Osteoarthritis and cartilage open最新文献

{"title":"Predictive validity of consensus-based MRI definition of osteoarthritis plus radiographic osteoarthritis for the progression of knee osteoarthritis: A longitudinal cohort study","authors":"Xing Xing ,&nbsp;Yining Wang ,&nbsp;Jianan Zhu ,&nbsp;Ziyuan Shen ,&nbsp;Flavia Cicuttini ,&nbsp;Graeme Jones ,&nbsp;Dawn Aitken ,&nbsp;Guoqi Cai","doi":"10.1016/j.ocarto.2025.100582","DOIUrl":"10.1016/j.ocarto.2025.100582","url":null,"abstract":"<div><h3>Objective</h3><div>Our previous study showed that magnetic resonance imaging (MRI)-defined tibiofemoral osteoarthritis (MRI-OA), based on a Delphi approach, in combination with radiographic OA (ROA) had a strong predictive validity for the progression of knee OA. This study aimed to compare whether the combination using traditional prediction models was superior to the Light Gradient Boosting Machine (LightGBM) models.</div></div><div><h3>Methods</h3><div>Data were from the Tasmanian Older Adult Cohort. A radiograph and 1.5T MRI of the right knee was performed. Tibial cartilage volume was measured at baseline, 2.6 and 10.7 years. Knee pain and function were assessed at baseline, 2.6, 5.1, and 10.7 years. Right-sided total knee replacement (TKR) were assessed over 13.5 years. The area under the curve (AUC) was applied to compare the predictive validity of logistic regression with the LightGBM algorithm. For significant imbalanced outcomes, the area under the precision-recall curve (AUC-PR) was used.</div></div><div><h3>Results</h3><div>574 participants (mean 62 years, 49 ​% female) were included. Overall, the LightGBM showed a clinically acceptable predictive performance for all outcomes but TKR. For knee pain and function, LightGBM showed better predictive performance than logistic regression model (AUC: 0.731–0.912 vs 0.627–0.755). Similar results were found for tibial cartilage loss over 2.6 (AUC: 0.845 vs 0.701, p ​&lt; ​0.001) and 10.7 years (AUC: 0.845 vs 0.753, p ​= ​0.016). For TKR, which exhibited significant class imbalance, both algorithms performed poorly (AUC-PR: 0.647 vs 0.610).</div></div><div><h3>Conclusion</h3><div>Compared to logistic regression combining MRI-OA, ROA, and common covariates, LightGBM offers valuable insights that can inform early risk identification and targeted prevention strategies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100582"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived barriers and facilitators to exercise adherence in osteoarthritis: A thematic synthesis of qualitative studies","authors":"Benedetto Giardulli ,&nbsp;Davide Marazzi ,&nbsp;Alessandro Nespoli ,&nbsp;Gaia Leuzzi ,&nbsp;Andrea Dell'Isola ,&nbsp;Yeliz Prior ,&nbsp;Simone Battista","doi":"10.1016/j.ocarto.2025.100584","DOIUrl":"10.1016/j.ocarto.2025.100584","url":null,"abstract":"<div><h3>Objective</h3><div>Exercise is a first-line intervention for osteoarthritis (OA). However, exercise adherence remains low, and existing studies exploring factors influencing adherence have yielded inconclusive results based on quantitative data. This study aims to synthesise qualitative studies focused on the perceived facilitators and barriers affecting exercise adherence in individuals with OA.</div></div><div><h3>Design</h3><div>A thematic synthesis of qualitative studies was conducted. Relevant articles were sourced from MEDLINE, Cochrane Central Register of Controlled Trials, Embase, CINAHL, and PsychInfo until November 2024. Studies focused on adults (≥16 years) with hip or knee OA who had participated in exercise programmes to manage OA. The quality of the studies was assessed using the Critical Appraisal Skills Programme (CASP) tool. Data analysis followed Thematic Synthesis by Thomas &amp; Harden to identify descriptive and analytical themes. The confidence of the evidence was evaluated through the Confidence in Evidence from Reviews of Qualitative Research (CERQual).</div></div><div><h3>Results</h3><div>A total of 21 studies involving 458 participants were included. From seven descriptive themes, three analytical themes were developed: (i) Mind-Body Connection, (ii) Social Support Systems, and (iii) Environmental Enablers. These themes underscore the importance of personal beliefs, experiences, and mindsets, alongside social and environmental factors, in promoting or hindering exercise adherence.