Osteoarthritis and cartilage open最新文献

{"title":"MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study","authors":"Christian J. Barton ,&nbsp;Michelle Dowsey ,&nbsp;Anne Smith ,&nbsp;Ilana N. Ackerman ,&nbsp;Zanfina Ademi ,&nbsp;Samantha Bunzli ,&nbsp;Peter Choong ,&nbsp;Kay M. Crossley ,&nbsp;Joanne Kemp ,&nbsp;Jason A. Wallis ,&nbsp;Alison Gibbs ,&nbsp;Vincent Lengkong ,&nbsp;Allison M. Ezzat ,&nbsp;Juanita Low ,&nbsp;Zhomart Orman ,&nbsp;Nicholas F. Taylor ,&nbsp;Anna Wong Shee ,&nbsp;Natasha A. Lannin ,&nbsp;Ewa M. Roos ,&nbsp;Raph Hau ,&nbsp;Danilo De Oliveira Silva","doi":"10.1016/j.ocarto.2025.100622","DOIUrl":"10.1016/j.ocarto.2025.100622","url":null,"abstract":"<div><h3>Objective</h3><div>This parallel cohort-implementation study, termed MonitOring the health Trajectory of patients with kNee osteoarthritis (MOTION), aims to understand treatment pathways and outcomes for people with knee osteoarthritis referred to Australian public hospitals for orthopaedic assessment (Part A cohort study), and how improving access to first-line care might improve outcomes (Part B implementation study).</div></div><div><h3>Methods and analysis</h3><div>We will recruit approximately 400 adults with knee osteoarthritis referred for orthopaedic opinion to one of four public hospitals in Victoria, Australia. A subgroup enrolled in the study (n ​= ​109) will receive improved access to community-based first-line care. Outcomes will be evaluated at baseline, 4-, 8-, 12- (primary end point), 24- and 60-months. The primary outcome will divide the cohort into 1's (willing to undergo, waitlisting for, or undergone, TKR surgery) or 0's (not willing to undergo, not undergone, and not waitlisted for, TKR surgery). Secondary outcomes include pain, knee- and health-related quality of life, physical activity participation and health care utilisation. Surgical and health trajectories will be reported descriptively, with factors associated with outcomes explored. The effectiveness of improving access to first-line care will be determined through propensity score methods. The cost-effectiveness of improving access to first-line care will be also be determined, and semi-structured interviews (1:1 and focus groups) involving participants, health professionals, administrators, and research team will inform a comprehensive process evaluation.</div></div><div><h3>Ethics and dissemination</h3><div>Approved by St Vincent's Hospital Melbourne Human Research Ethics Committee (HREC 251/21). Findings will be disseminated to stakeholders including via conferences, peer-reviewed journals, and social and mainstream media.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone shape changes over two years following acute anterior cruciate ligament injury: Reconstructed vs non-reconstructed knees","authors":"L. Hassanlou ,&nbsp;M.A. Bowes ,&nbsp;A. Turkiewicz ,&nbsp;J. Kvist ,&nbsp;H. Gauffin ,&nbsp;R. Frobell ,&nbsp;S. Saarakkala ,&nbsp;M. Englund","doi":"10.1016/j.ocarto.2025.100652","DOIUrl":"10.1016/j.ocarto.2025.100652","url":null,"abstract":"<div><h3>Objective</h3><div>To determine bone shape changes over two years after acute anterior cruciate ligament (ACL) injury and to compare knees treated with ACL reconstruction (ACLR) vs no ACLR.</div></div><div><h3>Design</h3><div>We used prospective data involving 129 young adults (46 ​% female, mean age 25 years) with recent ACL injury from a subcohort within the prospective multicenter NACOX study. Patients were treated according to Swedish guidelines with supervised rehabilitation before considering ACLR. 3D MR images obtained at baseline, 3-, 6-, 12, and 24-months post-injury were assessed for changes in the femur and tibia bone surface area using active appearance models. We used a linear mixed-effects model adjusted for age, sex, body mass index, and pre-injury Tegner physical activity level.