Osteoarthritis and cartilage open最新文献

{"title":"Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning","authors":"Cameron Kurz ,&nbsp;Liubov Arbeeva ,&nbsp;M. Andrea Azcarate-Peril ,&nbsp;Delisha A. Stewart ,&nbsp;B. Duncan X. Lascelles ,&nbsp;Richard F. Loeser ,&nbsp;Amanda E. Nelson","doi":"10.1016/j.ocarto.2025.100603","DOIUrl":"10.1016/j.ocarto.2025.100603","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate potentially novel and modifiable mechanisms of the effects of gut microbiome composition on obesity-related osteoarthritis (OA), focusing on cross-sectional relationships between microbiota, cytokines, and lipopolysaccharide (LPS).</div></div><div><h3>Design</h3><div>Johnston County OA Project participants (n ​= ​64) with (cases) and without (controls) OA in hands and knees, with age ≥55 years and obesity (BMI ≥30 ​kg/m²), provided samples for multiplex cytokine, LPS, and fecal microbiota analysis. Latent Dirichlet Allocation (LDA), a machine learning method to detect latent groups within data, was used to identify microbial enterotypes. LDA regression models were used to evaluate associations of enterotypes with demographics, cytokines associated with OA, and LPS.</div></div><div><h3>Results</h3><div>We identified 5 enterotypes. Enterotypes 3, 4 (most prevalent in our sample), and 5, dominated respectively by genera <em>Akkermansia</em>, <em>Bacteroides</em>, <em>Ruminococcus</em>/<em>Phascolarctobacterium</em>, were positively associated with control status, and inversely associated with levels of at least two cytokines associated with OA in our sample. We observed no associations of enterotypes with LPS levels. Enterotype 3 was inversely associated with thrombopoietin and IL-4 levels (b [95 ​% CIs] −0.19 [−0.43, 0.05] and −0.17 [−0.42, 0.08]), enterotype 5 with osteopontin and thrombopoietin (−0.23 [−0.49, 0.03] and −0.24 [−0.51, 0.04]), and enterotype 4 was inversely associated with all 3 of these cytokines (b −0.20 to −0.35).</div></div><div><h3>Conclusion</h3><div>Three of five identified enterotypes were inversely associated with OA status and levels of OA associated cytokines. These exploratory analyses revealed associations between the gut microbiome, cytokines, and OA outcomes, suggesting potentially cytokine-mediated mechanisms of the effects of gut composition on OA in obese individuals, and providing a basis for further investigation of the underlying causal mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100603"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of periostin in orthopedics","authors":"Mark D. Wishman,&nbsp;William M. Sgrignoli,&nbsp;Brendan M. Patterson,&nbsp;James V. Nepola,&nbsp;Brian R. Wolf,&nbsp;Maria Bozoghlian,&nbsp;Carter M. Lane,&nbsp;Mitchell C. Coleman,&nbsp;Joseph W. Galvin","doi":"10.1016/j.ocarto.2025.100600","DOIUrl":"10.1016/j.ocarto.2025.100600","url":null,"abstract":"<div><h3>Objective</h3><div>This review explores periostin (POSTN), a matricellular protein integral to developmental physiological, and pathological processes, by examining its structure, function, and emerging roles in orthopedic and non-musculoskeletal pathologies. It investigates POSTN's potential as a biomarker and therapeutic target in orthopedic diseases, with a focus on post-traumatic osteoarthritis (PTOA), addressing the need for a comprehensive analysis of its current and future clinical significance in orthopedic and musculoskeletal health.</div></div><div><h3>Methods</h3><div>A comprehensive literature review was performed, synthesizing current available literature surrounding POSTN, including findings from human and rodent studies. Data were compiled from multiple large publication databases to provide a broad and current perspective on its roles and applications.</div></div><div><h3>Results</h3><div>POSTN is upregulated in osteoarthritic cartilage and synovial fluid following joint injuries, such as ACL ruptures and anterior shoulder instability events. It promotes cartilage matrix degradation by upregulating catabolic enzymes and inflammatory pathways. Therapeutic silencing of POSTN with siRNA reduces inflammatory mediator expression and mitigates cartilage degeneration in rodent models. POSTN's differential expression across injury stages suggests its potential utility as a biomarker for monitoring disease progression.