</div></div><div><h3>Conclusion</h3><div>This study highlights the multifaceted cognitive, social, and environmental factors influencing exercise adherence in individuals with OA. The findings suggest that a ‘one-size-fits-all’ approach is insufficient for promoting sustained exercise engagement. Future quantitative research should build upon these insights to develop tailored strategies for enhancing exercise adherence in people with OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100584"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers 2024","authors":"","doi":"10.1016/j.ocarto.2025.100581","DOIUrl":"10.1016/j.ocarto.2025.100581","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100581"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kellgren-Lawrence grading of knee osteoarthritis using deep learning: Diagnostic performance with external dataset and comparison with four readers","authors":"Elias Vaattovaara ,&nbsp;Egor Panfilov ,&nbsp;Aleksei Tiulpin ,&nbsp;Tuukka Niinimäki ,&nbsp;Jaakko Niinimäki ,&nbsp;Simo Saarakkala ,&nbsp;Mika T. Nevalainen","doi":"10.1016/j.ocarto.2025.100580","DOIUrl":"10.1016/j.ocarto.2025.100580","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the performance of a deep learning (DL) model in an external dataset to assess radiographic knee osteoarthritis using Kellgren-Lawrence (KL) grades against versatile human readers.</div></div><div><h3>Materials and methods</h3><div>Two-hundred-eight knee anteroposterior conventional radiographs (CRs) were included in this retrospective study. Four readers (three radiologists, one orthopedic surgeon) assessed the KL grades and consensus grade was derived as the mean of these. The DL model was trained using all the CRs from Multicenter Osteoarthritis Study (MOST) and validated on Osteoarthritis Initiative (OAI) dataset and then tested on our external dataset. To assess the agreement between the graders, Cohen's quadratic kappa (k) with 95 ​% confidence intervals were used. Diagnostic performance was measured using confusion matrices and receiver operating characteristic (ROC) analyses.</div></div><div><h3>Results</h3><div>The multiclass (KL grades from 0 to 4) diagnostic performance of the DL model was multifaceted: sensitivities were between 0.372 and 1.000, specificities 0.691–0.974, PPVs 0.227–0.879, NPVs 0.622–1.000, and AUCs 0.786–0.983. The overall balanced accuracy was 0.693, AUC 0.886, and kappa 0.820. If only dichotomous KL grading (i.e. KL0-1 vs. KL2-4) was utilized, superior metrics were seen with an overall balanced accuracy of 0.902 and AUC of 0.967. A substantial agreement between each reader and DL model was found: the inter-rater agreement was 0.737 [0.685–0.790] for the radiology resident, 0.761 [0.707–0.816] for the musculoskeletal radiology fellow, 0.802 [0.761–0.843] for the senior musculoskeletal radiologist, and 0.818 [0.775–0.860] for the orthopedic surgeon.</div></div><div><h3>Conclusion</h3><div>In an external dataset, our DL model can grade knee osteoarthritis with diagnostic accuracy comparable to highly experienced human readers.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100580"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort","authors":"Alix Charton ,&nbsp;Romane Lacoste-Badie ,&nbsp;Sophie Tuffet ,&nbsp;Alexandra Rousseau ,&nbsp;Emmanuel Maheu ,&nbsp;Bruno Fautrel ,&nbsp;Maxime Dougados ,&nbsp;Francis Berenbaum ,&nbsp;Alice Courties ,&nbsp;Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100573","DOIUrl":"10.1016/j.ocarto.2025.100573","url":null,"abstract":"<div><h3>Background</h3><div>The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA.</div></div><div><h3>Methods</h3><div>Using the DIGICOD cohort, 352 HOA patients (85 ​% women, mean age 66.4 ​± ​7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 ​% confidence intervals (CI).</div></div><div><h3>Results</h3><div>MetS was present in 36 ​% of patients and associated with higher pain levels during activity (VAS OR ​= ​1.61, 95 ​% CI 1.02–2.57) and overall OA pain (AIMS2 OR ​= ​1.85, 95 ​% CI 1.14–2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR ​= ​1.66, 95 ​% CI 1.05–2.62), but significance was reduced when adjusting for HAD (OR ​= ​1.56, 95 ​% CI 0.98–2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR ​= ​2.58, 95 ​% CI 1.09–6.07). BMI was not found to be independently associated with pain.