Osteoarthritis and cartilage open最新文献

{"title":"Acellular placental extract outcomes in post-traumatic osteoarthritis model","authors":"Xue Ma ,&nbsp;Marcel G. Brown ,&nbsp;Matthew S. Gwilt ,&nbsp;Kaitlin Henry ,&nbsp;Ayobami Ogunsola ,&nbsp;Jesse Champi ,&nbsp;Seth Tomblyn ,&nbsp;Scott Washburn ,&nbsp;John S. Shields ,&nbsp;Thomas L. Smith","doi":"10.1016/j.ocarto.2025.100729","DOIUrl":"10.1016/j.ocarto.2025.100729","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the effect of human placental extract (HPE) on healthy and osteoarthritic articular cartilage.</div></div><div><h3>Method</h3><div>Post-traumatic osteoarthritis (PTOA) rodent model was utilized to assess functional and histologic outcomes of HPE administration at 1, 2 and 3 months. Matrix metalloproteinase (MMP), glycosaminoglycan (GAG) content were assessed via human and porcine cartilage explants exposed to either HPE or saline cohorts.</div></div><div><h3>Results</h3><div>Improved gait function of PTOA-induced rodents treated with HPE in 5 measured parameters, persisting to the 3-month time point against the saline control. No significant difference in medial or lateral joint space was found on MicroCT evaluation after normalizing results to the contralateral uninjured limb. OARSI scores of the medial compartment of PTOA rodents at 3-months showed preservation of cartilage in the HPE-treated cohort with a score of 1.8 for HPE versus 9.17 for saline (<em>p</em> &lt; 0.05). Porcine cartilage explants co-treated with HPE and IL-1 demonstrated marked reduction of MMP-1 (<em>p</em> = 0.001) and MMP-13 (<em>p</em> = 0.0023) expression compared to IL-1 alone. This effect was re-demonstrated in human cartilage with multiple MMP decreased. Reduced levels of GAG release occurred in HPE-treated cartilage explants in comparison to saline control (<em>p</em> = 0.004), with maintenance of structural architecture on histologic preparations.</div></div><div><h3>Conclusions</h3><div>HPE may be a promising treatment for OA by inhibiting the metabolic process of ECM breakdown and preserving the structural integrity of the knee joint in comparison to saline control.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100729"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of six-minute walk test performance in individuals with knee osteoarthritis","authors":"Sivakami Mylvaganam ,&nbsp;Philippa Nicolson ,&nbsp;Ian Stanaitis ,&nbsp;Gillian Hawker ,&nbsp;Lauren K. King","doi":"10.1016/j.ocarto.2025.100732","DOIUrl":"10.1016/j.ocarto.2025.100732","url":null,"abstract":"<div><h3>Objective</h3><div>The 6-minute walk test (6MWT), an Osteoarthritis Research Society International (OARSI)-recommended measure of physical function in knee osteoarthritis (OA), was originally developed to assess submaximal aerobic fitness in people with cardiovascular disease. The degree to which 6MWT performance reflects knee OA severity versus other patient factors remains unclear. Our objective was to assess the contributions of OA-related and non-OA-related patient characteristics to 6MWT performance in individuals with symptomatic knee OA.</div></div><div><h3>Design</h3><div>In this cross-sectional study, participants scheduled for total knee arthroplasty completed the 6MWT and standardized questionnaires. Participant characteristics were compared by tertiles of 6MWT distance. Multivariable linear regression modelling was used to assess associations between patient factors and 6MWT distance.</div></div><div><h3>Results</h3><div>Among 278 participants (mean age 67.1 years, 65.5% female, mean WOMAC pain 57.0, and mean 6MWT distance 323.1m), older age (adjusted beta coefficient -4.0 per year, 95% confidence interval [CI] −5.4, −2.5), female sex (adjusted beta [95% CI] −43.0 [−67.3, −18.7]), presence of obesity (adjusted beta [95% CI] -44.4 [−68.2, −20.5]), greater knee pain (adjusted beta [95% CI] per unit increase in WOMAC pain −1.12 [−2.1, −0.2]), worse knee-OA related function (adjusted beta [95% CI] per unit increase in KOOS-PS −1.1 [−2.0, −0.1]) were associated with shorter 6MWT distance. Greater arthritis coping efficacy (adjusted beta [95% CI] 5.2 [1.4, 9.0]) was associated with longer 6MWT distance.</div></div><div><h3>Conclusions</h3><div>While 6MWT distance declines with greater knee OA symptom severity, other demographic, biomedical and psychosocial factors also significantly influence 6MWT performance. These should be considered when interpreting the 6MWT in this population.