</div></div><div><h3>Conclusions</h3><div>POSTN is pivotal in musculoskeletal development, fracture healing and bone biology, offering potential as a prognostic biomarker for orthopedic conditions and a tool for monitoring disease progression. Its significant role in PTOA development suggests that targeting POSTN and its downstream inflammatory mediators offer innovative strategies for managing PTOA, warranting further research and clinical exploration.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100600"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing the narrative for exercise-based prehabilitation: Evidence-informed and shared decision making when discussing the need for a total knee arthroplasty with patients","authors":"Thomas Bandholm ,&nbsp;Rasmus Skov Husted ,&nbsp;Anders Troelsen ,&nbsp;Kristian Thorborg","doi":"10.1016/j.ocarto.2025.100601","DOIUrl":"10.1016/j.ocarto.2025.100601","url":null,"abstract":"<div><h3>Objective</h3><div>To examine a novel application of exercise-based prehabilitation in severe knee osteoarthritis—termed “pre-evaluation exercise\"—focused on supporting surgical decision-making and adherence to clinical guidelines, rather than attempting to enhance post-operative recovery.</div></div><div><h3>Design</h3><div>This narrative review discusses the usage of exercise in the clinical decision process for total knee arthroplasty (TKA). It synthesizes data from studies on exercise-based prehabilitation, covering patient selection, implementation, and its effects on surgical choices. Emphasis is placed on multi-disciplinary coordination within an Enhanced Recovery After Surgery (ERAS) framework.</div></div><div><h3>Results</h3><div>Evidence suggests that pre-evaluation exercise can improve symptom management and may lead to delayed or reduced surgical intervention. This approach shows significant potential in reducing the rate of TKA surgeries among patients with severe knee osteoarthritis by improving physical conditioning, addressing symptom variability, and enhancing informed, patient-centered surgical decisions.</div></div><div><h3>Conclusions</h3><div>Pre-evaluation exercise in knee osteoarthritis is a viable strategy that complements existing ERAS initiatives by facilitating guideline-conformant surgical decision-making. Incorporating this into pre-surgical care pathways can foster improved patient-related outcomes and healthcare resource optimization.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100601"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular joint degeneration arises spontaneously in STR/ort mice and is prevented by targeted aggrecanase inhibition","authors":"Kazuhiro Ooi ,&nbsp;Kazuhiro Yamamoto ,&nbsp;Yutaka Kobayashi ,&nbsp;Behzad Javaheri ,&nbsp;Anders Jensen ,&nbsp;Ioannis Kanakis ,&nbsp;Takao Sakai ,&nbsp;Fadi Jarad ,&nbsp;Hiroyuki Nakamura ,&nbsp;Andrew A. Pitsillides ,&nbsp;Shuichi Kawashiri ,&nbsp;George Bou-Gharios","doi":"10.1016/j.ocarto.2025.100599","DOIUrl":"10.1016/j.ocarto.2025.100599","url":null,"abstract":"<div><h3>Objective</h3><div>Temporomandibular joint osteoarthritis (TMJ-OA) is painful and causes masticatory dysfunction, but current treatment is limited to symptom relief due to an incomplete appreciation of aetiology. Herein, we develop morphological and histological methods for quantitative evaluation of TMJ-OA severity and examine whether STR/Ort mice, which are genetically predisposed to spontaneous knee OA, exhibit protection against TMJ-OA upon genetic gain-of-function modification of an aggrecanase-selective mutant of tissue inhibitor of metalloproteinase (TIMP)-3.</div></div><div><h3>Design</h3><div>We established morphological changes in mandibular condylar head adapted from human TMJ-OA criteria, and developed and verified the utility of TMJ-OA histological damage scoring adapted from the OARSI system. Mutant TIMP3 containing an extra alanine at the N-Terminus ([-1A] TIMP-3 was overexpressed in STR/Ort and CBA mice. Morphological changes in mandibular condyle and TMJ cartilage degradation were evaluated and quantified using micro-CT and histology in mice aged 10, 20 and 40 weeks.</div></div><div><h3>Results</h3><div>Whilst no evidence of TMJ-OA was observed in STR/Ort mice aged 10 weeks, bone erosion and osteophyte formation appeared in the mandibular condyle by 20 weeks, with remarkable deformity and bone resorption at 40 weeks in STR/Ort, but not the parental CBA strain. TMJ-OA was less severe in 40 week-old [-1A]TIMP-3 overexpressing STR/Ort and CBA compared to wild-type mice.