Allergologia et immunopathologia最新文献

{"title":"Correlation patterns among house dust mite allergens in allergic rhinitis: A molecular sensitization study in Mallorca.","authors":"Sendy Chugo, Jaime Pons, Danilo Escobar, Daniel Hervás","doi":"10.15586/aei.v53i6.1407","DOIUrl":"10.15586/aei.v53i6.1407","url":null,"abstract":"<p><strong>Introduction: </strong>Molecular characterization of house dust mite (HDM) and storage mite allergens provides valuable insights into sensitization patterns; however, relationships among different mite allergens and their clinical implications remain unclear.</p><p><strong>Methods: </strong>A total of 100 patients with allergic rhinitis sensitized to <i>Dermatophagoides pteronyssinus</i> were analyzed. Specific IgE (sIgE) levels were measured using singleplex and multiplex assays. Correlations among mite allergens and their associations with clinical and demographic variables were evaluated.</p><p><strong>Results: </strong>The median sIgE level to Der p was 15.8 kU/L (IQR: 50.25); no relevant Dermatophagoides spp. sensitization was found below 2 kU/L. Among patients with Der p >10 kU/L, 59 of 60 had significant sIgE to at least one major HDM allergen. The highest prevalence was for Der p 1 (92%), though its median level was low (3.19 kU/L, IQR: 8.18). Conversely, Der f 2 had the highest median sIgE (23.4 kU/L, IQR: 33.74). Multivariate analysis revealed that most allergen levels were predictable from clusters of other mite allergens (R²=0.27-0.98). Mite allergen sIgE (Aca s, Blo t 5/10/21, Der f 1/2, Der p 1/2/5/7) correlated positively with sensitization number. sIgE levels negatively correlated with age and positively correlated with atopic dermatitis (Der p 1/2/23, Der f 1/2), asthma (Aca s, Der p 21), food allergy (Aca s, Der f 1, Der p 1), and rural residence (Der p 7).</p><p><strong>Conclusion: </strong>Der p source allergen reliably excludes clinically relevant sIgE to HDM components. The correlations among mite allergens highlight challenges in clinical relevance assessment, emphasizing the need for component-resolved diagnostics to optimize immunotherapy responses.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"73-85"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and treatment outcomes in children with IgG subclass deficiency: A retrospective study.","authors":"Filiz Demir Şahin, Ozan Kapçay, Mehmet Kılıç","doi":"10.15586/aei.v53i6.1401","DOIUrl":"10.15586/aei.v53i6.1401","url":null,"abstract":"<p><strong>Introduction: </strong>Immunoglobulin G (IgG) subclass deficiencies are among the most common primary immunodeficiencies in children and are associated with increased susceptibility to infections. This study aimed to investigate the clinical features, associated immunological conditions, and treatment outcomes in affected pediatric patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 43 patients diagnosed with IgG subclass deficiency at the Allergy and Immunology Clinic of Fırat University between January 2019 and July 2024. Clinical records were reviewed for demographic data, immunoglobulin levels, and history of infections. The impact of prophylactic treatments-including intravenous immunoglobulin (IVIG), oral bacterial lysates, and antibiotics-on the frequency of infection was evaluated.</p><p><strong>Results: </strong>Among the 43 patients, 32 (74.4%) were male and 11 (25.6%) were female, with a mean age at diagnosis of 6.77 ± 2.30 years. The most common clinical presentation was recurrent upper respiratory tract infections, reported in 23 patients (53.5%). Isolated IgG3 deficiency was identified in 34 patients (79.1%). During follow-up, normalization of IgG levels was achieved in 39 patients (90.7%), with a mean time to normalization of 2.1 ± 1.19 years. Prophylactic interventions significantly reduced the annual infection rate from 18.12 ± 10.37 to 3.09 ± 2.40 (p < 0.001).</p><p><strong>Conclusion: </strong>IgG subclass deficiencies represent a significant health concern in children because of their association with recurrent infections. Early diagnosis and the implementation of appropriate prophylactic treatment strategies are crucial in reducing infection frequency and improving the quality of life. However, the retrospective nature of the study and the relatively small sample size may have limited the evaluation of clinical outcomes and treatment responses, potentially affecting the generalizability of the results. Despite these limitations, the findings highlight the potential benefits of prophylactic interventions in managing infections among children with IgG subclass deficiencies and emphasize the need for larger, prospective studies to inform evidence-based therapeutic strategies for this population.