PCN reports : psychiatry and clinical neurosciences最新文献

{"title":"Clozapine for treatment-resistant schizophrenia with epilepsy: A case report.","authors":"Toru Horinouchi, Mayusa Mito, Toshiyuki Ishikawa, Yuichi Nakamura, Shuhei Ishikawa, Naoki Hashimoto","doi":"10.1002/pcn5.70330","DOIUrl":"10.1002/pcn5.70330","url":null,"abstract":"<p><strong>Background: </strong>Treatment-resistant schizophrenia (TRS) poses a substantial clinical challenge for which clozapine (CLOZ) is the only effective treatment. However, clinicians may hesitate to prescribe CLOZ for TRS patients with epilepsy due to its presence because CLOZ is contraindicated in patients with uncontrolled epilepsy in some countries including Japan.</p><p><strong>Case presentation: </strong>A 36-year-old male with TRS and focal epilepsy underwent CLOZ therapy. CLOZ was initiated at 6.25 mg and gradually titrated to 250 mg over 3 months, achieving a plasma concentration of 449 ng/mL. Psychotic symptoms improved without worsening of seizure frequency or severity. Mild side effects such as drowsiness and drooling were manageable. Long-term video electroencephalography monitoring detected spike-and-wave activity centered in the frontal region, but did not detect any overt epileptic seizures.</p><p><strong>Conclusion: </strong>We report a case of TRS with comorbid epilepsy in which CLOZ therapy was both effective and safe.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 2","pages":"e70330"},"PeriodicalIF":1.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dystrophinopathy with a <i>DMD</i> exon 49-50 deletion in a female patient who developed schizophrenia: An autopsy case.","authors":"Shusei Arafuka, Youta Torii, Ayako Miwa, Itaru Kushima, Hirotaka Sekiguchi, Hiroshige Fujishiro, Chikako Habuchi, Hiroaki Miyahara, Yosuke Kawai, Ran Wei, Katsushi Tokunaga, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda","doi":"10.1002/pcn5.70327","DOIUrl":"10.1002/pcn5.70327","url":null,"abstract":"<p><strong>Background: </strong>Mutations in <i>DMD</i> affect not only muscles but also the brain. Cases of schizophrenia with <i>DMD</i> mutations have been described previously. Although female dystrophinopathy often has a milder phenotype, some affected females also have intellectual disabilities and psychiatric disorders. We herein present an integrated account of the clinical course, genetic information, and neuropathological findings of a female patient with dystrophinopathy who developed schizophrenia.</p><p><strong>Case presentation: </strong>The patient exhibited a developmental delay, intellectual disability, and schizophrenia, and died at 66 years of age from renal and heart failure. A copy number variation analysis and whole-genome sequencing revealed a heterozygous deletion in chrX:31774440-31859356 (hg38), encompassing exons 49 and 50 of <i>DMD</i> (NM_004006.3). A neuropathological examination showed that the cortical layers were largely preserved; however, in parts of the visual cortex, some neurons were densely arranged in a line across layers IV-V, and single-neuronal heterotopias were observed in the subependymal regions around the lateral ventricles and within the white matter of the middle frontal gyrus. These findings suggest focal abnormal brain development that was milder than that reported in Duchenne muscular dystrophy, which may in part reflect the reduced and mosaic expression of dystrophin due to X-chromosome inactivation.</p><p><strong>Conclusion: </strong>The neuropathological findings in this case and in previous studies of Duchenne muscular dystrophy partially overlap with those of schizophrenia. To elucidate the pathogenesis and relationship between schizophrenia and <i>DMD</i> mutations, clinical and research attention should be directed toward the coexistence of both disorders.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 2","pages":"e70327"},"PeriodicalIF":1.3,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional association between ADHD traits and gray matter volume in young adults: A voxel-based morphometry study.","authors":"Haruka Asaoka, Michio Takahashi, Kentaro Oba, Hikaru Takeuchi, Yasuyuki Taki","doi":"10.1002/pcn5.70325","DOIUrl":"10.1002/pcn5.70325","url":null,"abstract":"<p><strong>Aim: </strong>Prior structural magnetic resonance imaging (MRI) studies of attention-deficit/hyperactivity disorder (ADHD) have primarily focused on clinically diagnosed samples, whereas the neuroanatomical correlates of dimensional ADHD traits in healthy young adults (aged 18-27 years) remain insufficiently characterized, and it is unclear whether neuroanatomical patterns reported in clinically diagnosed samples generalize to subclinical trait variability in young adulthood. We therefore examined whole-brain voxelwise associations between gray matter volume (GMV) and the Conners' Adult ADHD Rating Scales (CAARS) Hyperactivity/Restlessness subscale as the primary analysis, and evaluated associations with other CAARS scales on an exploratory basis, using voxel-based morphometry (VBM).