Allergologia et immunopathologia最新文献_第5页

Morusin attenuates LPS-induced inflammation and oxidative stress in lung epithelial cells by inhibiting NLRP3 inflammasome activation. 松茸素通过抑制NLRP3炎性体激活，减轻lps诱导的肺上皮细胞炎症和氧化应激。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1365

Yan Li, Li Zhang

{"title":"Morusin attenuates LPS-induced inflammation and oxidative stress in lung epithelial cells by inhibiting NLRP3 inflammasome activation.","authors":"Yan Li, Li Zhang","doi":"10.15586/aei.v53i4.1365","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1365","url":null,"abstract":"Acute lung injury (ALI) is a pulmonary disorder characterized by severe lung tissue damage and inflammation. Morusin (a flavone, a type of flavonoid; C25H24O6), a flavonoid isolated from mulberry root bark, possesses notable anti-inflammatory and antioxidant properties. However, its regulatory effects on ALI progression remain unclear. This study aimed to investigate whether morusin could mitigate the development of ALI. Morusin was shown to enhance cell viability and reduce apoptosis in lipopolysaccharide (LPS)-stimulated A549 cells. Furthermore, morusin alleviated inflammation by decreasing the levels of interleukin-1β (IL-1β), IL-6, and prostaglandin E2 (PGE2) in LPS-challenged A549 cells. In addition, morusin effectively reduced oxidative stress in these cells. Mechanistically, morusin was found to suppress the activation of NLRP3 (nucleotide-binding domain, leucine rich-containing family, pyrin domain containing 3) inflammasome in LPS-stimulated A549 cells. Finally, this study demonstrated for the first time that morusin ameliorates LPS-induced inflammation and oxidative stress in lung epithelial cells by inhibiting both nuclear factor kappa B signaling pathway and NLRP3 inflammasome activation. However, this project was limited to cell experiments, and no animal experiments or clinical verifications were conducted. Our findings suggest that morusin could serve as a promising therapeutic agent for the treatment of ALI.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"112-118"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating large language models for WAO/EAACI guideline compliance in hereditary angioedema management. 评估遗传性血管性水肿治疗中WAO/EAACI指南依从性的大型语言模型。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1353

Mehmet Emin Gerek, Tuğba Önalan, Fatih Çölkesen, Şevket Arslan

{"title":"Evaluating large language models for WAO/EAACI guideline compliance in hereditary angioedema management.","authors":"Mehmet Emin Gerek, Tuğba Önalan, Fatih Çölkesen, Şevket Arslan","doi":"10.15586/aei.v53i4.1353","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1353","url":null,"abstract":"Introduction: Hereditary angioedema (HAE) is a rare but potentially life-threatening disorder characterized by recurrent swelling episodes. Adherence to clinical guidelines, such as the World Allergy Organization/European Academy of Allergy & Clinical Immunology (WAO/EAACI) guidelines, is crucial for effective management. With the increasing role of artificial intelligence in medicine, large language models (LLMs) offer potential for clinical decision support. This study evaluates the performance of ChatGPT, Gemini, Perplexity, and Copilot in providing guideline-adherent responses for HAE management.Methods: Twenty-eight key recommendations from the WAO/EAACI HAE guidelines were reformulated into interrogative formats and posed to the selected LLMs. Two independent clinicians assessed responses based on accuracy, adequacy, clarity, and citation reliability using a five-point Likert scale. References were categorized as guideline-based, trustworthy, or untrustworthy. A reevaluation with explicit citation instructions was conducted, with discrepancies resolved by a third reviewer.Results: ChatGPT and Gemini outperformed Perplexity and Copilot, achieving median accuracy and adequacy scores of 5.0 versus 3.0, respectively. ChatGPT had the lowest rate of unreliable references, whereas Gemini showed inconsistency in citation behavior. Significant differences in response quality were observed among models (p < 0.001). Providing explicit sourcing instructions improved performance consistency, particularly for Gemini.Conclusion: ChatGPT and Gemini demonstrated superior adherence to WAO/EAACI guidelines, suggesting that LLMs can support clinical decision-making in rare diseases. However, inconsistencies in citation practices highlight the need for further validation and optimization to enhance reliability in medical applications.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"51-59"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute typical food protein-induced enterocolitis syndrome triggered by egg white: Two case reports. 蛋清诱发急性典型食物蛋白性小肠结肠炎综合征2例报告

