Osteoarthritis and cartilage open最新文献

{"title":"In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis","authors":"H. Platzer ,&nbsp;M. Wellbrock ,&nbsp;G. Pourbozorg ,&nbsp;R. Mayakrishnan ,&nbsp;S. Gantz ,&nbsp;B. Khamees ,&nbsp;S. Maciej ,&nbsp;B. Moradi","doi":"10.1016/j.ocarto.2025.100642","DOIUrl":"10.1016/j.ocarto.2025.100642","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is driven by biomechanical and biochemical inflammatory processes, including CD4⁺ T cell infiltration and activation. However, the role of CD4⁺ T cell subsets interacting with neighboring cells shaping the local inflammatory milieu have remained largely unexplored. This study aimed to investigate in vitro whether interaction of chondrocyte and CD4⁺ T cells modulate cytokine and metalloproteinase production in OA, and to determine if this modulation differ depending on CD4⁺ T cell subsets.</div></div><div><h3>Method</h3><div>Nineteen patients with knee OA undergoing knee replacement were enrolled. From peripheral blood CD4⁺ T cells were isolated and differentiated into subsets (Th1, Th2, Th17, Treg) using a novel developed protocol. T cell differentiation was validated by flow cytometry. Chondrocytes were mono- and co-cultured with T cell subsets and in culture supernatant cytokine and metalloproteinase levels were quantified using ELISA and multiplex assays.</div></div><div><h3>Results</h3><div>Compared to monocultures levels MMP-1/3/9/13 and IL-6 were elevated in all co-cultures of chondrocytes and CD4⁺ T cell subsets, with the highest levels in Th17 co-cultures. GM-CSF, IL-9, IL-17 were specifically elevated in Th17 co-cultures and IFN-γ in Th1 co-cultures. TNF-α production was significantly reduced only in Treg co-culture compared to monoculture approach.</div></div><div><h3>Conclusion</h3><div>This study indicates that chondrocytes can interact with CD4⁺ T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4⁺ T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100642"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study","authors":"Caroline H. Dekkerhus ,&nbsp;Alexander Mathiessen ,&nbsp;Caroline M. Fjellstad ,&nbsp;Barbara Slatwkosky-Christensen ,&nbsp;Hilde Berner Hammer ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100640","DOIUrl":"10.1016/j.ocarto.2025.100640","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the frequency and severity of ultrasound-detected osteophytes and synovitis in people with and without knee osteoarthritis (OA), and to explore the association between these ultrasound features and pain.</div></div><div><h3>Design</h3><div>In the Nor-Hand study, both knees were assessed for osteophytes (0–3 scale, four locations per knee) and grey-scale synovitis (0–3 scale). The frequency and severity of the ultrasound-detected features were compared in individuals with and without knee OA defined by the American College of Rheumatology criteria. Pain was self-reported in each knee (yes/no) and by the Western/Ontario McMaster University index (WOMAC). The associations between ultrasound-detected features and pain were examined by regression analyses adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>We analyzed 286 participants. Osteophytes of all sizes were more common in participants with knee OA compared to those without (65.9 ​% vs. 40.8 ​%, p ​&lt; ​0.001). No between-group difference was found for the frequency of any grey-scale synovitis (45.5 ​% vs. 44.7 ​%, p ​= ​0.67), while severe synovitis was more common in those with knee OA. Ultrasound-detected osteophyte sum score, but not synovitis, was associated with WOMAC pain (B ​= ​0.18, 95 ​% CI 0.03–0.32). Osteophytes of all sizes were associated with pain in the same knee with odds ratio (OR, 95 ​% CI) ranging from 1.85 (1.20–2.84) to 9.02 (4.04–20.10). Statistically significant association was found for severe synovitis only (OR ​= ​6.63, 95 ​% CI 2.26–19.43).