Osteoarthritis and cartilage open最新文献

{"title":"Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review","authors":"Larissa Rix ,&nbsp;Samuel Tushingham ,&nbsp;Karina Wright ,&nbsp;Martyn Snow","doi":"10.1016/j.ocarto.2025.100577","DOIUrl":"10.1016/j.ocarto.2025.100577","url":null,"abstract":"<div><h3>Background</h3><div>Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.</div></div><div><h3>Objectives</h3><div>To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.</div></div><div><h3>Results</h3><div>PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.</div></div><div><h3>Conclusion</h3><div>Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms indicative of early knee osteoarthritis after ACL reconstruction: descriptive analysis of the SHIELD cohort","authors":"Anna Cronström ,&nbsp;May Arna Risberg ,&nbsp;Martin Englund ,&nbsp;Dorthe B. Strauss ,&nbsp;Paul Neuman ,&nbsp;Carl Johan Tiderius ,&nbsp;Eva Ageberg","doi":"10.1016/j.ocarto.2025.100576","DOIUrl":"10.1016/j.ocarto.2025.100576","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the SHIELD cohort in terms of symptoms indicative of early knee osteoarthritis (OA) and to investigate associations between patient characteristics (demographics, activity/injury-related) and these symptoms at 1 (cross-sectional) and 3 years (longitudinal) post anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Method</h3><div>106 participants (50 ​% women, mean [SD] age 25 [5] years) were included. Symptoms indicative of early knee OA were evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) subscale pain, KOOS subscale pain ≤72 (KOOSpain ≤72), and ≤85 on two out of four KOOS subscales (pain, symptoms, activity of daily living, quality of life) (modified Luyten).</div></div><div><h3>Results</h3><div>Mean (SD) KOOS pain scores were 83.2 (15.7) and 87.3 (12.7) at 1 and 3 years, respectively. At 1 year and 3 years post ACLR, 18/101 (18 ​%) and 14/86 (16 ​%) participants met the KOOSpain ≤72 criterion, whereas 83/101 (82 ​%) and 67/86 (78 ​%) met the modified Luyten criterion. 7/15 (47 ​%) (KOOSpain ≤72) and 59/70 (84 ​%) (modified Luyten) classified as having knee OA symptoms 1 year post ACLR were still classified as having OA symptoms after 3 years. Lower activity level at 1 year was the sole variable consistently associated with all three outcomes 3 years post ACLR.</div></div><div><h3>Conclusion</h3><div>The proportion of participants fulfilling existing classification criteria for symptoms indicative of early OA after ACLR is highly dependent on the criteria applied and different criteria seem to capture varying aspects of early OA symptoms. Future studies will reveal if these symptoms will persist long-term or just reflect more transient issues.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical phenotypes and associated factors in knee osteoarthritis in an African black population","authors":"Charles Sougué ,&nbsp;Malick Diallo ,&nbsp;Yannick Laurent Tchenadoyo Bayala ,&nbsp;Ismaël Ayouba Tinni ,&nbsp;Fulgence Kaboré ,&nbsp;Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo ,&nbsp;Patrick Wendpouiré Hamed Dakouré ,&nbsp;Dieu-Donné Ouedraogo","doi":"10.1016/j.ocarto.2025.100570","DOIUrl":"10.1016/j.ocarto.2025.100570","url":null,"abstract":"<div><h3>Objective</h3><div>Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.</div></div><div><h3>Methods</h3><div>This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.</div></div><div><h3>Results</h3><div>A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 ​%) exhibited the “osteoporotic” phenotype, 113 patients (35.2 ​%) exhibited the “metabolic” phenotype, 17 patients (5.3 ​%) exhibited the “genetic” phenotype, 24 patients (7.4 ​%) exhibited the “biomechanical” phenotype, and 15 patients (4.6 ​%) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR ​= ​1.13 [1.10; 1.16], p ​&lt; ​0.0001) and in women (OR ​= ​2.44 [1.20; 4.94], p ​&lt; ​0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR ​= ​1.93 [1.91; 1.96], p ​&lt; ​0.0001) and in those with tibiofemoral osteoarthritis (OR ​= ​0.44 [0.21; 0.94], p ​= ​0.034).</div></div><div><h3>Conclusion</h3><div>The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100570"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical development","authors":"Morten Asser Karsdal ,&nbsp;Lucio C. Rovati ,&nbsp;Jeyanesh Tambiah ,&nbsp;Olga Kubassova ,&nbsp;Christoph Ladel ,&nbsp;Francis Berenbaum ,&nbsp;Anne-Christine Bay-Jensen ,&nbsp;Lachy Mclean ,&nbsp;Richard Loeser ,&nbsp;Ali Mobasheri ,&nbsp;Virginia B. Kraus","doi":"10.1016/j.ocarto.2025.100572","DOIUrl":"10.1016/j.ocarto.2025.100572","url":null,"abstract":"<div><h3>Objective</h3><div>The inflammatory endotype is arguably one of the most well-established endotype in osteoarthritis (OA). While endotyping holds promise for advancing drug development, numerous potential challenges must be considered, addressed and resolved before successful clinical outcomes can be achieved.