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100732"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers 2025","authors":"","doi":"10.1016/j.ocarto.2026.100770","DOIUrl":"10.1016/j.ocarto.2026.100770","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100770"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A small lipidated peptide targeting NaV1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion","authors":"Raider Rodriguez ,&nbsp;Arin Bhattacharjee","doi":"10.1016/j.ocarto.2026.100750","DOIUrl":"10.1016/j.ocarto.2026.100750","url":null,"abstract":"<div><h3>Objective</h3><div>In clinical practice, intra-articular therapies are commonly used for the management of osteoarthritis (OA) pain. However, these current treatments for OA-related pain are recognized for compromising joint integrity over time. Previously, we demonstrated that disrupting the interaction between Na_V1.8 channels and the Magi-1 scaffold protein facilitated channel degradation in nociceptors, thereby reducing pain behavior in multiple animal models. In this study, we sought to investigate the effects of our small lipidated peptide targeting Na_V1.8 on OA-associated pain in rodents.</div></div><div><h3>Methods</h3><div>In vivo shRNA plasmid transfection was used to knock down Magi-1 in mouse DRG neurons to assess its effects on MIA-induced osteoarthritis (OA) pain behavior. Subsequently, a lipidated Na_V1.8 WW binding domain decoy peptide (PY(A)) was used to pharmacologically target the Na_V1.8-Magi-1 interaction and evaluate its effects on OA pain behavior in rats. A single intra-articular peptide injection (50 μL, 200 μM) was administered to each animal, and a scrambled peptide was used as a control. Histopathology analysis assessed MIA-induced cartilage degradation, and microCT imaging evaluated subchondral bone integrity.</div></div><div><h3>Results</h3><div>Magi-1 knockdown effectively reduced established OA pain in mice. An intra-articular injection of the PY(A) peptide inhibited pain for multiple weeks in rats. MicroCT imaging showed minimal changes in subchondral bone remodeling in the PY(A) peptide group compared to the scrambled peptide group.</div></div><div><h3>Conclusions</h3><div>The PY(A) peptide targeting the Na_V1.8-Magi-1 interaction alleviated OA pain and attenuated subchrondal bone remodeling. Intra-articular injection of lipidated peptides disrupting ion channel scaffolding in neurons provides effective and sustained analgesia for several weeks after a single administration.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100750"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MULTIple or ONE home strengthening exercise(s) for knee osteoarthritis: Protocol for the MULTI-ONE randomised controlled trial","authors":"Rana S. Hinman ,&nbsp;Belinda J. Lawford ,&nbsp;Penny K. Campbell ,&nbsp;Fiona McManus ,&nbsp;Ben R. Metcalf ,&nbsp;Karen E. Lamb ,&nbsp;Monica R. Maly ,&nbsp;Kim L. Bennell","doi":"10.1016/j.ocarto.2026.100754","DOIUrl":"10.1016/j.ocarto.2026.100754","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the effectiveness of a prescribed home exercise program comprised of a single strengthening exercise compared to i) a program with multiple (five) strengthening exercises and ii) control (usual care) for reducing walking pain in people with knee osteoarthritis (OA).</div></div><div><h3>Design</h3><div>A multi-centre superiority randomised controlled trial will be conducted, involving 144 people with chronic knee pain consistent with OA. Participants will be randomised to receive i) control (usual care); ii) a prescribed home program with one strengthening exercise or; iii) a prescribed home program with multiple (five) strengthening exercises. Participants in the exercise groups will have three consultations over 3 months with a physiotherapist for prescription, monitoring and progression of their exercise program, which will be performed independently at home. The primary outcome measure will be change in walking pain measured on a numerical rating scale. Secondary outcomes will include WOMAC pain and function subscales, quality-of-life; arthritis and exercise self-efficacy; fear of movement; global rating of change; muscle strength/power; and willingness for joint replacement. Primary time-point for re-assessment will be 3 months, with a secondary time-point of 9 months, after randomisation.</div></div><div><h3>Ethics and dissemination</h3><div>This trial is approved by the University of Melbourne Human Research Ethics Committee (#29890). Dissemination will occur via lay summaries, infographics, conference abstracts, oral presentations and journal papers.</div></div><div><h3>Clinical trial registration</h3><div>Australian New Zealand Clinical Trials Registry ACTRN12624001226594. Prospectively registered on 9/10/2024.</div></div><div><h3>Conclusions</h3><div>Findings will guide clinicians in choosing how many home strengthening exercises to prescribe for people with knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100754"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants","authors":"Simon Herger ,&nbsp;Wolfgang Wirth ,&nbsp;Corina Nüesch ,&nbsp;Oliver Bieri ,&nbsp;Christian Egloff ,&nbsp;Felix Eckstein ,&nbsp;Annegret Mündermann","doi":"10.1016/j.ocarto.2026.100755","DOIUrl":"10.1016/j.ocarto.2026.100755","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the 2-year changes in cartilage thickness and transverse relaxation time (T2) in magnetic resonance images (MRI) of ACL-injured (ACL_in) and uninjured contralateral knees (ACL_unin), compared to healthy controls (HEA).