Thoracic research and practice最新文献

{"title":"An Important Question: Can Serum Chitotriosidase Enzyme Predict the Activity and Clinical Course of Sarcoidosis Disease?","authors":"Ece Şahinoğlu, Haşim Boyacı, Hale Maral Kır, Ahmet Hamdi Ilgazlı, İlknur Başyiğit, Serap Argun Barış","doi":"10.4274/ThoracResPract.2025.2025-1-2","DOIUrl":"10.4274/ThoracResPract.2025.2025-1-2","url":null,"abstract":"<p><strong>Objective: </strong>Serum chitotriosidase (CHIT) is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. Our study aimed to evaluate the CHIT enzyme concerning the activity, prognosis, and treatment decision of sarcoidosis.</p><p><strong>Material and methods: </strong>The patients with the following characteristics were included in our single-center study as long as they agreed to participate. These patients were newly or previously diagnosed with sarcoidosis according to American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders and consulted the outpatient clinic of chest diseases in our university hospital between August 2020 and April 2021. The patients with sarcoidosis were categorized into 3 groups: 1) diagnosed as sarcoidosis but not having the treatment indication; 2) previouslytreated or currently receiving treatment; and 3) newly diagnosed and having a treatment indication.</p><p><strong>Results: </strong>A total of 126 sarcoidosis patients and 43 healthy volunteers were included. The median value of serum CHIT enzyme levels in patients with sarcoidosis was determined to be 9.8 ng/mL, while it was 5.1 ng/mL in the control group. It was determined that the serum CHIT levels were notably higher in patients with sarcoidosis (<i>P</i> = 0.000). In the serum CHIT levels of the newly-treated patient, a significant reduction was observed after the 6-month treatment (<i>P</i> = 0.008), in comparison with these levels noted at the time of diagnosis.</p><p><strong>Conclusion: </strong>Our study demonstrated that the serum CHIT has a high sensitivity and high specificity in the diagnosis of sarcoidosis and a reduction in the level of that enzyme occurs upon treatment.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"217-223"},"PeriodicalIF":0.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Effectiveness of a Program to Raise Awareness About Pneumococcal Vaccination Among Physicians and Patients with Chronic Respiratory Diseases: A Multicenter Cohort Study.","authors":"Zühal Karakurt, Enver Yalnız, Sedat Altın, Özlem Oruç, Özgür Uslu, Nurdan Şimşek Veske, Oğuz Kılınç, Seval Kul, Abdullah Sayıner","doi":"10.4274/ThoracResPract.2025.2025-2-2","DOIUrl":"10.4274/ThoracResPract.2025.2025-2-2","url":null,"abstract":"","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"262-263"},"PeriodicalIF":0.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and Practices of Family Physicians and Nurses in Evaluating Their Patients' Smoking Status: A Cross-sectional Study.","authors":"Ramazan Satılmış, Melda Dibek, Okay Başak","doi":"10.4274/ThoracResPract.2025.2025-1-5","DOIUrl":"10.4274/ThoracResPract.2025.2025-1-5","url":null,"abstract":"<p><strong>Objective: </strong>The low quit rate of smokers without support increases the importance of very brief clinical interventions for smoking cessation. The aim of this study was to determine the attitudes and practices of family physicians and nurses in primary care in evaluating patients' smoking status.</p><p><strong>Material and methods: </strong>This cross-sectional survey was conducted in family health centres in Aydın Efeler district between November and December 2020. A questionnaire developed on the basis of the \"modified very brief clinical intervention (3A-OR)\" model was used. Questionnaires were administered to all participants using the face-to-face method. In addition to descriptive statistical methods, univariate and multivariate analysis were performed. The statistical significance level was accepted as \"<i>P</i> < 0.05\".</p><p><strong>Results: </strong>Fifty-nine family physicians and 64 nurses participated in the study. Of the participants, 62.6% were female and the mean age was 44.9 years. The most common practices of family physicians and nurses concerning learning their patients' smoking behaviour were to offer assistance to smokers (82.4%) and to recommend that they quit (81.3%). Family physicians and nurses mostly thought that it was their responsibility to refer their smoker patients to stop smoking counselling centres (71.6%) and to offer assistance (61.8%). Family physicians had a 3.12 times more positive attitude than nurses in evaluating the smoking status of the patients (<i>P</i> = 0.008).