</div></div><div><h3>Conclusions</h3><div>Using our new mouse TMJ-OA scoring system we have found that OA affects joints other than the knee in the STR/Ort strain. Genetic gain-of-function modification of STR/Ort mice with an aggrecanase-selective mutant of tissue inhibitor of metalloproteinase (TIMP)-3 also affords in vivo chondroprotection against this TMJ-OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of erosions is not a risk factor for the development of knee OA in a hand OA population: Results from the Framingham OA study","authors":"T. Vanhaverbeke ,&nbsp;G. Miller ,&nbsp;N.C. Ukonu ,&nbsp;R. Wittoek ,&nbsp;I.K. Haugen ,&nbsp;D. Felson","doi":"10.1016/j.ocarto.2025.100591","DOIUrl":"10.1016/j.ocarto.2025.100591","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate whether there is a difference in risk of knee OA between individuals with erosive hand osteoarthritis (OA) compared to non-erosive hand OA, and to identify other risk factors for knee OA presence and development in hand OA patients.</div></div><div><h3>Methods</h3><div>Subjects were selected from the Framingham OA study's Offspring and Community cohorts. Bilateral knee and hand radiographs were scored. Generalized linear models compared knee OA prevalence and incidence rates among hand OA-free, non-erosive and erosive hand OA. Multivariable logistic regression identified risk factors for symptomatic knee OA (presence of hand OA, anatomical location, erosions, number of affected finger joints, radiographic grade changes), adjusted for age, sex and BMI.</div></div><div><h3>Results</h3><div>In total, 2367 participants were studied. Hand classification (hand OA-free, non-erosive and erosive hand OA) significantly impacted the prevalence of knee OA (P ​&lt; ​0.0001). Prevalence rates at baseline were 6.3 ​%, 17.9 ​% and 26.8 ​% for radiographic knee OA and 2.9 ​%, 9.7 ​% and 12.7 ​% for symptomatic knee OA for hand OA-free, non-erosive and erosive hand OA respectively. Post hoc analysis indicated differences were primarily between hand OA-free and hand OA groups (p ​&lt; ​0.001), with no significant differences between erosive and non-erosive hand OA (p ​= ​0.7 and p ​= ​0.8). Overall, hand OA was identified as a risk factor for knee OA development. Presence of erosions did not increase risk, but the number of affected finger joints and changes in Kellgren-Lawrence grade did.</div></div><div><h3>Conclusion</h3><div>Hand OA is associated with knee OA presence and incidence with no difference in the risk of knee OA between those with non-erosive vs erosive hand OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100591"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intra-articular injections for the treatment of osteoarthritis: A narrative review","authors":"Sam Si-Hyeong Park ,&nbsp;Biao Li ,&nbsp;Christopher Kim","doi":"10.1016/j.ocarto.2025.100596","DOIUrl":"10.1016/j.ocarto.2025.100596","url":null,"abstract":"<div><div>Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage loss, inflammation, and joint dysfunction. With profound effects on joint function and quality of life, OA imposes a substantial socio-economic burden. As of now, OA remains incurable, lacking approved medications, regenerative therapies, or procedures that can halt the progressive destruction of the joint. Intraarticular (IA) injections have emerged as a cornerstone in the management of knee OA, offering localized minimally invasive therapeutic options. Traditional IA therapies, including corticosteroids and hyaluronic acid (HA), primarily aim to reduce pain but lack regenerative capacity. Biologic IA therapies for knee OA including autologous blood-derived products like platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) and mesenchymal stromal cells (MSCs) have become more commonly used. Finally, newer IA therapies such as fibroblast growth factor 18 and gene therapy are being investigated. In this review, we highlight the current evidence around IA injections for the treatment of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100596"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals","authors":"Maren Dreiner ,&nbsp;Elie-Tino Godonou ,&nbsp;Annegret Mündermann ,&nbsp;Koray Tascilar ,&nbsp;Georg Schett ,&nbsp;Frank Zaucke ,&nbsp;Anna-Maria Liphardt ,&nbsp;Anja Niehoff","doi":"10.1016/j.ocarto.2025.100597","DOIUrl":"10.1016/j.ocarto.2025.100597","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartilage homeostasis biomarkers in healthy individuals.