Allergologia et immunopathologia最新文献

{"title":"Antibiotic and NSAI drug-induced enterocolitis syndrome?","authors":"Öner Özdemir","doi":"10.15586/aei.v53i2.1301","DOIUrl":"https://doi.org/10.15586/aei.v53i2.1301","url":null,"abstract":"","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"24-25"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the diagnostic accuracy of the IgE crosslinking-induced luciferase expression (EXiLE) method for walnut allergy.","authors":"Hikaru Sugita, Yuji Mori, Tetsushi Yoshikawa, Yasuto Kondo","doi":"10.15586/aei.v53i2.1267","DOIUrl":"10.15586/aei.v53i2.1267","url":null,"abstract":"<p><strong>Background: </strong>Walnut (<i>Juglans regia</i>) frequently triggers nut allergies in the United Kingdom and in the United States, with increasing cases in Japan. While oral food challenges (OFCs) are the definitive method for diagnosing these allergies, they pose the risk of symptom provocation, necessitating safer alternative tests. Our aim here was to evaluate the diagnostic utility of IgE (immunoglobulin E) crosslinking-induced luciferase expression (EXiLE) for walnut allergy compared with the walnut-specific IgE (sIgE) test, Jug r 1-sIgE test, and skin prick test (SPT).</p><p><strong>Methods: </strong>This retrospective study analyzed 55 patients tested for walnut allergy (WA) at Fujita Health University Bantane Hospital from January 2021 to December 2023. Among them, 38 had allergic reactions to walnuts based on history or OFCs and 17 did not. We evaluated the sensitivity, specificity, positive predictive value, negative predictive value, and the area under the curve (AUC) of the receiver operating characteristic curve.</p><p><strong>Results: </strong>The EXiLE method (AUC = 0.938) exhibited superior diagnostic accuracy compared to the walnut-sIgE and comparable performance to Jug r 1-sIgE and SPT. The optimal cutoff value of 1.26-fold change demonstrated high sensitivity (0.92), specificity (0.88), positive predictive value (0.92), and negative predictive value (0.82). The EXiLE method yielded positive results in all three cases with negative Jug r 1-sIgE (< 0.35 U_A/mL).</p><p><strong>Conclusion: </strong>The EXiLE method showed high sensitivity and specificity for diagnosing WA, indicating its potential clinical utility. Furthermore, the combination of Jug r 1-sIgE and EXiLE may enhance diagnostic accuracy. Future large-scale studies are warranted to confirm these findings and establish comprehensive diagnostic protocols.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"89-99"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Delphi consensus on diagnosis, management, and treatment with allergen immunotherapy of polysensitized children in Spain: CAPP study, Part 2.","authors":"Ana I Tabar, Helena Larramona Cabrera, Cristina Rivas-Juesas, Francisco J Canals Candela, Maria Del Mar Folqué, Miguel Tortajada-Girbés, Ana Martínez-Cañavate, José Manuel Lucas Moreno, María Mesa-Del-Castillo","doi":"10.15586/aei.v53i2.1221","DOIUrl":"10.15586/aei.v53i2.1221","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to evaluate the level of agreement between specialists in pediatric allergology regarding the diagnosis and indications for allergen immunotherapy (AIT) for dust mites, molds, animal dander, and Hymenoptera venom allergen, as well as mixtures of several allergen sources in polysensitized children in Spain.</p><p><strong>Materials and methods: </strong>A Delphi study was performed using an online survey designed by a committee of pediatric AIT experts: 46 and 44 panelists participated in Rounds 1 and 2, respectively. In Round 1, 204 statements on 8 dimensions were evaluated (Diagnosis, Therapeutic management, and Pollens - Part I; Mites, molds, animals, hymenoptera venom, and mixtures - Part II). A total of 148 statements were finally accepted after Round 2. Panel members rated their level of agreement with assessments on a 9-point Likert scale based on acceptance by ≥ 66.7 of them.</p><p><strong>Results: </strong>Panel experts recommended molecular diagnosis for dust mite allergy diagnosis in polysensitized pediatrics and mixtures of nonhomologous mites (<i>Dermatophagoides</i> and <i>Lepidoglyphus</i>) for optimal AIT management. Subcutaneous AIT with mold extracts is recommended, but no agreement was reached on mixing different mold types. Panel experts agreed that Fel d 1 and Can f 1 sIgE are better predictors for animal dander allergy , but no agreement exists on the acceptance of AIT with dander mixtures. Panelists accepted that Api m 2 (hyaluronidase) sIgE indicates <i>Vespid</i> and <i>Apis mellifera</i> cross-reactivity in children; and Api m 4 (melittin) sIgE is a marker of risk for systemic reaction with AIT in <i>Apis mellifera</i> allergy. According to the consensus, SCIT is more suitable for allergen mixtures than SLIT. and agreement was reached for pollen allergens and <i>Alternaria alternata</i> mixtures if stability, safety, and efficacy have been demonstrated.</p><p><strong>Conclusions: </strong>This Delphi study provides, where evidence is lacking, current expert-based opinions on clinical decision-making for managing polysensitized children.