</div></div><div><h3>Conclusion</h3><div>MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100573"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of quality indicators for hand osteoarthritis care – Results from an European consensus study","authors":"Daniel H. Bordvik ,&nbsp;Yeliz Prior ,&nbsp;Rachael Bamford ,&nbsp;Francis Berenbaum ,&nbsp;Mathilda Björk ,&nbsp;Thalita Blanck ,&nbsp;Barbara Slatkowsky Christensen ,&nbsp;Krysia Dziedzic ,&nbsp;John Edwards ,&nbsp;Nazemin Gilanliogullari ,&nbsp;Carol Graham ,&nbsp;Ida K. Haugen ,&nbsp;Margreet Kloppenburg ,&nbsp;Hellen Laheij ,&nbsp;Marco J.P.F. Ritt ,&nbsp;Tanja Stamm ,&nbsp;Anne Therese Tveter ,&nbsp;Nina Østerås ,&nbsp;Ingvild Kjeken","doi":"10.1016/j.ocarto.2025.100578","DOIUrl":"10.1016/j.ocarto.2025.100578","url":null,"abstract":"<div><h3>Background</h3><div>People with hand osteoarthritis (OA) often have poor access to recommended treatments. To enhance care quality, quality indicators (QIs) based on clinical recommendations are essential. Current QI sets, like the Osteoarthritis Quality Indicator Questionnaire (OA-QI v.2), primarily address hip- and knee OA, and not hand OA.</div></div><div><h3>Objectives</h3><div>To adapt the OA-QI v.2 for assessing patient-reported quality of hand OA care.</div></div><div><h3>Design</h3><div>We used the OA-QI v.2. set as a starting point and adapted it to reflect hand OA care. A literature search was performed to identify potential QIs for hand OA following the Rand/UCLA Appropriateness method. A European expert panel, comprising researchers, clinicians, and patient research partners, participated in online meetings to discuss adaptation and suggest new QIs based on treatment recommendations for hand OA, and anonymously rated each suggested QI regarding its importance, validity, usefulness, and feasibility. Consensus was defined by predefined rating cut-off scores. The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity.</div></div><div><h3>Results</h3><div>Our initial literature search provided 1670 articles, with none describing relevant QIs. After three voting rounds, sixteen QI items reached consensus, reflecting current hand OA care standards. Items were generally well understood, requiring only minor clarity amendments after patient interviews (N ​= ​28).</div></div><div><h3>Conclusion</h3><div>The OA-QI v.2 was successfully adapted into a 16-item Hand OA-QI set ensuring alignment with international care standards for hand OA through literature review, international expert panels and patient feedback on language and layout.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100578"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between sleep problems and pain outcomes in people with hand osteoarthritis – Data from the Nor-hand study","authors":"Daniel H. Bordvik ,&nbsp;Pernille Steen Pettersen ,&nbsp;Marthe Gløersen ,&nbsp;Elisabeth Mulrooney ,&nbsp;Tuhina Neogi ,&nbsp;Ingvild Kjeken ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100579","DOIUrl":"10.1016/j.ocarto.2025.100579","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relation of sleep problems to pain outcomes in people with hand osteoarthritis, and the extent to which central sensitization mediates these relationships.</div></div><div><h3>Design</h3><div>In total 299 participants from the Nor-Hand cohort study rated their sleep problems (no, slight, moderate or severe problems), hand pain intensity on a Numeric Rating Scale (NRS, range: 0–10) and Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range: 0–20), and overall bodily pain intensity (NRS). Central sensitization was evaluated by quantitative sensory testing. All pain questionnaires were repeated after 3.5 years. We explored the associations between sleep problems at baseline and pain outcomes at baseline and follow-up and fitted natural effect models to examine the extent to which measures of central sensitization mediated the effects of sleep problems on pain. All main analyses were adjusted for age, sex, education, comorbidities, and body mass index.</div></div><div><h3>Results</h3><div>Slight, moderate, and severe sleep problems were reported by 33.8 ​%, 26.8 ​% and 14.3 ​%, respectively. In general, individuals with severe versus without sleep problems reported relatively more intense pain at baseline and follow up (i.e., a 1.68 (95 ​% confidence interval 0.89–2.46) higher NRS hand pain at baseline). Associations between sleep and central sensitization were weak, with no mediating effects found. For example, the indirect effect of remote pressure pain thresholds was 0.06 (−0.27, 0.39) NRS points for hand pain among individuals reporting severe sleep problems.