</p><p><strong>Conclusion: </strong>Our study results have revealed that the positive attitudes of family physicians are not fully reflected in practice and that nurses generally do not adopt responsibilities related to evaluating patients' smoking habits, despite their efforts to make better practices.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"224-230"},"PeriodicalIF":0.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Systemic Inflammatory Indices of Earthquake Victims After the 6 February Kahramanmaraş Earthquake.","authors":"Merve Erçelik, Önder Öztürk, Tutku Aydın, Hilal Türkmen Kaya","doi":"10.4274/ThoracResPract.2025.2024-11-3","DOIUrl":"10.4274/ThoracResPract.2025.2024-11-3","url":null,"abstract":"<p><strong>Objective: </strong>Earthquakes cause many people to lose their lives, get injured and leave their homes. Earthquakes constitute a serious risk factor for physical and mental diseases primarily due to traumatic environmental experiences. Systemic inflammation indices are used to determine prognosis in many diseases. This study aims to investigate the effects of the distance of earthquake victims from the epicentre of the earthquake, whether trapped under debris, and their psychological distress on the systemic inflammatory indices.</p><p><strong>Material and methods: </strong>Systemic inflammatory indices were retrospectively calculated for all earthquake victims. Questionnaires were evaluated prospectively among earthquake victims who volunteered.</p><p><strong>Results: </strong>The systemic inflammation values were aggregate index of systemic inflammation (AISI) median 351.5, systemic inflammation response index (SIRI) median 1.30, and systemic inflammation index (SII) median 677.4. Although the number of earthquake survivors under rubble was lower than the number of earthquake survivors not under rubble, AISI (<i>P</i> = 0.001), SIRI (<i>P</i> = 0.03), and SII (<i>P</i> = 0.002) were found to be statistically significantly higher in those under rubble. Depression scores (mean, 37.8) and anxiety scores (mean, 43.6) were compatible with moderate and severe categories. There was a significant relationship between AISI (<i>P</i> = 0.018) and SIRI values (<i>P</i> = 0.05) and depression outcome. Similarly, there was a statistically significant relationship between anxiety outcome and SII values (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>A significant correlation was found between the physical and psychological trauma experienced by the earthquake victims and the high level of systemic inflammatory indices. Rehabilitation and close follow-up of the earthquake victims are of great importance given that systemic inflammation is one of the long-term health effects of earthquakes.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"231-237"},"PeriodicalIF":0.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Worldwide Bronchoscopy Practices and Training Methods: A WABIP Survey.","authors":"Silvia Quadrelli, Agustin Buero, Stefano Gasparini","doi":"10.4274/ThoracResPract.2025.2025-3-1","DOIUrl":"https://doi.org/10.4274/ThoracResPract.2025.2025-3-1","url":null,"abstract":"<p><p>The practice of bronchoscopy is not standardized. Regional and global variations in bronchoscopy practice are exacerbated by the paucity of recommendations regarding technical aspects in major bronchoscopy guidelines. The aim of this survey was to examine the prevalent practices, adherence to guidelines, and training requirements of bronchoscopy in different countries. The Membership Committee and the Education Committee of the World Association for Bronchology and Interventional Pulmonology designed an online survey that was sent to 1,300 consultant physicians in adult respiratory medicine from 64 countries across five continents. The questionnaire included questions regarding bronchoscopy practice. We obtained 879 responses (67.0%). In 81.2% of cases, the practice occurred in cities with over 200,000 inhabitants. The median number of years in practice was 14 (range 1-50). Only 11% of respondents perform routine bronchoscopy without anesthesia. Spirometry was always performed before bronchoscopy by only 106 physicians (12.4%), blood coagulation tests were always required by 533 (60.6%) and an electrocardiography was always required by 339 (38.5%). The main indications for performing a bronchoscopy were suspicion of cancer (78.6%), suspicion of non tuberculosis (TB) infection (10.6%), and suspicion of TB (6.7%). 39.3% of responders received formal training for at least 6 months with a formal certificate. Despite the wide availability of bronchoscopy guidelines, the way to do them in terms of preparation, anesthesia, technical aspects, etc., varies greatly in each country and physician.