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"141-159"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the connection: asthma and endometriosis - a comprehensive systematic review and meta-analysis.","authors":"Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, Negar Ansari, Shima Shokrzadeh, Seyyed Shamsadin Athari","doi":"10.15586/aei.v53i2.1276","DOIUrl":"10.15586/aei.v53i2.1276","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Asthma and endometriosis are two prevalent chronic conditions that affect a significant portion of the population. Both conditions have been linked to inflammatory processes and immune dysregulation, suggesting the possibility of a shared pathophysiological mechanism. Despite the growing interest in the connection between asthma and endometriosis, the current literature remains inconclusive. This systematic review and meta-analysis aim to consolidate the available evidence and provide a comprehensive understanding of the association between asthma and endometriosis.</p><p><strong>Materials and methods: </strong>We searched Embase, PubMed, Scopus, Web of Science, and Google Scholar to identify studies that met our criteria. The random effects model was used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for individuals with endometriosis and non-endometriosis controls who have asthma. Additionally, we performed subgroup analyses based on geographic region to identify potential sources of heterogeneity. The research protocol was registered on PROSPERO (CRD42024567249).</p><p><strong>Results: </strong>Six eligible case-control studies involving 66,997 cases and 3,253,658 controls were used to examine the association between asthma and endometriosis. Through a comprehensive search and analysis of relevant studies, a significant association between asthma and endometriosis was identified (OR: 1.786, 95% CI: 1.511-2.111, P < 0.001). The correlation showed significant heterogeneity in the study (I² = 75.709; P-value = 0.001), with geographic region identified as a significant factor contributing to this variation.</p><p><strong>Conclusion: </strong>Our meta-analysis demonstrates a significant link between asthma and endometriosis, highlighting the need for comprehensive management that addresses both conditions.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"42-49"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of administration route of allergen immunotherapy: Rates and causes.","authors":"Cristina Rivas-Juesas, Ana Delgado Vicente","doi":"10.15586/aei.v53i2.1196","DOIUrl":"10.15586/aei.v53i2.1196","url":null,"abstract":"<p><p>Allergen immunotherapy (AIT) has shown efficacy in the short and the long term in the management of allergic respiratory diseases, and it's administered subcutaneously (subcutaneous immunotherapy, or SCIT) or sublingually (sublingual immunotherapy, or SLIT), being both effective and safe options.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"10-12"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell-derived exosomes improved septic lung injury by reducing excessive NETs formation and alleviating inflammatory response.","authors":"Ting Zou, Jianshuang Lu, Yanke Zhu, Yue Xu, Yuanyuan Sun","doi":"10.15586/aei.v53i1.1238","DOIUrl":"10.15586/aei.v53i1.1238","url":null,"abstract":"<p><p>To illustrate the potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in mitigating septic lung injury by reducing the excessive formation of neutrophil extracellular traps (NETs), a mouse model of septic lung injury was induced through cecal ligation and puncture (CLP). The mice received intraperitoneal injections of MSC-Exos. Post injection, pathological alterations of the lung tissue were evaluated through HE staining, and the levels of inflammatory markers in each mouse group at various time points were assessed using ELISA kits. The presence of NETs markers in lung tissue (colocalization of CitH3 and MPO) was determined via immunofluorescence, and the levels of dsDNA in mouse serum were measured using a dsDNA kit. The findings indicated noticeable damage in the sepsis group postsurgically, whereas the severity of lung tissue damage was significantly diminished in mice of the MSC-Exos group. By the 72-h mark after the CLP procedure, there was an elevation in TNF-α, IL-6, IL-1β, and IL-10. Compared to the CLP group, the inflammatory factors in the serum of mice from the CLP + MSC-Exo group were higher at 12 and 24 h but decreased at the 72-h point. Furthermore, the fluorescence intensity of CitH3 and MPO and the dsDNA content increased in the CLP group mice over different time intervals, with MSC-Exos reversing these changes. In summary, MSC-Exos effectively suppressed sepsis-induced NETs formation and ameliorated lung injury.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"63-68"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced enterocolitis, a new condition under consideration.","authors":"Lucía Hernando Marín, Ana María Segura Machado, Marta Castro Ramos, Javier Torres-Borrego","doi":"10.15586/aei.v53i1.1202","DOIUrl":"10.15586/aei.v53i1.1202","url":null,"abstract":"<p><p>Drug-induced enterocolitis syndrome (DIES), little known due to its recent description, is analogous to food protein-induced enterocolitis syndrome (FPIES). Both processes are more frequent in pediatric age and share diagnostic criteria, the main one being the appearance of persistent vomiting 1-4 hours after ingestion of the drug or food, in the absence of IgE-mediated allergy symptoms.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"123-125"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis due to green beans (<i>Phaseolus vulgaris</i>): a new phenotype?","authors":"Estela Menéndez Rivero, Manuel Prados Castaño, Isabel María Domínguez Romero, María José Martínez Martínez, Fernando Pineda De La Losa","doi":"10.15586/aei.v53i1.1176","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1176","url":null,"abstract":"<p><strong>Background: </strong>Anaphylaxis is a severe allergic reaction with increasing incidence in Europe. It is often caused by food, insect venom, and drugs. White, red, and green beans (<i>Phaseolus vulgaris</i>) are legumes of the <i>Fabaceae</i> family consumed worldwide. In Spain, beans are the third most consumed legume species after chickpeas and lentils. Allergy to different legumes is very frequent in children and represents the fifth cause of food allergy.