</div></div><div><h3>Results</h3><div>We observed growth in bone areas over the first two years, particularly in the medial femur and medial tibia, with an average relative increase of 1.28 ​% (95 ​% CI 0.67 ​%, 1.88 ​%) and 1.04 ​% (0.44 ​%, 1.65 ​%), respectively. The lateral femur also showed growth, with an increase of 1.15 ​% (0.55 ​%, 1.75 ​%). We found little differences comparing ACLR patients to non-ACLR patients, adjusted relative percentage differences: medial femur, 0.01 ​% (95 ​% CI: 0.9 ​%, 1.1 ​%); medial tibia, −0.03 ​% (−1.2 ​%, 0.7 ​%); lateral femur, 0.04 ​% (−0.6 ​%, 1.4 ​%); and lateral tibia, −0.11 ​% (−2.1 ​%, −0.1 ​%).</div></div><div><h3>Conclusion</h3><div>After acute ACL injury, there is a growth primarily in the medial femoral and tibial condyles. The bone shape changes could hypothetically be a response to altered biomechanical conditions and may precede the development of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100652"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound findings in patients with knee osteoarthritis: Relationships with clinical characteristics, radiographic findings and generalized osteoarthritis","authors":"Ahmet Sumen ,&nbsp;Kubra Neslihan Kurt Oktay","doi":"10.1016/j.ocarto.2025.100656","DOIUrl":"10.1016/j.ocarto.2025.100656","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between ultrasound (US) findings and radiographic Kellgren–Lawrence (K/L) grades, symptom severity, and the presence of generalized osteoarthritis (GOA) in patients with knee osteoarthritis (OA), and to identify key US parameters associated with OA severity.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 patients (332 knees) with radiographically confirmed knee OA. US assessments included medial and lateral meniscus extrusion (MME, LME), suprapatellar effusion, synovitis, femoral cartilage thickness (FCT), femoral cartilage lesions, Baker's cyst, pes anserine bursitis, patellar tendinopathy, and Hoffa's fat pad pathology. K/L grades were determined by radiography. Pain and function were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). GOA was defined as OA in five or more joints or the presence of Heberden's nodes with additional joint involvement.</div></div><div><h3>Results</h3><div>MME showed a strong correlation with K/L grade (r ​= ​0.954, p ​&lt; ​0.001), with 91.57 ​% exact agreement. LME showed a moderate correlation (r ​= ​0.693, p ​&lt; ​0.001). GOA was identified in 12.65 ​% of patients and was independently associated with lower BMI, reduced FCT (&lt;2 ​mm), and the presence of femoral cartilage lesions. Moderate correlations were observed between K/L grade and pain, WOMAC scores, and symptom duration<strong>.</strong></div></div><div><h3>Conclusion</h3><div>MME and FCT measured by US are strong indicators of OA severity and may help identify patients at risk for GOA. US appears to be a practical, radiation-free tool for assessing and monitoring OA progression. Further validation in larger cohorts is recommended.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100656"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy","authors":"Peter M. van der Kraan","doi":"10.1016/j.ocarto.2025.100624","DOIUrl":"10.1016/j.ocarto.2025.100624","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a “wear and tear” condition, new insights suggest that OA may be part of an evolutionary, age-related biological process rather than mainly driven by mechanical damage.</div></div><div><h3>Design</h3><div>This conceptual paper discusses the model of antagonistic pleiotropy that proposes that certain genes beneficial early in life may contribute to diseases in the context of OA.</div></div><div><h3>Results</h3><div>Findings indicate that OA is connected to biological and not to chronological age supporting the idea that OA is not merely a wear and tear process. Chondrocyte hypertrophy, essential in endochondral bone formation at a (pre)reproductive age, is stimulated by a displaced and wrongly timed endochondral ossification quasi-program in age-related OA. Age-related chondrocyte hypertrophic differentiation in articular cartilage is likely driven by loss of loading-induced TGF-β signaling.</div></div><div><h3>Conclusion</h3><div>Comprehending OA within this evolutionary and biological frame provides a solid alternative to the theory of “wear and tear”, offering insights into further understanding, prevention and disease management.