</div></div><div><h3>Design</h3><div>Since 2017, the Osteoarthritis Research Society International (OARSI) has hosted the Clinical Trials Symposium (CTS). Each year, OARSI and the CTS steering committee encourage discussions on selected topics among a broad range of stakeholders, including regulators, drug developers, clinicians, clinical researchers, biomarker specialists, and basic scientists, with the aim of advancing drug development in the OA field.</div></div><div><h3>Results</h3><div>This report highlights the ongoing tension between academia's “blue ocean” strategy and the feasibility-driven approach of drug developers, all within the context of scientific efforts to find effective solutions. Understanding the needs, goals, constraints, and opportunities of all involved stakeholders is crucial for defining optimal drug development strategies for OA.</div></div><div><h3>Conclusion</h3><div>A multidisciplinary, collaborative approach is essential for developing effective OA treatments, balancing scientific discovery with regulatory and clinical feasibility.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100572"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping","authors":"Tommy Kok Annfeldt ,&nbsp;Elisabeth Ginnerup-Nielsen ,&nbsp;Eva Elisabeth Wæhrens ,&nbsp;Lene Vase ,&nbsp;Lars Erik Kristensen ,&nbsp;Tanja Schjødt Jørgensen","doi":"10.1016/j.ocarto.2025.100574","DOIUrl":"10.1016/j.ocarto.2025.100574","url":null,"abstract":"<div><h3>Objective</h3><div>This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA. It furthermore explored if other cognitive biases or heuristics were involved in the response to open-label placebo.</div></div><div><h3>Method</h3><div>A mixed method study in a pre-specified knee OA cohort. The influence of patient-experience, and the affect heuristic, on change in painful symptoms in response to an open-label placebo injection, were assessed using a questionnaire and multivariate linear regression. The group concept mapping method was used to characterise the expectations and hopes regarding the effect of an open-label placebo injection in non-responders and responders, defined as the lower- and upper quartile of the ΔVAS pain scores.</div></div><div><h3>Results</h3><div>103 participants received the questionnaire, and 60 finalised questionnaires were included in the analysis showing that the reduction in pain was associated with the patient-experience and that the affect heuristic acted as an effect modifier. Three workshops were held for non-responders (<em>n</em> ​= ​13) and responders (<em>n</em> ​= ​15) each generating respectively 113 and 119 statements. It was found that the two groups reported different expectations and hopes for the open label placebo injections.</div></div><div><h3>Conclusions</h3><div>The patient-experience influenced the response to an open label placebo injection in patients with knee OA, and this influence was moderated by the strength of the affect heuristic. Furthermore, non-responders and responders reported different hopes and expectation towards the open label placebo injection indicating the presence of the optimism bias in the responder group.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies","authors":"Jacinta Cheng ,&nbsp;Tia Solomon ,&nbsp;Mahnuma Estee ,&nbsp;Flavia M. Cicuttini ,&nbsp;Yuan Z. Lim","doi":"10.1016/j.ocarto.2025.100567","DOIUrl":"10.1016/j.ocarto.2025.100567","url":null,"abstract":"<div><h3>Objective</h3><div>There is significant interest in the potential of glucagon-like peptide 1 receptor agonists (GLP-1A) to improve outcomes in osteoarthritis. We systematically reviewed the evidence from pre-clinical and human studies for effect of glucagon-like peptide 1 receptor agonists (GLP-1A) in osteoarthritis.</div></div><div><h3>Method</h3><div>Ovid Medline, Embase and CINAHL were searched (inception to November 2024) using MeSH terms and key words to identify studies examining the association between GLP-1A use and outcomes related to osteoarthritis. Risk of bias assessment and data extraction were conducted by three reviewers independently. Qualitative evidence synthesis was performed and prospectively registered on PROSPERO (CRD42024522782 and CRD42024522787).</div></div><div><h3>Results</h3><div>This systematic review included 11 (7 pre-clinical; 4 human studies) studies. In pre-clinical studies, GLP-1A was assessed for its effect on structural (n ​= ​6); immunomodulation (n ​= ​7); analgesia (n ​= ​1) and molecular pathways in osteoarthritis (n ​= ​5). For human studies, GLP-1A were assessed for structural (n ​= ​1) and symptomatic (n ​= ​4) effects in osteoarthritis. Pre-clinical studies consistently demonstrated favourable chondroprotective and immunomodulatory effects of GLP-1A in osteoarthritis, with a dose-dependent effect, primarily driven by inhibition of NF-κB pathway. Limited human studies supported these findings in osteoarthritis.