Osteoarthritis and cartilage open最新文献

{"title":"Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study","authors":"S. Berkani ,&nbsp;S. Tuffet ,&nbsp;A. Rousseau ,&nbsp;N. Rincheval ,&nbsp;E. Maheu ,&nbsp;B. Combes ,&nbsp;A. Saraux ,&nbsp;B. Fautrel ,&nbsp;L. Gossec ,&nbsp;F. Berenbaum ,&nbsp;J. Sellam ,&nbsp;A. Courties","doi":"10.1016/j.ocarto.2025.100626","DOIUrl":"10.1016/j.ocarto.2025.100626","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD).</div></div><div><h3>Methods</h3><div>This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. Outcomes were pain intensity (≥40 on a 0–100 ​mm visual analog scale [VAS]), VAS fatigue, and functional impairment, measured by normalized (0–100) Health Assessment Questionnaire (HAQ) for RA and the AUStralian CANadian Osteoarthritis Hand (AUSCAN) function for EHOA and binarized by their medians. Comorbidities and CMD were also assessed. Logistic regression models adjusted for age, sex, body mass index, and socio-educational level were used to compare outcomes.</div></div><div><h3>Results</h3><div>We included 138 EHOA and 379 RA patients. EHOA patients were older (median age 67.3 <em>vs.</em> 48.6 years, p ​&lt; ​0.001). EHOA patients were more likely to experience higher pain at mobilization (OR ​= ​3.13 95 ​% CI [1.74 to 5.68]) and greater functional impairment (OR ​= ​2.27, 95 ​% CI [1.26 to 4.17]) than RA patients. There was no difference for fatigue and pain at rest. The overall risk of comorbidities was lower in EHOA patients in multivariate analysis (OR ​= ​0.25, 95%CI [0.13–0.48]). There was no significant difference in CMD risk.</div></div><div><h3>Conclusion</h3><div>After more than 10 years of disease duration, EHOA is associated with greater pain and functional impairment than treated RA but with fewer comorbidities. This highlights the significant unmet need for effective therapies for EHOA patients.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients","authors":"Ronan J. Anderson ,&nbsp;Brent A. Lanting ,&nbsp;C. Thomas Appleton ,&nbsp;Ryan M. Degen","doi":"10.1016/j.ocarto.2025.100625","DOIUrl":"10.1016/j.ocarto.2025.100625","url":null,"abstract":"<div><h3>Objective</h3><div>To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoarthritis, and advanced hip osteoarthritis.</div></div><div><h3>Methods</h3><div>Synovium biopsies were collected from ten FAI, fourteen FAI with early osteoarthritis, and twelve advanced osteoarthritis patients. Histopathological grading allowed assessment of osteoarthritis-associated features. Microvessel density and maturity were determined through immunofluorescent labelling of CD31 and α-smooth muscle actin. Immunohistochemical staining was applied to calculate CD105⁺ microvessel density, providing insight into microvessel activity.</div></div><div><h3>Results</h3><div>In all groups, vascularization was prominent, with a mean [95 ​% confidence interval] of 1.64 [1.40, 1.89]. In all three groups, mature microvessel density was greater than immature microvessel density (82.32 [62.92, 101.71] versus 14.84 [9.86, 19.83] microvessels/mm²). Low CD105⁺ microvessel density across all groups (3.14 [0.92, 5.37] microvessels/mm²) suggests microvessel inactivity. Inflammatory composite scores were significantly greater in the advanced OA (1.08 [0.84, 1.32]) versus the FAI group (0.47 [0.26, 0.68]), and in the advanced OA versus the FAI with early OA group (0.69 [0.49, 0.89]) (p ​&lt; ​0.017).</div></div><div><h3>Conclusion</h3><div>Synovium from patients with FAI (with and without hip osteoarthritis) demonstrated synovitis and other OA-associated changes. Mature, inactive microvasculature was prominent in all three groups investigated. Histopathological similarities between FAI and hip OA synovium indicate that disordered synovium appears in FAI patients. These findings highlight a potential role of synovial changes in the progression from FAI to hip OA, underscoring the need for early intervention and further investigation into early disease mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy","authors":"Peter M. van der Kraan","doi":"10.1016/j.ocarto.2025.100624","DOIUrl":"10.1016/j.ocarto.2025.100624","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a “wear and tear” condition, new insights suggest that OA may be part of an evolutionary, age-related biological process rather than mainly driven by mechanical damage.