Osteoarthritis and cartilage open最新文献

{"title":"Postnatal deletion of Phlpp1 in chondrocytes delays post-traumatic osteoarthritis in male mice","authors":"Samantha R. Weaver ,&nbsp;Katherine M. Arnold ,&nbsp;Eduardo Peralta-Herrera ,&nbsp;Manuela Oviedo ,&nbsp;Elizabeth L. Zars ,&nbsp;Elizabeth W. Bradley ,&nbsp;Jennifer J. Westendorf","doi":"10.1016/j.ocarto.2024.100525","DOIUrl":"10.1016/j.ocarto.2024.100525","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis is a chronic, debilitating disease that causes long-term pain and immobility. Germline deletion of Phlpp1 or administration of small molecules that inhibit Phlpp1 prevents post-traumatic osteoarthritis (PTOA) in mice. However, the chondrocyte-intrinsic role of Phlpp1 in PTOA progression is unknown. The objective of this study was to determine how postnatal, chondrocyte-directed deletion of Phlpp1 affects PTOA progression in the presence or absence of Phlpp inhibitors.</div></div><div><h3>Design</h3><div>Phlpp1^fl/fl; Agc-Cre^ERT2 and Agc-Cre^ERT2 mice were injected with tamoxifen at 12 weeks of age to generate Phlpp1-CKO_AgcERT and control (AgcERT) groups. Male mice underwent surgery to destabilize the medial meniscus (DMM) at 17 weeks of age. A separate cohort of male Phlpp1-CKO_AgcERT mice were administered an intra-articular injection of NSC117079, a Phlpp1/2 inhibitor, or saline seven weeks after DMM surgery. Activity and mechanical allodynia were monitored throughout the experiment and cartilage damage was evaluated 12 weeks post-surgery.</div></div><div><h3>Results</h3><div>Phlpp1-CKO_AgcERT mice had less cartilage damage than AgcERT littermates 12 weeks after DMM surgery but exhibited no differences in activity. Prg4 expression was also higher in articular chondrocytes of Phlpp1-CKO_AgcERT mice. Intra-articular administration of NSC117079 to Phlpp1-CKO_AgcERT mice improved cartilage structure, subchondral bone sclerosis, and mechanical allodynia at 12 weeks post-DMM.</div></div><div><h3>Conclusions</h3><div>Postnatal deletion of Phlpp1 in chondrocytes attenuates DMM-induced cartilage damage and subchondral bone sclerosis but does not prevent pain-related behaviors. Intra-articular injection of Phlpp inhibitors delays mechanical allodynia in Phlpp1-CKO_AgcERT mice. These data indicate that Phlpp1 in chondrocytes affects articular cartilage structure after injury, but pain-related behaviors are controlled by Phlpp1 or Phlpp2 in other cell types.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between changes in leg extensor muscle power and physical function after supervised exercise in patients with hip osteoarthritis. Secondary analysis from the hip booster trial","authors":"Troels Kjeldsen ,&nbsp;Ulrik Dalgas ,&nbsp;Søren T. Skou ,&nbsp;Frederik N. Foldager ,&nbsp;Bo M. Bibby ,&nbsp;Inger Mechlenburg","doi":"10.1016/j.ocarto.2024.100523","DOIUrl":"10.1016/j.ocarto.2024.100523","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate associations between changes in leg extensor muscle power of the affected limb (ΔLEP) and changes in physical function after 12 weeks of progressive resistance training (PRT) or neuromuscular exercise (NEMEX) in patients with hip osteoarthritis.</p></div><div><h3>Design</h3><p>Secondary analyses of a randomized controlled trial. From 160 participants enrolled in the clinical trial and cluster randomized to PRT (n ​= ​82) or NEMEX (n ​= ​78), a total of 147 (92%) had complete follow-up data and were included in the analyses. Simple linear and multivariate linear regression models estimated the crude and adjusted associations between ΔLEP normalized to body weight (watt/kg) and changes in performance-based and patient-reported measures of physical function.