</div></div><div><h3>Design</h3><div>Twelve male volunteers (age 34.2 ​± ​8.3 years; BMI 22.4 ​± ​1.7 ​kg/m²) participated in 6 days of baseline data collection (BDC), 21 days of 6° head-down-tilt (HDT) bed rest (CON) ​+ ​interventions HDT ​+ ​resistive vibration exercise (RVE; 2 times/week; 25 ​min) and HDT ​+ ​RVE ​+ ​nutrition (NeX; 0.6 ​g/kg body weight/day whey protein and 90 ​mmol KHCO₃/day bicarbonate supplementation), and 6 days of recovery (R) in a cross-over designed study. The starting HDT condition was randomized (CON-RVE-NeX, RVE-NeX-CON, NeX-CON-RVE). Blood samples were collected before, during and after HDT. Serum concentrations of COMP, MMP-3, MMP-9, YKL-40 and resistin were analyzed.</div></div><div><h3>Results</h3><div>The main effect of time was significant for all biomarkers tested (p ​&lt; ​0.001). While COMP (−36 ​% at HDT5, p ​&lt; ​0.001) and MMP-3 (−36 ​% at HDT21, p ​&lt; ​0.001) decreased during HDT bed rest, MMP-9 (+18 ​% at HDT5, p ​&lt; ​0.001) and resistin (+13 ​% at HDT21, p ​&lt; ​0.001) increased during HDT bed rest. Interestingly, during recovery, YKL-40 levels increased (+13 ​% at R1, p ​= ​0.022), while MMP-9 levels decreased (−19 ​% at R6, p ​= ​0.035). We identified correlations between COMP and MMP-3 (r_rm ​= ​0.58, p ​&lt; ​0.001) as well as between MMP-9 and resistin (r_rm ​= ​0.58, p ​&lt; ​0.001).</div></div><div><h3>Conclusions</h3><div>Immobilization affects serum concentrations of cartilage homeostasis biomarkers suggesting changes in cartilage metabolism that do not completely recover during re-ambulation. Both interventions had only minimal effects.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100597"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity","authors":"Luke G. Johnson ,&nbsp;Carly E. Jones ,&nbsp;Daniel G. Rosenbaum ,&nbsp;Benjamin Joseph ,&nbsp;Emily K. Schaeffer ,&nbsp;Kishore Mulpuri ,&nbsp;David R. Wilson","doi":"10.1016/j.ocarto.2025.100589","DOIUrl":"10.1016/j.ocarto.2025.100589","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether the relationship between cartilage T_1ρ relaxation time and age during adolescence and young adulthood is different in hips with Legg–Calvé–Perthes disease (LCPD) deformity compared to hips without LCPD deformity.</div></div><div><h3>Design</h3><div>We recruited 17 participants with LCPD deformity and 15 control participants aged 10–25 years in this frequency-matched cohort study. Quantitative magnetic resonance images were obtained for both hips in LCPD participants and one hip from each control using a T_1ρ MAPSS sequence. The average T_1ρ relaxation time in the weight-bearing articular cartilage was calculated, and we tested the interacting effects of age and participant group (LCPD vs non-LCPD) or subgroup (control, contralateral LCPD, spherical LCPD, and aspherical LCPD) on T_1ρ using mixed effects models.</div></div><div><h3>Results</h3><div>The main effect of age on T_1ρ relaxation time in hips without LCPD deformity was −0.63 ​ms/year (95 ​% confidence interval [−0.94, −0.32]). The age-adjusted main effect of LCPD deformity was +2.93 ​ms [0.65, 3.42] and the interaction effect of age and LCPD deformity was +0.46 ​ms/year [0.16, 0.76]. Moderate differences were observed between control and contralateral LCPD subgroups, and between spherical LCPD and aspherical LCPD subgroups.</div></div><div><h3>Conclusions</h3><div>Age-related changes in T_1ρ relaxation time differ between hips with and without LCPD deformity, suggesting that cartilage degradation in LCPD is progressive and begins early in the healed stage of LCPD. By young adulthood, the difference in T_1ρ between LCPD and non-LCPD hips is clinically important when considering osteoarthritis progression and outcomes.