Friction of osteoarthritic cartilage with patient-specific synovial fluid: Effect of different loading conditions

IF 2.8

Osteoarthritis and cartilage open Pub Date : 2025-01-16 DOI:10.1016/j.ocarto.2025.100568

Luisa de Roy , Jonas Walter Metzger , Martin Faschingbauer , Anita Ignatius , Andreas Martin Seitz

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Abstract

Objective

The objective of this study was to quantify the friction coefficients of degenerated human cartilage lubricated with patient-specific synovial fluid under four different loading regimes in order to identify those regimes that cause the highest friction.

Method

Lateral tibial plateaus and synovial fluid samples were obtained from six patients undergoing total knee replacement surgery. Friction tests were performed on cylindrical samples using an established cartilage against glass tribometer. Four different loading regimes were applied, representing physiologic loads and velocities observed during daily activities. To account for effects of osteoarthritis (OA)-related alterations in the synovial fluid (SF) on friction, patient-specific SF was used as lubricant. Friction coefficients were derived from the first (μ₀) and final 60 s (μ_end) of testing.

Results

Under stance phase conditions, friction was lowest at the beginning of testing (μ₀ = 0.021), but increased the most (+276 %, μ_end = 0.079) compared to low (+47 %) and moderate loading regimes (+31 %). Under swing phase conditions low friction was maintained over time (+0 %, μ₀ = 0.041, μ_end = 0.041).

Conclusion

The friction properties of degenerated cartilage samples indicated a strong dependency on the loading regime, whereby prolonged stance phase loading led to the highest time-dependent increase in friction. Moreover, our data suggested that osteoarthritic synovial fluid was sufficient to provide low cartilage friction.

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骨关节炎软骨与患者特异性滑液的摩擦：不同载荷条件的影响

目的本研究的目的是量化在四种不同的加载机制下，由患者特定的滑液润滑的退行性软骨的摩擦系数，以确定导致最高摩擦的那些机制。方法采集6例全膝关节置换术患者胫骨外侧平台及滑液标本。使用已建立的软骨与玻璃摩擦计对圆柱形样品进行摩擦试验。应用了四种不同的负荷制度，代表日常活动中观察到的生理负荷和速度。为了解释骨关节炎（OA）相关的滑液（SF）改变对摩擦的影响，患者特异性的SF被用作润滑剂。摩擦系数由试验的第一个（μ0）和最后60 s （μend）得到。结果在站立相条件下，摩擦在试验开始时最低（μ0 = 0.021），但与低加载（+ 47%）和中等加载（+ 31%）相比，摩擦增加最多（+276 %,μend = 0.079）。在摆动相条件下，随时间保持低摩擦（+ 0%,μ0 = 0.041, μend = 0.041）。结论：退行性软骨样品的摩擦特性与加载方式密切相关，延长的站立阶段加载导致最大的时间依赖性摩擦增加。此外，我们的数据表明，骨关节炎滑液足以提供低软骨摩擦。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量