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular treatments to reduce catabolic effects in human meniscus explant models","authors":"Amanda Sjögren ,&nbsp;Karin Lindblom ,&nbsp;Aleksandra Turkiewicz ,&nbsp;Martin Englund ,&nbsp;Patrik Önnerfjord","doi":"10.1016/j.ocarto.2025.100618","DOIUrl":"10.1016/j.ocarto.2025.100618","url":null,"abstract":"<div><h3>Objectives</h3><div>1. To validate catabolic meniscus explant models induced by cytokines: interleukin-6 ​+ ​interleukin-6 receptor ​+ ​tumor necrosis factor alpha (IL6/TNF) and oncostatin M ​+ ​tumor necrosis factor alpha (OSM/TNF). 2. To evaluate three potential anti-catabolic treatments: i) dexamethasone (DEX), ii) a Link-N peptide (Link-N) and iii) a peptide from chondroadherin (CKF).</div></div><div><h3>Design</h3><div>Healthy lateral menisci from deceased donors (n ​= ​6; age ​= ​25–70 years, 4 males, 2 females), were sliced and randomized for experimental groups (combinations of the catabolic models and anti-catabolic treatments) and a control group. Culture media were analyzed, every third day until day 18, by mass spectrometry-based proteomics. Linear mixed effect models were used to estimate differences in protein abundances between groups.</div></div><div><h3>Results</h3><div>A total of 662 proteins were identified in all menisci. Cytokine-treated meniscus explant models showed increased release of osteoarthritis-related proteins such as matrix metalloproteinases (MMPs). For example, MMP1: IL6/TNF vs. ctrl; log2 fold-change 2.2 95 ​% confidence interval [1.8, 2.5] and OSM/TNF vs. ctrl; log2 fold-change 2.8 [2.4, 3.1]. There was no treatment effect in explant meniscus with the addition of either Link-N or CKF. Treatment effects were, however, evident with the addition of DEX. For example, MMP1: IL6/TNF ​+ ​DEX vs. ctrl; log2 fold-change −1.8 [-2.2, −1.4] and OSM/TNF ​+ ​DEX vs. ctrl; log2 fold-change −0.3 [-0.7, 0.04].</div></div><div><h3>Conclusion</h3><div>We confirmed that both catabolic models induce changes in osteoarthritis-related proteins. DEX treatment is effective in mitigating the catabolic response in meniscus explant models and may be further explored for its effects in the treatment of meniscus degeneration.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis","authors":"Jack B. Roberts ,&nbsp;Jason S. Rockel ,&nbsp;Rick Mulders ,&nbsp;Terence D. Capellini ,&nbsp;C. Thomas Appleton ,&nbsp;Douglas H. Phanstiel ,&nbsp;Rik Lories ,&nbsp;Jeroen Geurts ,&nbsp;Shabana Amanda Ali ,&nbsp;Nidhi Bhutani ,&nbsp;Laura Stone ,&nbsp;Yenisel Cruz-Almeida ,&nbsp;Igor Jurisica ,&nbsp;Cindy G. Boer ,&nbsp;Yolande F.M. Ramos ,&nbsp;Sarah J. Rice ,&nbsp;Mohit Kapoor","doi":"10.1016/j.ocarto.2025.100621","DOIUrl":"10.1016/j.ocarto.2025.100621","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies. For over a decade, OA researchers have been working to determine epigenetic mechanisms underlying the disease to better understand pathology, identify biomarkers of progression, and pinpoint novel targets for therapeutic intervention.</div></div><div><h3>Design</h3><div>This article presents a summary of the 3rd International Workshop on the Epigenetics of Osteoarthritis held in Toronto, Ontario, Canada, in September 2024. The purpose of this meeting was to gather the international community to discuss the status of OA epigenetic research and share expertise on innovative techniques for future.</div></div><div><h3>Results</h3><div>Since the two previous meetings, there has been increasing adoption of advanced single-cell and spatial sequencing technologies and bioinfomatic analyses. Furthermore, investigations of multiple joint tissues has highlighted the shifting paradigm from OA as a cartilage centric disease to the consideration of all joint tissues.</div></div><div><h3>Conclusions</h3><div>The workshop provided a unique opportunity for early-career researchers to expand their network, and for all participants to discuss new or improved approaches to advance the field, including international consortia and data sharing. The highlights and outcomes from this OA epigenetics workshop are described in this report.