Allergologia et immunopathologia最新文献

{"title":"Research progress of Sinomenium in the treatment of rheumatoid arthritis and suggestions for future research.","authors":"Guanghui Zhou, Zhuoxu Gu, Xianquan Zhang, Lingfeng Zeng, Jun Liu","doi":"10.15586/aei.v53iSP1.1204","DOIUrl":"https://doi.org/10.15586/aei.v53iSP1.1204","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic autoimmune joint disease. Its main pathological manifestations are joint cartilage, bone tissue injury, synovial hyperplasia, and chronic inflammation. At present, the pathogenesis of the disease has not been fully defined, and delaying the disease to improve joint function is the existing treatment. Sinomenium (SIN) is an effective ingredient in <i>Sinomenium acutum</i> (Thunb.) Rehd. et Wils., with anti-inflammatory, analgesic, immunosuppressive, anti-tumor, and other pharmacological activities, which is quite effective in the treatment of RA. There are many SIN compound preparations in the market, such as Zhengqing Fengtongning capsule, Zhubi Huoluo prescription, and Qinxitong tablet. They all exhibit good anti-RA effect with less adverse reactions. This study summarized the mechanism of action of SIN in the treatment of RA and further explored the possibility of SIN in the treatment of RA combined with other diseases for future research.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 S Pt 1","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in serum periostin levels in uncontrolled asthma in children (DADO phase 2 study).","authors":"Alicia Habernau Mena, Maria Angela Gonzalo Garijo, Victoria Del Pozo Abejón, Francisco Félix Rodríguez Vidigal","doi":"10.15586/aei.v53i1.1134","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1134","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is an inflammatory airway condition and the most common chronic disease in children. However, there is a lack of biological markers for asthma, especially in children. This study aimed to analyze the changes in periostin levels in children with uncontrolled asthma after 12 months of optimized management. The secondary objectives were to evaluate the changes in symptoms, exacerbations, and other biomarkers after 12 months of follow-up.</p><p><strong>Methods: </strong>This was an observational, prospective study of children aged 5 to 14 with uncontrolled asthma who visited the Hospital Materno Infantil of Badajoz's Allergy Unit between September 2015 and June 2016. At the first visit and after a 12-month follow-up, lung function, asthma control test (ACT/cACT), quality of life by PAQLQ (Paediatric Asthma Quality of Life Questionnaire), blood eosinophils, total and specific IgE, and serum periostin levels were assessed. Periostin levels were also analyzed in a control group.</p><p><strong>Results: </strong>After the 12-month follow-up, the percentage of symptoms, the proportion of patients with FEV1 <80%, and the levels of blood eosinophils decreased, whereas ACT and PAQLQ increased. Children with uncontrolled asthma showed high serum periostin concentrations on their first visit (901.48 ng/ml), which decreased after 12 months (67.93 ng/ml) (p<0.001). In the control group, periostin levels were 56.12 ng/ml. The sensitivity and specificity of periostin were 77.8% and 54.8%, respectively, for the diagnosis of controlled and uncontrolled asthma.</p><p><strong>Conclusion: </strong>Our study showed that periostin levels in children with uncontrolled asthma decreased with the correct treatment after asthma control.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with asthma symptoms in Colombian subpopulations aged 1 to 17 and 18 to 59: Secondary analysis of the study \"Prevalence of asthma and other allergic diseases in Colombia 2009-2010\".","authors":"Elizabeth Garcia, María X Rojas, Maria C Ardila, Martín A Rondón, Augusto Peñaranda, Ana M Barragán, Adriana Pérez, Sergio Moreno, Lina Sotaquirá, Luis Caraballo, Rodolfo J Dennis","doi":"10.15586/aei.v53i1.1122","DOIUrl":"10.15586/aei.v53i1.1122","url":null,"abstract":"<p><strong>Background: </strong>Asthma, a chronic inflammatory lung disease, is one of the leading causes of disability, demands on health resources, and poor quality of life. It is necessary to identify asthma-related risk factors to reduce the presence and development of symptoms.