PCN reports : psychiatry and clinical neurosciences最新文献

{"title":"Interpersonal sensitivity mediates the effects of perceived parenting styles on state anxiety and negative assessment of life events in adult volunteers from the community.","authors":"Tomoteru Seki, Chihiro Morishita, Yoshitaka Ishii, Ayaka Deguchi, Motoki Higashiyama, Yoshio Iwata, Miki Ono, Mina Honyashiki, Jiro Masuya, Ichiro Kusumi, Takeshi Inoue","doi":"10.1002/pcn5.98","DOIUrl":"10.1002/pcn5.98","url":null,"abstract":"<p><strong>Aim: </strong>The association of parenting experiences in childhood with anxiety symptoms in adulthood has yet to be clarified. We hypothesized that interpersonal sensitivity (IPS) mediates the impacts of parenting experiences in childhood on anxiety symptoms and negative assessment of life events in adulthood.</p><p><strong>Methods: </strong>An observational cross-sectional study was carried out from January 2014 to August 2014 on 853 adults. Participants provided their demographic information and answered the following four self-administered questionnaires: Parental Bonding Instrument (PBI), Interpersonal Sensitivity Measure (IPSM), Life Experiences Survey (LES), and State-Trait Anxiety Inventory Form Y (STAI-Y). The data of a total of 404 participants who agreed to take part in this study were analyzed.</p><p><strong>Results: </strong>Multiple regression analysis with the State Anxiety subscale of STAI-Y as the dependent variable identified the following five out of the 15 independent variables as being statistically significant: IPSM total, LES positive and negative, PBI paternal overprotection, and employment status. This model explains 17.8% of the State Anxiety subscale score. In the structural equation models, the Care subscale showed significant indirect negative effects on State Anxiety subscale and LES negative score through a decrease in IPSM total score (<i>β</i> = -0.061 and -0.042, respectively). The former indirect effect accounted for 31.6%, and the latter accounted for 56.8% of the total effects. In contrast, Overprotection subscale had opposite effects to Care subscale.</p><p><strong>Conclusion: </strong>These results suggest that parenting experiences in childhood are related to adult anxiety symptoms and the negative assessment of life events indirectly through IPS.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e98"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46953451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between marital satisfaction of female patients with persistent depressive disorder, and their own and husbands' autism spectrum disorder or attention deficit/hyperactivity disorder traits.","authors":"Yuko Toshishige, Masaki Kondo, Takafumi Watanabe, Atsurou Yamada, Hiroya Hashimoto, Junya Okazaki, Nishikiran Tokuyama, Junya Kuwabara, Hiroko Mizushima, Tatsuo Akechi","doi":"10.1002/pcn5.95","DOIUrl":"10.1002/pcn5.95","url":null,"abstract":"<p><strong>Aim: </strong>Patients' and spouses' neurodevelopmental traits may influence marital relationships, which are significantly associated with depressive symptoms. However, no studies have examined marital relationships in persistent depressive disorder (PDD) in terms of neurodevelopmental traits. This study aimed to explore the association between the autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) traits of female PDD patients and both partners' (patient and husband) marital satisfaction.</p><p><strong>Methods: </strong>A cross-sectional online survey was administered during two predetermined consecutive months at seven institutions. Participants were female outpatients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for PDD and their husbands. The instruments of the study were the following validated surveys: the Quality Marriage Index (QMI), the Autism-Spectrum Quotient Japanese version-21 (AQ-J-21), and the Adult ADHD Self-Report Scale Part A (ASRS Part A).</p><p><strong>Results: </strong>The patients' AQ-J-21 showed a positive significant association with their QMI in all patients who responded to this study's questionnaire, whereas among couples wherein both patient and husband responded, the ASRS Part A exhibited a positive significant association with the patients' QMI. Conversely, the husbands' ASRS Part A exhibited a negative significant association with the patients' QMI.</p><p><strong>Conclusion: </strong>The patients' ASD and ADHD traits may play a positive role in the marital satisfaction of female PDD patients, while their husbands' ADHD traits may play a negative role. For female PDD patients with low marital satisfaction, it may be important to consider whether their husbands have ADHD traits; if so, it may be necessary to develop intervention strategies focused on the traits for improving the low marital satisfaction. However, our conclusions are not sufficiently convincing.