</p></div><div><h3>Results</h3><p>Adjusted estimates [95% confidence intervals] showed associations between ΔLEP (watt/kg) and changes in 30-s chair stand test (β: 2.34 [1.33; 3.35], R²: 0.13), 9-step timed stair climb test (β: −1.47 [-2.09; −0.85], R²: 0.38), 40-m fast paced walking test (β: −2.20 [-3.30; −1.11], R²: 0.09), Activities of Daily Life function (β: 8.63 [3.16; 14.10], R²: 0.23) and Sport and Recreation function (β: 10.57 [2.32; 18.82], R²: 0.21) subscales from the Hip disability and Osteoarthritis Outcomes Score. Group allocation to PRT did not lead to greater regression coefficients than in NEMEX.</p></div><div><h3>Conclusions</h3><p>Changes in leg extensor muscle power after supervised exercise are consistently associated with changes in physical function across performance-based and patient-reported measures in patients with hip osteoarthritis. These associations seem to be independent of allocation to PRT or NEMEX.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100523"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000906/pdfft?md5=95c386dcd34f5c693f37480cb6ac5883&pid=1-s2.0-S2665913124000906-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of an oral complementary medicine combination in people with symptomatic knee osteoarthritis: Protocol for the double-blind, randomized, placebo-controlled ATLAS trial","authors":"Arashi Shahid ,&nbsp;Xiaoqian Liu ,&nbsp;Karen Bracken ,&nbsp;Robin Christensen ,&nbsp;Leticia Alle Deveza ,&nbsp;Simone Collins ,&nbsp;Joanna Harnett ,&nbsp;David J. Hunter ,&nbsp;Andrew J. McLachlan ,&nbsp;Sarah Robbins ,&nbsp;Jocelyn L. Bowden","doi":"10.1016/j.ocarto.2024.100522","DOIUrl":"10.1016/j.ocarto.2024.100522","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the efficacy and safety of an oral complementary medicine combination formulation relative to placebo, on changes in pain intensity from baseline to week 12, in people with knee osteoarthritis (OA).</p></div><div><h3>Design</h3><p>A placebo-controlled, double-blind, two-arm, superiority, phase II, Randomized Controlled Trial (RCT) (ACTRN12623000380695). We will recruit 82 participants (∼41 per arm), aged ≥40 years, with a clinical diagnosis of symptomatic knee OA and radiographic change on x-ray (Kellgren-Lawrence Grade ≥2). Participants will be randomly allocated to receive either a complementary medicine formulation containing a daily dose of <em>Boswellia serrata</em> extract (Boswellin® Super, 250 ​mg/day), pine bark extract (Fenoprolic™ 70 Organic 100 ​mg/day), curcumin (500 ​mg/day), piperine (5 ​mg/day), and methylsulfonylmethane (MSM, 1500 ​mg/day), or placebo, for 12-weeks. The primary endpoint will be change from baseline in average knee pain intensity at 12-weeks (visual analogue scale). Secondary endpoints will include change in knee pain from baseline to 12-weeks in the Knee Injury and Osteoarthritis Outcome Score (KOOS), global assessment of disease activity, global rating of change, and health-related quality of life (AQoL-8D).</p></div><div><h3>Ethics and dissemination</h3><p>This protocol has been approved by the University of Sydney Human Research Ethics Committee (#2021/877). Dissemination will occur through lay summaries, infographics, conference abstracts, oral presentations, theses, and scientific publications.</p></div><div><h3>Conclusion</h3><p>This RCT will provide credible evidence about the efficacy and safety of this complementary medicine combination and inform updates to international clinical practice standards on the use of complementary medicines in the management of symptomatic knee OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100522"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266591312400089X/pdfft?md5=d1c5734d318abefb68d2c1e222b0edd0&pid=1-s2.0-S266591312400089X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Osteoarthritis scoring system to separate typical OA joint degeneration from non-typical lesions in male Sprague Dawley rats","authors":"Nada Abughazaleh ,&nbsp;Ruth-Anne Seerattan ,&nbsp;David A. Hart ,&nbsp;Raylene A. Reimer ,&nbsp;Walter Herzog","doi":"10.1016/j.ocarto.2024.100521","DOIUrl":"10.1016/j.ocarto.2024.100521","url":null,"abstract":"<div><h3>Objective</h3><p>To develop a novel scoring system to characterize osteoarthritis-related degeneration distinct from spontaneous subchondral bone lesions observed in the tibia and femur of male Sprague Dawley rats.