Osteoarthritis and cartilage open最新文献

{"title":"Budget impact of the Walk With Ease program for knee osteoarthritis","authors":"Mahima T. Kumara ,&nbsp;Rebecca J. Cleveland ,&nbsp;Aleksandra M. Kostic ,&nbsp;Serena E. Weisner ,&nbsp;Kelli D. Allen ,&nbsp;Yvonne M. Golightly ,&nbsp;Heather Welch ,&nbsp;Melissa Dale ,&nbsp;Stephen P. Messier ,&nbsp;David J. Hunter ,&nbsp;Jeffrey N. Katz ,&nbsp;Leigh F. Callahan ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2024.100463","DOIUrl":"10.1016/j.ocarto.2024.100463","url":null,"abstract":"<div><h3>Objective</h3><p>Walk With Ease (WWE) is an effective low-cost walking program. We estimated the budget impact of implementing WWE in persons with knee osteoarthritis (OA) as a measure of affordability that can inform payers’ funding decisions.</p></div><div><h3>Methods</h3><p>We estimated changes in two-year healthcare costs with and without WWE. We used the Osteoarthritis Policy (OAPol) Model to estimate per-person medical expenditures. We estimated total and per-member-per-month (PMPM) costs of funding WWE for a hypothetical insurance plan with 75,000 members under two conditions: 1) all individuals aged 45+ with knee OA eligible for WWE, and 2) inactive and insufficiently active individuals aged 45+ with knee OA eligible. In sensitivity analyses, we varied WWE cost and efficacy and considered productivity costs.</p></div><div><h3>Results</h3><p>With eligibility unrestricted by activity level, implementing WWE results in an additional $1,002,408 to the insurance plan over two years ($0.56 PMPM). With eligibility restricted to inactive and insufficiently active individuals, funding WWE results in an additional $571,931 over two years ($0.32 PMPM). In sensitivity analyses, when per-person costs of $10 to $1000 were added with 10–50% decreases in failure rate (enhanced sustainability of WWE benefits), two-year budget impact varied from $242,684 to $6,985,674 with unrestricted eligibility and from -$43,194 (cost-saving) to $4,484,122 with restricted eligibility.</p></div><div><h3>Conclusion</h3><p>Along with the cost-effectiveness of WWE at widely accepted willingness-to-pay thresholds, these results can inform payers in deciding to fund WWE. In the absence of accepted thresholds to define affordability, these results can assist in comparing the affordability of WWE with other behavioral interventions.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266591312400030X/pdfft?md5=fcf17763a67bc8c5ac2c88dd2b7749b9&pid=1-s2.0-S266591312400030X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subchondral bone expansion in advanced knee osteoarthritis: Relation with radiographic severity and role in surgical decision-making","authors":"Wei Wang ,&nbsp;Tianshu Jiang ,&nbsp;Jiang Zhang ,&nbsp;Jun Liu ,&nbsp;Lok Chun Chan ,&nbsp;Mengqi Lin ,&nbsp;Jia Li ,&nbsp;Changhai Ding ,&nbsp;Kwong Yuen Chiu ,&nbsp;Henry Fu ,&nbsp;Ping Keung Chan ,&nbsp;Chunyi Wen","doi":"10.1016/j.ocarto.2024.100461","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100461","url":null,"abstract":"<div><h3>Background</h3><p>Joint space width (JSW) is a traditional imaging marker for knee osteoarthritis (OA) severity, but it lacks sensitivity in advanced cases. We propose tibial subchondral bone area (TSBA), a new CT imaging marker to explore its relationship with OA radiographic severity, and to test its performance for classifying surgical decisions between unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) compared to JSW.</p></div><div><h3>Methods</h3><p>We collected clinical, radiograph, and CT data from 182 patients who underwent primary knee arthroplasty (73 UKA, 109 TKA). The radiographic severity was scored using Kellgren-Lawrence (KL) grading system. TSBA and JSW were extracted from 3D CT-reconstruction model. We used independent <em>t</em>-test to investigate the relationship between TSBA and KL grade, and binary logistic regression to identify factors associated with TKA risk. The accuracy of TSBA, JSW and established classification model in differentiating between UKA and TKA was assessed using AUC.