Allergologia et immunopathologia最新文献

{"title":"Delayed hypersensitivity reaction to cetirizine suggesting involvement of piperazine ring: a case report.","authors":"Florence Libon, Juliette Caron, Anne Herman, A F Nikkels","doi":"10.15586/aei.v54i3.1531","DOIUrl":"10.15586/aei.v54i3.1531","url":null,"abstract":"<p><p>Antihistamines (AHs) are widely prescribed for allergic conditions and are generally considered safe, with adverse reactions being rare. We report a case highlighting the possible involvement of piperazine ring in a delayed hypersensitivity reaction. A 25-year-old woman with a history of atopic dermatitis progressively developed a maculopapular drug eruption following intake of cetirizine. Patch testing was negative, but oral provocation with cetirizine reproduced the rash, confirming its causal role. Importantly, oral provocation with ciprofloxacin, which also contains a piperazine ring, elicited a similar reaction, supporting that this structural moiety itself was responsible for hypersensitivity. Alternatively, AHs lacking the piperazine ring, such as in bilastine and rupatadine, were well tolerated. This case provides the first direct evidence of delayed hypersensitivity manifesting as a maculopapular drug eruption, probably because of the piperazine ring, with cross-reactivity observed between structurally unrelated drugs. Clinicians should be aware of the potential for structural moiety-driven hypersensitivity to prevent recurrence across different drug classes.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 3","pages":"184-187"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic HBV infection, stemness pathways, and compromised immune surveillance in HCC development.","authors":"Negin Razaghi, Ashraf Kariminik, Mehdi Ranjbar, Morteza Bahaaldin-Beygi","doi":"10.15586/aei.v54i3.1411","DOIUrl":"10.15586/aei.v54i3.1411","url":null,"abstract":"<p><p>Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). This review elucidates the molecular pathways by which HBV promotes the expression of the stemness transcription factors OCT4, Sox2, and NANOG. Through a comprehensive literature review, we found that HBV enhances their expression via multiple mechanisms. These include HBxAg-induced chromatin remodeling, activation of histone demethylase KDM5B, and integration of the truncated HBx-ΔC protein into the host genome. Furthermore, chronic inflammation driven by persistent HBV infection acts as a key driver for their overexpression. This dysregulation is strongly associated with increased tumor proliferation, metastasis, and poor prognosis in HBV-infected HCC patients. Consequently, OCT4, Sox2, and NANOG emerge as promising biomarkers for early detection and prognosis, as well as potential therapeutic targets. Modulating their activity could offer novel strategies for targeted treatment. In conclusion, HBV-induced alterations in these transcription factors represent critical oncogenic mechanisms in HCC. Further research is essential to develop novel therapeutic approaches that regulate their activity, ultimately improving clinical outcomes for patients.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 3","pages":"222-228"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B12 allergy and desensitization.","authors":"Öner Özdemir","doi":"10.15586/aei.v54i3.1723","DOIUrl":"https://doi.org/10.15586/aei.v54i3.1723","url":null,"abstract":"","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 3","pages":"229-230"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between interleukin-27 and <i>Dermatophagoides</i>-specific IgE responses in children with allergic rhinitis and asthma.","authors":"Elif Azarsiz, Handan Duman Senol, Ezgi Topyildiz, Figen Gulen, Esen Demir","doi":"10.15586/aei.v54i3.1564","DOIUrl":"10.15586/aei.v54i3.1564","url":null,"abstract":"<p><strong>Purpose: </strong>House dust mite (HDM) allergy is a common cause of allergic rhinitis (AR) and allergic asthma (AA). Interleukin-27 (IL-27) is known to suppress Th2-mediated inflammation, a key driver of these diseases. This study aimed to assess regional sensitization to <i>Dermatophagoides</i> subspecies and to investigate the association between HDM-specific IgE responses and serum IL-27 levels.</p><p><strong>Methods: </strong>Fifty-eight children with HDM allergy were evaluated, of whom 53 were sensitized to D. Pteronyssinus. Serum Der p 1/Der p 2 specific IgE (sIgE) (FEIA) and IL-27, IL-5, and IL-13 levels (ELISA) were measured. Twenty-five healthy children served as controls.</p><p><strong>Results: </strong>Among patients (43% AR, 57% AA), Der p 1 and Der p 2 sensitization rates were 49% and 55%, respectively. Both Der p 1/Der p 2 sIgE levels were significantly elevated compared to controls (p < 0.001). Although IL-27 levels were lower in patients, the difference was not statistically significant (p = 0.98). However, IL-27 showed positive correlations with IL-5, IL-13, and Der p 1 sIgE (all p < 0.05). IL-27 levels were unexpectedly higher in Der p 1-sensitized patients (p = 0.006), particularly in AR (p = 0.02; r = 0.43), but not in AA.