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1345

Kosei Yamashita, Yuki Okada, Ikuya Sasaki, Sawa Seki, Toshiyuki Takagi, Megumi Okawa, Aiko Honda, Chihiro Kunigami, Mayu Maeda, Taro Kamiya, Takanori Imai

{"title":"Acute typical food protein-induced enterocolitis syndrome triggered by egg white: Two case reports.","authors":"Kosei Yamashita, Yuki Okada, Ikuya Sasaki, Sawa Seki, Toshiyuki Takagi, Megumi Okawa, Aiko Honda, Chihiro Kunigami, Mayu Maeda, Taro Kamiya, Takanori Imai","doi":"10.15586/aei.v53i4.1345","DOIUrl":"10.15586/aei.v53i4.1345","url":null,"abstract":"Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE)-mediated food allergy characterized by gastrointestinal symptoms such as vomiting and diarrhea. Since 2018, hen's egg yolk has been the most common trigger for FPIES in Japan, whereas typical egg white (TEW) FPIES remains rare. Herein, we present two cases of acute TEW FPIES in young children. A 17-month-old girl experienced recurrent vomiting and lethargy following egg white ingestion, despite previously tolerating half an egg yolk and 5 g of egg white. Initial tests showed no sensitization markers (egg white-specific IgE < 0.1 kUA/L; ovomucoid [OVM]-specific IgE < 0.1 kUA/L; skin prick test [SPT] negative). Three oral food challenges (OFCs) at 6-month intervals at our hospital all triggered vomiting and lethargy. Procalcitonin and thymus- and activation-regulated chemokine levels remained elevated for 24 hours, and even after 31 months, the patient had not achieved egg white tolerance. A 14-month-old girl presented with vomiting and lethargy after egg white ingestion while on a strict egg yolk- and egg white-free diet. Blood tests again showed no sensitization markers (egg white-specific IgE < 0.1 kUA/L; OVM-specific IgE < 0.1 kUA/L; SPT negative). Two OFCs at 6-month intervals confirmed FPIES, and even after 2 years, the patient had not achieved egg white tolerance. These cases highlight that egg white can trigger FPIES. Thorough medical history taking and diagnostic evaluation, including OFCs, are essential to distinguish FPIES from immediate-type food allergies.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"141-145"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of the European baseline series patch test in the geriatric population. 欧洲基线系列斑贴试验在老年人群中的结果。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1387

Merve Erkoç, Güzin Özden, Leyla Çevirme, Reyhan Sevil Cansunar, Hakan Basır, Susamber Dik

{"title":"Outcomes of the European baseline series patch test in the geriatric population.","authors":"Merve Erkoç, Güzin Özden, Leyla Çevirme, Reyhan Sevil Cansunar, Hakan Basır, Susamber Dik","doi":"10.15586/aei.v53i4.1387","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1387","url":null,"abstract":"Background: Skin aging causes various immunological and structural changes and increases the risk of many skin diseases such as contact dermatitis.Objective: Our aim was to share the allergen contact dermatitis sensitivities of the elderly population with the European baseline series (EBS) results.Materials and methods: Patients aged 65 years and older who were patch tested with EBS in the immunology and allergy clinic between January 1, 2018, and March 1, 2025, were included in the study.Results: The median age of the 62 patients included in the study was 69.5 years (25-75, 66.0-73.3 years); 54.8% of the patients were female; and 82.3% of the patients were under the age of 75. The rate of at least one positive patch test was 41.9%, and no positivity was observed in approximately half of the allergens included in the EBS. The rate of at least one positive test result was 37.3% in the 65-74 age group and 63.6% in the 75-84 age group (p = 0.177). The rate of at least one positive test result was 35.3% in women and 50% in men (p = 0.243). The most common allergen over the age of 65 was fragrance mix I (11.3%), followed by potassium dichromate (9.7%) and fragrance mix II (9.7%) in equal proportions.Conclusion: It is also very necessary to create an \"elderly baseline series\" by avoiding unnecessary allergens that are not detected as positive in patch tests. In addition, increasing the number of studies in geriatric patients will help in understanding trends in contact allergy.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"128-133"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of mast cell P815 for evaluating FcεRI-dependent and FcεRI-independent allergic effects. 肥大细胞P815在评价fc ε ri依赖性和fc ε ri非依赖性过敏反应中的应用。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1264