</p></div><div><h3>Results</h3><p>All parameters exhibited inter- and intra-class coefficients greater than 0.966. Patients with KL grade 4 had significantly larger TSBA than those with KL grade 3. TSBA (0.708 of AUC) was superior to minimal/average JSW (0.547/0.554 of AUC) associated with the risk of receiving TKA. Medial TSBA, together with gender and Knee Society Knee Score, emerged as independent classification factors in multivariate analysis. The overall AUC of composite model for surgical decision-making was 0.822.</p></div><div><h3>Conclusion</h3><p>Tibial subchondral bone area is an independent imaging marker for radiographic severity, and is superior to JSW for surgical decision-making between UKA and TKA in advanced OA patients.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100461"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000281/pdfft?md5=bda8dccb69284029542bce0241f7b5b0&pid=1-s2.0-S2665913124000281-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140187117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the SQUASH physical activity questionnaire using accelerometry: The NEO study","authors":"Sietse E.S. Terpstra ,&nbsp;Lotje A. Hoogervorst ,&nbsp;Jeroen H.P.M. van der Velde ,&nbsp;Renée de Mutsert ,&nbsp;Lotte A. van de Stadt ,&nbsp;Frits R. Rosendaal ,&nbsp;Margreet Kloppenburg","doi":"10.1016/j.ocarto.2024.100462","DOIUrl":"10.1016/j.ocarto.2024.100462","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the construct validity of the SQUASH (Short QUestionnaire to ASsess Health-enhancing physical activity).</p></div><div><h3>Design</h3><p>This is a cross-sectional analysis using baseline measurements from middle-aged participants in the Netherlands Epidemiology of Obesity (NEO) study. The SQUASH consists of questions on eleven physical activities investigating days per week, average duration per day and intensity, leading to a summed score in Metabolic Equivalent of Task hours (MET h) per week. To assess convergent validity, a Spearman's rank correlation between SQUASH and ActiHeart was calculated. To assess extreme group validity, three groups expected to differ in SQUASH total physical activity outcome were compared. For discriminative validity, a Spearman's rank correlation between SQUASH physical activity and participant height was investigated.</p></div><div><h3>Results</h3><p>SQUASH data were available for 6550 participants (mean age 56 years, 44% men, mean BMI 26.3, 15% with knee OA, 13% with hand OA). Median physical activity (interquartile range) was 118 (76; 154) MET h/week according to SQUASH and 75 (58; 99) according to ActiHeart. Convergent validity was weak (rho ​= ​0.20). For all three extreme group comparisons, a statistically significant difference was present. Discriminative validity was present (rho ​= ​0.01). Compared with the reference quintile, those with a discrepancy SQUASH ​&gt; ​ActiHeart and SQUASH ​&lt; ​ActiHeart were relatively younger and more often male.</p></div><div><h3>Conclusions</h3><p>The construct validity of the SQUASH seems sub-optimal. Physical activity reported by the SQUASH was generally higher than reported by ActiHeart. Whether the differences between SQUASH and ActiHeart are e.g. due to different underlying domains, limitations to our study, or reflect true differences needs further investigation.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000293/pdfft?md5=bf6a4e41d02f3627d6d9da3d09c28f1b&pid=1-s2.0-S2665913124000293-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth factors that drive aggrecan synthesis in healthy articular cartilage. Role for transforming growth factor-β?","authors":"Peter M. van der Kraan ,&nbsp;Arjan P.M. van Caam,&nbsp;Esmeralda N. Blaney Davidson,&nbsp;Martijn H.J. van den Bosch,&nbsp;Fons A.J. van de Loo","doi":"10.1016/j.ocarto.2024.100459","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100459","url":null,"abstract":"<div><h3>Introduction</h3><p>Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan of cartilage, aggrecan. Aggrecan has a relatively short half-life in cartilage and therefore continuous production of this molecule is essential.