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"55-60"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fucoxanthin mitigates inflammation and angiogenesis in rheumatoid arthritis via regulation of the PPAR-γ/CTGF pathway.","authors":"Ximing Zhao, Xingli Zhou, Famin Li","doi":"10.15586/aei.v53i6.1425","DOIUrl":"https://doi.org/10.15586/aei.v53i6.1425","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that causes joint pain and significantly impairs patients' quality of life. Fucoxanthin, a naturally occurring carotenoid found in seaweeds and diatoms, has been reported to exert various therapeutic effects in multiple pathological conditions. However, its regulatory role in the pathogenesis of RA remains largely undefined.</p><p><strong>Methods: </strong>Cell viability was assessed using the cell counting kit-8 (CCK-8) assay, while cell migration and invasion were evaluated through the wound healing and Transwell assays, respectively. Angiogenic potential was determined by the tube formation assay. The levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β, and IL-8, were measured using enzyme-linked-immunosorbent serologic assay. Intracellular reactive oxygen species (ROS) levels were analyzed via DCFH-DA staining, and protein expression was evaluated by Western blot analysis.</p><p><strong>Results: </strong>Fucoxanthin significantly suppressed tumor necrosis factor-α (TNF-α)-induced proliferation of MH7A synovial cells. Additionally, TNF-α stimulation enhanced cell migration and invasion, whereas these effects were reversed with fucoxanthin treatment. TNF-α also promoted angiogenesis, as evidenced by an increased number of tube formations, which were markedly reduced by fucoxanthin in a dose-dependent manner (control; TNF-α; TNF-α + fucoxanthin [2 μM]; and TNF-α + fucoxanthin [4 μM], with respective values of 1.33 ± 0.58; 26 ± 3.61; 17 ± 2.65; and 8.33 ± 1.53; P < 0.001). Moreover, fucoxanthin alleviated TNF-α-induced inflammatory cytokine release and oxidative stress. Mechanistically, fucoxanthin was found to regulate the PPAR-γ/CTGF signaling pathway.</p><p><strong>Conclusion: </strong>Fucoxanthin may attenuate inflammation and angiogenesis in RA by modulating the PPAR-γ/CTGF pathway, suggesting its potential as a therapeutic agent for managing RA.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"109-116"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluatıon of the taste, smell, and appearance of formulas used ın the management of cow's mılk proteın allergy: A multıcenter, prospectıve, sıngle-blınd, cross-sectıonal observatıonal study (CONTEST-2).","authors":"Hulya Anıl, Deniz Ozceker, Merve Karaca Sahin, Aysen Bingol, Fatma Dilara Kocacık Uygun, Mustafa Arga, Dilek Kacar, Metin Aydogan, Nezihe Nefise Uluc, Arzu Bakırtas, Hacer Ilbilge Ertoy Karagol, Zeynep Cavdar, Feride Candan, Figen Gulen, Handan Duman Senol, Pınar Uysal, Duygu Erge, Zeynep Ulker Altınel, Sibel Gürbüz, Koray Harmancı","doi":"10.15586/aei.v53i6.1470","DOIUrl":"10.15586/aei.v53i6.1470","url":null,"abstract":"<p><p>The main drawback of hypoallergenic formulas for cow's milk protein allergy (CMPA) is their low palatability. This study aims to examine the decisions made by mothers of infants diagnosed with CMPA and physicians regarding the taste of extensively hydrolyzed formulas (eHFs), amino acid-based formulas (AAFs), and rice-based formulas. This single-blind, multicenter study was conducted in nine pediatric allergy centers across Türkiye and included 181 pediatricians and 137 mothers of children with CMPA. Seven substitution formulas without added sweeteners or additional flavorings available on the market were tested: Two AAFs (Neocate-Numil^®, Alfamino-Nestlé^®), one AAF with synbiotics (Pregomin Syneo-Numil^®), one AAF specifically designed to meet the nutritional and lifestyle needs of children over 1 year of age (Neocate Junior-Numil^®), one synbiotic eHF (Aptamil Pepti Syneo-Numil^®), and two rice protein-based formulas (Evolvia RP1-Montero^® and Evolvia RP2-Montero^®). A sensory evaluation was conducted using a single-blind protocol, following the methodology previously applied in the CONTEST-1 study. Neocate Junior-Numil^® was the most preferred product in terms of taste, smell, and