</p><p><strong>Objective: </strong>This study aimed to explore the association of multiple possible factors with asthma symptoms in two subpopulations, children, adolescents, and adults, in six cities in Colombia.</p><p><strong>Materials and methods: </strong>This was an observational analytical case-control study based on a cross-sectional study conducted as a secondary analysis of the prevalence of asthma and other allergic diseases in Colombia during 2009 and 2010. Weighted logistic regressions were conducted for each population.</p><p><strong>Results: </strong>Out of the 5978 subjects in the cross-sectional survey, 747 were identified as cases, and 3109 were identified as controls. The prevalence of asthma was 30.8% in the child and adolescent population and 14.7% in the adult population. Among the various factors studied, those associated with asthma symptoms in children/adolescents were: a family history of asthma (OR 2.4; 95% CI 1.3-4.7) and rhinitis (OR 2.0; 95% CI 1.1-3.6); acetaminophen consumption at least once a month (OR 3.6; 95% CI 2.1-6.2); and the presence of birds at home (OR 2.0; 95% CI 1.1-3.8). Regarding food consumption: fruit consumption (OR 3.8; 95% CI 1.1-12.7). In adults, the factors that showed significant association were: a family history of allergic diseases (rhinitis OR 3.3; 95% CI 2.3-4.6), atopic eczema (OR 4.4; 95% CI 2.8-7.0), or asthma (OR 1.8;95% CI 1.3-2.6); acetaminophen consumption at least once a month (OR 2.0; 1.5-2.8); the presence of dogs at home (OR 1.4;95% CI 1.03-1.8), exposure to second-hand smoke (OR 1.7; 95% CI 1.2-2.2), and exposure to exhaust fumes during the day (OR 1.7; 95% CI 1.04-2.7).</p><p><strong>Conclusions: </strong>Our findings suggest that different cultural, environmental, and family factors are associated with asthma symptoms in children and adolescents, and these associations are evident in both males and females.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"69-85"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased expression of hsa-miR-142-3p and hsa-miR-155-5p in common variable immunodeficiency and involvement of their target genes and biological pathways.","authors":"Tayebeh Ranjbarnejad, Alieh Gholaminejad, Hassan Abolhassani, Roya Sherkat, Mansoor Salehi, Mohammadreza Sharifi","doi":"10.15586/aei.v53i1.1234","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1234","url":null,"abstract":"<p><p>Common variable immunodeficiency (CVID) is the most common symptomatic and heterogeneous type of inborn errors of immunity (IEI). However, the pathogenesis process of this disease is often unknown. Epigenetic modifications may be involved in unresolved patients. MiR-142 and miR-155 were identified as immune system modulators and dysregulated in autoimmune and inflammatory diseases. We assessed hsa-miR-142-3p and hsa-miR-155-5p expression in a selected cohort of unresolved CVID cases and identified experimentally validated targets of these miRNAs. We constructed a protein-protein interaction (PPI) network from the common targets of two miRNAs and determined the hub genes. The hub genes' expression was investigated in GEO datasets. Gene ontology (GO) and pathway enrichment analysis were done for target genes. Hsa-miR-142-3p and hsa-miR-155-5p expression were significantly reduced in CVID patients. Evaluation of the PPI network demonstrated some hub genes in which pathogenic mutations have been reported in IEI, and other hub genes directly contribute to immune responses and the pathophysiology of IEI. Expression analysis of hub genes showed that they were significantly dysregulated in validating the CVID cohort. The pathway enrichment analysis indicated the involvement of the FOXO-mediated signaling pathway, TGFβ receptor complex, and VEGFR2-mediated vascular permeability. Considering the dysregulation of hsa-miR-142-3p and hsa-miR-155-5p in CVID and the known role of their target genes in the immune system, their involvement in the pathogenesis of CVID can be suggested.