</div></div><div><h3>Design</h3><div>This conceptual paper discusses the model of antagonistic pleiotropy that proposes that certain genes beneficial early in life may contribute to diseases in the context of OA.</div></div><div><h3>Results</h3><div>Findings indicate that OA is connected to biological and not to chronological age supporting the idea that OA is not merely a wear and tear process. Chondrocyte hypertrophy, essential in endochondral bone formation at a (pre)reproductive age, is stimulated by a displaced and wrongly timed endochondral ossification quasi-program in age-related OA. Age-related chondrocyte hypertrophic differentiation in articular cartilage is likely driven by loss of loading-induced TGF-β signaling.</div></div><div><h3>Conclusion</h3><div>Comprehending OA within this evolutionary and biological frame provides a solid alternative to the theory of “wear and tear”, offering insights into further understanding, prevention and disease management.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mechanosensitive stress test in individuals following anterior cruciate ligament reconstruction: A pilot study","authors":"Prakash Jayabalan ,&nbsp;Rose Darcy ,&nbsp;Vikram Darbhe ,&nbsp;Zander Neuville ,&nbsp;Vehniah Tjong ,&nbsp;Levi Hargrove ,&nbsp;Leah Welty ,&nbsp;Thomas Schnitzer","doi":"10.1016/j.ocarto.2025.100619","DOIUrl":"10.1016/j.ocarto.2025.100619","url":null,"abstract":"<div><h3>Objectives</h3><div>1. Assess serum biomarker responses of the anterior cruciate ligament reconstructed (ACLR) knee compared to the non-injured contralateral knee in a lateral tilt paradigm. 2. Determine the relationship between kinematics at the ACLR knee and serum biomarker responses.</div></div><div><h3>Method</h3><div>Cross-sequential study. 16 participants 2–7 years post-ACLR, undertook two 30 ​min walking sessions on a 10° angular tilted treadmill towards the ACLR knee and/or contralateral non-injured knee. Serum collected at baseline and after 30 ​min of walking was tested for biomarkers associated with osteoarthritis (Cartilage oligomeric matrix protein [COMP]), C-terminal cross-linked telopeptides of type II collagen, matrix metalloproteinase-3,-13, ADAM a disintegrin and metalloproteinase with thrombospondin motifs 4-,-5 (ADAMTS-4,-5), interleukin-1β,-6,-8 and RANTES (regulated on activation, normal T-cell expressed and secreted). Kinematic measurements were also taken.</div></div><div><h3>Results</h3><div>When tilted towards the ACLR knee, there was a significant increase in COMP compared to baseline (mean 41.1 ​ng/mL (95%CI:13.8,68.4), not observed when tilted towards the contralateral knee. There was a significant correlation between change in COMP concentration and change in knee adduction/abduction angle (r ​= ​−0.58,p ​= ​0.02). There were no relationships to kinematics and the other biomarkers.</div></div><div><h3>Conclusions</h3><div>The tilt paradigm identified a differential response of a serum mechanosensitive marker (COMP) when testing an ACLR and contralateral knee. There was also a significant relationship between COMP response to tilt walking and the change in knee adduction angle of the ACLR knee. This paradigm could be an aid to provide individual knee biomarker response to a mechanical stress in asymptomatic individuals at risk of developing post-traumatic osteoarthritis at least 2 years post-ACLR.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study","authors":"Christian J. Barton ,&nbsp;Michelle Dowsey ,&nbsp;Anne Smith ,&nbsp;Ilana N. Ackerman ,&nbsp;Zanfina Ademi ,&nbsp;Samantha Bunzli ,&nbsp;Peter Choong ,&nbsp;Kay M. Crossley ,&nbsp;Joanne Kemp ,&nbsp;Jason A. Wallis ,&nbsp;Alison Gibbs ,&nbsp;Vincent Lengkong ,&nbsp;Allison M. Ezzat ,&nbsp;Juanita Low ,&nbsp;Zhomart Orman ,&nbsp;Nicholas F. Taylor ,&nbsp;Anna Wong Shee ,&nbsp;Natasha A. Lannin ,&nbsp;Ewa M. Roos ,&nbsp;Raph Hau ,&nbsp;Danilo De Oliveira Silva","doi":"10.1016/j.ocarto.2025.100622","DOIUrl":"10.1016/j.ocarto.2025.100622","url":null,"abstract":"<div><h3>Objective</h3><div>This parallel cohort-implementation study, termed MonitOring the health Trajectory of patients with kNee osteoarthritis (MOTION), aims to understand treatment pathways and outcomes for people with knee osteoarthritis referred to Australian public hospitals for orthopaedic assessment (Part A cohort study), and how improving access to first-line care might improve outcomes (Part B implementation study).