</div></div><div><h3>Conclusion</h3><div>There are consistent signals across limited pre-clinical and human studies to support a potential favourable structural protective, immunomodulatory and analgesic effects of GLP-1A in osteoarthritis. With the growing burden of obesity, high-quality trials are needed to determine the role of GLP-1A in osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100567"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in knee osteoarthritis prevalence over a 10-year period in Japan: The ROAD study 2005–2015","authors":"Gaku Tanegashima ,&nbsp;Toshiko Iidaka ,&nbsp;Shigeyuki Muraki ,&nbsp;Chiaki Horii ,&nbsp;Hiroyuki Oka ,&nbsp;Hiroshi Kawaguchi ,&nbsp;Kozo Nakamura ,&nbsp;Toru Akune ,&nbsp;Sakae Tanaka ,&nbsp;Noriko Yoshimura","doi":"10.1016/j.ocarto.2025.100569","DOIUrl":"10.1016/j.ocarto.2025.100569","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to clarify the trends in the prevalence of knee osteoarthritis (OA) and symptomatic knee OA among the general population using population-based cohort data from baseline and a survey 10 years later.</div></div><div><h3>Design</h3><div>The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted from 2005 to 2007; 3040 participants (1061 men and 1979 women; mean age 70.3 years) completed all OA examinations, including a questionnaire of medical information in the present/past and radiographic examination. The fourth survey was performed from 2015 to 2016; 2893 individuals (895 men and 1998 women, mean age 68.9 years) completed assessments identical to those at the baseline survey. Knee OA was defined using the Kellgren–Lawrence grading system.</div></div><div><h3>Results</h3><div>The prevalence of knee OA was 54.6 ​% (men, 42.0 ​%; women, 61.5 ​%) at the baseline survey and 39.3 ​% (men, 26.9 ​%; women, 44.9 ​%) at the fourth survey, with a significant decrease (p ​&lt; ​0.0001). The prevalence of symptomatic knee OA was 24.3 ​% (men, 16.9 ​%; women, 28.3 ​%) at the baseline survey and 20.6 ​% (men, 14.2 ​%; women, 23.5 ​%) at the fourth survey, showing a similar decrease (p ​&lt; ​0.0001). Thus, the prevalence of knee OA and symptomatic knee OA was lower at the fourth survey than at the baseline survey (p ​&lt; ​0.01).</div></div><div><h3>Conclusions</h3><div>In the population-based survey with a 10-year interval, the prevalence of knee OA and symptomatic knee OA decreased significantly. This preferable change in OA may suggest rejuvenation in the current population and could contribute to a decrease in the occurrence of disabilities in the future.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100569"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of heterogeneity of treatment effects across exercise-based interventions for knee osteoarthritis","authors":"Paul A. Dennis ,&nbsp;Livia Anderson ,&nbsp;Cynthia J. Coffman ,&nbsp;Sara Webb ,&nbsp;Kelli D. Allen","doi":"10.1016/j.ocarto.2025.100571","DOIUrl":"10.1016/j.ocarto.2025.100571","url":null,"abstract":"<div><h3>Objective</h3><div>Variability exists in the degree of improvement patients experience following exercise-based interventions (EBIs) for knee osteoarthritis (KOA), but understanding of this heterogeneity is limited. Using a machine learning approach, this study leveraged data from two randomized controlled trials (RCTs) to identify patient characteristics contributing to differential treatment effects.</div></div><div><h3>Design</h3><div>The RCTs enrolled n ​= ​621 patients and evaluated three EBIs (group-based physical therapy (PT), individual PT, and a Stepped Exercise Program) and an education control group. The primary outcome was change in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score from baseline to end of treatment. Predictors included 25 demographic, clinical, and psychosocial characteristics. Three metalearners with three machine learning algorithms each and a simple interpretable model-based regression tree were used to identify subgroups with differential treatment effects. Fit was evaluated with holdout/validation data using root mean square error and mean absolute error.</div></div><div><h3>Results</h3><div>The regression tree model outperformed all 9 metalearner models. Tree results suggested group-based PT yielded the largest improvement in mean WOMAC score. Only two subgroups were identified: baseline WOMAC score≤44 versus &gt;44. Group-based PT was the optimal treatment regardless of baseline WOMAC score, but results were more ambiguous for patients with higher initial WOMAC score. For all 3 EBIs, patients with higher baseline WOMAC score made greater improvements.