</p><p><strong>Methods: </strong>Participants were 534 healthy young adults (304 males, 230 females; aged 18-27 years) without an ADHD diagnosis. ADHD traits were assessed using CAARS. High-resolution T1-weighted structural MRI data were acquired on a 3-Tesla scanner. GMV was analyzed using VBM implemented in SPM12. Voxelwise multiple-regression analyses were conducted, with Hyperactivity/Restlessness as the primary scale of interest and other CAARS scales examined in separate exploratory models. Statistical significance was set at <i>p</i> < 0.05 (cluster-level family-wise error [FWE]-corrected), using a voxelwise cluster-forming threshold of <i>p</i> < 0.001 (uncorrected).</p><p><strong>Results: </strong>GMV in the right dorsolateral prefrontal cortex (DLPFC) showed a small but statistically significant positive association with Hyperactivity/Restlessness scores (cluster-level FWE-corrected <i>p</i> = 0.017). No significant associations were observed for other CAARS subscales, and no significant sex-stratified effects were detected.</p><p><strong>Conclusion: </strong>These findings are consistent with a dimensional perspective on ADHD-related traits and suggest that interindividual differences in Hyperactivity/Restlessness may be reflected in subtle GMV variation in the right DLPFC among healthy young adults. Further multimodal and longitudinal studies are warranted to clarify developmental and mechanistic interpretations.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 2","pages":"e70325"},"PeriodicalIF":1.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships among highly sensitive personality (HSP), neuroticism, mental health, neurodevelopmental traits, and adverse childhood experiences (ACEs).","authors":"Akari Matsuzawa, Tsubasa Sasaki, Eiji Shimizu","doi":"10.1002/pcn5.70322","DOIUrl":"10.1002/pcn5.70322","url":null,"abstract":"<p><strong>Aim: </strong>Awareness of mental health is important to reduce stigma and discrimination and increase access to care. From the viewpoint of mental health conditions, this study examined the relationships among highly sensitive personality (HSP) traits and neuroticism in the general population.</p><p><strong>Methods: </strong>After obtaining informed consents, an anonymous web-based survey for adult participants with equal data collection across genders and age groups (20s, 30s, and 40s) was conducted using self-report questionnaires about HSP, neuroticism, mental health conditions including depression, anxiety, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), trauma-related stress, adverse childhood experiences (ACEs), and awareness of HSP and neurodevelopmental disorders. Participants were divided into the three groups based on HSP or neuroticism, with low, medium, and high groups defined by the mean value ± 1 SD.</p><p><strong>Results: </strong>Data from 2593 participants were analyzed. High-HSP and high-neuroticism groups exhibited higher levels of depression, anxiety, ASD, ADHD traits, trauma-related stress, and ACEs, compared to the other medium and low groups, respectively. Regarding ACEs, both the high-HSP and high-neuroticism groups showed significantly high rates of psychological abuse and neglect. While the high-neuroticism group showed broad associations across all ACE categories, the high-HSP group showed specific and comparable, or slightly stronger, associations with household mental disorders and physical abuse. In the high-HSP group, more participants answered that being HSP or having a neurodevelopmental disorder was part of their identity.</p><p><strong>Conclusion: </strong>High HSP and high neuroticism show mental health similarities, but HSP uniquely internalizes traits as identity.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70322"},"PeriodicalIF":1.