</p><p><strong>Objective: </strong>Demonstrate a new phenotype in patients with green bean anaphylaxis.</p><p><strong>Material and methods: </strong>We report a 20-year-old woman who experienced anaphylaxis after consuming cooked green beans and required emergency treatment. There were no associated cofactors such as medications, alcohol, or physical exercise. After the episode, she tolerated well nuts, garlic, chickpeas, peas, and soy. Prick-prick with raw and cooked green bean, ISAC, SDS-PAGE and IgE-Western blot were performed.</p><p><strong>Results: </strong>The prick+prick test with raw and cooked green beans was positive. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis-immunoglobulin E (SDS-PAGE/IgE)-western blot analysis with white and red beans as well as cooked and raw green beans showed identification of several proteins with a molecular weight of 25-75 kDa in the extract of raw beans. Only one protein with a molecular weight of approximately 10 kDa was recognized in cooked beans.</p><p><strong>Conclusion: </strong>We present a case of anaphylaxis induced by green beans (<i>Phaseolus vulgaris</i>) because of a 10-kDa protein and tolerance to other legumes, which suggests a new phenotype.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"8-11"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a predictive model for allergic rhinitis complicating children with bronchial asthma.","authors":"Qi Zhang, Fengqin Xu, Fuzhe Chen","doi":"10.15586/aei.v53i1.1242","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1242","url":null,"abstract":"<p><p>This study aimed to investigate the factors influencing the complication of allergic rhinitis in children with bronchial asthma and to construct a nomogram model to predict the occurrence of allergic rhinitis. A total of 190 children with bronchial asthma admitted to our hospital from August 2020 to August 2024 were retrospectively analyzed. The children were randomly divided into the training cohort (133 cases) and validation cohort (57 cases) in a ratio of 7:3. The children in the modeling set were divided into an allergic rhinitis group (n=44) and a nonallergic rhinitis group (n=89) depending on the presence or absence of concomitant allergic rhinitis. A total of 62 cases in 190 children with bronchial asthma had complications with allergic rhinitis, with an incidence of 32.63%. In the training cohort, compared with the children in the nonallergic rhinitis group, percentage of smokers in the household, C-reactive protein (CRP), white blood cell count (WBC), and neutrophils/lymphocytes (NLR) were significantly higher in the allergic rhinitis group (P < 0.05). Multivariable logistic regression analysis showed that smokers in the household; IgE; early use of antibiotics; and elevated CRP, WBC, and NLR were all risk factors for the complication of allergic rhinitis in children with bronchial asthma (P < 0.05). A nomogram prediction model was constructed based on the above risk factors. The C-index of the nomogram was 0.919 (95% CI: 0.742-0.934) and 0.841 (95% CI: 0.773-0.902) for the training cohort and validation cohort, respectively. The Hosmer-Lemeshow test results of the training and validation cohorts were both P > 0.05, suggesting a good model fit. The results of DCA showed that the training and validation cohorts had good threshold probability and clinical net benefit. Smokers in the household, IgE, CRP, WBC, and NLR levels were all risk factors for the complication of allergic rhinitis in children with bronchial asthma. A nomogram model based on these risk factors may be a valuable clinical tool for predicting allergic rhinitis in children with bronchial asthma.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"131-138"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis in infancy: An area that needs to be highlighted.","authors":"Evanthia Chiampou, Konstantinos Douros, Anastasios Serbis, Fani Ladomenou, Alexandros Makis, Ekaterini Siomou, Sophia Tsabouri","doi":"10.15586/aei.v53i1.1212","DOIUrl":"10.15586/aei.v53i1.1212","url":null,"abstract":"<p><p>Anaphylaxis, the most severe end of the spectrum of allergic reactions, has shown increasing incidence globally over recent years. This hypersensitivity reaction can occur at any age, including infancy. Recent data, although scarce, show that anaphylaxis is increasingly reported in infancy, with food identified as the leading cause of anaphylaxis cases in this age group. Infants constitute a unique subgroup with specific challenges regarding diagnosis of anaphylaxis due to a variety of factors, such as lack of age-specific diagnostic criteria, inability of infants to describe their symptoms, and the broad spectrum of clinical manifestations that may be mistaken as normal findings. Additionally, there are special issues in reference to the treatment of anaphylaxis during infancy, such as the limited availability of weight-appropriate epinephrine autoinjectors for infants weighing <15 kg. In this study, we review the current literature regarding specific characteristics of anaphylaxis in infants as well as unique challenges in terms of diagnosis, acute treatment, and long-term management of this medical emergency in this vulnerable age group.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"139-145"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}