appearance, as rated by both mothers and physicians. It was the most preferred formula by both mothers (49.6%) and physicians (62.4%) in terms of taste. Aptamil Pepti Syneo-Numil^® ranked second (32.8% for mothers, 42.0% for physicians), followed by Evolvia RP2-Montero^® (23.4%) for mothers and Alfamino-Nestle^® (22.1%) for physicians. The fact that both mothers and physicians most frequently preferred Neocate Junior-Numil^® suggests that sensory characteristics of formulas used in CMPA management-such as taste, smell, and appearance-may play a decisive role in treatment adherence. This finding highlights the importance of considering not only nutritional adequacy but also acceptability when selecting a formula.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"94-101"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lonicerin alleviates LPS-evoked inflammation and apoptosis in HK2 cells.","authors":"Xuemei Hu, Huibin Chen, Qinghong Zhang, Xiuyan Shi, Yong Zhang, Shengli Hu","doi":"10.15586/aei.v53i6.1494","DOIUrl":"10.15586/aei.v53i6.1494","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-induced acute kidney injury (AKI) is one of the most common complications of sepsis, characterized by extensive renal inflammation and progressive tissue damage, and poses a serious threat to human health. Lonicerin, a flavonoid glycoside derived from <i>Lonicera japonica</i> Thunb., is reported to exert beneficial effects in various inflammatory diseases. However, its potential regulatory role in sepsis-induced AKI has not been elucidated completely.</p><p><strong>Objective: </strong>To investigate the regulatory impacts of lonicerin in sepsis-induced AKI.</p><p><strong>Material and methods: </strong>The cell viability was evaluated through CCK-8 assay. The LDH levels were examined through the LDH assay kit. The mRNA expression levels were analyzed through RT-qPCR. The levels of TNF-α, IL-6, and IL-1β were determined through ELISA. The ROS levels were detected through the DCF staining. Apoptosis rates were determined by flow cytometry. Protein expression levels were analyzed by western blot.</p><p><strong>Results: </strong>In this study, we demonstrated that lonicerin enhanced the viability of HK2 cells following lipopolysaccharide (LPS) stimulation. LPS significantly increased the inflammatory response, whereas this effect was attenuated after treatment with lonicerin. Furthermore, lonicerin effectively suppressed LPS-induced oxidative stress. In addition, although LPS stimulation promoted apoptosis in HK2 cells, this pro-apoptotic effect was largely counteracted by administration of lonicerin. Mechanistically, we found that activation of the nuclear factor kappa-B signaling pathway by LPS was inhibited in the presence of lonicerin.</p><p><strong>Conclusion: </strong>our findings provide that lonicerin can mitigate LPS-induced inflammation, oxidative stress, and apoptosis in HK2 cells. These results suggest that lonicerin may represent a promising therapeutic candidate for treating sepsis-induced AKI.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"117-125"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bronchial mucoza and minor salivary gland byopsy in patients with sarcoidosis by flow volume maneuver.","authors":"Zeynep Yegin Katran, Mustafa Erelel","doi":"10.15586/aei.v53i6.1516","DOIUrl":"10.15586/aei.v53i6.1516","url":null,"abstract":"<p><strong>Introductıon: </strong>The aim of our study was to determine predicting endobronchial sarcoidosis by considering minor salivary gland involvement, pulmonary function test, and bronchoscopic images.</p><p><strong>Material and methods: </strong>A total of 219 cases of sarcoidosis were retrospectively investigated. All cases were analyzed for age, gender, cigarette consumption, proven sarcoidosis skin biopsy, erythema nodosum, eye examination, minor salivary gland biopsy (MSGB), pulmonary functional evaluation, DLCO, six-minute walk test, angiotensin-converting enzyme level, erythrocyte sedimentation rate, radiologic stages, biopsies for diagnosis, bronchoscopic mucosal appearance, and biopsy results.