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-related differences and influencing factors of acute stress symptoms in university students exposed to suicide.","authors":"Isamu Yamazaki, Tohru Takahashi, Daimei Sasayama, Hiroshi Morita, Shinsuke Washizuka","doi":"10.1002/pcn5.70323","DOIUrl":"10.1002/pcn5.70323","url":null,"abstract":"<p><strong>Aim: </strong>Although clarifying the immediate psychological impact on students exposed to suicide is essential, standardized suicide postvention protocols in university settings are currently lacking. This study examined the temporal differences and contributing factors in the psychological impact of suicide exposure among university students using postvention records from a single Japanese university.</p><p><strong>Methods: </strong>We collected and analyzed the records of 32 student suicide cases at Shinshu University between 2009 and 2023. Of these, 10 were selected for further analysis based on the availability of both postvention interview records and scores from the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J). Among the 136 students who received postvention support, data from 129 students exposed to suicide were included in the analysis. Time-related differences in the initial IES-R-J scores were analyzed using analysis of variance, and the factors influencing the scores were examined using multiple regression analysis.</p><p><strong>Results: </strong>Postvention was implemented in 17 of 32 suicide cases. In the 10 selected cases, higher IES-R-J scores were associated with being female, discovering or witnessing the suicide, fewer days elapsed since the suicide, a documented relationship with the deceased, and personal vulnerability noted in records.</p><p><strong>Conclusion: </strong>This study identified key factors associated with acute stress responses among university students exposed to suicide. Although symptoms generally decline over time, several factors were associated with increased severity. Suicide prevention in universities should prioritize support for individuals at greater risk based on the risk factors identified in this study.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70323"},"PeriodicalIF":1.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-based analysis of ICD-10 psychiatric diagnoses in outpatients and inpatients after the 2024 Noto Peninsula Earthquake.","authors":"Yumeno Furukawa, Reiko Hashimoto, Hiroaki Kihara, Tatsuya Nagasawa, Yusuke Nitta, Takashi Uehara","doi":"10.1002/pcn5.70319","DOIUrl":"10.1002/pcn5.70319","url":null,"abstract":"<p><strong>Aim: </strong>This study examined temporal changes in patterns of clinically treated psychiatric conditions during the first year after the 2024 Noto Peninsula Earthquake. Although post-disaster psychiatric symptoms often peak within the first year, prior studies have frequently lacked standardized phase definitions. We applied disaster-response phases defined in the Ministry of Health, Labour and Welfare manual to clarify phase-specific diagnostic trends and inform allocation of psychiatric resources.</p><p><strong>Methods: </strong>Among 869 new outpatients and 133 new inpatients recorded at Kanazawa Medical University Hospital, the tertiary medical center closest to the epicenter, between January and December 2024, we analyzed 80 first-time outpatients and 29 newly admitted inpatients reporting earthquake-related damage. Medical records were reviewed for demographics, ICD-10 primary diagnoses, disaster-related stressors, and timing of presentation categorized by disaster-response phases.</p><p><strong>Results: </strong>Psychiatric presentations were concentrated within the first month after the disaster, with secondary increases around 7 months and a modest rise at 12 months among outpatients. Most cases occurred during Stage 4 (mid-term recovery; Months 2-12). Among outpatients, neurotic, stress-related, and somatoform disorders (F4; 37.5%) and mood disorders (F3; 27.5%) were most frequent, whereas among inpatients, mood disorders (F3; 44.8%) and schizophrenia spectrum disorders (F2; 24.1%) predominated. Mood disorders were prevalent from the early phase, while F4 disorders increased later. Relocation and housing-related problems were common stressors.</p><p><strong>Conclusion: </strong>Clinically treated psychiatric conditions showed phase-dependent patterns, underscoring the need for phase-specific interventions, including early management of mood disorders, mid-term support for displacement-related stress, and long-term monitoring for symptom re-emergence.