</div></div><div><h3>Conclusion</h3><div>Results suggest individuals with moderate or greater KOA symptoms may benefit more from EBIs than those with less severe symptoms and that group-based PT is a promising approach for KOA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100571"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Friction of osteoarthritic cartilage with patient-specific synovial fluid: Effect of different loading conditions","authors":"Luisa de Roy ,&nbsp;Jonas Walter Metzger ,&nbsp;Martin Faschingbauer ,&nbsp;Anita Ignatius ,&nbsp;Andreas Martin Seitz","doi":"10.1016/j.ocarto.2025.100568","DOIUrl":"10.1016/j.ocarto.2025.100568","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to quantify the friction coefficients of degenerated human cartilage lubricated with patient-specific synovial fluid under four different loading regimes in order to identify those regimes that cause the highest friction.</div></div><div><h3>Method</h3><div>Lateral tibial plateaus and synovial fluid samples were obtained from six patients undergoing total knee replacement surgery. Friction tests were performed on cylindrical samples using an established cartilage against glass tribometer. Four different loading regimes were applied, representing physiologic loads and velocities observed during daily activities. To account for effects of osteoarthritis (OA)-related alterations in the synovial fluid (SF) on friction, patient-specific SF was used as lubricant. Friction coefficients were derived from the first (μ₀) and final 60 ​s (μ_end) of testing.</div></div><div><h3>Results</h3><div>Under stance phase conditions, friction was lowest at the beginning of testing (μ₀ ​= ​0.021), but increased the most (+276 %, μ_end ​= ​0.079) compared to low (+47 %) and moderate loading regimes (+31 %). Under swing phase conditions low friction was maintained over time (+0 %, μ₀ ​= ​0.041, μ_end ​= ​0.041).</div></div><div><h3>Conclusion</h3><div>The friction properties of degenerated cartilage samples indicated a strong dependency on the loading regime, whereby prolonged stance phase loading led to the highest time-dependent increase in friction. Moreover, our data suggested that osteoarthritic synovial fluid was sufficient to provide low cartilage friction.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100568"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants","authors":"A. Hashmi ,&nbsp;S. Scott ,&nbsp;M. Jung ,&nbsp;Q.-J. Meng ,&nbsp;J.H. Tobias ,&nbsp;R.A. Beynon ,&nbsp;B.G. Faber","doi":"10.1016/j.ocarto.2025.100565","DOIUrl":"10.1016/j.ocarto.2025.100565","url":null,"abstract":"<div><h3>Objectives</h3><div>Shift work-induced circadian rhythm disruption has been identified as a risk factor for specific diseases. Additionally, physically demanding work has been linked to osteoarthritis. This study investigated the independent associations of shift work and physical work with risk of osteoarthritis.</div></div><div><h3>Design</h3><div>UK Biobank participants completed questionnaires detailing their employment status, including shift work, night shifts, heavy manual work and prolonged non-sedentary work. Responses were categorised into binary and categorical variables. Knee and hip osteoarthritis diagnoses were extracted from hospital records and osteoarthritis (any site) was self-reported. Logistic regression models, adjusted for age, sex, BMI, Townsend Deprivation Index and other work factors, were used to investigate the relationships between work characteristics and osteoarthritis outcomes.</div></div><div><h3>Results</h3><div>This study included 285,947 participants (mean age 52.7 years; males 48.0 ​%). Shift work and night shifts were associated with knee osteoarthritis (fully adjusted OR: 1.12 [95 ​% CI:1.07–1.17] and 1.12 [1.04–1.20], respectively), and self-reported osteoarthritis but there was little evidence of an association with hip osteoarthritis (1.01 [0.95–1.08] and 1.03 [0.93–1.14]). Heavy manual work and prolonged non-sedentary work were associated with increased risk of all osteoarthritis outcomes.</div></div><div><h3>Conclusions</h3><div>Shift work showed independent associations with knee osteoarthritis and self-reported osteoarthritis but not hip osteoarthritis, suggesting circadian rhythm dysfunction may play a role in knee osteoarthritis pathogenesis. Heavy manual work and prolonged non-sedentary work were associated with all outcomes, with stronger associations in knee osteoarthritis, possibly reflecting the knee’s higher susceptibility to biomechanical stress. Further research is needed to explore workplace interventions for reducing these risks.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100565"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}