</div></div><div><h3>Methods and analysis</h3><div>We will recruit approximately 400 adults with knee osteoarthritis referred for orthopaedic opinion to one of four public hospitals in Victoria, Australia. A subgroup enrolled in the study (n ​= ​109) will receive improved access to community-based first-line care. Outcomes will be evaluated at baseline, 4-, 8-, 12- (primary end point), 24- and 60-months. The primary outcome will divide the cohort into 1's (willing to undergo, waitlisting for, or undergone, TKR surgery) or 0's (not willing to undergo, not undergone, and not waitlisted for, TKR surgery). Secondary outcomes include pain, knee- and health-related quality of life, physical activity participation and health care utilisation. Surgical and health trajectories will be reported descriptively, with factors associated with outcomes explored. The effectiveness of improving access to first-line care will be determined through propensity score methods. The cost-effectiveness of improving access to first-line care will be also be determined, and semi-structured interviews (1:1 and focus groups) involving participants, health professionals, administrators, and research team will inform a comprehensive process evaluation.</div></div><div><h3>Ethics and dissemination</h3><div>Approved by St Vincent's Hospital Melbourne Human Research Ethics Committee (HREC 251/21). Findings will be disseminated to stakeholders including via conferences, peer-reviewed journals, and social and mainstream media.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular treatments to reduce catabolic effects in human meniscus explant models","authors":"Amanda Sjögren ,&nbsp;Karin Lindblom ,&nbsp;Aleksandra Turkiewicz ,&nbsp;Martin Englund ,&nbsp;Patrik Önnerfjord","doi":"10.1016/j.ocarto.2025.100618","DOIUrl":"10.1016/j.ocarto.2025.100618","url":null,"abstract":"<div><h3>Objectives</h3><div>1. To validate catabolic meniscus explant models induced by cytokines: interleukin-6 ​+ ​interleukin-6 receptor ​+ ​tumor necrosis factor alpha (IL6/TNF) and oncostatin M ​+ ​tumor necrosis factor alpha (OSM/TNF). 2. To evaluate three potential anti-catabolic treatments: i) dexamethasone (DEX), ii) a Link-N peptide (Link-N) and iii) a peptide from chondroadherin (CKF).</div></div><div><h3>Design</h3><div>Healthy lateral menisci from deceased donors (n ​= ​6; age ​= ​25–70 years, 4 males, 2 females), were sliced and randomized for experimental groups (combinations of the catabolic models and anti-catabolic treatments) and a control group. Culture media were analyzed, every third day until day 18, by mass spectrometry-based proteomics. Linear mixed effect models were used to estimate differences in protein abundances between groups.</div></div><div><h3>Results</h3><div>A total of 662 proteins were identified in all menisci. Cytokine-treated meniscus explant models showed increased release of osteoarthritis-related proteins such as matrix metalloproteinases (MMPs). For example, MMP1: IL6/TNF vs. ctrl; log2 fold-change 2.2 95 ​% confidence interval [1.8, 2.5] and OSM/TNF vs. ctrl; log2 fold-change 2.8 [2.4, 3.1]. There was no treatment effect in explant meniscus with the addition of either Link-N or CKF. Treatment effects were, however, evident with the addition of DEX. For example, MMP1: IL6/TNF ​+ ​DEX vs. ctrl; log2 fold-change −1.8 [-2.2, −1.4] and OSM/TNF ​+ ​DEX vs. ctrl; log2 fold-change −0.3 [-0.7, 0.04].</div></div><div><h3>Conclusion</h3><div>We confirmed that both catabolic models induce changes in osteoarthritis-related proteins. DEX treatment is effective in mitigating the catabolic response in meniscus explant models and may be further explored for its effects in the treatment of meniscus degeneration.