Ryosuke Misawa, Kazuhito Takemoto, Masaki Iji, Luo Hao, Akari Koresawa, Hiroyuki Watanabe

{"title":"Utility of mast cell P815 for evaluating FcεRI-dependent and FcεRI-independent allergic effects.","authors":"Ryosuke Misawa, Kazuhito Takemoto, Masaki Iji, Luo Hao, Akari Koresawa, Hiroyuki Watanabe","doi":"10.15586/aei.v53i4.1264","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1264","url":null,"abstract":"Introduction and objectives: The degranulation and release of inflammatory mediators mediated by the high-affinity immunoglobulin E (IgE) receptor (FcεRI) on mast cells in response to allergen contact is the driving force of anaphylaxis. This study shows that P815 cells, which were previously thought not to express FcεRI, cause a reaction similar to FcεRI-mediated degranulation in the presence of antigen and IgE.Materials and methods: The kinetics of degranulation were evaluated by comparing P815 cells with FcεRI-expressing a rat basophilic leukemia (RBL-2H3) (that typically indicates the specific clone or subline within that cell line) cell lines. Degranulation activity was measured using the release rate of β-hexosaminidase as an indicator. P815 cells showed significant degranulation when compound 48/80 or anti-dinitrophenyl (DNP)-IgE antibody and DNP-human serum albumin (HSA) antigen were added simultaneously. Gene expression analysis confirmed the expression of each FcεRI subunit-specifically, the γ subunit expressed markedly. Moreover, the expression of the phosphorylation enzymes Lyn, spleen tyrosine kinase (Syk), Fyn, and Bruton tyrosine kinase (Btk), which are involved in degranulation, was upregulated.Results: FcεRI has three subunits: α, β, and γ. P815 cells do not express FcεRI because they have messenger ribonucleic acid (mRNA) for the γ subunit but not for the α and β subunits. However, P815 expressed each subunit protein (α, β, and γ), as detected in the western blotting analysis of cell extracts in the presence of DNP-HSA antigen and anti-DNP-IgE.Conclusion: These results suggest that P815 may cause degranulation via FcεRI. Therefore, P815 is considered to be a cell model that can evaluate both FcεRI-mediated and FcεRI-independent degranulation reactions in response to allergens.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"119-127"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of response to omalizumab in patients with chronic spontaneous urticaria. 慢性自发性荨麻疹患者对omalizumab反应的生物标志物。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1343

Özge Öztürk Aktaş, Dilek Öksüzer Çimşir, Esra Nur Bülbül, Neyran Şerbetçi, Türkan Zeynep Fendoğlu, Esra İnan, Begüm Görgülü Akın, Şengül Beyaz, Zeynep Çelebi Sözener, Şadan Soyyiğit

