Tetrahedron chem最新文献_第6页

Copper-catalyzed intermolecular formal [4 + 1] annulation of 1,5-diynes with benzocyclobutenones 铜催化 1,5-二炔与苯并环丁烯酮的分子间正规 [4 + 1] 环化反应

Tetrahedron chem Pub Date : 2024-08-14 DOI: 10.1016/j.tchem.2024.100090

Jia-Cheng Li , Tian-Qi Hu , Zhou Xu , Bo Zhou , Long-Wu Ye

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l-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions 可持续条件下 l-脯氨酸催化合成具有生物前景的杂环化合物

Tetrahedron chem Pub Date : 2024-08-01 DOI: 10.1016/j.tchem.2024.100087

Rajiv Karmakar , Chhanda Mukhopadhyay

{"title":"l-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions","authors":"Rajiv Karmakar , Chhanda Mukhopadhyay","doi":"10.1016/j.tchem.2024.100087","DOIUrl":"10.1016/j.tchem.2024.100087","url":null,"abstract":"<div>Catalysis field wherein a tiny organic molecule like l-proline is an efficient and selectively catalyzed organic reaction. Catalyst-supported organic synthesis is confirmed to be involved in the fast synthesis of novel compounds with selectivity and enhanced biological activities. l-proline catalyzed reactions are valuable tools for the making of different heterocycles, acyclic, and carbocyclic scaffolds that signify the main framework of most of the bio-active compounds. A few decades ago, novel tools for the manufacturing of bio-active molecules had a huge impact on organic chemistry. Subsequently, the synthesis of biologically important heterocycles through a synthetically proficient and environmentally benign route is the important purpose of modern synthetic chemistry. In this review, we discuss only l-proline catalyzed organic reactions (including condensation, addition, asymmetric, multi-components, and other modular reactions) for the sustainable synthesis of biologically promising heterocycles in a single trencher that may provide as a piece of reliable literature for further research in this field.</div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"11 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X24000263/pdfft?md5=7360970aaabda90d1ad3e7b8516a7217&pid=1-s2.0-S2666951X24000263-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoroalcohols for chemical modification of biomolecules 用于生物大分子化学修饰的氟醇

Tetrahedron chem Pub Date : 2024-08-01 DOI: 10.1016/j.tchem.2024.100088

Mohammad Nuruzzaman , Zeinab M. Nizam , Jun Ohata

引用次数: 0

Reactivities and mechanisms in organic reactions involving activation of elemental sulfur under basic conditions 基本条件下涉及元素硫活化的有机反应的反应活性和机理

Tetrahedron chem Pub Date : 2024-08-01 DOI: 10.1016/j.tchem.2024.100086

Peter Conen , Michael A.R. Meier

引用次数: 0

Expedient synthesis of 8-membered azasultams: A combined synthetic, DFT, and in vitro study 8 元氮杂环丁烷的快速合成：综合合成、DFT 和体外研究

Tetrahedron chem Pub Date : 2024-07-17 DOI: 10.1016/j.tchem.2024.100085

Heorhii V. Posternak , Olena D. Semoshkina , Vasyl Y. Hys , Demyd S. Milokhov , Pavlo A. Virych , Svitlana V. Shishkina , Yulian M. Volovenko , Alexey V. Dobrydnev