</p></div><div><h3>Methods</h3><p>In this narrative review we discuss what is the role of growth factors in driving the synthesis of aggrecan in articular cartilage. A literature search has been done using the search items; cartilage, aggrecan, explant, Transforming Growth factor-β (TGF-β), Insulin-like Growth Factor (IGF), Bone Morphogenetic Protein (BMP) and the generic term “growth factors”. Focus has been on studies using healthy cartilage and models of cartilage regeneration have been excluded.</p></div><div><h3>Results</h3><p>In healthy adult articular cartilage IGF is the main factor that drives aggrecan synthesis and maintains adequate levels of production. BMP's and TGF-β have a very limited role but appear to be more important during chondrogenesis and cartilage development. The major role of TGF-β is not stimulation of aggrecan synthesis but maintenance of the differentiated articular cartilage chondrocyte phenotype.</p></div><div><h3>Conclusion</h3><p>TGF-β is a factor that is generally considered as an important factor in stimulating aggrecan synthesis in cartilage but its role in this might be very restrained in healthy, adult articular cartilage.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000268/pdfft?md5=da0f4a3e9575d6b5d31a3c77d456544d&pid=1-s2.0-S2665913124000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140096370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise and intra-articular injections versus exercise alone for the treatment of knee osteoarthritis: A scoping review of the evidence","authors":"Sydney C. Liles ,&nbsp;Bradley Bley ,&nbsp;Daniel K. White","doi":"10.1016/j.ocarto.2024.100456","DOIUrl":"10.1016/j.ocarto.2024.100456","url":null,"abstract":"<div><h3>Objective</h3><p>Current treatment for knee Osteoarthritis (OA) includes exercise and intra-articular injections with corticosteroid (CS), hyaluronic acid (HA), etc., which address OA-related pain and functional limitation. While these interventions can be given together, little is known about the efficacy of a multi-modal approach. The purpose of this scoping review is to examine studies that compare combining exercise and intra-articular knee injections to exercise alone for the management of knee OA.</p></div><div><h3>Methods</h3><p>A search was performed using PubMed, CINAHL, and Clinicaltrials.gov with MeSH terms “knee osteoarthritis” AND “exercise” AND “injections”. Abstracts were screened to meet inclusion criteria of both intervention groups including exercise and one group receiving an injection for treatment of knee OA. Full text articles were screened to meet inclusion criteria and rated using the Pedro Scale.</p></div><div><h3>Results</h3><p>11 studies that met inclusion criteria. The included studies utilized CS, hyaluronic acid (HA), and Bone Marrow Concentrate (BMC), botulinum toxin A, or a combination of dextrose and lidocaine injections. Most studies included supervised exercise interventions with all studies including strengthening of the quadriceps. CS and exercise compared to exercise alone showed similar improvements in pain. The HA injection studies yielded mixed results with two studies finding HA and exercise was not superior than exercise alone while two other studies found that HA and exercise were superior.</p></div><div><h3>Conclusion</h3><p>There was a paucity of literature investigating multimodal approaches. Most of the included studies did not find superior effects of adding a knee injection to exercise compared to exercise alone for knee OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100456"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000232/pdfft?md5=236af1f1e522eb9e2f1863494e231d9c&pid=1-s2.0-S2665913124000232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing an osteoarthritis management program to deliver guideline-driven care for knee and hip osteoarthritis in a U.S. academic health system","authors":"Kathryn A. Miller ,&nbsp;Linda M. Baier Manwell ,&nbsp;Christie M. Bartels ,&nbsp;Tommy Yue Yu ,&nbsp;Divya Vundamati ,&nbsp;Marley Foertsch ,&nbsp;Roger L. Brown","doi":"10.1016/j.ocarto.2024.100452","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100452","url":null,"abstract":"<div><h3>Objective</h3><p>Assess implementation feasibility and outcomes for an Osteoarthritis Management Program (OAMP) at an academic center.