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis","authors":"Jack B. Roberts ,&nbsp;Jason S. Rockel ,&nbsp;Rick Mulders ,&nbsp;Terence D. Capellini ,&nbsp;C. Thomas Appleton ,&nbsp;Douglas H. Phanstiel ,&nbsp;Rik Lories ,&nbsp;Jeroen Geurts ,&nbsp;Shabana Amanda Ali ,&nbsp;Nidhi Bhutani ,&nbsp;Laura Stone ,&nbsp;Yenisel Cruz-Almeida ,&nbsp;Igor Jurisica ,&nbsp;Cindy G. Boer ,&nbsp;Yolande F.M. Ramos ,&nbsp;Sarah J. Rice ,&nbsp;Mohit Kapoor","doi":"10.1016/j.ocarto.2025.100621","DOIUrl":"10.1016/j.ocarto.2025.100621","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies. For over a decade, OA researchers have been working to determine epigenetic mechanisms underlying the disease to better understand pathology, identify biomarkers of progression, and pinpoint novel targets for therapeutic intervention.</div></div><div><h3>Design</h3><div>This article presents a summary of the 3rd International Workshop on the Epigenetics of Osteoarthritis held in Toronto, Ontario, Canada, in September 2024. The purpose of this meeting was to gather the international community to discuss the status of OA epigenetic research and share expertise on innovative techniques for future.</div></div><div><h3>Results</h3><div>Since the two previous meetings, there has been increasing adoption of advanced single-cell and spatial sequencing technologies and bioinfomatic analyses. Furthermore, investigations of multiple joint tissues has highlighted the shifting paradigm from OA as a cartilage centric disease to the consideration of all joint tissues.</div></div><div><h3>Conclusions</h3><div>The workshop provided a unique opportunity for early-career researchers to expand their network, and for all participants to discuss new or improved approaches to advance the field, including international consortia and data sharing. The highlights and outcomes from this OA epigenetics workshop are described in this report.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation","authors":"Luke Childress ,&nbsp;Landon B. Gatrell ,&nbsp;Hong Wu ,&nbsp;Elisabeth Ferreira ,&nbsp;Intawat Nookaew ,&nbsp;Ryan M. Porter","doi":"10.1016/j.ocarto.2025.100620","DOIUrl":"10.1016/j.ocarto.2025.100620","url":null,"abstract":"<div><h3>Objective</h3><div>Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. Our objective was to determine whether senescent cells contribute to fibrocartilage repair using a rodent model of marrow stimulation.</div></div><div><h3>Design</h3><div>A 1 ​mm osteochondral defect was generated in the trochlear groove of young adult and middle-aged Lewis rats, modeling the age range when humans receive marrow stimulation. Some rats were treated by intra-articular (IA) injection of senolytic drugs navitoclax or dasatinib plus quercetin. Repair tissue was characterized during the first months after marrow stimulation by histology as well as bulk and single cell transcriptomic analysis.</div></div><div><h3>Results</h3><div>Multiple senescence markers were measured within repair tissue during the first months of repair, in contrast to adjacent, intact articular cartilage. The IA delivery of senolytic drugs reduced p16^Ink4a-immunopositive cell numbers but did not promote chondrogenesis. The numbers of p16-positive cells were similar between young adult and middle-aged rats, despite proteoglycan deposition decreasing markedly with age. Bulk RNA sequencing of repair tissue demonstrated sustained upregulation of factors linked to established forms of the senescence-associated secretory phenotype. Single cell RNA sequencing revealed heterogeneity in mesenchymal cells within the early repair tissue, confirmed differences in senescence marker expression between newly-formed chondrocytes and those within adjacent intact cartilage, and established differences in oxidative stress response between these two populations during the chondrogenic phase of repair.</div></div><div><h3>Conclusions</h3><div>Senescent cells, including neochondrocytes, are abundant within inferior repair tissue following marrow stimulation. While their fibrogenic SASP is associated with poor healing, their removal after senescence induction does not improve repair tissue quality, possibly due to the lack of a replacement chondrogenic population.