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Events in Non-invasive Ventilation Approaches: Systematic Review.","authors":"Hatice Aslan Sirakaya, Ana Torrano Ferrández, Antonio M Esquinas","doi":"10.4274/ThoracResPract.2025.2025-4-8","DOIUrl":"https://doi.org/10.4274/ThoracResPract.2025.2025-4-8","url":null,"abstract":"<p><p>Non-invasive ventilation (NIV) plays a critical role in the management of acute and chronic respiratory failure, offering benefits over invasive mechanical ventilation. However, its use is associated with various adverse events that may impact clinical outcomes. This systematic review aimed to evaluate the types, frequencies, and clinical consequences of complications related to NIV. A systematic search of PubMed, EMBASE, and Cochrane Library databases was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 'PRISMA' guidelines, covering studies published between 2000 and February 2023. Eligible studies included randomized controlled trials, observational cohorts, and systematic reviews reporting adverse events in adults receiving NIV for respiratory failure. Thirty-two studies involving approximately 6,000 patients were analyzed. NIV-related complications were frequently reported, including, physiological (e.g., hypercapnia 2-10%, hypoxemia 1-5%), mechanical (e.g., skin breakdown 5-15%, air leaks 5-25%), and patient-related events (e.g., discomfort 10-30%, anxiety 5-15%). Face masks were linked to higher rates of air leaks and intolerance, while helmet interfaces showed fewer complications. Helmet interfaces and newer ventilator technologies showed advantages in minimizing certain adverse events. Although NIV offers substantial benefits compared to invasive ventilation, its effectiveness can be compromised by preventable complications. Structured monitoring, early intervention, and a multidisciplinary care approach are essential for maximizing outcomes. Further research is needed to develop strategies that enhance patient comfort, minimize complications, and optimize NIV application across different clinical settings.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Tracheal, Bronchus, and Lung Cancer in Adults Over 55 Years Old Based on Socio demographic Status and Geographical and Gender Differences from 2010-2021.","authors":"Afrooz Mazidimoradi, Elham Shabani, Fatemeh Rezaei, Fariba Shahraki-Sanavi, Zahra Shahabinia, Leila Allahqoli, Hamid Salehiniya","doi":"10.4274/ThoracResPract.2024.24081","DOIUrl":"10.4274/ThoracResPract.2024.24081","url":null,"abstract":"<p><strong>Objective: </strong>This study presented the tracheal, bronchus, and lung cancer (TBLC) trend in adults ≥55 based on the socio-demographic index and geographical regions.</p><p><strong>Material and methods: </strong>We obtained annual TBLC data from 2010 to 2021 from the 2021 Global Burden of Disease (GBD) Study and analyzed the incidence, death rates, and disability-adjusted life years (DALYs) rates across different geographical classifications of 204 national and territorial.</p><p><strong>Results: </strong>In adults ≥55 years, the TBLC incidence rate decreased from 2010 to 2021 by globally 20.9% and 9.6% in males, while increasing by 3.8% in females. Approximately 60% of TBLC cases occurred in Asian countries. European countries exhibit the highest incidence rate (169.16 per 100,000). Males across all continents showed a decreasing trend, only the Americas reported a decreasing trend for women, with a noted change of 17.3%. The Western Pacific Region (World Health Organization region), East Asia (GBD region), Monaco, and countries with advanced health systems reported the highest incidence, death, and DALY numbers and rates for all genders. World Bank Upper middle-income countries recorded the highest DALY numbers and rates, incidence, and death numbers, all showing a downward trend, similar to high-income countries.</p><p><strong>Conclusion: </strong>The global burden of TBLC is predominantly in Asian countries (mainly East Asia), with a slower decrease in incidence, death, DALY, and burden rates. Therefore, reducing exposure to risk factors, expanding screening and diagnostic programs, especially for high-risk male smokers and females, and improving treatment procedures to reduce the progression of this cancer are urgent.