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e95"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44071466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22.","authors":"Hitoshi Sakimoto, Yuka Urata, Takanori Ishizuka, Hiroshi Kimotsuki, Motofumi Kasugai, Ryuji Fukuhara, Akira Sano, Masayuki Nakamura","doi":"10.1002/pcn5.92","DOIUrl":"10.1002/pcn5.92","url":null,"abstract":"<p><strong>Aim: </strong>Auditory Charles Bonnet syndrome (aCBS) is characterized by musical hallucinations (MHs) that accompany acquired hearing impairments. This hallucination is the acoustic perception of music, sounds, or songs in the absence of an outside stimulus, and it may be associated with hyperactivity of the superior temporal lobes. Some studies have reported the possibility of improving MH with antiepileptics. To elucidate in detail the brain regions responsible for aCBS, we analyzed the regions that changed functionally after treatment.</p><p><strong>Methods: </strong>Before and after treatment with carbamazepine (four cases), clonazepam (one case), and a hearing aid (one case), cerebral perfusion single-photon emission computed tomography (SPECT) and the Auditory Hallucination Rating Scale (AHRS) were applied to six patients with hearing-loss-associated MHs.</p><p><strong>Results: </strong>Cerebral blood flow analysis using SPECT revealed hyperperfusion in Brodmann area (BA) 22-the posterior region of the superior temporal gyrus-in the nondominant hemisphere in all six patients in the pretreatment phase. After treatment, the hyperperfusion region improved in all patients. The area percentages with hyperperfusion in the nondominant BA22 were strongly positively correlated with the AHRS score.</p><p><strong>Conclusion: </strong>The results suggest that aCBS, which was treatable with antiepileptics or hearing aids, was involved in hyperexcitement in BA22, and that MH strength was correlated with degree of excitement.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e92"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46995026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective temperaments mediate the effect of childhood maltreatment on bipolar depression severity.","authors":"Itsuki Terao, Chihiro Morishita, Yu Tamada, Jiro Masuya, Yota Fujimura, Hiroyuki Toda, Ichiro Kusumi, Hajime Tanabe, Takeshi Inoue","doi":"10.1002/pcn5.94","DOIUrl":"10.1002/pcn5.94","url":null,"abstract":"<p><strong>Aim: </strong>Bipolar disorder is a leading disorder contributing to global disease burden, and bipolar depression often becomes severe and refractory. Therefore, clarifying the pathophysiology of bipolar disorder is an urgent issue. Previous reports suggested that factors, such as affective temperaments and childhood maltreatment, aggravate bipolar depression severity. However, to our knowledge, no reports to date have clarified the interrelationship between the above factors and bipolar depression severity. We here hypothesized that childhood maltreatment worsens bipolar depression severity via increasing affective temperaments. To test this hypothesis, a covariance structural analysis was conducted.</p><p><strong>Methods: </strong>The following information was evaluated for a total of 75 people with bipolar disorder using self-administered questionnaires: demographic characteristics, depressive symptoms (Patient Health Questionnaire-9), history of childhood maltreatment (Child Abuse and Trauma Scale), and affective temperaments (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire). The results were analyzed using covariance structure analysis.</p><p><strong>Results: </strong>A significant indirect effect of childhood maltreatment on bipolar depression severity via increasing affective temperaments was identified, whereas the direct effect of childhood maltreatment was not significant.</p><p><strong>Conclusion: </strong>Our results reveal that affective temperaments can mediate the adverse effects of childhood maltreatment on the severity of bipolar depression.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e94"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47026151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment strategy for late-life depression.","authors":"Hajime Baba","doi":"10.1002/pcn5.91","DOIUrl":"10.1002/pcn5.91","url":null,"abstract":"<p><p>With the unprecedented aging of the world's population, the number of elderly patients with depression is expected to increase. However, management and treatment of late-life depression (LLD) is more difficult than in early adults. Prior to treatment, diagnosis must take into account the differentiation from, and comorbidity with, organic brain diseases such as dementia and delirium, as well as depression caused by other physical diseases or medications. As clinical features of LLD, treatment response tends to be poor in older patients and recurrence rates are higher than those in early adult patients, therefore psycho-social interventions on the basis of the patient's background and condition are important for LLD. The first-line treatment strategy generally depends on the severity of the depression. Systematic psychotherapies, including cognitive behavioral therapy and problem-solving therapy, have been reported to reduce depressive symptoms in LLD. Regarding pharmacotherapy, newer antidepressants are recommended for LLD, but careful attention to adverse events is required. Treatment using neuromodulation is also reported to be useful for LLD. In the current review, for further-line treatment, treatment strategies were divided according to the level of first-line treatment response. Evidence indicates that LLD is more heterogeneous than depression in younger adults, therefore when treating LLD patients it is necessary to take various conditions and situations into consideration, and to provide detailed treatment that is tailored to each patient.