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100589"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel uses of healthcare technology for individuals with mild to moderate hip or knee osteoarthritis: The technology, exercise and activity prescription for enhanced mobility (TEAM) study randomized controlled trial protocol","authors":"Jane Thornton ,&nbsp;Kristen I. Barton ,&nbsp;Laura Churchill ,&nbsp;Jenna M. Schulz ,&nbsp;Dianne Bryant ,&nbsp;Ashley Ambrose ,&nbsp;Harvi F. Hart ,&nbsp;Daryl Stephenson ,&nbsp;Guangyong Zou ,&nbsp;Susana Correa ,&nbsp;Steven J. MacDonald ,&nbsp;Ryan Degen ,&nbsp;Merrick Zwarenstein ,&nbsp;Alan Getgood","doi":"10.1016/j.ocarto.2025.100586","DOIUrl":"10.1016/j.ocarto.2025.100586","url":null,"abstract":"<div><h3>Objectives</h3><div>Patient education, physical activity, and exercise are recommended as first-line treatments for mild to moderate hip and knee osteoarthritis (OA). We developed two novel healthcare interventions: an electronic medical record-embedded physical activity prescription tool (PARx) for physicians, and a free, online educational platform (Joint Management (JM)) with exercise programming and optional telerehabilitation with a physiotherapist for patients. Objectives: 1) Determine the effectiveness of PARx ​± ​JM on patient-reported outcomes, physical activity levels, and performance-based functional outcomes in individuals with mild to moderate hip or knee OA, versus usual care; 2) evaluate engagement and adherence to PARx ​+ ​JM; and 3) explore the feasibility of PARx and PARx ​+ ​JM.</div></div><div><h3>Registration</h3><div>NCT04544904.</div></div><div><h3>Methods</h3><div>Randomized controlled trial (type 1 hybrid implementation effectiveness). We will recruit 339 (113/group) participants ≥40 years old with mild to moderate hip or knee OA and randomize them into three groups: PARx, PARx ​+ ​JM, or control (usual care). Follow-up appointments will be completed at 2-, 6-, and 12-months. Primary outcome: Knee Injury/Hip Disability and OA Outcome Score. Secondary outcomes: physical activity levels, anthropometric measurements, physical function, and other patient-reported outcomes. We will assess intervention feasibility and hold focus groups with patients and providers to explore perceptions of the interventions.</div></div><div><h3>Conclusion</h3><div>Two novel healthcare interventions will be used to provide physical activity and exercise programming for individuals with mild-moderate knee and hip OA. This study will allow us to determine the effectiveness of these interventions on patient-reported outcomes, physical activity levels, and performance-based functional outcomes.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100586"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing osteoarthritis care through clinical and community partnership: Results of an exploratory trial","authors":"Kelli D. Allen ,&nbsp;Liubov Arbeeva ,&nbsp;Leigh F. Callahan ,&nbsp;Katherine Combs ,&nbsp;Tamara Godfrey ,&nbsp;Yvonne M. Golightly ,&nbsp;Derek Hales ,&nbsp;Carla Hill ,&nbsp;Katie F. Huffman ,&nbsp;Amanda E. Nelson ,&nbsp;Jennifer Rees ,&nbsp;Todd A. Schwartz","doi":"10.1016/j.ocarto.2025.100588","DOIUrl":"10.1016/j.ocarto.2025.100588","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>To conduct an exploratory trial of a clinic-community care model (OA CARE) for managing osteoarthritis (OA).</div></div><div><h3>Design</h3><div>Participants (n ​= ​60) with symptomatic knee or hip OA and overweight/obesity were randomized to OA CARE or a usual care control group (UC). Participants in the OA CARE group received a 12-month medical membership to a local YMCA, which included a 12-week weight loss program and access to exercise programming, as well as referrals to rehabilitation, nutrition, sleep-related and psychological services. Participants’ primary care clinicians were given a video-based summary of OA treatment guidelines. Feasibility metrics included engagement with the weight loss program and exercise resources. Outcomes were assessed at baseline, 6-months and 12-months. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Outcomes were analyzed between groups across time points using general linear mixed models.</div></div><div><h3>Results</h3><div>Eighty-seven percent of the OA CARE group participated in the weight loss program, with a mean attendance of 9.2 sessions; 57 ​% participated in an exercise class. At 6-months, there was a statistically significant between-group difference in change in WOMAC total scores, with the OA CARE group showing greater improvement (−11.0, 95 ​% Confidence Interval −20.1, −1.9). At 12-months, the between-group change in WOMAC score was not statistically significant, though there was a small difference in favor of OA CARE Group (−4.9, 95 ​% Confidence Interval −14.1, 4.3).</div></div><div><h3>Conclusion</h3><div>Feasibility metrics were positive, but effects of OA CARE were modest, and a more intensive approach may be needed to enhance impacts.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}