</p></div><div><h3>Method</h3><p>Knee joints from male rats following 12 weeks of a diet-induced obesity model of osteoarthritis (OA) were assessed. OA histopathological changes (OAHC) were assessed in the knee joints. All scores were evaluated using a modified Mankin score and a modified Osteoarthritis Research Society International histological score. OAHC were divided into 3 categories: (I) Typical OA score evaluating the changes in cartilage structure, cellularity, proteoglycan depletion, and tidemark integrity, (II) A novel Non-typical OA score evaluating cartilage integrity, and the size of local thickening, fragmentation and degeneration along the tidemark and the size and severity of the subchondral bone lesion, and (III) Total OA score comprised of both, the Typical and the Non-typical scores.</p></div><div><h3>Results</h3><p>Rats exposed to a high fat/high sucrose diet had higher Typical OA score compared to a control group (Chow). Non-typical and Total OA scores revealed no differences in the severity of the lesions between the HFS and the Chow group animals. All scoring systems had excellent intra- and inter-examiner reliability.</p></div><div><h3>Conclusion</h3><p>The spontaneous bone lesions observed in male Sprague Dawley rats can obscure the effect of the diet-induced obesity if the classical scoring system is used to assess joint degeneration. The newly proposed scoring method provides a reliable method to distinguish classical OA joint degeneration from spontaneous Non-typical lesions occurring in these rats.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000888/pdfft?md5=7eb89a62b40a993fe2c8f1c9d6a7880c&pid=1-s2.0-S2665913124000888-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study","authors":"Sten Rasmussen ,&nbsp;Christopher Aboo ,&nbsp;Jacob Skallerup ,&nbsp;Allan Stensballe","doi":"10.1016/j.ocarto.2024.100514","DOIUrl":"10.1016/j.ocarto.2024.100514","url":null,"abstract":"<div><h3>Objective</h3><p>In a previous pilot study, we have shown that intraarticular gold micro-particles can reduce knee osteoarthritis (KOA) pain at two years follow-up. Proteomic changes in serum and synovial fluid within eight weeks were associated with multiple inflammatory and immunological processes. The relation between the different biomarkers and the outcome measures is not known. We hypothesized that improvement in pain and function were associated with specific groups of biomarkers. We present the integrative analyses between proteomic biomarkers and outcomes.</p></div><div><h3>Design</h3><p>A cohort of 30 patients, with moderate KOA, were included. Using the patients’ synovial fluid as the carrier, 20 ​mg gold microparticles were injected intraarticularly. Clinical outcome measures at inclusion, 8 weeks, and 2 years, were the PainDetect questionnaire, WOMAC pain, stiffness, and function. In addition, Quantitative Sensory Testing, Pain Pressure Threshold, Temporal Summation, Conditioned Pain Modulation, and pain diary were assessed at inclusion and after 8 weeks. Proteomic analysis was performed on SF and blood samples before and after 8 weeks of treatment.</p></div><div><h3>Results</h3><p>Linear combinations of serum or synovial biomarkers changed significantly alongside the effect measures and PainDetect scores following gold micro-particle treatment. Of particular interest was identifying multiple members of a molecular complex that is suggestive of neural tissue regeneration and modulation following gold micro-particle treatment.</p></div><div><h3>Conclusions</h3><p>Gold microparticles are a possible future option for the treatment of knee osteoarthritis. The treatment triggers putative regenerative and inflammation-modulating molecular mechanisms.