非洲黑人膝骨关节炎的临床表型和相关因素

IF 2.8
Charles Sougué , Malick Diallo , Yannick Laurent Tchenadoyo Bayala , Ismaël Ayouba Tinni , Fulgence Kaboré , Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo , Patrick Wendpouiré Hamed Dakouré , Dieu-Donné Ouedraogo
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引用次数: 0

摘要

我们的目的是研究撒哈拉以南非洲黑人人群的风湿病膝骨关节炎的临床表型。方法本研究于2022年10月1日至2023年9月30日在风湿病科进行。研究对象是患有膝骨关节炎的成年患者。研究人员使用k均值聚类分析来确定不同的表型,并使用逻辑回归来确定相关因素。结果共纳入321例患者。平均年龄58.7岁(21 ~ 92岁),性别比0.23 (M/F)。本研究通过聚类鉴定出5种临床表型:152例(47.3%)患者表现为“骨质疏松”表型,113例(35.2%)患者表现为“代谢”表型,17例(5.3%)患者表现为“遗传”表型,24例(7.4%)患者表现为“生物力学”表型,15例(4.6%)患者表现为“创伤后”表型。“骨质疏松”表型在60岁及以上的患者中更为常见(or = 1.13 [1.10;[1.16], p <;0.0001)和女性(OR = 2.44 [1.20;4.94], p <;0.0001)。另一方面,“创伤后”表型在60岁以下的患者中更为常见(OR = 1.93;[1.96], p <;0.0001)和胫股骨关节炎(OR = 0.44 [0.21;0.94], p = 0.034)。结论骨质疏松和代谢表型是最常见的表型。骨质疏松表型在60岁以上的女性和患者中更为常见,而创伤后表型在60岁以下的胫股骨关节炎中更为普遍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical phenotypes and associated factors in knee osteoarthritis in an African black population

Objective

Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.

Methods

This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.

Results

A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 ​%) exhibited the “osteoporotic” phenotype, 113 patients (35.2 ​%) exhibited the “metabolic” phenotype, 17 patients (5.3 ​%) exhibited the “genetic” phenotype, 24 patients (7.4 ​%) exhibited the “biomechanical” phenotype, and 15 patients (4.6 ​%) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR ​= ​1.13 [1.10; 1.16], p ​< ​0.0001) and in women (OR ​= ​2.44 [1.20; 4.94], p ​< ​0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR ​= ​1.93 [1.91; 1.96], p ​< ​0.0001) and in those with tibiofemoral osteoarthritis (OR ​= ​0.44 [0.21; 0.94], p ​= ​0.034).

Conclusion

The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.
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来源期刊
Osteoarthritis and cartilage open
Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation
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