</div></div><div><h3>Conclusions</h3><div>Ultrasound-detected osteophytes were prevalent in people with knee OA and were associated with pain. OA pathology in individuals without fulfilling the knee OA criteria may reflect early or subclinical OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100640"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of multiple MRI-based quantitative structural measurements of knee osteoarthritis in a case control study – association with pain and structural progression and comparison to semi-quantitative scoring","authors":"Stacy E. Smith ,&nbsp;Lawrence Lo ,&nbsp;Meera Sury ,&nbsp;Sara M. Bahouth ,&nbsp;Ming Yin ,&nbsp;Lena F. Schaefer ,&nbsp;Jamie E. Collins ,&nbsp;Jeffrey Duryea","doi":"10.1016/j.ocarto.2025.100638","DOIUrl":"10.1016/j.ocarto.2025.100638","url":null,"abstract":"<div><h3>Objective</h3><div>To use software-based magnetic resonance imaging (MRI) measures of multiple features of knee osteoarthritis (KOA) to predict radiographic and pain progression in persons with KOA, and compare to a study that used primarily semi-quantitative (SQ) scoring.</div></div><div><h3>Design</h3><div>Data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) nested case-control study (600 subjects divided into case and control groups based on knee pain and/or radiographic progression) were used. The MRI Osteoarthritis Software Scoring (MOSS) was used to quantitatively assess medial femoral cartilage, bone marrow lesions, osteophyte volume, effusion-synovitis volume, and a measure of Hoffa's synovitis at baseline and 24-months using readers with diverse levels of expertise. Association between baseline and baseline to 24-month change with progressor status was examined and discriminative ability assessed using the c-statistic (AUC) computed under 10-fold cross validation.</div></div><div><h3>Results</h3><div>AUC values ranged from 0.690 to 0.726 to predict combined pain/radiographic progression and from 0.709 to 0.804 to predict radiographic progression alone. Bone marrow lesions and osteophyte volume played a role in all analyses. Medial femoral cartilage was significant for all but the cross-sectional analysis involving pain progression. Comparison to results from a separate publication showed that MOSS offered similar discrimination to a published model that primarily used SQ scoring.</div></div><div><h3>Conclusions</h3><div>We found a high level of discrimination particularly for radiographic progression analysis. Use of fast automated software and readers with varied prior experience make MOSS a useful tool for enriching future clinical trials and for other large studies of KOA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives - A nationwide Swedish family study","authors":"Christian Anker-Hansen,&nbsp;MirNabi Pirouzifard,&nbsp;Jan Sundquist,&nbsp;Kristina Sundquist,&nbsp;Bengt Zöller","doi":"10.1016/j.ocarto.2025.100637","DOIUrl":"10.1016/j.ocarto.2025.100637","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a common degenerative disease with a genetic contribution. However, no large nationwide family study concerning the heredity of OA has been published. This first nationwide study aimed to determine the familial risks of the main types of OA in twins, full-siblings, half-siblings, and cousins in Sweden.</div></div><div><h3>Design</h3><div>The Swedish Multigeneration register was linked to the National Patient Register (NPR) to investigate the heredity of OA (poly-, hip-, knee-, first carpometacarpal joint-, and other-OA) between 1997 and 2018. Offspring born by Swedish parents were included. The adjusted familial hazard ratios (HRs) with 95 ​% confidence interval (CI) were determined for OA among twins, full-siblings, half-siblings, and cousins. Adjustments were made for birth year, sex, educational level, and comorbidities (chronic obstructive pulmonary disease, alcoholism, and obesity).</div></div><div><h3>Results</h3><div>A total of 6 547 966 individuals (48.77 ​% women) were included with mean age 41.44 years (range 0–86.96 years) at end of follow-up. Familial HRs were increased for all five types of OA (even in cousins) and correlated to degree of genetic resemblance between relatives. For instance, adjusted HRs among full-siblings were for poly-OA 2.29 (95 ​% CI 2.09–2.51), hip-OA 2.04 (95 ​% CI 1.98–2.07), knee-OA 1.75 (95 ​% CI 1.73–1.77), thumb-OA 2.60 (95 ​% CI 2.45–2.76), and other-OA 1.52 (95 ​% CI 1.48–1.56).