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"153-169"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Basophil Activation Test in the Diagnosis of Pediatric Egg Allergy in Turkey: A Comparison of Clinical and Laboratory Findings with Real-Life Data.","authors":"Şefika İlknur Kökcü Karadağ, Fadıl Öztürk, Recep Sancak, Alişan Yıldıran","doi":"10.15586/aei.v53i1.1187","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1187","url":null,"abstract":"<p><strong>Background: </strong>Egg allergy is among the most common food allergies in children, significantly affecting the dietary habits and quality of life of both the affected children and their families. This study aims to assess the clinical role of the Basophil Activation Test (BAT) in children with egg allergy and to evaluate its diagnostic accuracy in comparison to other tests.</p><p><strong>Methods: </strong>The study included 46 children with egg allergy. Patients were classified into three groups: IgE-mediated, non-IgE-mediated, and mixed-type allergies. Each patient underwent a Skin Prick Test, serum-specific IgE test, BAT, and Oral Food Challenge. The sensitivity and specificity of each diagnostic test were evaluated.</p><p><strong>Results: </strong>Egg SpIgE positivity was observed in all patients with IgE-mediated allergy (100%) and in 77.78% of those with mixed-type allergy, while only 47.1% of patients with non-IgE-mediated allergy were positive (p = 0.008). BAT positivity was significantly higher in IgE-mediated (72.7%) and mixed-type allergies (50.0%) compared to non-IgE-mediated allergies (17.6%) (p = 0.013). Compared to the oral provocation test, Egg SpIgE had a sensitivity of 0.73 and specificity of 0.33, BAT had a sensitivity of 0.46 and specificity of 0.67, and SPT had a sensitivity of 0.44 and specificity of 0.60. Although Egg SpIgE demonstrated the highest sensitivity, its low specificity makes it less reliable for accurately identifying non-allergic individuals. In contrast, BAT, with its highest specificity and moderate sensitivity, aligns more closely with the oral provocation test in accurately diagnosing egg allergy.</p><p><strong>Conclusion: </strong>When comparing the positivity rates of Egg SpIgE, BAT, and SPT according to allergy types, IgE-mediated allergies showed significantly higher positivity rates. BAT demonstrated high specificity and moderate sensitivity in both IgE-mediated and mixed-type allergies, making it the most compatible test with the oral provocation test for the accurate diagnosis of egg allergy. Given that this test is currently used only for research purposes in our country, it is recommended that BAT be more widely adopted in clinical practice in accordance with guideline recommendations.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"32-39"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive ımmune system evaluation in familial mediterranean fever: clinical and ımmunological analysis.","authors":"Sefika Ilknur Kokcu Karadag, Fatih Eren, Zeynep Gizem Gündüz, Alisan Yıldıran","doi":"10.15586/aei.v53i1.1185","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1185","url":null,"abstract":"<p><strong>Background: </strong>Familial Mediterranean Fever is a common genetic autoinflammatory disease prevalent in the Mediterranean region. The clinical course of the disease is characterized by fever and serositis attacks. While defects in the innate immune system are known to play a role in the pathogenesis of the disease, the impact of the adaptive immune system remains unclear. Therefore, the main objective of this study is to analyze the adaptive immune system cells in FMF patients and investigate their relationship with the disease.</p><p><strong>Methods: </strong>Our study includes 88 FMF patients with confirmed MEFV gene mutations. The demographic characteristics, clinical symptoms, genetic profiles, treatment methods, and any accompanying diseases of the patients were thoroughly examined. Additionally, lymphocyte subpopulations were analyzed using flow cytometry, and inflammatory markers and immunoglobulin levels were evaluated.</p><p><strong>Results: </strong>Significant differences were observed in the distribution of adaptive immune system cells in FMF patients compared to the healthy reference group. In the analysis of lymphocyte subgroups, levels of CD3, CD4, CD19, CD16+56+, CD3CD4CD45RACD31, CD4+CD45RA+, CD8+CD45RA+, CD19+CD27+IgD+IgM+, CD19+CD27+IgD-IgM-, and CD19+CD38+CD21 were found to be lower compared to healthy individuals. Additionally, CD8, CD19+CD27-IgD+, and CD3/CD8/TCRGD cells were found to be higher. Moreover, in FMF patients with accompanying diseases, CD3, CD4, and CD19 values were statistically lower (p<0.001).