Tetrahedron chem最新文献_第10页

Enantioselective α-heterofunctionalization reactions of catalytically generated C1-Lewis base enolates 催化生成的 C1-路易斯碱烯醇的对映体选择性 α-heterofunctionalization 反应

Tetrahedron chem Pub Date : 2024-03-01 Epub Date: 2024-01-23 DOI: 10.1016/j.tchem.2024.100063

Magdalena Piringer , Lotte Stockhammer , Lukas Vogl , David Weinzierl , Paul Zebrowski , Mario Waser

引用次数: 0

Supramolecular hydrogelation triggered by a gold catalyst 金催化剂引发的超分子水凝胶作用

Tetrahedron chem Pub Date : 2024-03-01 Epub Date: 2023-12-18 DOI: 10.1016/j.tchem.2023.100058

Tomoya Yamamoto , Akiko Nakamura , Akari Mukaimine , Katsunori Tanaka

{"title":"Supramolecular hydrogelation triggered by a gold catalyst","authors":"Tomoya Yamamoto , Akiko Nakamura , Akari Mukaimine , Katsunori Tanaka","doi":"10.1016/j.tchem.2023.100058","DOIUrl":"10.1016/j.tchem.2023.100058","url":null,"abstract":"<div><p>Supramolecular gels formed by self-assembly of low-molecular-weight gelators have been attracting attention as biomaterials. In particular, various triggers for supramolecular hydrogelation, such as enzymatic reactions, have been developed to selectively induce the formation of gels at targeted sites <em>in vivo</em>. However, there are still limitations to the methods for triggering self-assembly, such as the selectivity of hydrogelation at targeted sites. Here, we report the first example of a low-molecular-weight hydrogelator whose gelation is triggered by catalytic amount of transition-metal complexes. This gelator consists of a substrate structure for a ring-closing reaction catalyzed by gold, and this reaction transforms the morphology of fibrils to induce hydrogelation in the presence of peptide additives. This novel trigger for hydrogelation will expand the applicability of a low-molecular-weight gelator <em>in vivo</em> when used with biocompatible metal catalysts.</p></div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"9 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X23000244/pdfft?md5=6872d804de8e5cf9bc4845ce5bf65596&pid=1-s2.0-S2666951X23000244-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The photoinduced electron transfer (PET) reactions of silyl ethers and their application 硅基醚的光诱导电子转移 (PET) 反应及其应用

Tetrahedron chem Pub Date : 2024-03-01 Epub Date: 2024-02-24 DOI: 10.1016/j.tchem.2024.100067

Guizhou Yue , Bo Liu

引用次数: 0

Ynones in dearomative spirocyclisation processes; a review 脱芳螺环化过程中的炔酮；综述

Tetrahedron chem Pub Date : 2024-03-01 Epub Date: 2024-01-14 DOI: 10.1016/j.tchem.2023.100055

Richard J.K. Taylor, William P. Unsworth

{"title":"Ynones in dearomative spirocyclisation processes; a review","authors":"Richard J.K. Taylor, William P. Unsworth","doi":"10.1016/j.tchem.2023.100055","DOIUrl":"10.1016/j.tchem.2023.100055","url":null,"abstract":"<div><p>This review concentrates on our research into the discovery of novel ynone-based dearomative spirocyclisation processes, whilst placing the new chemistry into the context of existing knowledge. The genesis of the research programme, the development of efficient synthetic routes to prepare the novel natural products spirobacillene A (<strong>1</strong>) and spirobacillene B (<strong>2</strong>), utilised the dearomative spirocyclisation of indole ynones. This stimulated a much wider study to explore the reactivity of ynones in dearomative spirocyclisation processes more generally. Routes to generate a wide range of spirocycles were subsequently developed, with dearomative reactions of ynones tethered to indoles, benzofurans, benzisoxazoles, pyrroles, pyridines, isoquinolines, pyrazines, cyclic ketimines, and anisoles all discussed herein, with these reactions initiated by catalytic Ag(I), Cu(II), Pd(0), visible light and many other reagents. Asymmetric variants of some of the reactions are also discussed, as is further elaboration of the spirocyclic products to give carbazoles, quinolones, polycycles and other useful synthetic building blocks. Finally, applications of the new methodology in natural product synthesis (<em>e.g</em>. spirobacillene A, lasubine II and indolizidine 209D) are described.</p></div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"9 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X23000219/pdfft?md5=b00a306f15e6e5497d6dca88968ed40d&pid=1-s2.0-S2666951X23000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic synthetic studies on the hicksoane alkaloids 山核桃烷生物碱的仿生合成研究

Tetrahedron chem Pub Date : 2024-03-01 Epub Date: 2023-12-19 DOI: 10.1016/j.tchem.2023.100060

Stephanie Lee, Tilo Söhnel, Jonathan Sperry

引用次数: 0

Organocatalytic Regio- and Enantioselective (3+3)-Annulation of 2-(4H-Benzo[d][1,3]oxazin-4-yl)acrylates with 2,4-Dihydro-3H-pyrazol-3-ones 2-(4h-苯并[d][1,3]恶嗪-4-基)丙烯酸酯与2,4-二氢- 3h -吡唑-3-酮的有机催化区域和对映选择性(3+3)环化