</div></div><div><h3>Conclusions</h3><div>Heredity is an important predictor of future risk of OA for all five types of OA in the Swedish population. Strongest heredity was observed for first carpometacarpal joint -OA followed by poly-OA and hip-OA. Weakest heredity was observed for knee-OA and other-OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100637"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study","authors":"Anne Kamps ,&nbsp;Jos Runhaar ,&nbsp;Katerina Trajanoska ,&nbsp;William D. Thompson ,&nbsp;Weiya Zhang ,&nbsp;Bahar Sedaghati-khayat ,&nbsp;Joyce B.J. van Meurs ,&nbsp;Sita M.A. Bierma-Zeinstra","doi":"10.1016/j.ocarto.2025.100636","DOIUrl":"10.1016/j.ocarto.2025.100636","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a prevalent chronic disease associated with disability worldwide, and obesity is a key modifiable risk factor for OA. The study's aim was to investigate the causal relationship between obesity and OA.</div></div><div><h3>Method</h3><div>This study employed a two-sample Mendelian randomization (MR) approach to investigate the bidirectional causal relationship between obesity, using body mass index (BMI) as its proxy, and OA of the knee, hip, and hand. Genetic instruments were derived from large-scale GWAS meta-analyses, including ∼681,000 individuals for BMI and ∼827,000 individuals (177,000 OA cases) for OA. Inverse variance weighted with multiplicative random effects analysis was performed as primary analysis, and in addition sensitivity analyses relying on different assumptions were performed.</div></div><div><h3>Results</h3><div>The MR analysis revealed that genetically predicted BMI had a causal effect on increased risk of knee (OR 1.91, 95 ​% CI 1.80–2.03), hip (OR 1.52, 95 ​% CI 1.41–1.64) and hand OA (OR 1.21, 95 ​% CI 1.04–1.23). Sensitivity analyses confirmed the robustness of these associations. However, there was no evidence for a causal effect from knee, hip or hand OA on BMI.</div></div><div><h3>Conclusion</h3><div>This study provides strong evidence supporting a causal effect of obesity (measured by BMI) on OA, with a more pronounced effect in weight-bearing knee &amp; hip joints compared to non-weight-bearing hand joint. There was no causal evidence for the reverse direction. Future research could look more in depth into differences in the genetic variants that may represent different biological underlying mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessment of Burden of Chronic Conditions (ABCC-) tool: A valid and reliable tool for hip, knee, hand, wrist, foot and ankle osteoarthritis","authors":"V.H.J. Debie ,&nbsp;T.A.E.J. Boymans ,&nbsp;A.H.M. Gidding-Slok ,&nbsp;O.C.P. van Schayck ,&nbsp;R.P.G. Ottenheijm","doi":"10.1016/j.ocarto.2025.100623","DOIUrl":"10.1016/j.ocarto.2025.100623","url":null,"abstract":"<div><h3>Objective</h3><div>The Assessment of Burden of Chronic Conditions (ABCC-) tool was developed to provide a comprehensive, holistic evaluation of disease burden on physical, emotional and social level in patients with one or more chronic conditions. This study aimed to assess the validity and reliability of the recently developed module for the ABCC-tool for osteoarthritis (OA).</div></div><div><h3>Design</h3><div>A cross-sectional questionnaire-based study was conducted among patients with hip, knee, hand, wrist, foot and ankle OA. Validity was assessed as (1) the convergent validity with three OA-joint-specific questionnaires measuring pain and stiffness amongst others; (2) the discriminant validity with radiographic Kellgren-Lawrence (KL) scores; and (3) known-groups validity (groups: number of affected joints, and the presence/absence of anxiety, depression, kinesiophobia, and pain catastrophizing). Reliability was assessed as the (1) internal consistency; and (2) test-retest with a two-week interval.