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100514"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000815/pdfft?md5=7a36a8aab88d0d54537cf3daf9406d2b&pid=1-s2.0-S2665913124000815-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-modal evaluation of experimental pain and psychological function in women with carpometacarpal osteoarthritis","authors":"Tamara Ordonez Diaz ,&nbsp;Terrie Vasilopoulos ,&nbsp;Thomas W. Wright ,&nbsp;Yenisel Cruz-Almeida ,&nbsp;Jennifer A. Nichols","doi":"10.1016/j.ocarto.2024.100515","DOIUrl":"10.1016/j.ocarto.2024.100515","url":null,"abstract":"<div><h3>Objective</h3><p>Thumb carpometacarpal osteoarthritis (CMC1 OA) is a prevalent and debilitating condition that lacks effective treatments. Understanding the multidimensional pain experience across CMC1 OA disease stages is crucial to improving treatment outcomes. This study examined how radiographic CMC1 OA severity is associated with physical, psychological, and somatosensory function.</p></div><div><h3>Method</h3><p>Thirty-one women with early-stage (Eaton-Littler 1–2) or end-stage (Eaton-Littler 3–4) radiographic CMC1 OA completed validated questionnaires to assess pain, disability, and psychological function. Additionally, experimental pain was measured in each participant using quantitative sensory testing (QST) (mechanical, pressure, vibratory, thermal) at seven body sites (thenar, hypothenar, brachioradialis bi-laterally; quadriceps on affected side). Cohort differences (early-vs. end-stage) across all variables were analyzed using a multivariable modeling approach that included fixed effects and interactions; notably, age was controlled as a confounder.</p></div><div><h3>Results</h3><p>End-stage CMC1 OA participants had higher scores in the pain (p ​= ​0.01) and function (p ​= ​0.02) portions of the AUSCAN assessment, self-reported disability of the DASH questionnaire (p ​= ​0.04), and painDETECT scores (p ​= ​0.03), indicating greater pain and disability compared to early-stage participants. Additionally, end-stage CMC1 OA participants demonstrated reduced vibratory detection and heat pain thresholds at multiple body sites (p's ​&lt; ​0.05), with significant interactions observed across the mechanical and cold stimuli.</p></div><div><h3>Conclusion</h3><p>Findings revealed women with end-stage CMC1 OA exhibited increased neuropathic pain characteristics and somatosensory loss compared to those with early-stage CMC1 OA. These results underscore the importance of addressing both peripheral and centralized pain mechanisms and the need for multimodal approaches in the treatment of CMC1 OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100515"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000827/pdfft?md5=4fd69a3a578dd41d6041495c5fb7823e&pid=1-s2.0-S2665913124000827-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KArAT (Knee Arthroplasty Activity Trial): Rationale and design features of a multicenter randomized controlled trial","authors":"Elena Losina ,&nbsp;Jamie E. Collins ,&nbsp;Mahima Kumara ,&nbsp;Linda Ehrlich-Jones ,&nbsp;Maame Opare-Addo ,&nbsp;Clare Safran-Norton ,&nbsp;Neil A. Segal ,&nbsp;Lauren M. Mitchell ,&nbsp;Paul T. Kopp ,&nbsp;Faith Selzer ,&nbsp;Hanna Mass ,&nbsp;Michael Paskewicz ,&nbsp;Rowland W. Chang ,&nbsp;Dorothy Dunlop ,&nbsp;Antonia F. Chen ,&nbsp;Samuel Lerner ,&nbsp;Samantha Chin ,&nbsp;Christine Pellegrini ,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2024.100512","DOIUrl":"10.1016/j.ocarto.2024.100512","url":null,"abstract":"<div><h3>Background</h3><div>Total knee arthroplasty (TKA) is commonly performed to relieve pain in persons with severe knee osteoarthritis. Despite substantial pain reduction and functional improvements, physical activity (PA) does not necessarily increase post TKA. The premise for this randomized trial is that a behavioral intervention invoking internal and external motivators could lead to improvement in PA uptake post TKA.