{"title":"Biomarkers of response to omalizumab in patients with chronic spontaneous urticaria.","authors":"Özge Öztürk Aktaş, Dilek Öksüzer Çimşir, Esra Nur Bülbül, Neyran Şerbetçi, Türkan Zeynep Fendoğlu, Esra İnan, Begüm Görgülü Akın, Şengül Beyaz, Zeynep Çelebi Sözener, Şadan Soyyiğit","doi":"10.15586/aei.v53i4.1343","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1343","url":null,"abstract":"Background and objectives: Managing chronic spontaneous urticaria (CSU) resistant to anti-histamines remains challenging, and predictors of omalizumab efficacy are not fully understood. This study evaluated omalizumab's effectiveness, response patterns, and predictors in CSU patients.Materials and methods: A retrospective analysis was conducted on 72 patients receiving omalizumab for at least six months. Factors influencing response to anti-IgE therapy were examined.Results: Among the 72 patients with chronic spontaneous urticaria (CSU), 86.1% responded to omalizumab: 58.3% had a good response (UAS-7 <6), 27.8% showed a partial response, and 13.9% were non-responders. Baseline total IgE levels were significantly higher in responders compared to non-responders (good: 291.4 kUA/L vs. 60.2 kUA/L, p = 0.003; partial: 148 kUA/L vs. 60.2 kUA/L, p = 0.049). ROC analysis identified a total IgE cut-off of 64 kUA/L for predicting omalizumab response (AUC: 0.67, p = 0.019; sensitivity: 82%, specificity: 48%). Non-responders had significantly higher erythrocyte sedimentation rates (20.0 mm/h vs. 8.25 mm/h, p = 0.018). Patients with recurrence post-treatment had elevated thyroid-stimulating hormone (TSH) and C-reactive protein (CRP) levels (p = 0.006, p = 0.007). Among responders, 29% had an early response and 71% a late response. Early responders had significantly lower anti-thyroglobulin (anti-TG) and antinuclear antibody (ANA) positivity (p = 0.036, p = 0.035). Systemic inflammatory indices (SII, SIRI) did not predict response.Conclusions: Baseline total IgE may predict omalizumab response, while ANA and anti-TG positivity correlate with delayed response. Elevated TSH and CRP levels may indicate a higher recurrence risk after treatment discontinuation.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"7-13"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitizations to aeroallergens in Israel: Prevalences and profiles. 以色列的空气过敏原致敏：患病率和概况。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1335

Menachem Rottem, Mahmoud Noujedat, Youssef Awni

{"title":"Sensitizations to aeroallergens in Israel: Prevalences and profiles.","authors":"Menachem Rottem, Mahmoud Noujedat, Youssef Awni","doi":"10.15586/aei.v53i4.1335","DOIUrl":"10.15586/aei.v53i4.1335","url":null,"abstract":"Background: Most of the literature on aeroallergen sensitization have been generated in North America and Western Europe.Objectives: To determine aeroallergen sensitization prevalences and patterns among patients with physician-diagnosed allergic rhinitis (AR) in Israel.Methods: We conducted a retrospective, observational study of sensitization to 20 aeroallergen extracts in skin prick tests (SPTs) among consecutive pediatric and adult patients with AR attending the allergy clinic at Emek Medical Center (Afula, Israel) and an affiliated regional outpatient clinic (Nazareth, Israel) from 2021 to 2023.Results: A total of 1993 patients (547 females, 27.4%) were included (median [range] age: 24 [6-82]). The five allergens or groups of allergens with the highest SPT positivity rates were house dust mite (HDM: Dermatophagoides pteronyssinus and D. farinae; 74.8%), tree pollens (44.3%), olive pollen (34.1%), grass pollens (25.6%), and cat dander (22.6%). Of the 1993 patients, 947 (47.5%) had a positive SPT for just one of the 20 tested extracts. Patients sensitized to cat dander were significantly (12-fold) more likely to be sensitized to dog dander and vice versa. Patients living in an urban environment were more likely to be sensitized to cypress pollen (19.3% vs. 12.0% in a nonurban environment; p = 0.002, chi-squared test) and pellitory pollen (21.6% vs. 15.1%, respectively; p = 0.010, chi-squared test). Our suggestion is that in the Middle East, patients with symptoms of AR can be effectively screened with a standard \"European\" panel of allergen extracts for SPTs (such as that suggested by the Global Allergy and Asthma European Network [GA2LEN] organization), plus Johnson grass, Bermuda grass, and oak and eucalyptus pollen extracts.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"101-111"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockdown of ITIH4 reduces inflammatory damage and apoptosis of A549 cells induced by Mycoplasma pneumoniae through NLRP3 inflammation. 敲低ITIH4可通过NLRP3炎症降低肺炎支原体诱导的A549细胞的炎症损伤和凋亡。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1367