</p><p><strong>Conclusions: </strong>This is the first clinical study to investigate the relationship between IL-27 and HDM-sIgE in children and to demonstrate a phenotype-specific interaction. IL-27 may act as a context-dependent immunomodulator rather than a simple Th2 suppressor. The positive correlation between IL-27 and Der p 1 sIgE in AR patients may indicate a compensatory feedback mechanism triggered by allergen-specific inflammation.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 3","pages":"17-23"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to bedside: advances in standardized oral immunotherapy and early predictors of persistent cow's milk allergy in children.","authors":"Asena Pinar Sefer, Elif Karakoc Aydiner","doi":"10.15586/aei.v54isp1.1638","DOIUrl":"10.15586/aei.v54isp1.1638","url":null,"abstract":"<p><p>Immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) remains the most prevalent pediatric food allergy and a major cause of early-life anaphylaxis, with a substantial proportion of children developing persistent disease despite traditional avoidance-based management. Oral immunotherapy (OIT) has emerged as a proactive strategy that modulates the allergic immune response through controlled and sustained allergen exposure, shifting immunity from T-helper (Th) 2-dominant pathways toward a more regulatory and tolerogenic profile. Current evidence from randomized trials and real-world cohorts demonstrates that cow's milk oral immunotherapy (CM-OIT) achieves desensitization in most treated children, reduces accidental reaction risk, and improves quality of life, although sustained unresponsiveness remains variable and protocol-dependent. Marked heterogeneity exists across protocols regarding dosing, antigen formulation, maintenance targets, and escalation speed, reflecting differing therapeutic philosophies rather than standardized practice. Safety concerns, including dose-related reactions and rare cases of eosinophilic esophagitis, underscore the need for careful patient selection, optimization of comorbid atopic diseases, and shared decision-making. Advances in precision immunology, including component-resolved diagnostics, epitope mapping, basophil activation testing, and emerging transcriptomic and microbiome signatures, now enable the earlier identification of children at high risk of persistent CMA who may benefit most from OIT, while low-risk phenotypes can be safely observed. Adjunctive biologic therapy, particularly anti-IgE agents, has improved tolerability and expanded eligibility in high-risk patients. This review synthesizes current evidence on efficacy, safety, biomarkers, protocols, and adjunctive strategies, emphasizing a personalized, risk-adapted approach to CM-OIT and outlining future directions toward standardized formulations, biomarker-guided stratification, and integrated biologic-assisted immunomodulation.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 S Pt 1","pages":"18-27"},"PeriodicalIF":2.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Deciphering the mechanism of cimifugin in mitigating LPS-induced neuroinflammation in BV-2 cells.","authors":"Zhang Bu, Shan Xu, Feng Xu","doi":"10.15586/aei.v54i2.1764","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1764","url":null,"abstract":"<p><p>This corrects the article DOI: 10.15586/aei.v52i4.1107.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"186-187"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Lysine hydroxylase 1 (PLOD1) regulates glucose metabolism and promotes Th17 cell differentiation in psoriasis.","authors":"Zhen Yue, Wanlu Zhang, Gege Zhu, Huiya Sun, Congjun Jiang","doi":"10.15586/aei.v54i2.1761","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1761","url":null,"abstract":"<p><p>This corrects the article DOI: 10.15586/aei.v53i2.1269.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"185"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Isoorientin alleviates ovalbumin-stimulated allergic rhinitis in mice by restoring Th1/Th2 balance.","authors":"Jianyi Huang, Ran Ji, Xueshen Qian, Yuli Shen","doi":"10.15586/aei.v54i2.1760","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1760","url":null,"abstract":"<p><p>This corrects the article DOI: 10.15586/aei.v52i5.1154.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"184"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Knockdown of ANXA3 regulates NF-κB/STAT3 pathway to alleviate inflammation and hyperproliferation in psoriasis models.","authors":"Jin Li, Fang Ren, Hongshan Yuan, Wenliang Yan","doi":"10.15586/aei.v54i2.1759","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1759","url":null,"abstract":"<p><p>This corrects the article DOI: 10.15586/aei.v53i2.1260.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"183"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: DUOX1 inhibits the progression of rheumatoid arthritis by regulating the NF-κB pathway in vitro.","authors":"Dan Xuan, Dandan Feng, Fuyong Qianga, Yonghui Xia","doi":"10.15586/aei.v54i2.1758","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1758","url":null,"abstract":"<p><p>This corrects the article DOI: 10.15586/aei.v53i2.1293.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"181-182"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}