</p></div><div><h3>Design</h3><p>This open study assessed an OAMP designed to deliver care in 1–5 individual or group visits across ≤12 months. Eligibility included adults with knee or hip osteoarthritis with ≥1 visit from 7/1/2017–1/15/2021. A multidisciplinary care team provided: education on osteoarthritis, self-management, exercise, weight loss; pharmacologic management; assessments of mood, sleep, quality of life, and diet. Clinic utilization and growth are reported through 2022. Patient outcomes of body mass index (BMI), pain, and function were analyzed using multivariable general linear models. OAMP outcomes were feasibility and sustainability.</p></div><div><h3>Results</h3><p>Most patients were locally referred by primary care. 953 patients attended 2531 visits (average visits 2.16, treatment duration 187.9 days). Most were female (72.6%), older (62.1), white (91.1%), and had medical insurance (95.4%). Obesity was prevalent (84.7% BMI ≥30, average BMI 40.9), mean Charlson Comorbidity Index was 1.89, and functional testing was below average. Longitudinal modeling revealed statistically but not clinically significant pain reduction (4.4–3.9 on 0–10 scale, p ​= ​0.002). BMI did not significantly change (p ​= ​0.87). Higher baseline pain and BMI correlated with greater reductions in each posttreatment. Uninsured patients had shorter treatment duration. Increasing clinic hours (4–24 ​h weekly) and serving 953 patients over four years demonstrated OAMP sustainability.</p></div><div><h3>Conclusions</h3><p>OAMP implementation was feasible and sustainable. Patients with high baseline pain and BMI were more likely to improve. Noninsurance was a barrier. These results contribute to understanding OAMP outcomes in U.S. healthcare.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100452"},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000190/pdfft?md5=8682adf63911d98831c57444d3722162&pid=1-s2.0-S2665913124000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of B-score for predicting joint replacement in the context of osteoarthritis phenotypes: Data from the osteoarthritis initiative","authors":"F. Saxer ,&nbsp;D. Demanse ,&nbsp;A. Brett ,&nbsp;D. Laurent ,&nbsp;L. Mindeholm ,&nbsp;P.G. Conaghan ,&nbsp;M. Schieker","doi":"10.1016/j.ocarto.2024.100458","DOIUrl":"10.1016/j.ocarto.2024.100458","url":null,"abstract":"<div><h3>Objective</h3><p>Developing new therapies for knee osteoarthritis (KOA) requires improved prediction of disease progression. This study evaluated the prognostic value of clinical clusters and machine-learning derived quantitative 3D bone shape B-score for predicting total and partial knee replacement (KR).</p></div><div><h3>Design</h3><p>This retrospective study used longitudinal data from the Osteoarthritis Initiative. A previous study used patients' clinical profiles to delineate phenotypic clusters. For these clusters, the distribution of B-scores was assessed (employing Tukey's method). The value of both cluster allocation and B-score for KR-prediction was then evaluated using multivariable Cox regression models and Kaplan-Meier curves for time-to-event analyses. The impact of using B-score vs. cluster was evaluated using a likelihood ratio test for the multivariable Cox model; global performances were assessed by concordance statistics (Harrell's C-index) and time dependent receiver operating characteristic (ROC) curves.</p></div><div><h3>Results</h3><p>B-score differed significantly for the individual clinical clusters (p ​&lt; ​0.001). Overall, 9.4% of participants had a KR over 9 years, with a shorter time to event in clusters with high B-score at baseline. Those clusters were characterized clinically by a high rate of comorbidities and potential signs of inflammation. Both phenotype and B-score independently predicted KR, with better prediction if combined (P ​&lt; ​0.001). B-score added predictive value in groups with less pain and radiographic severity but limited physical activity.