</div></div><div><h3>Results</h3><div>409 OA patients were included. For all joints its convergent validity was according to the hypothesis, i.e. r ​≥ ​0.7 (hip OA r ​= ​-0.73; knee OA r ​= ​-0.75; hand and wrist OA r ​= ​0.74; foot and ankle OA r ​= ​-0.41). As expected according to the hypothesis, no correlation between burden of OA and KL-scores was found for the discriminant validity. The ABCC-tool was able to distinguish all predefined known-groups (all <em>p</em> ​&lt; ​0.05). The ABCC-tool demonstrated good internal consistency across all domains and joints (total scale in all joints ≥0.87). Test-retest reliability was high (all ICC ≥0.81).</div></div><div><h3>Conclusion</h3><div>The ABCC-tool is a valid and reliable tool for assessing the multidimensional burden of OA across different joints.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100623"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study","authors":"S. Berkani ,&nbsp;S. Tuffet ,&nbsp;A. Rousseau ,&nbsp;N. Rincheval ,&nbsp;E. Maheu ,&nbsp;B. Combes ,&nbsp;A. Saraux ,&nbsp;B. Fautrel ,&nbsp;L. Gossec ,&nbsp;F. Berenbaum ,&nbsp;J. Sellam ,&nbsp;A. Courties","doi":"10.1016/j.ocarto.2025.100626","DOIUrl":"10.1016/j.ocarto.2025.100626","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD).</div></div><div><h3>Methods</h3><div>This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. Outcomes were pain intensity (≥40 on a 0–100 ​mm visual analog scale [VAS]), VAS fatigue, and functional impairment, measured by normalized (0–100) Health Assessment Questionnaire (HAQ) for RA and the AUStralian CANadian Osteoarthritis Hand (AUSCAN) function for EHOA and binarized by their medians. Comorbidities and CMD were also assessed. Logistic regression models adjusted for age, sex, body mass index, and socio-educational level were used to compare outcomes.</div></div><div><h3>Results</h3><div>We included 138 EHOA and 379 RA patients. EHOA patients were older (median age 67.3 <em>vs.</em> 48.6 years, p ​&lt; ​0.001). EHOA patients were more likely to experience higher pain at mobilization (OR ​= ​3.13 95 ​% CI [1.74 to 5.68]) and greater functional impairment (OR ​= ​2.27, 95 ​% CI [1.26 to 4.17]) than RA patients. There was no difference for fatigue and pain at rest. The overall risk of comorbidities was lower in EHOA patients in multivariate analysis (OR ​= ​0.25, 95%CI [0.13–0.48]). There was no significant difference in CMD risk.</div></div><div><h3>Conclusion</h3><div>After more than 10 years of disease duration, EHOA is associated with greater pain and functional impairment than treated RA but with fewer comorbidities. This highlights the significant unmet need for effective therapies for EHOA patients.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients","authors":"Ronan J. Anderson ,&nbsp;Brent A. Lanting ,&nbsp;C. Thomas Appleton ,&nbsp;Ryan M. Degen","doi":"10.1016/j.ocarto.2025.100625","DOIUrl":"10.1016/j.ocarto.2025.100625","url":null,"abstract":"<div><h3>Objective</h3><div>To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoarthritis, and advanced hip osteoarthritis.</div></div><div><h3>Methods</h3><div>Synovium biopsies were collected from ten FAI, fourteen FAI with early osteoarthritis, and twelve advanced osteoarthritis patients. Histopathological grading allowed assessment of osteoarthritis-associated features. Microvessel density and maturity were determined through immunofluorescent labelling of CD31 and α-smooth muscle actin. Immunohistochemical staining was applied to calculate CD105⁺ microvessel density, providing insight into microvessel activity.</div></div><div><h3>Results</h3><div>In all groups, vascularization was prominent, with a mean [95 ​% confidence interval] of 1.64 [1.40, 1.89]. In all three groups, mature microvessel density was greater than immature microvessel density (82.32 [62.92, 101.71] versus 14.84 [9.86, 19.83] microvessels/mm²). Low CD105⁺ microvessel density across all groups (3.14 [0.92, 5.37] microvessels/mm²) suggests microvessel inactivity. Inflammatory composite scores were significantly greater in the advanced OA (1.08 [0.84, 1.32]) versus the FAI group (0.47 [0.26, 0.68]), and in the advanced OA versus the FAI with early OA group (0.69 [0.49, 0.89]) (p ​&lt; ​0.017).