{"title":"Expedient synthesis of 8-membered azasultams: A combined synthetic, DFT, and in vitro study","authors":"Heorhii V. Posternak , Olena D. Semoshkina , Vasyl Y. Hys , Demyd S. Milokhov , Pavlo A. Virych , Svitlana V. Shishkina , Yulian M. Volovenko , Alexey V. Dobrydnev","doi":"10.1016/j.tchem.2024.100085","DOIUrl":"10.1016/j.tchem.2024.100085","url":null,"abstract":"<div>Herein we describe the novel approach to the synthesis of functionalized ind(az)olo-fused 1,2,4-thiadiazocine 1,1-dioxides through the CSIC (Carbanion-mediated Sulfonate (Sulfonamide) Intermolecular Coupling (Intramolecular Cyclization) reaction strategy. 1,2,4-Thiadiazocine 1,1-dioxides (put simply 8-membered azasultams) are increasingly popular but quite underrepresented in the literature compounds, were prepared in two simple steps and good yield from readily available reagents. Particularly, the alkylation of 7-functionalized ind(az)oles with N-(chloromethyl)-N-methylmethanesulfonamide gave the corresponding N-((1H-ind(az)ol-1-yl)methyl)-N-methylmethane-sulfonamides which underwent base-mediated cyclization affording the target 8-membered azasultams. The method worked well and provided azasultams decorated with a set of synthetically valuable handles. The conducted DFT calculations explained and rationalized the experimental data thus allowing us to formulate the rules of the structure‒activity relationship. Despite the prepared compounds showing weak cytotoxicity against the MDA-MB-231 breast cancer cell line, they are considered novel building blocks and perspective pharmacological templates prone to further optimization.</div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"11 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X2400024X/pdfft?md5=8a5acacf07f97bf098fa955907034fa1&pid=1-s2.0-S2666951X2400024X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atroposelective total synthesis of strecintide 839 斯特林肽的逆选择全合成 839

Tetrahedron chem Pub Date : 2024-07-10 DOI: 10.1016/j.tchem.2024.100084

Hiroshige Ogawa, Hugh Nakamura

引用次数: 0

Electrochemical oxidations through hypervalent iodine redox catalysis 通过超价碘氧化还原催化实现电化学氧化

Tetrahedron chem Pub Date : 2024-07-05 DOI: 10.1016/j.tchem.2024.100081

Ronit S. Bernard , Ajit Kumar Jha , Marcin Kalek

引用次数: 0

Asymmetric carbohydroxylation of alkenes via sequential photocatalytic oxo-alkylation and enzymatic reduction 通过顺序光催化氧化-烷基化和酶还原实现烯烃的不对称羧羟化反应

Tetrahedron chem Pub Date : 2024-07-04 DOI: 10.1016/j.tchem.2024.100083

Yiyin Liu , Kun Zhu , Xuemei Li , Xiaoyun Wu , Jinhui Feng , Atefeh Roosta , Qiaqing Wu , Dunming Zhu

引用次数: 0

Recent advances in copper-catalyzed asymmetric propargylic substitution 铜催化不对称丙炔基取代的最新进展

Tetrahedron chem Pub Date : 2024-07-03 DOI: 10.1016/j.tchem.2024.100082

Meng-Die Li, Xin-Ru Wang, Tao-Yan Lin

引用次数: 0

Repurposing HER catalysis toward metal hydride-mediated electro-reductive transformations 将 HER 催化重新用于金属氢化物介导的电还原转化

Tetrahedron chem Pub Date : 2024-06-27 DOI: 10.1016/j.tchem.2024.100080

Sheng Zhang, Man-Bo Li

{"title":"Repurposing HER catalysis toward metal hydride-mediated electro-reductive transformations","authors":"Sheng Zhang, Man-Bo Li","doi":"10.1016/j.tchem.2024.100080","DOIUrl":"https://doi.org/10.1016/j.tchem.2024.100080","url":null,"abstract":"<div>Hydrogen evolution reaction (HER) is known as one of the most cardinal reactions in energy chemistry. In the field, tremendous efforts have been devoted to discovering highly efficient catalysts and investigating the reaction mechanism. Metal hydrides are the most critical intermediates in the HER catalysis, and they also exhibit versatile reactivity in organic transformations. Redirecting HER catalysis for metal hydride-mediated electrochemical transformations would provide effective solutions for some challenging issues in conventional organic chemistry. Although some remarkable progress has recently been achieved in the cross-subject, the synthetic chemistry community has yet to fully understand the related catalytic mechanism and catalyst design. Herein, we conclude the catalytic HER mechanism and catalyst design principles to facilitate the repurposing HER catalysis toward organic electrochemistry. Recent examples of metal hydride-mediated electro-reductive transformations have also been covered, including the reduction of unsaturated bonds and the functionalization of C–H bonds. Additionally, we discussed challenges and future developments in the field.</div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"11 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X24000196/pdfft?md5=69ceaa5807bacf0325ed1656a32e9535&pid=1-s2.0-S2666951X24000196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0