</p><p><strong>Results: </strong>A total of of 219 cases (M:41, F:178); mean age was 45.9 ± 11.8 (20-75). Erythema nodosum in 67 (30.6%) cases. Radiological stages: Grade 0: 15 (6.9%), Grade 1: 104 (47.6%), Grade 2: 67 (30.5%), Grade 3: 22 (10%), and Grade 4: 11(5%). Of the total cases, 215 (98.1%) were diagnosed with at least one invasive procedure; 155 (70.7%) were from two or more sites. Sarcoidosis involvement of endobronchial mucosa with bronchoscopic imaging was found in 25 (16%); mucosal biopsy was found in 64 (41%); microscopic findings suggestive of sarcoidosis were observed in 30 (46.9%). Forty (18.2%) cases had obstructive pattern in the end airway. Thirty (46.9%) cases were diagnosed with endobronchial sarcoidosis by mucosal biopsy, and terminal airway stenosis was seen in seven (23.3%) cases. In patients diagnosed with endobronchial sarcoidosis by mucosal biopsy, terminal airway stenosis was observed in 23.3%, compared with 18.2% in the overall cohort. Bronchoscopic mucosal biopsy was positive in 25.8% (n= 8) of the cases with positive MSGB. Eight cases had MSGB, and findings were suggestive of sarcoidosis in the bronchoscopic appearance. The number of cases with positive mucosal biopsy results was 62.5% (n=5); a weak, significant correlation was found between positivity of MSGB and bronchoscopic transbronchial lymph node aspiration. There was also a weak, significant correlation between MSGB and bronchoscopic mucosal biopsy positivity. A statistically weak correlation was found between MSGB and bronchoscopic appearance and endobronchial sarcoidosis involvement.</p><p><strong>Conclusion: </strong>MSGB positivity can be used to predict bronchoscopic direct examination and mucosal biopsy positivity.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"102-108"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerance induction to LTP in patients with anaphylaxis: Serological response markers.","authors":"Antonio Carbonell Martínez, Alejandra Gonzalez Perez, Soledad Zamarro Parra, R A Sola Martinez","doi":"10.15586/aei.v53i6.1431","DOIUrl":"10.15586/aei.v53i6.1431","url":null,"abstract":"<p><strong>Introduction: </strong>Allergy to lipid transfer proteins (LTP) is one of the leading causes of anaphylaxis in the Mediterranean region. Oral immunotherapy, sublingual immunotherapy (SLIT), with peach extract has emerged as a strategy to induce tolerance.</p><p><strong>Objective: </strong>This study aimed to evaluate the efficacy of SLIT with peach extract and the usefulness of serological biomarkers as predictors of clinical response in patients with LTP-related anaphylaxis.</p><p><strong>Methods: </strong>Observational study involving 80 patients diagnosed with LTP syndrome. Total IgE levels, specific IgE, and IgG4 specific to Pru p 3 were measured before and after 1 year of treatment. Patients were classified based on tolerance at the end of therapy.</p><p><strong>Results: </strong>Sixty-one patients (76.3%) tolerated the final oral challenge. Baseline levels of total IgE, specific IgE, and IgG4 specific to Pru p 3 were significantly higher in the tolerance group. IgG4 levels increased significantly in both groups after treatment. Specific IgE levels increased only in the nontolerance group.</p><p><strong>Conclusions: </strong>SLIT with peach extract may induce tolerance in the majority of patients with LTP allergy. Elevated baseline levels of total IgE, specific IgE, and IgG4 specific to Pru p 3 could serve as markers of clinical response.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"185-190"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-guided probiotic metabolite therapy for acne vulgaris to target <i>Cutibacterium acnes</i> CAMP factors through <i>Pediococcus acidilactici</i> BCBH1 fatty acids.","authors":"Jasra Naseeb, Abid Sarwar, Yang Zhennai, Tariq Aziz, Manal F Elkhadragy, Maher S Alwethaynani, Areej A Alhhazmi, Deema Fallatah, Mai M Almsaud, Wafa A Alshehri, Saleh A Alsanie, Nouf Abdullah Alharbi","doi":"10.15586/aei.v53i6.1497","DOIUrl":"10.15586/aei.v53i6.1497","url":null,"abstract":"<p><p>Acne vulgaris is a chronic inflammatory skin disorder predominantly caused by <i>Cutibacterium acnes</i> and its virulence-associated CAMP (Christie-Atkins-Munch-Petersen) factors, particularly CAMP1 and CAMP2, which contribute to inflammation and bacterial survival. With increasing antibiotic resistance and concerns over microbiome disruption from conventional treatments, probiotic-derived postbiotics present a promising alternative. This study aimed to investigate the anti-acne potential of fatty acids produced by <i>Pediococcus acidilactici</i> BCBH1, targeting CAMP1 and CAMP2 proteins of <i>C. acnes</i> using a network pharmacology-guided approach. Metabolite profiling via GC-MS identified vaccenic acid as a major fatty acid metabolite (4.88 mg/L at 48 h under 10% linoleic acid