</p><p><strong>Conclusion: </strong>This study reveals that adaptive immune system cells are affected in FMF patients, suggesting their significant role in the disease's pathophysiology. Immunological evaluations should be prioritized in the management of FMF, enabling personalized treatment plans for more effective outcomes.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"26-31"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of STAU1 inhibits inflammation and autophagy in <i>in vitro</i> chronic obstructive pulmonary disease model by regulating AMPK-mTOR signaling pathway.","authors":"Rixi Xie, Fang Wang","doi":"10.15586/aei.v53i1.1218","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1218","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, airway obstruction, and lung damage, often triggered by cigarette smoke. Dysregulated autophagy and inflammation are key contributors to its progression. Although double-stranded RNA-binding protein Staufen homolog 1 (STAU1), a multifunctional protein primarily involved in mRNA transport and localization, is identified as a potential biomarker, its role in COPD pathogenesis remains unclear. This study investigates the effects of STAU1 knockdown on inflammation and autophagy in an <i>in vitro</i> COPD model. We found that STAU1 expression was significantly elevated in the <i>in vitro</i> COPD model. Knockdown of STAU1 led to a marked reduction in inflammation in cigarette smoke extract (CSE)-induced non-tumorigenic human bronchial epithelial cells (BEAS-2B). Additionally, STAU1 knockdown suppressed autophagy in CSE-induced BEAS-2B cells. Mechanistically, it inhibited the activation of the adenosine monophosphate-activated protein kinase-mechanistic target of rapamycin (AMPK/mTOR) pathway. In summary, STAU1 knockdown inhibits inflammation and autophagy by modulating the AMPK/mTOR axis. Targeting STAU1 could provide new avenues for the treatment of COPD.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"146-152"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of 1 mcg/mL as the starting dose in cluster protocol for hymenoptera immunotherapy.","authors":"Mohammad Hassan Bemanian, Saba Arshi, Mohammad Nabavi, Morteza Fallahpour, Sima Shokri, Niusha Sharifinejad, Sima Bahrami","doi":"10.15586/aei.v53i1.1151","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1151","url":null,"abstract":"<p><strong>Background: </strong>Hymenoptera venom allergy is a potentially severe allergic reaction in the general population. The only preventative approach in these cases is venom immunotherapy (VIT), which follows different protocols. The recommended initial dose is 0.001-0.1 mcg of venom extract. However, few reports have declared the safety of 1 mcg venom as the starting dose.</p><p><strong>Methods: </strong>The study was conducted on Iranian patients with a history of anaphylaxis to venom. Skin tests confirmed hypersensitivity to honeybee, yellow jacket, and/or paper wasp from subfamily Polistes using <i>Apis melifera, Vespula spp</i>, and <i>Polistes spp</i> venom extracts, respectively. Subsequently, the patients were treated with the cluster protocol.</p><p><strong>Results: </strong>Twenty-two patients (17 males and 5 females, aged 28.3±11.8 years) were enrolled in the study. Skin prick tests and intradermal tests showed positive results for yellow jacket in 17 (77.3%) and 21 (95.4%) patients, honeybee in 14 (63.6%) and 17 (77.3%) patients, and wasp in 14 (63.6%) and 17 (77.3%) patients, respectively. Upon administering the initial dose of 1 mcg/mL, 40.9% (9 cases) of patients presented mild local reactions, including 7 with yellow jacket allergy, 5 with honeybee allergy, and 3 with wasp allergy. One patient with yellow jacket allergy had a mild systemic reaction. Patients with a positive skin test for wasp had significantly lower rate of reactions after the first dose of venom (p=0.026). Throughout the entire build-up phase, more than 90% (20 of 22) of patients experienced mild local reactions, followed by large local reactions (3 cases, 13.6%), mild systemic reactions (1 case at 1 mcg/mL dose), and moderate-to-severe systemic reactions (3 cases, 13.6%). Large local and moderate-to-severe systemic reactions were detected after injecting 50 mcg (each one case) and 100 mcg (each 2 cases) of venom extracts.