</div></div><div><h3>Method</h3><div>Baseline and 2-year follow-up MRIs were acquired in both knees of 78 participants (ACL-injured 2–10 years prior, 20–30 years, n = 20; 40–60 years, n = 14; healthy, 20–30 years, n = 23; 40–60 years, n = 21). Weight bearing femorotibial cartilages were manually segmented to determine cartilage thickness and laminar (deep and superficial) T2. 2-year changes were compared between ACL_in, ACL_unin and HEA knees using estimated marginal means (EMM) and group differences in femorotibial compartments, (sub-)regions, and location-independent ordered values (OV).</div></div><div><h3>Results</h3><div>From baseline to 2-year follow-up, cartilage thickness decreased in at least 50 % of regions/subregions whereas significant T2 changes ([95 % CI] ∉ 0) were rare. In ACL_in, cartilage EMM thinning (adjusted: MRI acquisition time, participant age) was strongest in the lateral tibia (LT) and its subregions (∼50 μm). In the interior LT subregion, thinning was 46 [70, 22], 46 [70, 22] and 13 [34, 8]μm in ACL_in, ACL_unin and HEA, respectively. In OV1 and OV2 of ACL_in, thinning was 178 [207, 150] and 130 [148, 111] μm, respectively and greater than in HEA. No EMM group differences were found for 2-year change in T2.</div></div><div><h3>Conclusions</h3><div>ACL-injured knees displayed greater cartilage thinning, particularly using location-independent measures. Change in T2, in contrast, was limited and not specific to injury. Our findings underscore the need for relevant thresholds of cartilage thickness and T2 changes, to define early OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100755"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing deep learning based knee cartilage segmentation in MRI: Innovations, challenges and applications","authors":"Sheheryar Khan ,&nbsp;Muhammad Ammar Khawer ,&nbsp;Junru Zhong ,&nbsp;Rizwan Qureshi ,&nbsp;Muhammad Asim ,&nbsp;Weitian Chen","doi":"10.1016/j.ocarto.2025.100702","DOIUrl":"10.1016/j.ocarto.2025.100702","url":null,"abstract":"<div><h3>Objective</h3><div>Recent advancements in deep learning (DL) have advanced knee cartilage segmentation in Magnetic Resonance Imaging (MRI), offering scalable, automated solutions that markedly reduce reader time and address the limitations of traditional manual approaches. Automated segmentation can substantially aid osteoarthritis (OA) assessment using MRI, facilitating consistent, reproducible quantification across large longitudinal cohorts, reduces inter-/intra-observer variability, capabilities that are impractical with manual workflows.</div></div><div><h3>Method</h3><div>This study presents a concise review of state-of-the-art DL-based approaches for knee cartilage segmentation, focusing on the evaluation of various architectures, techniques, and their adaptability to diverse datasets and imaging protocols. This review highlights key challenges in knee cartilage segmentation, including data scarcity, domain shifts, and imaging variability, while also discussing proposed solutions such as semi-supervised learning, domain adaptation, augmentation strategies, and foundation models. Additionally, the clinical significance of knee cartilage segmentation is underscored through its diverse applications.</div></div><div><h3>Results</h3><div>The study highlights substantial improvements against conventional methods in segmentation accuracy and efficiency using DL-based methods, given challenging scenarios of knee MRI. Solutions to key challenges are presented, and clinical applications showcase the potential of automated segmentation for cartilage thickness mapping and OA assessment.</div></div><div><h3>Conclusion</h3><div>DL-based segmentation is advancing musculoskeletal imaging by offering reliable and automated solutions. Despite persistent challenges such as data scarcity, domain shifts, and imaging variability, advancements in areas like semi-supervised learning, domain adaptation, augmentation strategies, and foundation models present significant opportunities to enhance model robustness and expand clinical applicability.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100702"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial predictive factors for developing chronic postsurgical pain after hip replacement surgery: A systematic review","authors":"Rachel J.H. Smits ,&nbsp;Rosa Poppen ,&nbsp;Jetze Visser ,&nbsp;Kris C.P. Vissers ,&nbsp;Selina E.I. van der Wal","doi":"10.1016/j.ocarto.2025.100725","DOIUrl":"10.1016/j.ocarto.2025.100725","url":null,"abstract":"<div><h3>Objective</h3><div>Total hip arthroplasty for end stage osteoarthritis is a common and often successful procedure. However, 14 ​% of patients experience chronic postsurgical pain after 1 year. The risk of developing chronic pain is multifactorial. The aim of this systematic review is to provide an overview of recent literature on predictive factors for developing postsurgical chronic pain after total hip arthroplasty to create a prognostic model for better recognition, perioperative optimization or reconsideration.