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e91"},"PeriodicalIF":0.0,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46254416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of inpatient family-based treatment for anorexia nervosa: A case report.","authors":"Sayaka Nishiura, Dai Miyawaki, Ayako Goto, Hirai Kaoru, Shoko Sakamoto, Hiroki Hama, Shin Kadono, Koki Inoue","doi":"10.1002/pcn5.89","DOIUrl":"10.1002/pcn5.89","url":null,"abstract":"<p><strong>Background: </strong>Family-based treatment (FBT) is effective for the treatment of anorexia nervosa (AN) in children and adolescents. However, its availability in Japan is limited because it requires adherence to specific guidelines, commitment of sufficient time for frequent outpatient treatment, as well as the entire family's participation. We present a case of a patient with AN who was treated with modified FBT during hospitalization.</p><p><strong>Case presentation: </strong>Our patient was a 14-year-old girl with AN. She was hospitalized for malnutrition and dehydration, and was introduced to FBT during this period. After discharge, she continued FBT on an outpatient basis and was in remission 1 year later.</p><p><strong>Conclusion: </strong>This case shows that initiation of FBT during hospitalization may be useful in patients with physically severe AN. Flexible adaptation to each of the diverse healthcare systems and cultural differences may be necessary for the widespread use of FBT.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e89"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45166412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-disorder explained: Yasunaga's \"Phantom Space Theory\" on schizophrenia.","authors":"Tsutomu Kumazaki, Naoki Hayashi","doi":"10.1002/pcn5.90","DOIUrl":"10.1002/pcn5.90","url":null,"abstract":"<p><p>The present article revisits the theoretical model of schizophrenia by Hiroshi YASUNAGA (1929-2011). Yasunaga restated ego disturbance in schizophrenia as the \"Pattern Reversal\" between selfhood and otherness, based on British philosopher Wauchope's concept of \"pattern.\" This concept is meant as asymmetrical relatedness (A/B) within a pair of concepts, such as life and death, quality and quantity, and self and other, prioritizing the former (A side) over the latter (B side). When applied to the pair of self and other, the pattern is vital for human experiences, and its disruption fundamentally alters every lived experience. Subsequently, Yasunaga extended the theory of pattern and invented his original \"Phantom Space Theory,\" in which he postulated \"Phantom Space,\" an experiential space that constitutes system <i>a</i> (A-side-led and consciously determined distance) and system <i>a'</i> (B-side-dominated and extra-consciously given distance). He then constructed a kind of neural system model composed of systems <i>a</i> and <i>a'</i>, and thereby schematically presented a novel viewpoint on experiences of self and the outside world. The theory further illustrated how the hypothesized imbalance (Phantom Space shrinkage or diminished elasticity of system <i>a'</i>) causes symptoms of schizophrenia, such as ego disturbances, auditory hallucinations, and other unspecific symptoms. This article then examines the clinical and theoretical implications of Yasunaga's psychiatric works. Phantom Space Theory is a non-stigmatizing account of schizophrenia because it does not presuppose personal or existential causes of psychosis. The relationship between Phantom Space Theory and dual-process theory is also explored.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e90"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43918055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the forced-choice coin test for detecting malingering during forensic psychiatric examinations.","authors":"Keisuke Tsuji","doi":"10.1002/pcn5.87","DOIUrl":"10.1002/pcn5.87","url":null,"abstract":"<p><strong>Background: </strong>In general clinical psychiatric practice, open questions are favored over closed ones because they are considered more therapeutically effective and less likely to make the patients pander to us. However, in forensic psychiatric examinations, suspects may attempt malingering.</p><p><strong>Case presentation: </strong>Using a simple examination based on a forced-choice technique, the author proved that the level of intelligence of a theft suspect pretending to have an intellectual developmental disorder was not so low. The author prepared two sets consisting of a few coins each and asked the suspect to choose which set had a higher total value. The suspect was questioned repeatedly over multiple trials. He always selected the wrong set over the course of more than 10 trials.