Tetrahedron chem Pub Date : 2023-12-01 Epub Date: 2023-09-07 DOI: 10.1016/j.tchem.2023.100048

Zhongyue Lu, Xuling Chen, Pengfei Li

引用次数: 0

Recent developments in transition metal-catalyzed asymmetric borrowing hydrogen catalysis 过渡金属催化的不对称借氢催化研究进展

Tetrahedron chem Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.1016/j.tchem.2023.100054

Nidhi Garg, Ishika Agrawal, Dhananjay Satav, Doppalapudi Vineet Kumar, Basker Sundararaju

{"title":"Recent developments in transition metal-catalyzed asymmetric borrowing hydrogen catalysis","authors":"Nidhi Garg, Ishika Agrawal, Dhananjay Satav, Doppalapudi Vineet Kumar, Basker Sundararaju","doi":"10.1016/j.tchem.2023.100054","DOIUrl":"https://doi.org/10.1016/j.tchem.2023.100054","url":null,"abstract":"<div><p>Asymmetric Borrowing Hydrogen (BH) catalysis is a versatile, one-step approach for synthesizing enantioenriched amines/carbonyl derivatives from biomass-derived oxidized hydrocarbons with water as the sole by-product. These valuable chiral moieties are ubiquitous in natural products, fragrances, agrochemicals, and pharmaceuticals; hence, efficient methodologies that can directly form C–C and C–N bonds to diversify the synthetic utility are highly desired. Over the last decade, numerous contributions involving noble metals have been documented in this area, which largely relies on the choice of a suitable transition metal catalyst that facilitates a succession of oxidation/reduction steps. Only very recently, 3d metals were utilized for C–C and C–N bond formation in an asymmetric manner using the BH strategy. This article describes the current state-of-the-art for controlling the stereochemistry in the formation of a new stereogenic center <em>via</em> multiple catalysis, rational ligand design, <em>etc</em>. Several other strategies are outlined, such as asymmetric reductive functionalization, dynamic kinetic resolution, enantioconvergent processes, <em>etc</em>. New chiral catalysts based on 3d metals are anticipated to arise and find applications in the field of asymmetric borrowing hydrogen catalysis.</p></div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"8 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X23000207/pdfft?md5=c87883cd936f5a5efe186b0f8c5a6c25&pid=1-s2.0-S2666951X23000207-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and application of stimulus-triggered cyclic caged oligonucleotides for gene expression regulation 刺激触发环笼寡核苷酸的合成及其在基因表达调控中的应用

Tetrahedron chem Pub Date : 2023-12-01 Epub Date: 2023-10-24 DOI: 10.1016/j.tchem.2023.100051

Wen-Da Chen , Liang Cheng

{"title":"Synthesis and application of stimulus-triggered cyclic caged oligonucleotides for gene expression regulation","authors":"Wen-Da Chen , Liang Cheng","doi":"10.1016/j.tchem.2023.100051","DOIUrl":"https://doi.org/10.1016/j.tchem.2023.100051","url":null,"abstract":"<div><p>Cyclically caged oligonucleotides are a distinct category of altered biomacromolecules. They are created by incorporating caged motifs into oligonucleotides and subsequently undergoing cyclization through chemical or enzymatic means. The cyclic structure of these oligonucleotides significantly affects their characteristics and functionality, resulting in enhanced ribonuclease stability and loss of the ability to form complementary base pairs. However, when a specific stimulus is introduced, the ring structure can be deactivated, thereby restoring the oligonucleotide's function. This enables precise regulation of gene expression in both space and time by triggering a designated stimulus. In recent years, various cyclization strategies have been employed to modify antisense oligodeoxynucleotides, siRNAs, and gRNAs. This review will delve into the main synthesis methods used to generate cyclically caged oligonucleotides in the past decade. Moreover, we will explore the applications of these oligonucleotides in gene expression regulation, encompassing gene silencing and gene editing. This offers a valuable tool for comprehending the role of genes in the processes of biological growth and development.</p></div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"8 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666951X23000177/pdfft?md5=4f789c5fdb17e0af62268e3b37691309&pid=1-s2.0-S2666951X23000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92046279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The visible-light-promoted intermolecular para-cycloadditions of allenamides on naphthalene 可见光促进烯丙酰胺在萘上的分子间对环加成

Tetrahedron chem Pub Date : 2023-12-01 Epub Date: 2023-11-10 DOI: 10.1016/j.tchem.2023.100053

Maurizio Chiminelli, Gabriele Scarica, Davide Balestri, Luciano Marchiò, Nicola Della Ca’, Giovanni Maestri

引用次数: 0

The seriatim Cu(I) activation of 1,1,1′,1′-tetrapinacolborylethane to prospective ring closing 1,1,1 '，1 ' -四聚氨基甲酸乙酯的连续Cu(I)活化对预期闭合环的影响

Tetrahedron chem Pub Date : 2023-12-01 Epub Date: 2023-08-22 DOI: 10.1016/j.tchem.2023.100045

Sara González , Dario Del Carratore , Ricardo J. Maza , Elena Fernández

引用次数: 0