</p><p><strong>Conclusion: </strong>This study recommends 1 mcg/mL of the venom extract as a safe starting dose for VIT. This accelerated protocol could successfully reduce the time and costs of therapy for patients undergoing out-patient cluster VIT.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"86-90"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of formula type on the prognosis of allergic proctocolitis due to cow's milk allergy.","authors":"Mehmet Halil Çeliksoy, Sezin Naiboglu, Erdem Topal, Şefika İlknur Kökçü Karadağ, Ercan Yılmaz, Hamit Bologur","doi":"10.15586/aei.v53i1.1240","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1240","url":null,"abstract":"<p><strong>Background: </strong>Food protein-induced allergic proctocolitis is a nonimmunoglobulin E-mediated, self-limited food allergy of the rectum and the colon. Cow's milk protein is the most common allergen responsible for the disease.</p><p><strong>Objective: </strong>This study aimed to investigate the roles of different types of formulas in building early tolerance to food protein-induced allergic proctocolitis in infants.</p><p><strong>Methods: </strong>The medical records of 45 pediatric patients diagnosed with proctocolitis due to cow's milk allergy between August 2021 and August 2023 and whose disease progression was followed in three tertiary care centers were reviewed retrospectively.</p><p><strong>Results: </strong>The study included 45 patients who were diagnosed with proctocolitis due to cow's milk allergy (24 males, 21 females; median age: 4 months). Among them, 24 patients were fed an amino acid-based formula, and 21 (46.7%) patients were fed an extensively hydrolyzed formula. The average age of acquisition of cow's milk tolerance was lower in the group fed with the amino acid-based formula than in the group fed with extensively hydrolyzed formula (P = 0.038). Furthermore, the group fed with amino acid-based formula had a shorter tolerance period than the group fed with the extensively hydrolyzed formula group (P = 0.044).</p><p><strong>Conclusion: </strong>Compared to an extensively hydrolyzed formula, an amino acid-based formula led to the early development of tolerance in children with allergic proctocolitis induced by cow's milk.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"126-130"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the correct use of intranasal aerosols and symptom improvement in allergic rhinitis.","authors":"Gabriela Galindo Rodríguez, Karen Patricia Chávez Jiménez, Sandra Nora González Díaz, Carlos Macouzet Sánchez, Cindy Elizabeth de Lira Quezada","doi":"10.15586/aei.v53i1.1200","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1200","url":null,"abstract":"<p><strong>Objective: </strong>Allergic rhinitis (AR) is highly prevalent worldwide. Good patient adherence ensures successful treatment. This study aimed to identify the association between the intranasal aerosol technique and symptom improvement.</p><p><strong>Methods: </strong>This is an analytical, prospective, and longitudinal study that included 36 patients diagnosed with AR. The Rhinitis Control Assessment Test (RCAT) questionnaire was administered to both an experimental population and a control group. The 11 steps of the intranasal aerosol technique were explained to the experimental group, and performance was graded using a pamphlet for patient follow-up in subsequent controls.</p><p><strong>Results: </strong>Of the participants, 63.9% were women and 36.1% were men, with a median age of 30 years (IQR 24-42) and an age range from 18 to 69 years. An average RCAT percentage of 55.6% was observed in both groups during the first consultation. On the second visit, a difference in disease control was noted. In the experimental group, 83.3% had controlled symptoms, whereas only 61.1% of the control group did. At the third visit, 76.5% of the experimental group had controlled symptoms, compared to 58.8% of the control group. In the experimental group, 52.9% of patients demonstrated good technique, while only 5.9% in the control group did (p=0.004).</p><p><strong>Conclusions: </strong>Patient education and training, compared to an untrained group, benefit the patient by aiding in the remission of symptoms and improving quality of life.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"55-62"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}