergens in fish extracts were analyzed.</p><p><strong>Result: </strong>Eleven children, with a median age of 3 years, were recruited; the median age of onset was 1.25 years. Cutaneous symptoms were the most frequent clinical manifestation (63.6%). Tilapia and catfish were the most common triggers. All participants showed positive SPT and/or sIgE results for fish species. The immunoblot analysis revealed IgE binding to 40-50 kDa protein in all participants, while only seven participants (63.6%) showed IgE binding to the 11 kDa protein.</p><p><strong>Conclusion: </strong>Tilapia and catfish are the most common triggers of fish allergies in Thai children. The 40-50 kDa proteins were identified as a major fish allergen in tested cohort.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"108-112"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic and NSAI drug-induced enterocolitis syndrome?","authors":"Öner Özdemir","doi":"10.15586/aei.v53i2.1301","DOIUrl":"https://doi.org/10.15586/aei.v53i2.1301","url":null,"abstract":"","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"24-25"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the diagnostic accuracy of the IgE crosslinking-induced luciferase expression (EXiLE) method for walnut allergy.","authors":"Hikaru Sugita, Yuji Mori, Tetsushi Yoshikawa, Yasuto Kondo","doi":"10.15586/aei.v53i2.1267","DOIUrl":"10.15586/aei.v53i2.1267","url":null,"abstract":"<p><strong>Background: </strong>Walnut (<i>Juglans regia</i>) frequently triggers nut allergies in the United Kingdom and in the United States, with increasing cases in Japan. While oral food challenges (OFCs) are the definitive method for diagnosing these allergies, they pose the risk of symptom provocation, necessitating safer alternative tests. Our aim here was to evaluate the diagnostic utility of IgE (immunoglobulin E) crosslinking-induced luciferase expression (EXiLE) for walnut allergy compared with the walnut-specific IgE (sIgE) test, Jug r 1-sIgE test, and skin prick test (SPT).</p><p><strong>Methods: </strong>This retrospective study analyzed 55 patients tested for walnut allergy (WA) at Fujita Health University Bantane Hospital from January 2021 to December 2023. Among them, 38 had allergic reactions to walnuts based on history or OFCs and 17 did not. We evaluated the sensitivity, specificity, positive predictive value, negative predictive value, and the area under the curve (AUC) of the receiver operating characteristic curve.</p><p><strong>Results: </strong>The EXiLE method (AUC = 0.938) exhibited superior diagnostic accuracy compared to the walnut-sIgE and comparable performance to Jug r 1-sIgE and SPT. The optimal cutoff value of 1.26-fold change demonstrated high sensitivity (0.92), specificity (0.88), positive predictive value (0.92), and negative predictive value (0.82). The EXiLE method yielded positive results in all three cases with negative Jug r 1-sIgE (< 0.35 U_A/mL).</p><p><strong>Conclusion: </strong>The EXiLE method showed high sensitivity and specificity for diagnosing WA, indicating its potential clinical utility. Furthermore, the combination of Jug r 1-sIgE and EXiLE may enhance diagnostic accuracy. Future large-scale studies are warranted to confirm these findings and establish comprehensive diagnostic protocols.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"89-99"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Delphi consensus on diagnosis, management, and treatment with allergen immunotherapy of polysensitized children in Spain: CAPP study, Part 2.","authors":"Ana I Tabar, Helena Larramona Cabrera, Cristina Rivas-Juesas, Francisco J Canals Candela, Maria Del Mar Folqué, Miguel Tortajada-Girbés, Ana Martínez-Cañavate, José Manuel Lucas Moreno, María Mesa-Del-Castillo","doi":"10.15586/aei.v53i2.1221","DOIUrl":"10.15586/aei.v53i2.1221","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to evaluate the level of agreement between specialists in pediatric allergology regarding the diagnosis and indications for allergen immunotherapy (AIT) for dust mites, molds, animal dander, and Hymenoptera venom allergen, as well as mixtures of several allergen sources in polysensitized children in Spain.</p><p><strong>Materials and methods: </strong>A Delphi study was performed using an online survey designed by a committee of pediatric AIT experts: 46 and 44 panelists participated in Rounds 1 and 2, respectively. In Round 1, 204 statements on 8 dimensions were evaluated (Diagnosis, Therapeutic management, and Pollens - Part I; Mites, molds, animals, hymenoptera venom, and mixtures - Part II). A total of 148 statements were finally accepted after Round 2. Panel members rated their level of agreement with assessments on a 9-point Likert scale based on acceptance by ≥ 66.7 of them.</p><p><strong>Results: </strong>Panel experts recommended molecular diagnosis for dust mite allergy diagnosis in polysensitized pediatrics and mixtures of nonhomologous mites (<i>Dermatophagoides</i> and <i>Lepidoglyphus</i>) for optimal AIT management. Subcutaneous AIT with mold extracts is recommended, but no agreement was reached on mixing different mold types. Panel experts agreed that Fel d 1 and Can f 1 sIgE are better predictors for animal dander allergy , but no agreement exists on the acceptance of AIT with dander mixtures. Panelists accepted that Api m 2 (hyaluronidase) sIgE indicates <i>Vespid</i> and <i>Apis mellifera</i> cross-reactivity in children; and Api m 4 (melittin) sIgE is a marker of risk for systemic reaction with AIT in <i>Apis mellifera</i> allergy. According to the consensus, SCIT is more suitable for allergen mixtures than SLIT. and agreement was reached for pollen allergens and <i>Alternaria alternata</i> mixtures if stability, safety, and efficacy have been demonstrated.