</div></div><div><h3>Conclusion</h3><div>Synovium from patients with FAI (with and without hip osteoarthritis) demonstrated synovitis and other OA-associated changes. Mature, inactive microvasculature was prominent in all three groups investigated. Histopathological similarities between FAI and hip OA synovium indicate that disordered synovium appears in FAI patients. These findings highlight a potential role of synovial changes in the progression from FAI to hip OA, underscoring the need for early intervention and further investigation into early disease mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy","authors":"Peter M. van der Kraan","doi":"10.1016/j.ocarto.2025.100624","DOIUrl":"10.1016/j.ocarto.2025.100624","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a “wear and tear” condition, new insights suggest that OA may be part of an evolutionary, age-related biological process rather than mainly driven by mechanical damage.</div></div><div><h3>Design</h3><div>This conceptual paper discusses the model of antagonistic pleiotropy that proposes that certain genes beneficial early in life may contribute to diseases in the context of OA.</div></div><div><h3>Results</h3><div>Findings indicate that OA is connected to biological and not to chronological age supporting the idea that OA is not merely a wear and tear process. Chondrocyte hypertrophy, essential in endochondral bone formation at a (pre)reproductive age, is stimulated by a displaced and wrongly timed endochondral ossification quasi-program in age-related OA. Age-related chondrocyte hypertrophic differentiation in articular cartilage is likely driven by loss of loading-induced TGF-β signaling.</div></div><div><h3>Conclusion</h3><div>Comprehending OA within this evolutionary and biological frame provides a solid alternative to the theory of “wear and tear”, offering insights into further understanding, prevention and disease management.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mechanosensitive stress test in individuals following anterior cruciate ligament reconstruction: A pilot study","authors":"Prakash Jayabalan ,&nbsp;Rose Darcy ,&nbsp;Vikram Darbhe ,&nbsp;Zander Neuville ,&nbsp;Vehniah Tjong ,&nbsp;Levi Hargrove ,&nbsp;Leah Welty ,&nbsp;Thomas Schnitzer","doi":"10.1016/j.ocarto.2025.100619","DOIUrl":"10.1016/j.ocarto.2025.100619","url":null,"abstract":"<div><h3>Objectives</h3><div>1. Assess serum biomarker responses of the anterior cruciate ligament reconstructed (ACLR) knee compared to the non-injured contralateral knee in a lateral tilt paradigm. 2. Determine the relationship between kinematics at the ACLR knee and serum biomarker responses.</div></div><div><h3>Method</h3><div>Cross-sequential study. 16 participants 2–7 years post-ACLR, undertook two 30 ​min walking sessions on a 10° angular tilted treadmill towards the ACLR knee and/or contralateral non-injured knee. Serum collected at baseline and after 30 ​min of walking was tested for biomarkers associated with osteoarthritis (Cartilage oligomeric matrix protein [COMP]), C-terminal cross-linked telopeptides of type II collagen, matrix metalloproteinase-3,-13, ADAM a disintegrin and metalloproteinase with thrombospondin motifs 4-,-5 (ADAMTS-4,-5), interleukin-1β,-6,-8 and RANTES (regulated on activation, normal T-cell expressed and secreted). Kinematic measurements were also taken.</div></div><div><h3>Results</h3><div>When tilted towards the ACLR knee, there was a significant increase in COMP compared to baseline (mean 41.1 ​ng/mL (95%CI:13.8,68.4), not observed when tilted towards the contralateral knee. There was a significant correlation between change in COMP concentration and change in knee adduction/abduction angle (r ​= ​−0.58,p ​= ​0.02). There were no relationships to kinematics and the other biomarkers.</div></div><div><h3>Conclusions</h3><div>The tilt paradigm identified a differential response of a serum mechanosensitive marker (COMP) when testing an ACLR and contralateral knee. There was also a significant relationship between COMP response to tilt walking and the change in knee adduction angle of the ACLR knee. This paradigm could be an aid to provide individual knee biomarker response to a mechanical stress in asymptomatic individuals at risk of developing post-traumatic osteoarthritis at least 2 years post-ACLR.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}