</p></div><div><h3>Conclusions</h3><p>B-scores correlated with phenotypes based on clinical patient profiles. B-score and phenotype independently predicted KR surgery, with higher predictive value if combined. This can be used for patient stratification in drug development and potentially risk prediction in clinical practice.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000256/pdfft?md5=3700ef530ef0c631960569aeebbb827e&pid=1-s2.0-S2665913124000256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year trends in values of joint space width and osteophyte area of knee joints: Comparison of the baseline and fourth ROAD study surveys","authors":"Banri Kitamura ,&nbsp;Toshiko Iidaka ,&nbsp;Chiaki Horii ,&nbsp;Shigeyuki Muraki ,&nbsp;Hiroyuki Oka ,&nbsp;Hiroshi Kawaguchi ,&nbsp;Kozo Nakamura ,&nbsp;Toru Akune ,&nbsp;Yuta Otsuka ,&nbsp;Takayuki Izumo ,&nbsp;Takao Tanaka ,&nbsp;Tomohiro Rogi ,&nbsp;Hiroshi Shibata ,&nbsp;Sakae Tanaka ,&nbsp;Noriko Yoshimura","doi":"10.1016/j.ocarto.2024.100454","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100454","url":null,"abstract":"<div><h3>Objective</h3><p>Considering the joint space width and osteophyte area (OPA) of the knee joints of Japanese adults, this study elucidated the ten-year trends in medial minimum joint space width (mJSW) and OPA using data of two independent cohorts from a population-based cohort study.</p></div><div><h3>Methods</h3><p>The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability study was conducted from 2005 to 2007; 2975 participants (1041 men, 1934 women) completed all knee osteoarthritis (OA) examinations. The fourth survey was performed from 2015 to 2016; distinct 2445 participants (764 men, 1681 women) completed identical examinations. The medial mJSW and medial tibial OPA were measured bilaterally using an automated system.</p></div><div><h3>Results</h3><p>The mean medial mJSW (standard deviation) was 3.22 (0.96) mm and 2.65 (0.95) mm at baseline and 3.81 (1.20) mm and 3.13 (1.15) mm in the fourth survey for men and women, respectively. The mean medial mJSW in the fourth survey was significantly greater in both men and women in all age groups than at baseline (<em>p</em> ​&lt; ​0.01). The mean OPAs in men aged 40–49 and 60–69 years and women aged 40–49, 50–59, 60–69, and 70–79 years were significantly smaller in the fourth survey (<em>p</em> ​&lt; ​0.05). The trend in mJSW remained the same even after adjusting for confounding factors in the multivariate analysis, but the trend in OPA was weakened.</p></div><div><h3>Conclusions</h3><p>A significant improvement in the medial mJSW within 10 years could decrease the incidence and progression of knee OA and prevent the risk of walking disability.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100454"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000219/pdfft?md5=5b9a793d0ff4c5048940fb312f025f56&pid=1-s2.0-S2665913124000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline levels of circulating galectin-1 associated with radiographic hand but not radiographic knee osteoarthritis at a two-year follow-up","authors":"M.L.E. Andersson ,&nbsp;M. Zimmerman ,&nbsp;E. Brogren ,&nbsp;S. Bergman ,&nbsp;L. Strindberg ,&nbsp;E. Fryk ,&nbsp;P.A. Jansson","doi":"10.1016/j.ocarto.2024.100455","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100455","url":null,"abstract":"<div><h3>Objective</h3><p>We tested the potential of circulating galectin-1, interleukin (IL)-1 beta, IL-6, and tumour necrosis factor alpha (TNF alpha) levels at baseline in individuals with knee pain as biomarkers for development of radiographic knee and/or hand osteoarthritis (OA).