Nasal allergen challenge with Blomia tropicalis in children and adolescents.

IF 2.5 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.15586/aei.v52i6.1193

Fausto Yoshio Matsumoto, Tessa Rachel Tranquilini Gonçalves, Dirceu Solé, Gustavo Falbo Wandalsen

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引用次数: 0

Abstract

Background: Local allergic rhinitis (LAR) is a well-defined phenotype in adults, but still there is little data available on children. This scarcity of data can be partly attributed to the lack of standardized protocols for Nasal Allergen Challenges (NAC) in this demographic.

Methods: 20 controls (control group) and 24 patients (rhinitis group) with allergic rhinitis diagnosis sensitized to Blomia tropicalis (Bt) underwent the NAC with Bt. The acoustic rhinometry was performed after instillation of increasing concentrations of Bt (5,000 BU/mL).

Results: The median reduction in the volume of the nasal cavity in its first five centimeters (V5) by the conclusion of the NAC in the rhinitis group was markedly higher than that observed in the control group, at -22.9% (range: -21.1% to -26.2%) compared to -7.7% (ranging: -4.8% to +12.8%).

Conclusions: Our research demonstrates the efficacy and safety of the NAC protocol utilizing Bt in distinguishing allergic from non-allergic children.

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儿童和青少年对热带布洛姆痢疾杆菌鼻过敏原的挑战。

背景：局部过敏性鼻炎（LAR）在成人中是一种定义明确的表型，但有关儿童的数据仍然很少。方法：20 名对照组（对照组）和 24 名被诊断为对热带布洛菌（Bt）过敏的鼻炎患者（鼻炎组）接受了 Bt 鼻过敏原挑战（NAC）。在注入浓度不断增加的 Bt（5,000 BU/mL）后，进行了鼻声学测量：结果：鼻炎组在 NAC 结束时鼻腔前 5 厘米（V5）体积减少的中位数明显高于对照组，为-22.9%（范围：-21.1% 至 -26.2%），而对照组为-7.7%（范围：-4.8% 至 +12.8%）：我们的研究证明了使用 Bt 的 NAC 方案在区分过敏性和非过敏性儿童方面的有效性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.