Zhinan Zhang, Yixian Zhang, Bihe Zeng

{"title":"Knockdown of ITIH4 reduces inflammatory damage and apoptosis of A549 cells induced by Mycoplasma pneumoniae through NLRP3 inflammation.","authors":"Zhinan Zhang, Yixian Zhang, Bihe Zeng","doi":"10.15586/aei.v53i4.1367","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1367","url":null,"abstract":"Background: Mycoplasma pneumoniae (MP) is a leading cause of community-acquired respiratory infections in pediatric patients. This study aimed to investigate whether the pro-inflammatory function of inter-alpha-trypsin inhibitor heavy chain (ITIH4) contributes to the pathogenesis of MP-induced pneumonia.Method: A549 cells were stimulated with MP to model pneumonia in vitro. ITIH4 expression was knocked down in A549 cells using lentiviral transfection. Cell viability was measured using the Cell Counting Kit-8 (CCK-8) assay, while cell apoptosis was assessed via flow cytometry. The concentrations of pro-inflammatory (IL-6, TNF-α) and anti-inflammatory (IL-10) cytokines were quantified using enzyme-linked immunosorbent assay (ELISA). Western blotting was conducted to detect apoptosis-related proteins and components of the NLRP3 inflammasome.Result: MP stimulation led to increased ITIH4 expression in A549 cells, and knockdown of ITIH4 prevented the MP-induced reduction in cell viability. Moreover, ITIH4 knockdown reduced the release of inflammatory cytokines in response to MP and significantly decreased MP-induced apoptosis. In addition, ITIH4 knockdown inhibited activation of the NLRP3 inflammasome, while reactivation of NLRP3 reversed the protective effects associated with ITIH4 knockdown.Conclusion: ITIH4 knockdown alleviates MP-induced inflammatory damage and cell death in A549 cells by inhibiting activation of the NLRP3 inflammasome.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"14-20"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-life management of gastrointestinal cow's milk protein allergy in Brazilian infants. 巴西婴儿胃肠道牛奶蛋白过敏的现实管理。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i4.1323

Vanessa C C Rodrigues, Marcelo C M Fonseca, Dirceu Solé, Adiana Sanudo, Mauro B Morais

{"title":"Real-life management of gastrointestinal cow's milk protein allergy in Brazilian infants.","authors":"Vanessa C C Rodrigues, Marcelo C M Fonseca, Dirceu Solé, Adiana Sanudo, Mauro B Morais","doi":"10.15586/aei.v53i4.1323","DOIUrl":"https://doi.org/10.15586/aei.v53i4.1323","url":null,"abstract":"Objective: To evaluate physicians' management of non-immunoglobulin E-mediated gastrointestinal cow's milk protein allergy (non-IgE-GI-CMPA) in Brazilian infants.Methods: A total of 447 physicians from all the regions of Brazil answered an online questionnaire concerning their management of formula-fed infants with mild-to-moderate (Case 1) or severe (Case 2) clinical manifestations of non-IgE-GI-CMPA.Results: In total, 95.3% and 86.0% of the interviewed physicians in cases 1 and 2 prescribed a cow's milk elimination diet (p < 0.001). In the initial management, the prescription rates of formulas based on extensively hydrolyzed protein and amino acid were 81.7% and 14.6% for Case 1 and 32.7% and 65.4% for Case 2 (p < 0.001); the percentages of answers for prescriptions of drugs or probiotics were 8.3% and 12.1% in cases 1 and 2 (p < 0.001); and requests for laboratory tests were 12.3% and 37.7 % (p = 0.016). The oral food challenge (OFC) test for the diagnosis of non-IgE-GI-CMPA was indicated by 55.1% and 42.7% of the physicians in cases 1 and 2 (p < 0.001). The OFC test was chosen to assess tolerance development by 92% of the interviewees. Performing the diagnostic OFC (D-OFC) test was positively associated with having board certification in pediatric gastroenterology and < 20 years of professional experience and negatively associated with using baked foods as a protein source in the oral tolerance OFC test.Conclusions: Most interviewees followed the guidelines regarding prescribing an elimination diet; however, many should include the OFC test in diagnosing infants with non-IgE-GI-CMPA. Not performing the D-OFC may have negative consequences on patients and on the public healthcare system.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 4","pages":"68-77"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the interplay between oxidative stress and autophagy in asthma: Pathophysiology and therapeutic potential. 探讨哮喘中氧化应激和自噬之间的相互作用：病理生理学和治疗潜力。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1217

Ying Liu, Tongtong Wang, Yu-Ang Dong, Jun Zhang

引用次数: 0