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70319"},"PeriodicalIF":1.3,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe enduring anorexia nervosa with significant height increase in adulthood: A case report.","authors":"Fuyuki Michiba, Haruka Kozuki, Keima Tose, Takeru Yamauchi, Ami Keidai, Toshiya Murai, Masanori Isobe","doi":"10.1002/pcn5.70296","DOIUrl":"10.1002/pcn5.70296","url":null,"abstract":"<p><strong>Background: </strong>Anorexia nervosa (AN) is a severe psychiatric disorder characterized by restrictive eating, low body weight, and distorted body image, and is often complicated by endocrine dysfunction. While hypogonadism and delayed puberty are well documented in female patients, reports in males remain scarce because of the lower prevalence of AN in this group. Hypogonadism may result in impaired pubertal development, growth arrest, and reduced testicular volume in male patients. Although weight restoration can sometimes enable catch-up growth when AN begins before puberty, the long-term potential for pubertal onset and height gain in severe enduring anorexia nervosa (SEAN) remains unclear.</p><p><strong>Case presentation: </strong>We present the case of a male patient with SEAN who showed persistent growth delay and absence of pubertal development during adolescence and early adulthood. Radiographic evaluation revealed the presence of unfused epiphyseal plates. Following sustained nutritional rehabilitation and partial weight restoration, the patient showed delayed pubertal onset accompanied by significant height gain. Endocrine assessment confirmed activation of the hypothalamic-pituitary-gonadal axis, with normalization of testosterone levels and gonadal function.</p><p><strong>Conclusion: </strong>This case demonstrates the potential for delayed puberty and substantial catch-up growth in adult male patients with SEAN, provided that epiphyseal closure has not yet occurred. Sustained nutritional rehabilitation is essential for pubertal activation. These findings highlight height gain as a clinically relevant and potentially motivational factor in treatment, while also contributing to a broader understanding of growth outcomes in chronically malnourished populations.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70296"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postictal psychosis concealed during long-term video-electroencephalographic monitoring and unmasked after discharge: A case report.","authors":"Shotaro Fujiwara, Takuto Ishida, Ryotaro Higuchi, Ayumu Kocha, Yo Muraoka, Yuki Nagashima, Hiroki Kocha, Atsuo Nakagawa, Yoshiyo Oguchi","doi":"10.1002/pcn5.70321","DOIUrl":"10.1002/pcn5.70321","url":null,"abstract":"<p><strong>Background: </strong>Postictal psychosis (PIP) is a serious complication that can follow seizure clusters, including those provoked during long-term video-electroencephalographic monitoring (LTVEM). Early detection and appropriate treatment of PIP are crucial to implement LTVEM safely. However, managing PIP becomes challenging when patients conceal symptoms, and psychotic symptoms are ambiguous.</p><p><strong>Case presentation: </strong>A female patient in her 30s with drug-resistant mesial temporal lobe epilepsy due to right hippocampal sclerosis underwent LTVEM at an epilepsy center. After seizure clusters occurred on hospital Days 2 and 3, she remained superficially stable apart from subtle psychotic symptoms beginning on hospital Day 4. Despite a thorough psychiatric assessment, she denied any psychotic experiences and was discharged as scheduled on hospital Day 7. Immediately after discharge, however, she displayed overt psychotic symptoms, necessitating emergency involuntary psychiatric admission. Her psychotic symptoms resolved within 16 days of psychiatric hospitalization. Upon recovery, she disclosed that she had concealed her symptoms during LTVEM because auditory command hallucinations had discouraged her from discussing the symptoms with her physicians, and her persecutory delusions, which were directed specifically toward the hospital and medical staff, had fostered a profound mistrust.</p><p><strong>Conclusion: </strong>The present case highlights a diagnostic pitfall caused by overlooking PIP occurring during LTVEM, particularly in patients in whom the psychotic content is directed against the hospital and medical staff. The absence of overt behavioral disturbances does not exclude PIP. Close multidisciplinary collaboration between epileptologists and psychiatrists is essential to ensure the patient's safety.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70321"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided internet-delivered compassion-focused therapy for women with recurrent pregnancy loss: A protocol of a randomized controlled trial.","authors":"Yuka Ito, Yuki Kawai Iwasaki, Kenichi Asano, Masatake Toshimitsu, Eisuke Sakakibara, Hinano Yumura, Yoshiaki Kanamori, Sawako Kamo, Saki K Doi, Natsu Sasaki, Kotaro Imamura, Keiichi Kumasawa, Takayuki Iriyama, Daisuke Nishi","doi":"10.1002/pcn5.70293","DOIUrl":"10.1002/pcn5.70293","url":null,"abstract":"<p><strong>Aim: </strong>This randomized controlled trial aims to examine the effects of an internet-delivered compassion-focused therapy program on depressive symptoms in women with recurrent pregnancy loss.