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory mechanisms underlying metabolic syndrome-associated and potential treatments","authors":"Shiqian Huang ,&nbsp;Jiawei Chen ,&nbsp;Hao Zhang ,&nbsp;Wenjing Wu ,&nbsp;Song Xue ,&nbsp;Zhaohua Zhu ,&nbsp;Changhai Ding","doi":"10.1016/j.ocarto.2025.100614","DOIUrl":"10.1016/j.ocarto.2025.100614","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoarthritis (OA), a debilitating disease, has been recognized as a heterogenous disease, with metabolic syndrome-associated osteoarthritis (MetS-OA) emerging as a significant area of interest. Currently, the understanding of MOA remains limited, with a prevailing consensus attributing its etiology to the core components of metabolic syndrome: obesity, hyperglycemia, dyslipidemia, and hypertension. The aim of this review is to summarize the current understanding of the complex relationship between metabolic syndrome and OA from the perspectives of epidemiology and molecular biology, and to explore potential targeting strategies for metabolic syndrome in MetS-OA management.</div></div><div><h3>Methods</h3><div>This narrative review evaluated literature (2010–2024) from PubMed, examining clinical and mechanistic evidence linking metabolic syndrome to OA, including therapeutic studies targeting MetS-OA.</div></div><div><h3>Results</h3><div>Metabolic syndrome aggravate the cartilage injury in MetS-OA through metabolic biomarkers (adipokines, advanced glycation end-products and oxidized LDL), metabolic responses (oxidative stress, insulin resistance and ischemic hypoxic injuries), and abnormally activated cells (adipocytes and macrophages). It ultimately lead to the aggravation of synovitis in MetS-OA through inflammatory mediators.</div></div><div><h3>Conclusions</h3><div>The exploration of the relationship between metabolic syndrome and OA could benefit the development of targeting strategies for MetS-OA, including currently FDA-approved drugs for the treatment of metabolic syndrome and potential drugs targeting metabolic factors, which might provide a novel avenue for the future management of MetS-OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of expectations regarding exercise therapy of patients with hip and knee osteoarthritis: A scoping review","authors":"A.P.M. Konings-Pijnappels ,&nbsp;M.C. van der Steen ,&nbsp;H. Seetsen-van Schelven ,&nbsp;I. Hoogendoorn ,&nbsp;T.P.M. Vliet Vlieland ,&nbsp;R.P.A. Janssen","doi":"10.1016/j.ocarto.2025.100617","DOIUrl":"10.1016/j.ocarto.2025.100617","url":null,"abstract":"<div><h3>Objective</h3><div>While exercise therapy generally yields positive outcomes in patients with hip or knee osteoarthritis (HOA or KOA), individual results vary. Expectations may influence treatment results, but research on this topic is scarce. Therefore, this study aimed to describe methods to assess pre-treatment expectations of patients with HOA or KOA with respect to exercise therapy.</div></div><div><h3>Design</h3><div>Scoping review, with the Pubmed, Embase, CINAHL and Cochrane databases searched for original clinical studies of any design reporting a method or instrument to assess expectations of exercise therapy in patients with HOA or KOA. Data extraction from selected studies concerned study characteristics and the method or instrument used, as well as their content, categorized into expectations of structure, process or outcomes of exercise therapy treatment.</div></div><div><h3>Results</h3><div>Twenty-nine studies met the inclusion criteria. Twenty-three different methods used to address expectations were identified, 3 of which had a qualitative nature (interviews) and 20 concerned questionnaires. There was a large variation in number of items and measurement scales in the identified methods. Nine methods addressed expectations of outcomes of treatment, 7 addressed both outcomes and the process/structure of treatment. One instrument was found to measure willingness to receive exercise rather than expectations. For the remaining 6 instruments no content nor aspects measured were reported.</div></div><div><h3>Conclusion</h3><div>In the literature, apart from interviews, mainly quantitative methods have been used to measure expectations with regard to exercise therapy in patients with HOA or KOA. Most of their content concerned the outcomes of care, rather than its structure and/or process.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100617"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}