Sara González , Dario Del Carratore , Ricardo J. Maza , Elena Fernández
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The seriatim Cu(I) activation of 1,1,1′,1′-tetrapinacolborylethane to prospective ring closing
The synthesis and characterization of 1,1,1′1′-tetrapinacolborylethane is conducted to study the functionalization of that densely borylated small molecules through Cu-catalyzed coupling with allyl halides. A second Cu-catalyzed allylic alkylation of the homoallyl triboronate products gave access to mixed dihomoallyl diboronates. The intramolecular concatenated allylic alkylation version produced methylenecyclopentane-1,2-dipinacolboronic ester with 2:1 diastereoselection on the trans-diastereoisomer.
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