</p><p><strong>Methods: </strong>The target population will be non-pregnant women aged 18-50 years with at least two pregnancy losses who visit the recurrent pregnancy loss outpatient clinics. Participants who fulfill the eligibility criteria will be randomly assigned to either a 5-week intervention group (<i>n</i> = 55) or a waitlist control group (<i>n</i> = 55). Participants in the intervention group will be asked to complete four weekly video modules (20-25 min each), including psychoeducation, experiential exercises, and homework assignments based on compassion-focused therapy principles. The intervention incorporates psychiatrist-guided support through weekly messages encouraging participants to share insights and questions about the program. The primary outcome is depression severity measured by the Patient Health Questionnaire-9. Secondary outcomes are psychological distress, perinatal grief, self-compassion, rumination, and worry about future pregnancies. Assessments will be conducted at baseline, 5-week follow-up (post-intervention), and 13-week follow-up. Mixed model analyses will be conducted to test the effectiveness of the intervention.</p><p><strong>Results: </strong>As this is a study protocol, results are not yet available.</p><p><strong>Conclusion: </strong>If the intervention program demonstrates significant benefits, it could be offered to all women with recurrent pregnancy loss in Japan.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70293"},"PeriodicalIF":1.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical cortical neural activity in internet gaming disorder comorbid with autism spectrum disorder during a cue reactivity task: A magnetoencephalography study.","authors":"Faisal Budisasmita Paturungi Parawansa, Atsunori Sugimoto, Ekachaeryanti Zain, Yukina Nakazawa, Fuuta Sakuma, Kiyohiro Yoshinaga, Muhammad Dwi Wahyu, Hiroyuki Kasahara, Jun Egawa, Hiroshi Shirozu, Atsuhiko Iijima, Shuken Boku","doi":"10.1002/pcn5.70312","DOIUrl":"10.1002/pcn5.70312","url":null,"abstract":"<p><strong>Aim: </strong>Significant, positive correlations between internet gaming disorder (IGD) and autism spectrum disorder (ASD) are known. Individuals with ASD are prone to problematic internet use due to addiction or restricted interests. Here, we examined cortical neural activity in individuals with IGD comorbid with ASD during a gaming-related cue reactivity task, using magnetoencephalography (MEG).</p><p><strong>Methods: </strong>MEG was used to record neural activity in right-handed male participants aged 11-20 years (11 IGD-ASD, 13 healthy controls; intelligence quotient [IQ] ≥ 80). IGD and ASD were diagnosed per DSM-5-TR criteria. During MEG recording, participants viewed gaming cues and neutral base stimuli in a cue reactivity task. Source-level cortical activity was estimated using minimum norm estimation (MNE), and statistical comparisons were performed using two-tailed nonparametric permutation tests with false discovery rate (FDR) correction.</p><p><strong>Results: </strong>In the IGD-ASD group, neural activity was significantly elevated at 137 ms in the right fusiform gyrus during gaming cues compared with the base condition (<i>p</i> = 0.000039). Between-group comparisons under cue conditions (200-270 ms) showed higher right frontal activation (<i>p</i> = 0.0028) and lower activation in left lateral occipital (<i>p</i> = 0.000092), fusiform (<i>p</i> = 0.00025), lingual (<i>p</i> = 0.0017), and parahippocampal regions (<i>p</i> = 0.000049) in the IGD-ASD group compared with controls.</p><p><strong>Conclusion: </strong>The IGD-ASD group showed increased right frontal activity and decreased left occipital, fusiform, lingual, and parahippocampal activity during exposure to the gaming cue, suggesting atypical visual and cognitive processing mechanisms in this comorbid group. Further studies comparing individuals with ASD and those with IGD-ASD, as well as by examining the neurophysiological characteristics of individuals with ASD who develop or recover from IGD, might clarify the pathology of these populations.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"5 1","pages":"e70312"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}