</div></div><div><h3>Conclusion</h3><div>Sleep problems are commonly reported and related to pain intensity in people with hand osteoarthritis, while the underlying mechanisms and temporal relationship remain unclear.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study","authors":"Khara A. James ,&nbsp;Tuhina Neogi ,&nbsp;David T. Felson ,&nbsp;Patrick Corrigan ,&nbsp;Cara L. Lewis ,&nbsp;Irene S. Davis ,&nbsp;Kathryn L. Bacon ,&nbsp;James C. Torner ,&nbsp;Cora E. Lewis ,&nbsp;Michael C. Nevitt ,&nbsp;Joshua J. Stefanik","doi":"10.1016/j.ocarto.2025.100575","DOIUrl":"10.1016/j.ocarto.2025.100575","url":null,"abstract":"<div><h3>Objective</h3><div>Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA.</div></div><div><h3>Design</h3><div>Participants from the Multicenter Osteoarthritis study were included.</div><div>Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex.</div></div><div><h3>Results</h3><div>Among 1600 participants (60.3 ​% female, age 67.1 ​± ​7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 ​% (RR ​= ​1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR ​= ​0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR ​= ​1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed.</div></div><div><h3>Conclusion</h3><div>Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100575"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review","authors":"Larissa Rix ,&nbsp;Samuel Tushingham ,&nbsp;Karina Wright ,&nbsp;Martyn Snow","doi":"10.1016/j.ocarto.2025.100577","DOIUrl":"10.1016/j.ocarto.2025.100577","url":null,"abstract":"<div><h3>Background</h3><div>Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.</div></div><div><h3>Objectives</h3><div>To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.</div></div><div><h3>Results</h3><div>PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.</div></div><div><h3>Conclusion</h3><div>Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms indicative of early knee osteoarthritis after ACL reconstruction: descriptive analysis of the SHIELD cohort","authors":"Anna Cronström ,&nbsp;May Arna Risberg ,&nbsp;Martin Englund ,&nbsp;Dorthe B. Strauss ,&nbsp;Paul Neuman ,&nbsp;Carl Johan Tiderius ,&nbsp;Eva Ageberg","doi":"10.1016/j.ocarto.2025.100576","DOIUrl":"10.1016/j.ocarto.2025.100576","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the SHIELD cohort in terms of symptoms indicative of early knee osteoarthritis (OA) and to investigate associations between patient characteristics (demographics, activity/injury-related) and these symptoms at 1 (cross-sectional) and 3 years (longitudinal) post anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Method</h3><div>106 participants (50 ​% women, mean [SD] age 25 [5] years) were included. Symptoms indicative of early knee OA were evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) subscale pain, KOOS subscale pain ≤72 (KOOSpain ≤72), and ≤85 on two out of four KOOS subscales (pain, symptoms, activity of daily living, quality of life) (modified Luyten).</div></div><div><h3>Results</h3><div>Mean (SD) KOOS pain scores were 83.2 (15.7) and 87.3 (12.7) at 1 and 3 years, respectively. At 1 year and 3 years post ACLR, 18/101 (18 ​%) and 14/86 (16 ​%) participants met the KOOSpain ≤72 criterion, whereas 83/101 (82 ​%) and 67/86 (78 ​%) met the modified Luyten criterion. 7/15 (47 ​%) (KOOSpain ≤72) and 59/70 (84 ​%) (modified Luyten) classified as having knee OA symptoms 1 year post ACLR were still classified as having OA symptoms after 3 years. Lower activity level at 1 year was the sole variable consistently associated with all three outcomes 3 years post ACLR.</div></div><div><h3>Conclusion</h3><div>The proportion of participants fulfilling existing classification criteria for symptoms indicative of early OA after ACLR is highly dependent on the criteria applied and different criteria seem to capture varying aspects of early OA symptoms. Future studies will reveal if these symptoms will persist long-term or just reflect more transient issues.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}