{"title":"评估SPECT/CT对膝关节软骨病变的识别:一项系统综述","authors":"Larissa Rix , Samuel Tushingham , Karina Wright , Martyn Snow","doi":"10.1016/j.ocarto.2025.100577","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.</div></div><div><h3>Objectives</h3><div>To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.</div></div><div><h3>Results</h3><div>PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.</div></div><div><h3>Conclusion</h3><div>Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100577"},"PeriodicalIF":2.8000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review\",\"authors\":\"Larissa Rix , Samuel Tushingham , Karina Wright , Martyn Snow\",\"doi\":\"10.1016/j.ocarto.2025.100577\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.</div></div><div><h3>Objectives</h3><div>To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.</div></div><div><h3>Results</h3><div>PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.</div></div><div><h3>Conclusion</h3><div>Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.</div></div>\",\"PeriodicalId\":74377,\"journal\":{\"name\":\"Osteoarthritis and cartilage open\",\"volume\":\"7 1\",\"pages\":\"Article 100577\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Osteoarthritis and cartilage open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2665913125000135\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteoarthritis and cartilage open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2665913125000135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
单光子发射计算机断层扫描与传统计算机断层扫描(SPECT/CT)是一项新兴技术,可能对膝关节软骨病变的识别具有临床价值。SPECT/CT摄取示踪剂的强度和分布可以在其他成像方式没有结构变化的情况下识别生理和结构信息。目的系统评估SPECT/CT在伴有或不伴有结构改变的膝关节疼痛患者中检测膝关节软骨病变的应用价值。结果检索spubmed、Science Direct、Web of Knowledge和NHS数据库,查找有关SPECT/CT对膝关节软骨病变和膝关节疼痛诊断价值的英文文章。排除动物研究、尸体研究、SPECT/CT以外的比较放射学技术或膝关节软骨病变以外的病理患者。从搜索中,确定了11,982份手稿,并筛选了相关性。有7项研究在QUADAS-2偏倚评价中得分较低。SPECT/CT与其他成像方式及术中评估发现的病变相关。此外,在某些情况下,SPECT/CT在检测软骨病变方面优于其他方式。结论有证据表明SPECT/CT可能是检测和定位软骨病变的有用工具,特别是在其他成像方式没有病变或与患者症状缺乏相关性的差异病例中。需要进一步的研究来证实这一综述的结论。
Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review
Background
Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.
Objectives
To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.
Results
PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.
Conclusion
Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.