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness","authors":"Hanna Mass ,&nbsp;Jamie E. Collins ,&nbsp;Catherine Yang ,&nbsp;David J. Hunter ,&nbsp;Morgan H. Jones ,&nbsp;Love Tsai ,&nbsp;Stephen P. Messier ,&nbsp;Tuhina Neogi ,&nbsp;Jeffrey N. Katz ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2025.100641","DOIUrl":"10.1016/j.ocarto.2025.100641","url":null,"abstract":"<div><h3>Objective</h3><div>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.</div></div><div><h3>Methods</h3><div>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.</div></div><div><h3>Results</h3><div>In the base case, ICERs were $8300/QALY for saline compared to no injection, $54,500/QALY for HA compared to saline, and $112,100/QALY for PRP compared to HA. CS was dominated (more costly, less effective) by saline. <strong>If saline was not included, ICER for HA was reduced to $22,400/QALY.</strong> In sensitivity analyses that assumed CS does not increase OA progression, ICERs were $6000/QALY for CS compared to no injection, HA dominated compared to CS. ICER for PRP was estimated at $151,300/QALY. ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost.</div></div><div><h3>Conclusions</h3><div>CS could offer good value for knee OA management if the impact on OA progression is small. <strong>Value of PRP depends greatly on its price, with current prices leading to value exceeding well</strong><strong>-</strong><strong>accepted cost-effectiveness thresholds</strong>. Better data on the impact of CS on OA progression and pain efficacy related to PRP would offer critical insights for policymakers into the value of specific IAIs in the management of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100641"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex activation during daily movements and its association with clinical symptoms in knee osteoarthritis","authors":"Soyoung Lee ,&nbsp;Ehyun Kim ,&nbsp;Baekdong Cha ,&nbsp;Claudio L. Ferre ,&nbsp;Meryem Yücel ,&nbsp;Deepak Kumar","doi":"10.1016/j.ocarto.2025.100615","DOIUrl":"10.1016/j.ocarto.2025.100615","url":null,"abstract":"<div><h3>Objective</h3><div>For people with knee osteoarthritis (OA), step-up is one of the most physically demanding and pain-evoking daily movements. Given the significant role of the prefrontal cortex (PFC) in executive function and pain modulation, our objectives were (1) to assess PFC activation during walking and step-up in people with knee OA and (2) to examine the association of pain and psychological outcomes with changes in PFC activation from walking to step-up.</div></div><div><h3>Design</h3><div>This cross-sectional study included 44 individuals with symptomatic knee OA. Participants completed Knee Injury and Osteoarthritis Outcome Score (KOOS), Pain, Enjoyment of Life, and General Activity (PEG) scale, Patient Health Questionnaire (PHQ-8) for mood, 3-item Pain Catastrophizing Scale (PCS), and Fear-Avoidance Beliefs Questionnaire (FABQ). Oxygenated hemoglobin concentration changes (HbO₂) in the bilateral PFC were assessed using functional Near-Infrared Spectroscopy. HbO₂ were compared between tasks using repeated measures ANCOVA. Multiple linear regression models tested the association between clinical outcomes and changes in HbO₂ from walking to step-up while adjusting for confounders.</div></div><div><h3>Results</h3><div>HbO₂ during step-up was higher compared to walking, with moderate effect size (<em>d</em> ​= ​0.3–0.5). Greater pain catastrophizing (R² ​= ​0.10) was correlated with smaller changes in HbO₂ from walking to step-up.</div></div><div><h3>Conclusion</h3><div>People with knee OA utilized greater executive control during step-up compared to walking. Similar to stair climbing, step-up is more physically demanding and more frequently impaired than walking. Greater pain catastrophizing was related to smaller increases in PFC activation from walking to step-up, reflecting the availability of fewer executive resources to maintain task performance.