</p></div><div><h3>Design</h3><p>This study comprised 212 individuals with knee pain from the Halland osteoarthritis cohort (HALLOA). Clinical characteristics and serum/plasma levels of galectin-1, IL-1 beta, IL-6, and TNF alpha were measured at baseline, and knee and hand radiographs were obtained at a two-year follow-up. The predictive value of circulating inflammatory markers and clinical variables at baseline was assessed using multinominal logistic regression for those who developed radiographic OA in knees only (n ​= ​25), in hands only (n ​= ​40), and in both knees and hands (n ​= ​43); the group who did not develop OA (n ​= ​104) was used as reference. Correlations were assessed using Spearman's correlation coefficients.</p></div><div><h3>Results</h3><p>As expected, age was identified as a risk factor for having radiographic knee and/or hand OA at the two-year follow-up. Baseline circulating galectin-1 levels did not associate with developing radiographic knee OA but associated with developing radiographic hand OA (odds ratio (OR) for a 20% increased risk: 1.14, 95% confidence interval (CI) 1.01–1.29) and both radiographic knee and hand OA (OR for a 20% increased risk: 1.18, 95% CI 1.05–1.30). However, baseline IL-1 beta, IL-6, and TNF alpha did not associate with developing radiographic knee and/or hand OA.</p></div><div><h3>Conclusion</h3><p>Non-age adjusted circulating galectin-1 is superior to IL-6, IL-1 beta, and TNF alpha in predicting radiographic hand but not knee OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100455"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000220/pdfft?md5=5b97554730a551facc1ccf5b7a1561c7&pid=1-s2.0-S2665913124000220-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive electrophysical therapies used in addition to land-based exercise therapy for osteoarthritis of the hip or knee: A systematic review and meta-analysis","authors":"Helen P. French ,&nbsp;Joice Cunningham ,&nbsp;Rose Galvin ,&nbsp;Sania Almousa","doi":"10.1016/j.ocarto.2024.100457","DOIUrl":"10.1016/j.ocarto.2024.100457","url":null,"abstract":"<div><h3>Objectives</h3><p>To review evidence for effectiveness of electrophysical therapies (EPTs), used adjunctively with land-based exercise therapy, for hip or knee osteoarthritis (OA), compared with 1) placebo EPTs delivered with land-based exercise therapy or 2) land-based exercise therapy only.</p></div><div><h3>Methods</h3><p>Six databases were searched up to October 2023 for randomised controlled trials (RCTs)/quasi-RCTs comparing adjunctive EPTs alongside land-based exercise therapy versus 1) placebo EPTs alongside land-based exercise, or 2) land-based exercise in hip or knee OA. Outcomes included pain, function, quality of life, global assessment and adverse events. Risk of bias and overall certainty of evidence were assessed. We back-translated significant Standardised Mean Differences (SMDs) to common scales: 2 points/15% on a 0–10 Numerical Pain Rating Scale and 6 points/15% on the WOMAC physical function subscale.</p></div><div><h3>Results</h3><p>Forty studies (2831 patients) evaluated nine different EPTs for knee OA. Medium-term effects (up to 6 months) were evaluated in seven trials, and one evaluated long-term effects (&gt;6 months). Adverse events were reported in one trial. Adjunctive laser therapy may confer short-term effects on pain (SMD -0.68, 95%CI -1.03 to −0.34; mean difference (MD) 1.18 points (95% CI -1.78 to −0.59) and physical function (SMD -0.60, 95%CI -0.88 to −0.34; MD 12.95 (95%CI -20.05 to −5.86)) compared to placebo EPTs, based on very low-certainty evidence. No other EPTs (TENS, interferential, heat, shockwave, shortwave, ultrasound, EMG biofeedback, NMES) showed clinically significant effects compared to placebo/exercise, or exercise only.</p></div><div><h3>Conclusions</h3><p>Very low-certainty evidence supports laser therapy used adjunctively with exercise for short-term improvement in pain and function. No other EPTs demonstrated clinically meaningful effects.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100457"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000244/pdfft?md5=1bb822366f3cd21b9158c8e2e9545296&pid=1-s2.0-S2665913124000244-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140089204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}