</p><p><strong>Conclusion: </strong>If the suspect really did not know the correct answer, the probability of getting the answer right or wrong in a binary choice question is 50% for both. The probability of answering the question wrong by chance 10 times in a row is (1/2),¹⁰ in other words, about 0.1%. It was evident that the suspect intentionally kept answering incorrectly. When suspects who pretend to have an intellectual developmental disorder answer only \"I do not know\" to all questions without actively playing out the symptoms, it is difficult to demonstrate that the symptoms are psychiatrically conflicting and prove that they are malingering. Even in such cases, this type of test based on a forced-choice technique can be used to prove that suspects are behaving falsely.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e87"},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42672559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical ethics problems in psychiatry and the need for clinical ethics consultation in Japan: A cross-sectional study.","authors":"Hiroyuki Sato, Yoshiyuki Takimoto","doi":"10.1002/pcn5.86","DOIUrl":"10.1002/pcn5.86","url":null,"abstract":"<p><strong>Aim: </strong>Psychiatrists often encounter ethical dilemmas in their daily clinical practice. Clinical ethics consultations (CECs) have been recently increasing, especially in general hospitals. However, the current situation in the psychiatric field is unclear. This study clarifies clinical ethics problems in psychiatry and determines the need for CECs.</p><p><strong>Methods: </strong>We conducted an anonymous self-administered questionnaire survey in February 2022, which targeted directors and supervisors of psychiatric specialty training programs at 1224 psychiatry facilities.</p><p><strong>Results: </strong>Responses were received from 311 facilities (response rate: 25.4%). CEC systems existed in 223 (72.2%) facilities, and medical safety committees were the most common. Clinical ethics problems occurred at 248 (80.3%) facilities; the most common method for managing the problems was discussions at case conferences without using CECs. The top four reasons for psychiatrists to solicit advice were conflicts with patients' relatives, treating a patient with cognitive impairment, discontinuation of treatment, and suicide/attempted suicide. Most respondents (89.9%) considered CECs necessary.</p><p><strong>Conclusion: </strong>Although CECs exist in psychiatry, they may not meet the needs of clients. Future studies are needed to investigate client satisfaction and CEC evaluation methods in facilities where psychiatric CECs are provided.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e86"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45161685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of suvorexant and lemborexant for insomnia treatment.","authors":"Teruaki Hayashi, Takehiko Yamanashi, Masaaki Iwata","doi":"10.1002/pcn5.85","DOIUrl":"10.1002/pcn5.85","url":null,"abstract":"<p><strong>Aim: </strong>Although suvorexant and lemborexant, which have orexin receptor antagonist activity, are used as sleep medications in Japan, no report has directly compared their efficacy and safety. This study compared the efficacy and safety of the drugs.</p><p><strong>Methods: </strong>This retrospective cohort study included patients who presented to the Outpatient Department of Psychiatry at Tottori University Hospital between December 1, 2020, and December 31, 2021. Information was obtained from 108 patients who were newly treated with suvorexant or lemborexant. Data were analyzed after excluding one case of discontinuation due to a post-administration allergic reaction. Improvement in sleep status after administration was assessed retrospectively from medical records by using the Clinical Global Impressions-Improvement (CGI-I) Scale, which is a subscale of the Clinical Global Impressions (CGI) Scale. The incidence of side-effects was obtained from the medical records of the patient's first visit after administration.</p><p><strong>Results: </strong>There was no significant difference between the CGI-I scores in the suvorexant (mean [SD], 3.05 [0.93]) and lemborexant groups (mean [SD], 3.38 [0.83]) (<i>p</i> = 0.10). The incidence of side-effects with continued treatment was not significantly different between the suvorexant group (12.5%) and the lemborexant group (2.9%) (<i>p</i> = 0.10). Patients who switched from suvorexant to lemborexant had CGI-I scores ≤4, and no side-effects were observed after switching to lemborexant.</p><p><strong>Conclusion: </strong>There was no difference in effectiveness between suvorexant and lemborexant. However, lemborexant might cause side-effects less frequently than suvorexant, at least in the early stages of treatment.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":" ","pages":"e85"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44430577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}