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100615"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis – 4-year follow-up data from the Osteoarthritis Initiative","authors":"Virginie Kreutzinger ,&nbsp;Katharina Ziegeler ,&nbsp;Gabby B. Joseph ,&nbsp;John A. Lynch ,&nbsp;Zehra Akkaya ,&nbsp;Nancy E. Lane ,&nbsp;Charles E. McCulloch ,&nbsp;Michael Nevitt ,&nbsp;Thomas M. Link","doi":"10.1016/j.ocarto.2025.100653","DOIUrl":"10.1016/j.ocarto.2025.100653","url":null,"abstract":"<div><h3>Objective</h3><div>Weight loss can modify the progression of osteoarthritis (OA), and this may, in part, be achieved by decreased synovitis, a known accelerator of cartilage degeneration. The purpose of this study was to investigate whether change in synovitis mediates the beneficial effect of weight loss on longitudinal cartilage outcomes.</div></div><div><h3>Method</h3><div>We analyzed right knees with baseline Kellgren &amp; Lawrence grades 1–3 of 1153 obese and overweight participants of the Osteoarthritis Initiative (OAI) cohort with Whole Organ MRI Scores (WORMS) and semi-quantitative assessment of effusion synovitis and synovial proliferation scores form 3T MRIs at baseline and 48 months. There were 295 participants with weight-loss &gt;5 ​% and 858 stable weight controls. Ordered logistic regression was used to assess the association of weight-loss status with concurrent changes in synovitis as well as cartilage WORMS scores; models were adjusted for age, gender, race, presence of radiographic OA, and abdominal circumference at baseline. A mediation analysis was used to determine whether change in overall cartilage degeneration was mediated by change in synovitis scores.</div></div><div><h3>Results</h3><div>Individuals who lost weight had significantly lower odds for a higher grade on the scale assessing change in overall synovitis (OR 0.72; 95%CI 0.54, 0.95; p ​= ​0.018). Mediation analysis showed that slowing synovitis during weight loss had a small mediating effect on longitudinal cartilage outcomes.</div></div><div><h3>Conclusion</h3><div>Decreased cartilage degeneration during weight loss was partially mediated by concurrent deceleration in synovitis, showing that decreasing systemic inflammation during weight-loss may not be mirrored in imaging markers of joint inflammation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100653"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis","authors":"H. Platzer ,&nbsp;M. Wellbrock ,&nbsp;G. Pourbozorg ,&nbsp;R. Mayakrishnan ,&nbsp;S. Gantz ,&nbsp;B. Khamees ,&nbsp;S. Maciej ,&nbsp;B. Moradi","doi":"10.1016/j.ocarto.2025.100642","DOIUrl":"10.1016/j.ocarto.2025.100642","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is driven by biomechanical and biochemical inflammatory processes, including CD4⁺ T cell infiltration and activation. However, the role of CD4⁺ T cell subsets interacting with neighboring cells shaping the local inflammatory milieu have remained largely unexplored. This study aimed to investigate in vitro whether interaction of chondrocyte and CD4⁺ T cells modulate cytokine and metalloproteinase production in OA, and to determine if this modulation differ depending on CD4⁺ T cell subsets.</div></div><div><h3>Method</h3><div>Nineteen patients with knee OA undergoing knee replacement were enrolled. From peripheral blood CD4⁺ T cells were isolated and differentiated into subsets (Th1, Th2, Th17, Treg) using a novel developed protocol. T cell differentiation was validated by flow cytometry. Chondrocytes were mono- and co-cultured with T cell subsets and in culture supernatant cytokine and metalloproteinase levels were quantified using ELISA and multiplex assays.</div></div><div><h3>Results</h3><div>Compared to monocultures levels MMP-1/3/9/13 and IL-6 were elevated in all co-cultures of chondrocytes and CD4⁺ T cell subsets, with the highest levels in Th17 co-cultures. GM-CSF, IL-9, IL-17 were specifically elevated in Th17 co-cultures and IFN-γ in Th1 co-cultures. TNF-α production was significantly reduced only in Treg co-culture compared to monoculture approach.</div></div><div><h3>Conclusion</h3><div>This study indicates that chondrocytes can interact with CD4⁺ T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4⁺ T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100642"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}