</div></div><div><h3>Methods</h3><div>KArAT (the Knee Arthroplasty Activity Trial) is a three-arm multi-center randomized controlled trial designed to establish the efficacy and sustainability of a personalized behavioral intervention in improving PA among TKA recipients with a primary diagnosis of knee osteoarthritis. The three arms include: 1) usual care, 2) attention control with Fitbit activity trackers, and 3) health coaching and financial incentives for reaching personalized PA goals. The primary outcome is defined as the proportion of participants engaged in at least 150 ​min of moderate-to-vigorous physical activity over a given week after the 6-month intervention. We also plan to conduct a cost-effectiveness analysis to establish the value and affordability of the KArAT interventions.</div></div><div><h3>Discussion</h3><div>This paper aims to outline the rationale, study design, and implementation of KArAT.</div></div><div><h3>Trial Registration</h3><div>Clinicaltrials.gov <span><span>NCT04107649</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100512"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study","authors":"Felix Eckstein ,&nbsp;Susanne Maschek ,&nbsp;Wolfgang Wirth ,&nbsp;Christoph Ladel ,&nbsp;Asger Reinstrup Bihlet ,&nbsp;Chris Knight ,&nbsp;Kenneth Somberg ,&nbsp;Luping Zhao","doi":"10.1016/j.ocarto.2024.100513","DOIUrl":"10.1016/j.ocarto.2024.100513","url":null,"abstract":"<div><h3>Objective</h3><p>Post-treatment cartilage morphometry in the FORWARD study was performed without blinding to MRI acquisition order, involving potential reader bias. Here we obtained unbiased estimates of cartilage change post-treatment, reading year (Y)2 and Y5 MRIs with blinding to time point. We studied whether post-treatment cartilage thickness change differed between sprifermin- and placebo-treated knees.</p></div><div><h3>Methods</h3><p>FORWARD was a 5-year randomized control trial in 549 knee osteoarthritis patients. Here, Y2/Y5 images were analyzed with blinding to relative temporal order and treatment group. Cartilage change during Y2→Y5 was obtained in 337 participants: n ​= ​57 treated with placebo intra-articular injections every 6 months (q6M); n ​= ​69 with 30 ​μg sprifermin every 12 months (q12 ​M), n ​= ​67 with 30 ​μg q6M, n ​= ​73 with 100 ​μg q12 ​M, and n ​= ​71 with 100 ​μg q6M between baseline (BL) and 18 ​M. Total femorotibial joint (TFTJ) cartilage thickness was the primary analytic focus.</p></div><div><h3>Results</h3><p>TFTJ cartilage thickness change during Y2→Y5 was −26μm (SD64; 95%CI -32,-19) across the cohort; no statistically significant difference (p ​= ​0.80) was observed between Sprifermin treated or placebo arms (one-way ANOVA). All groups lost cartilage, but the treatment-related difference in cartilage thickness in Sprifermin arms relative to placebo at Y2 was maintained until Y5. Annualized cartilage change in placebo participants was −8.2 ​μm (SD21; 95%CI -14,-2.5) during Y2→Y5 vs. −5.4 ​μm (SD27; 95%CI -13,1.8) during BL→Y2; no significant difference was identified (<em>t</em>-test).</p></div><div><h3>Conclusion</h3><p>FORWARD is the first study evaluating post-treatment benefits of a potential disease modifying osteoarthritis drug. Cartilage thickness gained with 100 ​μg sprifermin at Y2 is maintained to Y5 and thus appears viable and sustainable.</p><p>This is a post-hoc analysis of the FORWARD trial: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: NCT01919164.