</div></div><div><h3>Design</h3><div>Studies were eligible if patients were over 18 years old, biopsychosocial risk factors and the occurrence of pain &gt;3 months after surgery was reported. PubMed, EMBASE and CENTRAL were searched up to June 16th, 2025. The selected studies were screened and assessed on quality and risk of bias.</div></div><div><h3>Results</h3><div>Fifteen studies met the inclusion criteria. These studies identified multiple biopsychosocial factors that may contribute to the development of chronic postsurgical pain. These include body mass index, preoperative (neuropathic) pain, the presence of comorbidities and functional disability, smoking, non-white race, sleep disturbances, depressive symptoms, anxiety, central sensitization, and pain catastrophizing. Additional associations were found for (younger) age and female sex. Some studies failed to demonstrate significant associations of certain factors, highlighting the complexity of chronic pain.</div></div><div><h3>Conclusion</h3><div>The identified, modifiable risk factors could be targets for prehabilitation and optimization. Personalized multimodal analgesia strategies might be more beneficial in high risk patients. Chronic postsurgical pain should be part of the informed consent and non-operative options could be considered in high risk patients.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100725"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145796676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data","authors":"Matthew F. Wipperman ,&nbsp;Peter J. Ehmann ,&nbsp;Debra A.G. McIntyre ,&nbsp;Chen Guang Wang ,&nbsp;Haitao Gao ,&nbsp;Poulabi Banerjee ,&nbsp;Kei Ogawa ,&nbsp;Yoshiteru Ushirogawa ,&nbsp;Erica Chio ,&nbsp;Dateng Li ,&nbsp;Stefanie Hectors ,&nbsp;Henry G. Wei ,&nbsp;Jennifer D. Hamilton ,&nbsp;Sara C. Hamon ,&nbsp;Kristie T. Ota ,&nbsp;Simon Eng ,&nbsp;Garen Manvelian ,&nbsp;Tina Ho ,&nbsp;Bret J. Musser ,&nbsp;Stephen J. DiMartino ,&nbsp;Gregory P. Geba","doi":"10.1016/j.ocarto.2025.100735","DOIUrl":"10.1016/j.ocarto.2025.100735","url":null,"abstract":"<div><h3>Objective</h3><div>Nerve growth factor (NGF) inhibitors have been shown to provide pain relief in patients with osteoarthritis but are associated with adjudicated arthropathies (AAs). Exploratory analyses were performed to identify whether peripheral biomarkers routinely collected in trials can predict AAs, independent of known clinical covariates.</div></div><div><h3>Methods</h3><div>Clinical and biomarker data from seven phase 2/3 fasinumab trials were pooled, and 33 laboratory baseline and week 16 change variables were assessed. Individuals with AA were identified and propensity score matched 1:1 to non-AA controls, creating four unique sets of non-AA individuals. Random forest machine learning models were used. Variables with &gt;30 % missing data were excluded. The training/validation set included 75 % of the available dataset; 10 % formed the working validation test set, and 15 % a held-back test set. Area under the curve of the receiving operating characteristic (AUROC) and ranked feature importance were assessed across models using peripheral biomarkers to predict AA vs non-AA individuals.</div></div><div><h3>Results</h3><div>Of the final dataset (n = 11,490), 911 AA individuals were compared with four unique sets of non-AA individuals (n = 878–908). The AUROC was 0.51–0.57 for biomarkers at baseline and 0.54–0.62 for biomarker changes at week 16. Change in alkaline phosphatase (ALP) from baseline to week 16 was the only important variable identified consistently across models. ALP was also elevated by several points on average in individuals receiving fasinumab.</div></div><div><h3>Conclusion</h3><div>Change in ALP (baseline to week 16) was associated with AA events after treatment with fasinumab. Other measured peripheral biomarkers were not linked with AA events.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100735"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Effect of a multidisciplinary lifestyle intervention on body composition in people with osteoarthritis: Secondary analysis of the “Plants for Joints” randomized controlled trial’ [Osteoarthritis and Cartilage Open 6 (2024) 100524]","authors":"C.A. Wagenaar ,&nbsp;W. Walrabenstein ,&nbsp;C.S. de Jonge ,&nbsp;M. Bisschops ,&nbsp;M. van der Leeden ,&nbsp;M. van der Esch ,&nbsp;P.J.M. Weijs ,&nbsp;M.A. Troelstra ,&nbsp;M.A. Korteweg ,&nbsp;A.J. Nederveen ,&nbsp;D. van Schaardenburg","doi":"10.1016/j.ocarto.2025.100722","DOIUrl":"10.1016/j.ocarto.2025.100722","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100722"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}