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"155-175"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transbronchial Mediastinal Cryobiopsy Diagnostic Yield and Perioperative Patient Management: A Single Tertiary Center Experience.","authors":"Nadia Corcione, Alfonso Pecoraro, Andrea Fidecicchi, Severo Campione, Lina Zuccatosta, Giuseppe Failla","doi":"10.4274/ThoracResPract.2025.2024-12-4","DOIUrl":"10.4274/ThoracResPract.2025.2024-12-4","url":null,"abstract":"<p><strong>Objective: </strong>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used to diagnose mediastinal lesions; however, small cytology samples from EBUS-TBNA may be inadequate in cases of benign lung diseases, hematologic disorders, and to assess the molecular profile of primary lung cancer (PLC). EBUS-guided transbronchial mediastinal cryobiopsy (TMC) obtains histological samples and potentially implies a higher diagnostic yield (DY) than EBUS-TBNA. The clinical impact of this technique and the perioperative patient management are still unclear. Our aim was to critically analyze our experience with TMC.</p><p><strong>Material and methods: </strong>A single center retrospective study was conducted to evaluate TMC DY and perioperative routine over 11 months (February 2023-January 2024).</p><p><strong>Results: </strong>Forty-one patients were included. The overall DY was 41.5% and 95.1% for EBUS-TBNA and TMC, respectively. TMC provided a higher DY than EBUS-TBNA in cases of hematologic disorders, benign diseases, and uncommon tumors (31% for EBUS-TBNA and 100% for TMC; 95% confidence interval (CI): 52.1-85.8, <i>P</i> < 0.001). For PLC, the DY and the assessment of immunohistochemical marker expression did not significantly differ between the two techniques (80% for EBUS-TBNA and 100% for TMC; 95% CI: -4.79-44.8, <i>P</i> = 0.13). The management of antithrombotic therapy was the same as that of EBUS-TBNA. Sedatives were administered to achieve deep sedation. After the procedure, no step-up in the level of care was observed, either in outpatients or in patients with a Charlson Comorbidity Index ≥5.</p><p><strong>Conclusion: </strong>TMC had a better DY than EBUS-TBNA in hematologic disorders, benign lung disease, and uncommon tumors, with an optimal tolerability profile.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"183-190"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considering Patient Perspective Through Visual Representatives: Telemedicine Gives Voice to Rare Interstitial Lung Disease Patients.","authors":"Nazlı Çetin, Sabri Serhan Olcay, Utku Tapan, Pelin Duru Çetinkaya, Francis X McCormack, Göksel Altınışık","doi":"10.4274/ThoracResPract.2025.2025-1-4","DOIUrl":"10.4274/ThoracResPract.2025.2025-1-4","url":null,"abstract":"","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"208-210"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Pulmonary Genetic Variations in the Pathogenesis of Pediatric Postinfectious Bronchiolitis Obliterans.","authors":"Sedef Narin Tongal, Gülsüm Kayhan, Özge Yılmaz, Merve Öçalan, Hasan Yüksel","doi":"10.4274/ThoracResPract.2025.2024-11-1","DOIUrl":"10.4274/ThoracResPract.2025.2024-11-1","url":null,"abstract":"<p><strong>Objective: </strong>Postinfectious bronchiolitis obliterans (PIBO) is a chronic airway disease. The severity of the damage and the subsequent obstructive and inflammatory processes varies from one individual to another. The objective was to identify genetic variations that may be associated with pulmonary diseases in patients with PIBO.</p><p><strong>Material and methods: </strong>This retrospective descriptive study was carried out to define potential genetic changes that may be associated with PIBO. Medical records were used to obtain sociodemographic characteristics. Neutrophil, lymphocyte, platelet counts, immunoglobulins and C-reactive protein values, thoracic computed tomography (CT) findings and genetic analysis results for pulmonary panel using next-generation sequencing technology were recorded.</p><p><strong>Results: </strong>Sixteen patients were enrolled. Median age at diagnosis was 27.5 months (range: 7-195 months). Wheezing was the most common presenting symptom. The most prevalent finding on thoracic CT was a mosaic pattern. In all but one, a wide range of variations genes related to both pulmonary structure and function were identified. The genes identified included those related to primary ciliary dyskinesia (DNAH genes), surfactant metabolism disorder (ABCA3, CSF2RB), pulmonary fibrosis (MUC5B, SFTP), and bronchiectasis (SCNN1B).</p><p><strong>Conclusion: </strong>Heterozygous variations associated with pulmonary diseases, including the <i>MUC5B</i> and <i>DNAH</i> genes, and CSF2RB, were identified in most patients diagnosed with PIBO, which may have clinical significance. These data are valuable in hypothesis formation that may lead to the evaluation of these three genes in the pathogenesis of PIBO in children.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"191-196"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}