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100513"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000803/pdfft?md5=862e7f47b535b92ba1ddb27a2b95b9d7&pid=1-s2.0-S2665913124000803-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities","authors":"João Henriques ,&nbsp;Francis Berenbaum ,&nbsp;Ali Mobasheri","doi":"10.1016/j.ocarto.2024.100511","DOIUrl":"10.1016/j.ocarto.2024.100511","url":null,"abstract":"<div><div>Osteoarthritis (OA) is a significant global burden, affecting more than half a billion people across the world. It is characterized by degeneration and loss of articular cartilage, synovial inflammation, and subchondral bone sclerosis, leading to pain and functional impairment. After age, obesity is a major modifiable risk factor for OA, and it has recently been identified as a chronic disease by the World Health Organization (WHO). Obesity is associated with high morbidity and mortality, imposing a significant cost on individuals and society. Obesity increases the risk of knee OA through increased joint loading, altered body composition, and elevated pro-inflammatory adipokines in the systemic circulation. Moreover, obesity triggers fibrotic processes in different organs and tissues, including those involved in OA. Fibrosis in OA refers to the abnormal accumulation of fibrous tissue within and around the joints. It can be driven by increased adiposity, low-grade inflammation, oxidative stress, and metabolic alterations. However, the clinical outcomes of fibrosis in OA are unclear. This review focuses on the link between obesity and OA, explores the mechanism of obesity-driven fibrosis, and examines potential therapeutic opportunities for targeting fibrotic processes in OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 4","pages":"Article 100511"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and agreement of manual and automated morphological radiographic hip measurements","authors":"F. Boel ,&nbsp;N.S. Riedstra ,&nbsp;J. Tang ,&nbsp;D.F. Hanff ,&nbsp;H. Ahedi ,&nbsp;V. Arbabi ,&nbsp;N.K. Arden ,&nbsp;S.M.A. Bierma-Zeinstra ,&nbsp;M.M.A. van Buuren ,&nbsp;F.M. Cicuttini ,&nbsp;T.F. Cootes ,&nbsp;K. Crossley ,&nbsp;D. Eygendaal ,&nbsp;D.T. Felson ,&nbsp;W.P. Gielis ,&nbsp;J. Heerey ,&nbsp;G. Jones ,&nbsp;S. Kluzek ,&nbsp;N.E. Lane ,&nbsp;C. Lindner ,&nbsp;R. Agricola","doi":"10.1016/j.ocarto.2024.100510","DOIUrl":"10.1016/j.ocarto.2024.100510","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the reliability and agreement of manual and automated morphological measurements, and agreement in morphological diagnoses.</p></div><div><h3>Methods</h3><p>Thirty pelvic radiographs were randomly selected from the World COACH consortium. Manual and automated measurements of acetabular depth-width ratio (ADR), modified acetabular index (mAI), alpha angle (AA), Wiberg center edge angle (WCEA), lateral center edge angle (LCEA), extrusion index (EI), neck-shaft angle (NSA), and triangular index ratio (TIR) were performed. Bland-Altman plots and intraclass correlation coefficients (ICCs) were used to test reliability. Agreement in diagnosing acetabular dysplasia, pincer and cam morphology by manual and automated measurements was assessed using percentage agreement. Visualizations of all measurements were scored by a radiologist.</p></div><div><h3>Results</h3><p>The Bland-Altman plots showed no to small mean differences between automated and manual measurements for all measurements except for ADR. Intraobserver ICCs of manual measurements ranged from 0.26 (95%-CI 0–0.57) for TIR to 0.95 (95%-CI 0.87–0.98) for LCEA. Interobserver ICCs of manual measurements ranged from 0.43 (95%-CI 0.10–0.68) for AA to 0.95 (95%-CI 0.86–0.98) for LCEA. Intermethod ICCs ranged from 0.46 (95%-CI 0.12–0.70) for AA to 0.89 (95%-CI 0.78–0.94) for LCEA. Radiographic diagnostic agreement ranged from 47% to 100% for the manual observers and 63%–96% for the automated method as assessed by the radiologist.</p></div><div><h3>Conclusion</h3><p>The automated algorithm performed equally well compared to manual measurement by trained observers, attesting to its reliability and efficiency in rapidly computing morphological measurements. This validated method can aid clinical practice and accelerate hip osteoarthritis research.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100510"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000773/pdfft?md5=bae0c0edee31aa2d8632256c86a68ef3&pid=1-s2.0-S2665913124000773-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}