</p><p><strong>Conclusions: </strong>This Delphi study provides, where evidence is lacking, current expert-based opinions on clinical decision-making for managing polysensitized children.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"141-159"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the connection: asthma and endometriosis - a comprehensive systematic review and meta-analysis.","authors":"Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, Negar Ansari, Shima Shokrzadeh, Seyyed Shamsadin Athari","doi":"10.15586/aei.v53i2.1276","DOIUrl":"10.15586/aei.v53i2.1276","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Asthma and endometriosis are two prevalent chronic conditions that affect a significant portion of the population. Both conditions have been linked to inflammatory processes and immune dysregulation, suggesting the possibility of a shared pathophysiological mechanism. Despite the growing interest in the connection between asthma and endometriosis, the current literature remains inconclusive. This systematic review and meta-analysis aim to consolidate the available evidence and provide a comprehensive understanding of the association between asthma and endometriosis.</p><p><strong>Materials and methods: </strong>We searched Embase, PubMed, Scopus, Web of Science, and Google Scholar to identify studies that met our criteria. The random effects model was used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for individuals with endometriosis and non-endometriosis controls who have asthma. Additionally, we performed subgroup analyses based on geographic region to identify potential sources of heterogeneity. The research protocol was registered on PROSPERO (CRD42024567249).</p><p><strong>Results: </strong>Six eligible case-control studies involving 66,997 cases and 3,253,658 controls were used to examine the association between asthma and endometriosis. Through a comprehensive search and analysis of relevant studies, a significant association between asthma and endometriosis was identified (OR: 1.786, 95% CI: 1.511-2.111, P < 0.001). The correlation showed significant heterogeneity in the study (I² = 75.709; P-value = 0.001), with geographic region identified as a significant factor contributing to this variation.</p><p><strong>Conclusion: </strong>Our meta-analysis demonstrates a significant link between asthma and endometriosis, highlighting the need for comprehensive management that addresses both conditions.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"42-49"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of administration route of allergen immunotherapy: Rates and causes.","authors":"Cristina Rivas-Juesas, Ana Delgado Vicente","doi":"10.15586/aei.v53i2.1196","DOIUrl":"10.15586/aei.v53i2.1196","url":null,"abstract":"<p><p>Allergen immunotherapy (AIT) has shown efficacy in the short and the long term in the management of allergic respiratory diseases, and it's administered subcutaneously (subcutaneous immunotherapy, or SCIT) or sublingually (sublingual immunotherapy, or SLIT), being both effective and safe options.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"10-12"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell-derived exosomes improved septic lung injury by reducing excessive NETs formation and alleviating inflammatory response.","authors":"Ting Zou, Jianshuang Lu, Yanke Zhu, Yue Xu, Yuanyuan Sun","doi":"10.15586/aei.v53i1.1238","DOIUrl":"10.15586/aei.v53i1.1238","url":null,"abstract":"<p><p>To illustrate the potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in mitigating septic lung injury by reducing the excessive formation of neutrophil extracellular traps (NETs), a mouse model of septic lung injury was induced through cecal ligation and puncture (CLP). The mice received intraperitoneal injections of MSC-Exos. Post injection, pathological alterations of the lung tissue were evaluated through HE staining, and the levels of inflammatory markers in each mouse group at various time points were assessed using ELISA kits. The presence of NETs markers in lung tissue (colocalization of CitH3 and MPO) was determined via immunofluorescence, and the levels of dsDNA in mouse serum were measured using a dsDNA kit. The findings indicated noticeable damage in the sepsis group postsurgically, whereas the severity of lung tissue damage was significantly diminished in mice of the MSC-Exos group. By the 72-h mark after the CLP procedure, there was an elevation in TNF-α, IL-6, IL-1β, and IL-10. Compared to the CLP group, the inflammatory factors in the serum of mice from the CLP + MSC-Exo group were higher at 12 and 24 h but decreased at the 72-h point. Furthermore, the fluorescence intensity of CitH3 and MPO and the dsDNA content increased in the CLP group mice over different time intervals, with MSC-Exos reversing these changes. In summary, MSC-Exos effectively suppressed sepsis-induced NETs formation and ameliorated lung injury.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"63-68"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}