stress). Virulence prediction confirmed high pathogenicity of CAMP1 (score 0.9055) and CAMP2 (score 0.9927). Molecular docking revealed strong binding affinities of vaccenic acid to CAMP1 and CAMP2 with binding energies of -9.6 kJ/mol and -9.3 kJ/mol, respectively, outperforming traditional anti-acne compound 4-terpineol (-9.0 kJ/mol and -8.7 kJ/mol). Molecular dynamics simulations further validated the stable interaction of vaccenic acid with CAMP proteins over 100 ns. Pharmacokinetic analyses indicated vaccenic acid's favorable absorption and safety profiles with no blood-brain barrier permeability. These findings highlight vaccenic acid as a potent, microbiome-friendly therapeutic candidate for acne management. Future work should focus on experimental validation, formulation development, and combinatorial strategies to enhance clinical efficacy and safety.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"126-140"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with disease duration in chronic spontaneous urticaria: A short- to midterm evaluation.","authors":"Selma Yeşilkaya","doi":"10.15586/aei.v53i6.1403","DOIUrl":"10.15586/aei.v53i6.1403","url":null,"abstract":"<p><p>This retrospective study was conducted to identify clinical, demographic, and biochemical factors associated with prolonged disease duration in chronic spontaneous urticaria (CSU) by including adults diagnosed with CSU between October 2023 and October 2024. Laboratory data examined included complete blood counts, C-reactive protein, hemoglobin, and serum iron, as well as specific measurements such as anti-thyroperoxidase antibodies and antinuclear antibody (ANA) positivity and total IgE. Age (at initial visit), sex, disease duration, presence of angioedema were retrieved from electronic records. Disease duration was calculated as the time from symptom onset to the most recent episode based on local hospital records and the Turkish Ministry of Health's National Health System (e-nabız) records. The population size was 203 (~70% females), with a mean age of 40.27 ± 15.03 years. Disease duration was unassociated with age (p = 0.794) and sex (p = 0.366). Angioedema and ANA positivity were respectively detected in 43.35% and 52.26% of patients, but were not associated with disease duration (p = 0.301 and p = 0.824). Notably, patients with a disease duration of >12 months had significantly lower total IgE (p = 0.042) and higher basophils (p = 0.019) compared to those with shorter disease duration. No significant relationships were found when disease duration was classified with thresholds of 24, 36, or 60 months. Basophil count was the only parameter with a very weak but significant correlation with disease duration (r = 0.142, p = 0.044). These results suggest that prolonged CSU duration may be associated with basophil counts and IgE levels; however, it appears that these relationships are weak and likely non-linear. Further research is needed to better understand whether quantifiable parameters might have use in predicting CSU-related characteristics.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"1-6"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single food allergy and reasons for multiple exclusions: A prospective study.","authors":"Paula Mendonça P S Gomes, Isadora C M Francescantonio, Mayra B Dorna, Antonio C Pastorino, Ana Paula M Castro","doi":"10.15586/aei.v53i6.1388","DOIUrl":"10.15586/aei.v53i6.1388","url":null,"abstract":"<p><p>Food Allergies (FA) presents an increasing global challenge, influenced by factors such as genetic predisposition, ethnicity, age, and cultural dietary practices. Patients diagnosed with IgE-mediated FA must adhere to strict dietary restrictions to avoid potential life-threatening anaphylactic reactions. Such restrictions are crucial but come with significant consequences as increased nutritional risks, higher costs for special meal preparations and medical care with potential social and psychological impacts on both the individual and their family The impact of FA on quality of life is frequently surrounded by persistent fear of adverse reactions after consuming certain foods. To better understand the behavior of patients with FA this study aims to explore whether patients with confirmed IgE-mediated FA tend to exclude other foods and to identify possible reasons for such exclusions.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 6","pages":"206-208"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}